CN107406421A - sGC刺激物 - Google Patents
sGC刺激物 Download PDFInfo
- Publication number
- CN107406421A CN107406421A CN201580062197.4A CN201580062197A CN107406421A CN 107406421 A CN107406421 A CN 107406421A CN 201580062197 A CN201580062197 A CN 201580062197A CN 107406421 A CN107406421 A CN 107406421A
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- Prior art keywords
- alkyl
- yuan
- ring
- hetero
- circle heterocycles
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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| US201562204698P | 2015-08-13 | 2015-08-13 | |
| US62/204,698 | 2015-08-13 | ||
| PCT/US2015/050467 WO2016044446A2 (en) | 2014-09-17 | 2015-09-16 | Sgc stimulators |
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| CN107406421A true CN107406421A (zh) | 2017-11-28 |
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| CN201580062197.4A Pending CN107406421A (zh) | 2014-09-17 | 2015-09-16 | sGC刺激物 |
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| EP (1) | EP3194386A2 (enExample) |
| JP (1) | JP2017527604A (enExample) |
| CN (1) | CN107406421A (enExample) |
| AU (1) | AU2015317823A1 (enExample) |
| CA (1) | CA2961489A1 (enExample) |
| IL (1) | IL251113A0 (enExample) |
| MX (1) | MX2017003518A (enExample) |
| WO (1) | WO2016044446A2 (enExample) |
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| WO2016044445A2 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| AU2015317818A1 (en) * | 2014-09-17 | 2017-03-23 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| WO2017106175A2 (en) * | 2015-12-14 | 2017-06-22 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION |
| JP7098214B2 (ja) * | 2016-02-01 | 2022-07-11 | サイクレリオン・セラピューティクス，インコーポレーテッド | 非アルコール性脂肪性肝炎（ＮＡＳＨ）の処置のためのｓＧＣ刺激物質の使用 |
| ES2885003T3 (es) * | 2016-09-02 | 2021-12-13 | Cyclerion Therapeutics Inc | Estimuladores de SGC fusionados bicíclicos |
| EP3554488A2 (en) * | 2016-12-13 | 2019-10-23 | Cyclerion Therapeutics, Inc. | Use of sgc stimulators for the treatment of esophageal motility disorders |
-
2015
- 2015-09-16 US US15/511,888 patent/US10844064B2/en not_active Expired - Fee Related
- 2015-09-16 AU AU2015317823A patent/AU2015317823A1/en not_active Abandoned
- 2015-09-16 WO PCT/US2015/050467 patent/WO2016044446A2/en not_active Ceased
- 2015-09-16 MX MX2017003518A patent/MX2017003518A/es unknown
- 2015-09-16 CN CN201580062197.4A patent/CN107406421A/zh active Pending
- 2015-09-16 EP EP15778428.1A patent/EP3194386A2/en not_active Withdrawn
- 2015-09-16 CA CA2961489A patent/CA2961489A1/en not_active Abandoned
- 2015-09-16 JP JP2017515197A patent/JP2017527604A/ja not_active Withdrawn
-
2017
- 2017-03-13 IL IL251113A patent/IL251113A0/en unknown
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| WO2012003405A1 (en) * | 2010-06-30 | 2012-01-05 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2013101830A1 (en) * | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111836811A (zh) * | 2018-03-07 | 2020-10-27 | 塞科里昂医疗股份有限公司 | 制备可溶性鸟苷酸环化酶刺激剂的方法 |
| CN111836811B (zh) * | 2018-03-07 | 2024-11-22 | 帝善多制药公司 | 制备可溶性鸟苷酸环化酶刺激剂的方法 |
| CN111423377A (zh) * | 2020-05-12 | 2020-07-17 | 中国药科大学 | 5-氨基-1h-吡唑衍生物、制备方法及医药用途 |
| CN111423377B (zh) * | 2020-05-12 | 2021-06-01 | 中国药科大学 | 5-氨基-1h-吡唑衍生物、制备方法及医药用途 |
| WO2025102245A1 (zh) * | 2023-11-14 | 2025-05-22 | 浙江天宇药业股份有限公司 | 一种双重内皮素受体拮抗剂阿普昔腾坦的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017527604A (ja) | 2017-09-21 |
| EP3194386A2 (en) | 2017-07-26 |
| WO2016044446A2 (en) | 2016-03-24 |
| CA2961489A1 (en) | 2016-03-24 |
| IL251113A0 (en) | 2017-04-30 |
| WO2016044446A3 (en) | 2016-06-16 |
| US20180155345A1 (en) | 2018-06-07 |
| AU2015317823A1 (en) | 2017-03-23 |
| MX2017003518A (es) | 2017-07-28 |
| US10844064B2 (en) | 2020-11-24 |
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