CN107406451B - 作为泛素特异性蛋白酶7抑制剂的吡咯并嘧啶和吡唑并嘧啶 - Google Patents

作为泛素特异性蛋白酶7抑制剂的吡咯并嘧啶和吡唑并嘧啶 Download PDF

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Publication number
CN107406451B
CN107406451B CN201580077002.3A CN201580077002A CN107406451B CN 107406451 B CN107406451 B CN 107406451B CN 201580077002 A CN201580077002 A CN 201580077002A CN 107406451 B CN107406451 B CN 107406451B
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methyl
pyrimidin
pyrazolo
phenyl
hydroxypiperidin
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CN107406451A (zh
Inventor
S.约安尼迪斯
A.C.塔尔博特
B.福洛斯
A.J.巴克梅尔特
M.王
A-M.坎贝尔
D.R.施密特
D.J.格林
J.A.卡拉韦拉
R.B.迪博尔德
A.埃里克森
小戴维.兰西亚
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Overall Early Discovery Co ltd
Wallow Early Discovery Inc
Valo Health Inc
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Forma Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201580077002.3A 2014-12-30 2015-12-29 作为泛素特异性蛋白酶7抑制剂的吡咯并嘧啶和吡唑并嘧啶 Active CN107406451B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098141P 2014-12-30 2014-12-30
US62/098,141 2014-12-30
PCT/US2015/067831 WO2016109515A1 (en) 2014-12-30 2015-12-29 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

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CN107406451A CN107406451A (zh) 2017-11-28
CN107406451B true CN107406451B (zh) 2019-12-17

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EP (2) EP3240791B1 (enExample)
JP (1) JP6649388B2 (enExample)
KR (1) KR102581827B1 (enExample)
CN (1) CN107406451B (enExample)
AR (1) AR103297A1 (enExample)
AU (2) AU2015374170B2 (enExample)
CA (1) CA2972797C (enExample)
CL (1) CL2017001687A1 (enExample)
CO (1) CO2017006997A2 (enExample)
EA (1) EA038204B1 (enExample)
EC (1) ECSP17049010A (enExample)
ES (1) ES2768996T3 (enExample)
IL (1) IL252773A0 (enExample)
MA (1) MA40706A1 (enExample)
MX (2) MX373788B (enExample)
PH (1) PH12017501224A1 (enExample)
SA (1) SA517381839B1 (enExample)
SG (1) SG11201704897QA (enExample)
TW (2) TWI770525B (enExample)
WO (1) WO2016109515A1 (enExample)
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