CN107375894A - Treat outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof - Google Patents

Treat outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof Download PDF

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CN107375894A
CN107375894A CN201710790912.7A CN201710790912A CN107375894A CN 107375894 A CN107375894 A CN 107375894A CN 201710790912 A CN201710790912 A CN 201710790912A CN 107375894 A CN107375894 A CN 107375894A
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parts
chinese medicine
pain
neck
lumbago
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申峰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
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Abstract

Outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof is treated, it belongs to technical field of traditional Chinese medicines.The present invention fully extracts medicinal material active ingredient using ethanol extraction with reference to advanced extraction process, and the root of bidentate achyranthes, anisetree bark, giant knotweed, lycopodium calvatum, which have, is used for dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, for treating arthralgic effect；Notopterygium root, teasel root, snow is upper, and one high, the banksia rose can anti-inflammatory analgetic, dispelling wind and eliminating dampness；Radix ampelopsis, the fruit of summer cypress have the effect of clearing heat and detoxicating, carbuncle that disappears dissipating bind；Radix Angelicae Sinensis, pseudo-ginseng, the radix paeoniae rubrathe, ginger are added to reconcile medicine attribute, Radix Angelicae Sinensis is warm-natured, pseudo-ginseng, the radix paeoniae rubrathe have the function that it is good promoting blood circulation and removing blood stasis, it is ginger acrid flavour, peppery, big heat, unobstructed gods, ward off epidemic disease, and help the gas of hair tonic, energy dispelling wind evil；Fritillary bulb, the addition of dandelion, radix glycyrrhizae, the toxicity that remaining herbal medicine is brought can be released, alleviates the strong of medicine, there is antibacterial, the usage time of the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain can be extended.

Description

Treat outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of outer emplastrum of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain and its preparation Method.
Background technology
Neck-shoulder pain, lumbago and leg pain be mostly caused by chronic strain and aseptic inflammation with patient part pain, swelling even function by It is limited to one group of disease of master.Common disease includes：Cervical spondylopathy, scapulohumeral periarthritis, tenosynovitis, waist dish outstanding, lumbar muscle strain, osteoproliferation Etc. disease.Because onset is more hidden, weight when light when atypical symptom or pain, even can voluntarily alleviate sometimes, thus it is wideless Big patient is recognized, so as to miss the best opportunity for the treatment of.
The pain of neck, shoulder, waist and leg cause of disease is generally acute injury of soft tissue, soft tissue chronic strain or the wet factor of chill etc..
Acute injury of soft tissue is soft tissue by the unexpected strike of external force, gravity compressing and more than soft tissue physiological range Drawing, reverse and caused damage.It can cause the pain of neck, shoulder, waist and leg different parts according to the difference of damage location.It is if acute The non-timely processing of damage and rest, can form chronic migration lesion, clinical signs are：(1) rest pain, pain into A part for life；(2) just fallen ill when the slightly more lost articles found of even bending over of activity, sneezing, in great pain, function limitation；(3) it is overcast and rainy It or wind-engaging are caught a cold and can cause the recurrence or exacerbation of pain.
Soft tissue chronic strain is the reason such as habits and customs or occupational position, such as：It is long-term bow bend over the desk, sitting, it is long when Between bend over and sleeping posture it is improper or using high pillow it is first-class, make Portions of soft tissue for a long time be in drawing state, be pulled tissue Interior blood vessel is chronically at that half is unobstructed and the histanoxia state that is formed, the permeability of blood vessel is changed, haemocyte oozes out, Tissue degeneratiaon, interfibrillar substance increase, and lesion occurs for soft tissue so as to cause neck, waist and leg pain symptom.Many people have such experience, Before sleep well, sleep rear stiff neck；Also just not, waist is as having fractureed seemingly at station after bending over for a long time by somebody 's.The soft tissue of these people is typically accompanied by chronic strain.
The chill of the wet factor of chill is wet to reduce tolerance of the body to pain, shrinks muscle cramp, thin vessels, lymph Backflow slows down, obstacle occurs for soft tissue blood circulation, aseptic inflammation is produced, so as to produce neck-shoulder pain, lumbago and leg pain.Especially soft group The serious patient of lesion is knitted, draught of haveing broken up sometimes, the time on cool stool is sitting in and soon just has an attack of one's old illness.
The expectant treatment of neck-shoulder pain, lumbago and leg pain is taken medicine, forced on, physiotherapy, traction etc., plaster is generally black plaster, red ointment In the majority, plaster application time is short, and curative effect is poor, traditional black plaster using when need to heat and make it have viscosity, when temperature drops Easily from skin exfoliation when low, and heavy metal substance is inevitably introduced in the preparation method of black plaster, red ointment, when long Between stick to human body tool have a certain impact.
The content of the invention
It is an object of the present invention to provide emplastrum outside a kind of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain and preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of outer emplastrum of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain are mainly It is made up of the traditional Chinese medicinal material raw materials of following weight proportion：450~550 parts of fritillary bulb, 900~1100 parts of radix ampelopsis, Radix Angelicae Sinensis 200~300 Part, 200~300 parts of the banksia rose, 900~1100 parts of giant knotweed, 900~1100 parts of the root of bidentate achyranthes, 200~300 parts of anisetree bark, notopterygium root 450~ 550 parts, 450~550 parts of teasel root, 700~800 parts of pseudo-ginseng, 1200~1300 parts of the radix paeoniae rubrathe, upper one high 45~55 parts are avenged, Pu Gong 1450~1550 parts of English, 200~300 parts of radix glycyrrhizae, 80~120 parts of the fruit of summer cypress, 1450~1550 parts of lycopodium calvatum, ginger 2450~ 2550 parts, 80~120 parts of borneol.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, comprises the following steps：
Step 1, the fritillary bulb for weighing according to parts by weight certain mass, radix ampelopsis, Radix Angelicae Sinensis, the banksia rose, giant knotweed, the root of bidentate achyranthes, maple Skin, notopterygium root, teasel root, pseudo-ginseng, the radix paeoniae rubrathe, the upper high, borneol of snow, powder in medicinal herb grinder is respectively placed in by load weighted Chinese medicine Broken, the medicinal powder after crushing is well mixed rear standby；
Step 2, herb powder of the step 1 after well mixed weighed, alleged quality 6 is poured into the herb powder mixed ~10 times of alcoholic solution, carries out alcoholic extract under the cooperation of microwave, uninterrupted microwave, per hour 5~15min of microwave, microwave 300~800Hz of power, 5~10h of alcoholic extract time, takes supernatant stand-by, and remaining filter residue continues to use wine according to the method described above Once, the supernatant merged after extracting twice is stand-by for smart solution extraction；
Step 3, the dandelion for weighing according to parts by weight certain mass, radix glycyrrhizae, the fruit of summer cypress, lycopodium calvatum, ginger, by ginger Section, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, standby after the medicinal powder after crushing is well mixed；
Step 4, herb powder of the step 2 after well mixed weighed, alleged quality is poured into the herb powder mixed 10~15 times of alcoholic solution, refluxing extraction 2 times at 80 DEG C extract 1.5~2h every time, filtering, merge the decoctions of 2 extractions, It is stand-by；
The decoction of step 5, the supernatant of combining step 2 and step 4, by being evaporated under reduced pressure recovered alcohol, control temperature 55 ~65 DEG C, pressure -0.1MPa, obtain Chinese medicine composite extract medicinal extract；
Step 6, Chinese medicine composite extract medicinal extract, 15 made from 10~15 parts of step 5 are weighed according to parts by weight respectively ~30 parts of stearic acid, 5~10 parts of vaseline, 1~3 part of glycerine, 1~3 part of polyethylene glycol, 1~3 part of carbomer, 0.01~0.05 part of ethylparaben, it is stand-by；
Step 7, after mixing load weighted stearic acid and vaseline, 80~85 DEG C are heated to, under conditions of stirring slowly Glycerine, polyethylene glycol, carbomer, ethylparaben are added, is eventually adding Chinese medicine composite extract medicinal extract, treats that temperature drops after mixing Low to 65~70 DEG C, stand cream, press mold, sealing, emplastrum outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is made.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, medicinal herb grinder powder in step 1 Broken 3~10min of time, medicinal herb grinder 1.5~2.5kw of power, 5000~10000rad/min of rotating speed.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, medicinal herb grinder powder in step 3 Broken 1~3min of time, medicinal herb grinder 1.5~2.5kw of power, 5000~10000rad/min of rotating speed.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, Chinese medicine compound collecting in step 5 The density of thing medicinal extract is 1.1~1.2g/ml.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, according to parts by weight in step 6 Chinese medicine composite extract medicinal extract made from 12 parts of step 5,20 parts of stearic acid, 7 parts of vaseline, 2 parts sweet are weighed respectively Oil, 2 parts of polyethylene glycol, 2 parts of carbomer, 0.03 part of ethylparaben are stand-by.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, the substrate that cream is spread out in step 7 are Non-woven fabrics, specification are 16 × 16cm, and press mold material is PP films, pack sealing.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, fritillary bulb is also known as level ground shellfish, fritillaria, flat shellfish, is hundred The bulb of conjunction section plant fritillary bulb, bulb breeding 1-2 harvests, seminal propagation 5-6 harvests.Late May or early June adopt Receive, bulb is dug out, remove soil and fibrous root, dry or dry；It is fritillary bulb bitter, pungent；Cold nature, bulb contain imperialine -3 β-D-Glucose glucoside, imperialine, there is antiulcer action, there is central inhibitory action.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, radix ampelopsis is the dried pieces of vitaceae radix ampelopsis Root, it is bitter in taste, pungent, it is slightly cold, the thoughts of returning home, stomach, Liver Channel, there is the effect of clearing heat and detoxicating, carbuncle that disappears dissipating bind.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, Radix Angelicae Sinensis property of medicine temperature,《Compendium of Materia Medica》Described in when Gui Zhi has a headache, and all pains of trusted subordinate, ease constipation stomach muscles and bones skin, controls ulcer, Apocenosis pain relieving, and blood and enriches blood.Radix Angelicae Sinensis can reduce myocardium excitation Property；Coronary artery is expanded, increases coronary flow；Reduce myocardial oxygen consumption, drop in blood pressure；There are antiarrhythmic effect, anti-atherogenic Hardening effect, also improving micro_circulation effect.Radix Angelicae Sinensis has anti-inflammatory, anti-allergy action.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, the banksia rose are feverfew Aplotaxis auriculata, radix jurineae Dry root, nature and flavor are pungent, bitter, temperature, channel tropism returns spleen, stomach, large intestine, gallbladder channel.Containing volatile oil, saussurine, resin, synanthrin.Volatile oil Main Ingredients and Appearance is constuslactone, costic acid, costol, α-costene and beta-costene etc..Chest gastral cavity distending pain, weight after rush down dysentery, food Product does not disappear, do not feel like eating.Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.Banksia rose pungent-warm perfume (or spice) is dry, with fritillary bulb, radix ampelopsis compatibility, can suppress deficiency of Yin fire It is prosperous, there is the effect of antibacterial and antifungic action, wind dispelling, promoting qi circulation and relieving pain.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, giant knotweed for polygonaceae plant giant knotweed dry rhizome and Root.Spring, the excavation of season in autumn two, remove fibrous root, clean, take advantage of fresh-cut short section or sheet, dry, giant knotweed is mostly cylindrical short section or do not advised Then sheet, long 1~7cm, diameter 0.5~2.5cm.Crust sepia, there are vertical wrinkle and mark of fibrous root, section skin zone is relatively thin, woody part Broadness, brown color, ray irradiation shape, skin zone are more easily separated with woody part.Have in rhizome marrow every or in empty shape.Matter is hard.Its root Fear quinone and anthraquinone glycoside containing free with rhizome.Predominantly rheum emodin, Physcion and Chrysophanol, and anthracene glucoside A, anthracene glucoside B.In root Also contain 3,4 ', 5- resveratrols -3- β-D-Glucose glucoside.It is another contain tannin and several polysaccharide, stem contain tannin 3.3%, Isoquercitrin, Rheum emodin etc..Withe contains tannin 13.4%.Gas is micro-, mildly bitter flavor, puckery.Property slight bitter, be slightly cold, Return liver, courage, lung channel, cure mainly wind-dispelling profit Wet, scattered stasis pain is relieving cough and reducing sputum, for joint pain, injury from falling down, carbuncle sore tumefacting virus.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, the root of bidentate achyranthes is the dry root of the amaranthaceous plant root of bidentate achyranthes.Winter Season cauline leaf it is withered when excavate, remove fibrous root and silt, be bundled into wisp, shine to shriveling, top is trimmed, dry, in elongated circle Cylindricality, slightly bent, upper end is slightly thick, and lower end is thinner, long 15~50cm, 0.4~1cm of diameter.Surface lark or light brown, there is summary Distort and trickle vertical wrinkle, grow crosswise hole skin and sparse radicula trace.Matter is hard and crisp, frangibility, makes moist, and limbers up, section flat Smooth, yellowish-brown, micro- glossy in cutin sample, center vascular bundle woody part is larger, yellow-white, and its periphery dissipates the dimension pipe for having most point-like Beam, it is arranged in 2~4 wheels.Gas is micro-, the micro- sweet tea of taste and it is slightly bitter.The root of bidentate achyranthes is bitter, acid, puts down, and returns liver and kidney channel, filling liver kidney, strengthening the bones and muscles, by The stasis of blood is stimulated the menstrual flow, and is ensuringd proper downward flow of the blood.For soreness of waist and knee joint, muscles and bones is powerless, Amenorrhea abdominal mass, dizziness due to hyperactivity of liver-YANG, life scattered blood stasis, subduing inflammation.Carbuncle It is swollen, traumatic injury.It is ripe to use filling liver kidney, strengthening the bones and muscles.Control control waist and knee ostalgia, spasm of limbs, Impotence numbness.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, anisetree bark is the tree of Winteraceae plant anisetree bark Skin, spring, Qiu Shengjicai.First old strains in more than 10 years, the upper and lower ends of bark are sawed in the side of tree, has knife directly to draw, bark is peeled, Remaining bark, which retains, not to be shelled, and bark is put and dried in the shade outside ventilation.Anisetree bark 0.30%-0.71% containing volatile oil, inside has：α-and β-pinane Alkene (pinene), lauro lene (camphene), 1, 8-Cineole (1,8-cineole), linalool (linalool), safrole (safrole) 28 compositions such as, camphor (camphor), Bronyl acetate (bornylacetate), laurene (myrcene). Property is pungent；It is puckery；It is warm-natured；Mild toxicity, returns spleen；Stomach, there is dispelling wind and eliminating dampness；The function of promoting qi circulation and relieving pain.Cure mainly rheumatic arthritis；Psoas labor Damage.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, notopterygium root is samphire notopterygium root or notopterygium forbesii Drying root and rhizome；Property it is pungent, bitter, temperature.Return bladder, kidney channel, there is cold dispelling, wind-dispelling, dehumidifying, the function of analgesic, cure mainly chill Cold headache, arthralgia pain due to rheumatism, aching pain in shoulder and back, notopterygium root and Radix Angelicae Sinensis compatibility, compensate for notopterygium root deficiency of blood numbness pain and avoid the shortcomings that using.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, teasel root is the drying of Dipsacaceae plant teasel Root.Autumn excavates, and removes root head and fibrous root, is dried to low baking temperature half-dried, when banking up " sweating " to internal virescence, then dries.This Product are in cylinder, slightly flat, some microbends, long 5~15cm, 0.5~2cm of diameter.Surface taupe or yellowish-brown, have and slightly distort Or the vertical wrinkle and rill substantially distorted, it is seen that the hole skin of transverse fissure and a small number of marks of fibrous root.Matter is soft, is hardened after being long placed in, frangibility, section Unevenness, skin zone is blackish green or brown, outer rim brown or filbert, woody part yellowish-brown, vessel cluster are arranged radially.Gas is micro- Perfume (or spice), bitter, micro- sweet tea are then puckery.Teasel root is bitter, tepor, belongs to the yang-tonifying drug classified under qi-restoratives medicine, filling liver kidney, continuous muscles and bones：For liver Soreness of waist and knee joint, rheumatalgia and the traumatic injury of kidney deficiency.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, Roots of Panax Notoginseng are in the plump nahlock shape of fist shape, long by 3~ 6 centimetres, about 3 centimetres of diameter, surface taupe brown or brown color all to have strumae and interrupted arcuation rill more, in projection Often there are stem foot or bud scar in thing top, and there is fibrous root bottom or fractureed.Matter is solid, is not easily broken, and section is uneven, white when fresh, Drying person is in faint yellow, there is radial striations.Gas is without slight bitter after slightly sweet flavor.With drying, neat, the bright person of matter heavily fortified point, free from admixture, section Being preferred property sweetness and bitterness, temperature, cure mainly blood-breaking and dissipate the stasis of blood, stop blooding, detumescence, traumatic injury, traumatic bleeding.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, the radix paeoniae rubrathe are ranunculaceae plant Chinese herbaceous peony or the river radix paeoniae rubrathe Dry root.Spring, the excavation of season in autumn two, remove rhizome, fibrous root and silt, dry；It is slightly bent in cylinder, long 5~40cm, diameter 0.5~3cm.Surface sepia, it is coarse, there are longitudinal furrow and wrinkle, and have the hole skin of mark of fibrous root and lateral projection, some crusts are easily de- Fall.Matter is hard and crisp, frangibility, and section white powder or pink, skin zone is narrow, and the radial texture of woody part is obvious, and some has crack.Gas Micro-perfume, it is mildly bitter flavor, sour and astringent；Property it is bitter, be slightly cold, cure mainly clearing heat and cooling blood, blood stasis removing analgesic, for febrile virulent maculae, hematemesis and epistaxis, hot eyes swells Bitterly, liver-depressed hypochondrium pain, closed dysmenorrhea, abdominal mass stomachache, injury from falling down, carbuncle swells sore, the radix paeoniae rubrathe can be purified the blood a point real heat, and scattered blood stasis is detained, For blood system real heat, it is good at promoting blood circulation to remove blood stasis.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, upper one of snow is high to produce upper one of snow for Dongchuan District, Yunnan Province The root tuber of wormwood artemisia, there are 5 kinds of alkaloids：Bullatine A, B prime, C prime, D prime and element in heptan, dried root is in elongated cylindrical, directly About 0.5~1.7 centimetre of footpath, up to more than 5~8 centimetres.Appearance is in dark brown or yellowish-brown, and full, wrinkle is fine, is also had relatively aobvious Bright person, it is more with vertical wrinkle, often there is the mark of break of lateral root, the person that occasionally has branch.Matter is hard crisp easily broken, and section is slightly rounded, existing white powder.Bolt Skin is belittled, and skin zone is wider, and woody part and marrow account for diameter 1/3, and nearby color is deeper for forming layer, in dark brown circle.Gas is faint, acrid flavour It is peppery and numb.With color of the leather is dark brown, core white, silty, have black circle, full, smooth person is preferred, there is anti-inflammatory analgetic, dispelling wind and eliminating dampness, cure mainly Traumatic injury, fracture, treating rheumatic ostealgia.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, borneol is Dipterocarpaceae aiphyllium plant borneol Botany bar gum processed goods, or the trunk of kapur crystallize through distilling obtained by cooling, and property is pungent, bitter, is slightly cold, and the thoughts of returning home, spleen, lung channel, opens Key inducing resuscitation, the effect of clearing away heat to and alleviating pain are used for sore swell and ache curative, are not held back after bursting.Borneol also plays the role of clearing heat and detoxicating, erosion prevention and muscle growing.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, dandelion are feverfew dandelion, alkali ground Pu Public English or the drying herb for belonging to several plants together, for composition containing taraxasterol, choline, synanthrin, tartaric acid etc., property is bitter, sweet, trembles with fear, returns Liver, stomach, have the function that antibacterial.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, radix glycyrrhizae have sweet temperature, the characteristic of coordinating the drug actions of a prescription, processed Then middle benefit gas, raw then purging intense heat.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle Swollen sore, alleviate drug toxicity, strong.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, fruit of summer cypress bitter, trembles with fear, nontoxic.Main bladder heat, profit Urine, bowl spares strengthening the essence gas, removes hot gas in skin, dissipates malignant sore hernia lump in the abdomen, Qiang Yin.Long term usage normal hearing and eyesight, make light of one's life by commiting suicide resistance to old, make one moist. One ground certain herbaceous plants with big flowers, a ground wheat.Raw Jing Zhou Ping Ze and field.August, October adopt reality, dry in the shade, its leaf bitter, tremble with fear, nontoxic.Main large intestine Diarrhea, only dysentery, gentle, puckery stomach, solution malignant sore poison.Control mesh pain and narrow and slander suddenly, because there is the heat person of setting.Fruit of summer cypress white sauce is taken to note In mesh, fidgets of palms and soles pain is treated.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, lycopodium calvatum are complete for the drying of lycopsid lycopod Grass.Summer, two season of autumn cauline leaf it is luxuriant when harvest, remove impurity, dry, this product stolon is reachable in thin cylinder, slightly curved song, length 2m, 1~3mm of diameter, there is yellow-white radicula under it.Erect stern makees two dichotomies.On the dense stem of leaf, helical arrangement, shrinkage Bending, linear or aciculiform, long 3~5mm, yellow green to fallow, hairless, tip aristiform, full edge is easily cataclasm.Matter is soft, breaks Musculus cutaneus portion is light yellow, woody part off-white color.It is odorless, lightly seasoned, property slight bitter, pungent, temperature, Return liver, spleen, kidney channel, for dispelling wind and eliminating dampness, relaxing muscles and tendons It is active.For joint pain, joint stuffiness.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, it is ginger acrid flavour, peppery, big heat, unobstructed gods, ward off Epidemic disease, and the gas of hair tonic is helped, can dispelling wind evil.Ginger being proficient in the law of natural movement, ancient will.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, to causing channels and collaterals to damage caused by traumatic injury Wound, qi depression to blood stasis, so as to produce pain as bore, the stagnation of QI-blood type neck-shoulder pain, lumbago and leg pain of fixed pain, due to wind-cold damp pathogen visitor in Qi and blood stagnation is caused after bladder warp and governor vessel, damp evil channels and collaterals occlusion type neck-shoulder pain, lumbago and leg pain of being caught cold caused by train of thought is obstructed, year Age is larger, and the course of disease is more long, and constitution is poor, worn with age, kidney qi loss, and tendon and vessel, which is lost, supports caused renal deficiency type neck-shoulder pain, lumbago and leg pain, institute The outer emplastrum of Chinese medicine for the treatment neck-shoulder pain, lumbago and leg pain stated can be used continuously 2~3 days, root directly against in patient's sore spot per note plaster Number of days is sticked according to conditions of patients selection, the serious every dressing in 2 days of conditions of patients once, after skin breathes freely half a day afterwards, can continue Stick, 5 patch be 1 course for the treatment of, be used continuously 2~5 courses for the treatment of after, can fully recover and have it is notable the effect of.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, the root of bidentate achyranthes, anisetree bark, giant knotweed, lycopodium calvatum, which have, to be used In dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, for treating arthralgic effect；Notopterygium root, teasel root, snow is upper, and one high, the banksia rose can anti-inflammatory stop Bitterly, dispelling wind and eliminating dampness, wind dispelling evil removing, traumatic injury is cured mainly, fractured, treating rheumatic ostealgia；Radix ampelopsis, the fruit of summer cypress have clearing heat and detoxicating, and disappear carbuncle The effect of dissipating bind；In order to adjust above Chinese medicine it is bitter, cold can, add Radix Angelicae Sinensis, pseudo-ginseng, the radix paeoniae rubrathe, ginger to reconcile medicine attribute, Radix Angelicae Sinensis is warm-natured, pseudo-ginseng, the radix paeoniae rubrathe have the function that it is good promoting blood circulation and removing blood stasis, it is ginger acrid flavour, peppery, big heat, unobstructed gods, ward off epidemic disease, and The gas of hair tonic is helped, can dispelling wind evil；Fritillary bulb, the addition of dandelion, radix glycyrrhizae, the toxicity that remaining herbal medicine is brought can be released, alleviated Medicine it is strong, there is antibacterial, the usage time of the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain can be extended.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain of the present invention, using advanced extraction process combine it is advanced in Medicine composite extract medicinal extract process for dispersing, medicinal material active ingredient is fully extracted, drugloading rate is big, and matrix release is good, skin permeation Well, there is no sensitization to skin.The present invention adds stearic acid, vaseline, sweet using the Chinese medicine composite extract medicinal extract of extraction Oil, polyethylene glycol, carbomer, ethylparaben, compared to red lead is added in traditional black plaster matrix, containing poisonous to human body Lead element, can infiltrate through in vivo, and in black plaster preparation process, the extraction of medicinal material sesame oil high temperature, temper, effectively in use Composition is easily destroyed, and the polarity very little of sesame oil, the larger effective component of chinese medicine of many polarity is difficult to be dissolved in sesame oil, such as by medicinal material Powder is added in the matrix tempered and used, and active ingredient discharges very slowly from crude drug cell, and skin, which absorbs, also accordingly to be subtracted Slowly, and sesame oil caused small molecule aldehyde compound during tempering, anaphylaxis is also easy to produce to skin, the present invention compensate for Black plaster all of the above deficiency.
Embodiment
Embodiment one：
A kind of outer emplastrum of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain are mainly It is made up of the traditional Chinese medicinal material raw materials of following weight proportion：500 parts of fritillary bulb, 1000 parts of radix ampelopsis, 250 parts of Radix Angelicae Sinensis, 250 parts of the banksia rose, tiger 1000 parts of cane, 1000 parts of the root of bidentate achyranthes, 250 parts of anisetree bark, 500 parts of notopterygium root, 500 parts of teasel root, 750 parts of pseudo-ginseng, 1250 parts of the radix paeoniae rubrathe, on snow One high 50 parts, 1500 parts of dandelion, 250 parts of radix glycyrrhizae, 100 parts of the fruit of summer cypress, 1500 parts of lycopodium calvatum, 2500 parts of ginger, borneol 100 Part.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, for treating stagnation of QI-blood type neck, shoulder, waist and leg Bitterly, damp evil of catching cold channels and collaterals occlusion type neck-shoulder pain, lumbago and leg pain, tendon and vessel, which is lost, supports caused renal deficiency type neck-shoulder pain, lumbago and leg pain, for 3 kinds of diseases Example, every kind of people of case patient 100, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is directly against in patient's sore spot, every note cream Medicine can be used continuously 2~3 days, and number of days is sticked according to conditions of patients selection, the serious every dressing in 2 days of conditions of patients once, afterwards Skin was breathed freely after half a day, can continue to stick, and 5 patches are 1 course for the treatment of, after 2 courses for the treatment of are used continuously, can be fully recovered and be treated with significant Effect, therapeutic effect are shown in Table 1：
Table the effect of emplastrum outside the Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in table 1
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, after 2 courses for the treatment of are used continuously, cure rate energy Enough reach more than 92%.
Embodiment two：
The preparation method of emplastrum outside the Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to embodiment one, including it is as follows Step：
Step 1, the fritillary bulb for weighing according to parts by weight certain mass, radix ampelopsis, Radix Angelicae Sinensis, the banksia rose, giant knotweed, the root of bidentate achyranthes, maple Skin, notopterygium root, teasel root, pseudo-ginseng, the radix paeoniae rubrathe, the upper high, borneol of snow, powder in medicinal herb grinder is respectively placed in by load weighted Chinese medicine Broken, the medicinal powder after crushing is well mixed rear standby；
Step 2, herb powder of the step 1 after well mixed weighed, alleged quality 6 is poured into the herb powder mixed Times alcoholic solution, carry out alcoholic extract under the cooperation of microwave, uninterrupted microwave, microwave 15min per hour, microwave power 800Hz, alcoholic extract time 10h, takes supernatant stand-by, and remaining filter residue continues to extract one with alcoholic solution according to the method described above Secondary, the supernatant merged after extracting twice is stand-by；
Step 3, the dandelion for weighing according to parts by weight certain mass, radix glycyrrhizae, the fruit of summer cypress, lycopodium calvatum, ginger, by ginger Section, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, standby after the medicinal powder after crushing is well mixed；
Step 4, herb powder of the step 2 after well mixed weighed, alleged quality is poured into the herb powder mixed 10 times of alcoholic solution, refluxing extraction 2 times, extracts 2h every time at 80 DEG C, filters, and merges the decoctions of 2 extractions, stand-by；
The decoction of step 5, the supernatant of combining step 2 and step 4, by being evaporated under reduced pressure recovered alcohol, control temperature 65 DEG C, pressure -0.1MPa, obtain Chinese medicine composite extract medicinal extract；
Step 6, weigh respectively according to parts by weight Chinese medicine composite extract medicinal extract made from 15 parts of step 5,30 parts Stearic acid, 10 parts of vaseline, 3 parts of glycerine, 3 parts of polyethylene glycol, 3 parts of carbomer, 0.05 part of ethylparaben, are treated With；
Step 7, after load weighted stearic acid and vaseline are mixed, 85 DEG C are heated to, is slowly added under conditions of stirring Glycerine, polyethylene glycol, carbomer, ethylparaben, Chinese medicine composite extract medicinal extract is eventually adding, treats that temperature is reduced to after mixing 65~70 DEG C, stand cream, press mold, sealing, emplastrum outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is made.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 1 Machine grinding time 10min, medicinal herb grinder power 2.5kw, rotating speed 5000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 3 Machine grinding time 1min, medicinal herb grinder power 1.5kw, rotating speed 5000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine is compound in step 5 The density of extract medicinal extract is 1.1g/ml.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, the base of cream is spread out in step 7 Bottom is non-woven fabrics, and specification is 10 × 6cm, and press mold material is PP films, pack sealing.
Embodiment three：
A kind of outer emplastrum of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain are mainly It is made up of the traditional Chinese medicinal material raw materials of following weight proportion：450 parts of fritillary bulb, 900 parts of radix ampelopsis, 200 parts of Radix Angelicae Sinensis, 200 parts of the banksia rose, giant knotweed 900 parts, 900 parts of the root of bidentate achyranthes, 200 parts of anisetree bark, 450 parts of notopterygium root, 450 parts of teasel root, 700 parts of pseudo-ginseng, 1200 parts of the radix paeoniae rubrathe, upper one of snow High 45 parts, 1450 parts of dandelion, 200 parts of radix glycyrrhizae, 80 parts of the fruit of summer cypress, 1450 parts of lycopodium calvatum, 2450 parts of ginger, 80 parts of borneol.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, carry out multiple intact skin irritant test and Disposable damaged skin irritant test：
Multiple intact skin Irritation Test Method is selection body weight 20-25kg health white rabbit 3, and 24h will before experiment The hair of white rabbit back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, neck-shoulder pain, lumbago and leg pain will be treated The outer emplastrum uniform fold of Chinese medicine is in side skin of unhairing surface, and opposite side skin of unhairing is as blank control.4h is smeared, with distillation Water removes residual tested material, smears once daily, continuously smears 72h, if necessary cropping, do not damage skin.After each smear 24h observes result；
Disposable damaged skin irritant test selection body weight 20-25kg health white rabbit 3,24h is by rabbit before experiment The hair of back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, first sterilized with concentration for 75% alcohol wipe Unhairing area skin, with the damaged wound of injection needle standardized " well " shape in dermatotome, the Chinese medicine of neck-shoulder pain, lumbago and leg pain will be treated Outer emplastrum is covered on the 4 layers of gauze covered on damaged part skin, is then covered with one layer of oilpaper, then with nonirritant adhesive plaster It is fixed.Opposite side unhairing damaged skin is by the use of equivalent sterile purified water as control, with the same processing of preceding work.After application 4h, with steaming Distilled water removes the outer emplastrum of Chinese medicine of Residual-curative neck-shoulder pain, lumbago and leg pain, 1 after tested material is removed, 24,48h, observe skin office React in portion.
The conclusion of two groups of skin irritation tests is：Skin irritation test result shows, treats in neck-shoulder pain, lumbago and leg pain The outer emplastrum of medicine, without significant change, is determined as nonirritant to the multiple irritant test rabbit epidermis of rabbit intact skin；Rabbit is broken The disposable irritant test of skin is damaged, rabbit epidermis is determined as nonirritant without significant change.
Embodiment four：
The preparation method of emplastrum outside the Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to embodiment three, including it is as follows Step：
Step 1, the fritillary bulb for weighing according to parts by weight certain mass, radix ampelopsis, Radix Angelicae Sinensis, the banksia rose, giant knotweed, the root of bidentate achyranthes, maple Skin, notopterygium root, teasel root, pseudo-ginseng, the radix paeoniae rubrathe, the upper high, borneol of snow, powder in medicinal herb grinder is respectively placed in by load weighted Chinese medicine Broken, the medicinal powder after crushing is well mixed rear standby；
Step 2, herb powder of the step 1 after well mixed weighed, alleged quality is poured into the herb powder mixed 10 times of alcoholic solution, carries out alcoholic extract under the cooperation of microwave, uninterrupted microwave, per hour microwave 10min, microwave power 500Hz, alcoholic extract time 8h, takes supernatant stand-by, and remaining filter residue continues to extract one with alcoholic solution according to the method described above Secondary, the supernatant merged after extracting twice is stand-by；
Step 3, the dandelion for weighing according to parts by weight certain mass, radix glycyrrhizae, the fruit of summer cypress, lycopodium calvatum, ginger, by ginger Section, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, standby after the medicinal powder after crushing is well mixed；
Step 4, herb powder of the step 2 after well mixed weighed, alleged quality is poured into the herb powder mixed 10 times of alcoholic solution, refluxing extraction 2 times, extracts 2h every time at 80 DEG C, filters, and merges the decoctions of 2 extractions, stand-by；
The decoction of step 5, the supernatant of combining step 2 and step 4, by being evaporated under reduced pressure recovered alcohol, control temperature 60 DEG C, pressure -0.1MPa, obtain Chinese medicine composite extract medicinal extract；
Step 6, weigh respectively according to parts by weight Chinese medicine composite extract medicinal extract made from 12 parts of step 5,20 parts Stearic acid, 7 parts of vaseline, 2 parts of glycerine, 2 parts of polyethylene glycol, 2 parts of carbomer, 0.03 part of ethylparaben are treated With stand-by；
Step 7, after load weighted stearic acid and vaseline are mixed, 85 DEG C are heated to, is slowly added under conditions of stirring Glycerine, polyethylene glycol, carbomer, ethylparaben, Chinese medicine composite extract medicinal extract is eventually adding, treats that temperature is reduced to after mixing 65 DEG C, stand cream, press mold, sealing, emplastrum outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is made.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 1 Machine grinding time 5min, medicinal herb grinder power 1.55kw, rotating speed 8000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 3 Machine grinding time 2min, medicinal herb grinder power 2kw, rotating speed 5000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine is compound in step 5 The density of extract medicinal extract is 1.2g/ml.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, according to weight in step 6 Number weigh respectively Chinese medicine composite extract medicinal extract made from 12 parts of step 5,20 parts of stearic acid, 7 parts of vaseline, 2 parts Glycerine, 2 parts of polyethylene glycol, 2 parts of carbomer, 0.03 part of ethylparaben it is stand-by.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, the base of cream is spread out in step 7 Bottom is non-woven fabrics, and specification is 10 × 8cm, and press mold material is PP films, pack sealing.
Embodiment five：
A kind of outer emplastrum of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain are mainly It is made up of the traditional Chinese medicinal material raw materials of following weight proportion：550 parts of fritillary bulb, 1100 parts of radix ampelopsis, 300 parts of Radix Angelicae Sinensis, 300 parts of the banksia rose, tiger 1100 parts of cane, 1100 parts of the root of bidentate achyranthes, 300 parts of anisetree bark, 550 parts of notopterygium root, 550 parts of teasel root, 800 parts of pseudo-ginseng, 1300 parts of the radix paeoniae rubrathe, on snow One high 55 parts, 1550 parts of dandelion, 300 parts of radix glycyrrhizae, 120 parts of the fruit of summer cypress, 1550 parts of lycopodium calvatum, 2550 parts of ginger, borneol 120 Part.
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, for treating stagnation of QI-blood type neck, shoulder, waist and leg Bitterly, damp evil of catching cold channels and collaterals occlusion type neck-shoulder pain, lumbago and leg pain, tendon and vessel, which is lost, supports caused renal deficiency type neck-shoulder pain, lumbago and leg pain, for 3 kinds of diseases Example, every kind of people of case patient 100, the outer emplastrum of Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is directly against in patient's sore spot, every note cream Medicine can be used continuously 2~3 days, and number of days is sticked according to conditions of patients selection, the serious every dressing in 2 days of conditions of patients once, afterwards Skin was breathed freely after half a day, can continue to stick, and 5 patches are 1 course for the treatment of, after 4 courses for the treatment of are used continuously, can be fully recovered and be treated with significant Effect, therapeutic effect are shown in Table 2：
Table the effect of emplastrum outside the Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in table 2
The outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, after four courses for the treatment of are used continuously, cure rate More than 97% can be reached.
Embodiment six：
The preparation method of emplastrum outside the Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to embodiment five, including it is as follows Step：
Step 1, the fritillary bulb for weighing according to parts by weight certain mass, radix ampelopsis, Radix Angelicae Sinensis, the banksia rose, giant knotweed, the root of bidentate achyranthes, maple Skin, notopterygium root, teasel root, pseudo-ginseng, the radix paeoniae rubrathe, the upper high, borneol of snow, powder in medicinal herb grinder is respectively placed in by load weighted Chinese medicine Broken, the medicinal powder after crushing is well mixed rear standby；
Step 2, herb powder of the step 1 after well mixed weighed, alleged quality 9 is poured into the herb powder mixed Times alcoholic solution, carry out alcoholic extract under the cooperation of microwave, uninterrupted microwave, microwave 7min per hour, microwave power 500Hz, alcoholic extract time 10h, takes supernatant stand-by, and remaining filter residue continues to extract one with alcoholic solution according to the method described above Secondary, the supernatant merged after extracting twice is stand-by；
Step 3, the dandelion for weighing according to parts by weight certain mass, radix glycyrrhizae, the fruit of summer cypress, lycopodium calvatum, ginger, by ginger Section, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, standby after the medicinal powder after crushing is well mixed；
Step 4, herb powder of the step 2 after well mixed weighed, alleged quality is poured into the herb powder mixed 15 times of alcoholic solution, refluxing extraction 2 times, extracts 1.5h every time at 80 DEG C, filters, and merges the decoctions of 2 extractions, stand-by；
The decoction of step 5, the supernatant of combining step 2 and step 4, by being evaporated under reduced pressure recovered alcohol, control temperature 65 DEG C, pressure -0.1MPa, obtain Chinese medicine composite extract medicinal extract；
Step 6, Chinese medicine composite extract medicinal extract, 15 made from 10~15 parts of step 5 are weighed according to parts by weight respectively The stearic acid of part, 5 parts of vaseline, 2 parts of glycerine, 2 parts of polyethylene glycol, 2 parts of carbomer, 0.05 part of nipalgin second Ester, it is stand-by；
Step 7, after load weighted stearic acid and vaseline are mixed, 85 DEG C are heated to, is slowly added under conditions of stirring Glycerine, polyethylene glycol, carbomer, ethylparaben, Chinese medicine composite extract medicinal extract is eventually adding, treats that temperature is reduced to after mixing 65 DEG C, stand cream, press mold, sealing, emplastrum outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is made.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 1 Machine grinding time 3min, medicinal herb grinder power 2.5kw, rotating speed 10000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine crushes in step 3 Machine grinding time 1min, medicinal herb grinder power 2.5kw, rotating speed 10000rad/min.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, Chinese medicine is compound in step 5 The density of extract medicinal extract is 1.1g/ml.
The preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain described in present embodiment, the base of cream is spread out in step 7 Bottom is non-woven fabrics, and specification is 8 × 8cm, and press mold material is PP films, pack sealing.

Claims (10)

1. the outer emplastrum of a kind of Chinese medicine for treating neck-shoulder pain, lumbago and leg pain, it is characterised in that outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain Emplastrum is mainly made up of the traditional Chinese medicinal material raw materials of following weight proportion：450~550 parts of fritillary bulb, 900~1100 parts of radix ampelopsis, when Return 200~300 parts, 200~300 parts of the banksia rose, 900~1100 parts of giant knotweed, 900~1100 parts of the root of bidentate achyranthes, 200~300 parts of anisetree bark, 450~550 parts of notopterygium root, 450~550 parts of teasel root, 700~800 parts of pseudo-ginseng, 1200~1300 parts of the radix paeoniae rubrathe, upper one high 45 of snow~ 55 parts, 1450~1550 parts of dandelion, 200~300 parts of radix glycyrrhizae, 80~120 parts of the fruit of summer cypress, 1450~1550 parts of lycopodium calvatum, life 2450~2550 parts of ginger, 80~120 parts of borneol.
2. the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 1, it is characterised in that described treatment neck shoulder The outer emplastrum of the Chinese medicine of pain in waist and lower extremities is mainly made up of the traditional Chinese medicinal material raw materials of following weight proportion：450 parts of fritillary bulb, 900 parts of radix ampelopsis, 200 parts of Radix Angelicae Sinensis, 200 parts of the banksia rose, 900 parts of giant knotweed, 900 parts of the root of bidentate achyranthes, 200 parts of anisetree bark, 450 parts of notopterygium root, 450 parts of teasel root, pseudo-ginseng 700 parts, 1200 parts of the radix paeoniae rubrathe, upper one high 45 parts of snow, 1450 parts of dandelion, 200 parts of radix glycyrrhizae, 80 parts of the fruit of summer cypress, lycopodium calvatum 1450 Part, 2450 parts of ginger, 80 parts of borneol.
3. the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 1, it is characterised in that described treatment neck shoulder The outer emplastrum of the Chinese medicine of pain in waist and lower extremities is mainly made up of the traditional Chinese medicinal material raw materials of following weight proportion：550 parts of fritillary bulb, radix ampelopsis 1100 Part, 300 parts of Radix Angelicae Sinensis, 300 parts of the banksia rose, 1100 parts of giant knotweed, 1100 parts of the root of bidentate achyranthes, 300 parts of anisetree bark, 550 parts of notopterygium root, 550 parts of teasel root, 800 parts of pseudo-ginseng, 1300 parts of the radix paeoniae rubrathe, upper one high 55 parts of snow, 1550 parts of dandelion, 300 parts of radix glycyrrhizae, 120 parts of the fruit of summer cypress, lycopodium calvatum 1550 parts, 2550 parts of ginger, 120 parts of borneol.
4. the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 1, it is characterised in that described treatment neck shoulder The outer emplastrum of the Chinese medicine of pain in waist and lower extremities is mainly made up of the traditional Chinese medicinal material raw materials of following weight proportion：500 parts of fritillary bulb, radix ampelopsis 1000 Part, 250 parts of Radix Angelicae Sinensis, 250 parts of the banksia rose, 1000 parts of giant knotweed, 1000 parts of the root of bidentate achyranthes, 250 parts of anisetree bark, 500 parts of notopterygium root, 500 parts of teasel root, 750 parts of pseudo-ginseng, 1250 parts of the radix paeoniae rubrathe, upper one high 50 parts of snow, 1500 parts of dandelion, 250 parts of radix glycyrrhizae, 100 parts of the fruit of summer cypress, lycopodium calvatum 1500 parts, 2500 parts of ginger, 100 parts of borneol.
5. the preparation method of the outer emplastrum of Chinese medicine of the treatment neck-shoulder pain, lumbago and leg pain described in a kind of one of claim 1-4, its feature exist In comprising the following steps：
Step 1, the fritillary bulb for weighing according to parts by weight certain mass, radix ampelopsis, Radix Angelicae Sinensis, the banksia rose, giant knotweed, the root of bidentate achyranthes, anisetree bark, Qiang Work, teasel root, pseudo-ginseng, the radix paeoniae rubrathe, the upper high, borneol of snow, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, is crushed It is standby after medicinal powder afterwards is well mixed；
Step 2, herb powder of the step 1 after well mixed weighed, alleged quality 6~10 is poured into the herb powder mixed Times alcoholic solution, carry out alcoholic extract under the cooperation of microwave, uninterrupted microwave, 5~15min of microwave per hour, microwave power 300~800Hz, 5~10h of alcoholic extract time, takes supernatant stand-by, and remaining filter residue continues molten with alcohol according to the method described above Liquid extracts once, and the supernatant merged after extracting twice is stand-by；
Step 3, the dandelion for weighing according to parts by weight certain mass, radix glycyrrhizae, the fruit of summer cypress, lycopodium calvatum, ginger, ginger is cut Piece, load weighted Chinese medicine is respectively placed in medicinal herb grinder and crushed, it is standby after the medicinal powder after crushing is well mixed；
Step 4, herb powder of the step 2 after well mixed weighed, to the herb powder mixed pour into alleged quality 10~ 15 times of alcoholic solution, refluxing extraction 2 times at 80 DEG C, 1.5~2h is extracted every time, filtering, merges the decoctions of 2 extractions, it is stand-by；
The decoction of step 5, the supernatant of combining step 2 and step 4, by being evaporated under reduced pressure recovered alcohol, control temperature 55~65 DEG C, pressure -0.1MPa, obtain Chinese medicine composite extract medicinal extract；
Step 6, Chinese medicine composite extract medicinal extract, 15~30 made from 10~15 parts of step 5 are weighed according to parts by weight respectively Part stearic acid, 5~10 parts of vaseline, 1~3 part of glycerine, 1~3 part of polyethylene glycol, 1~3 part of carbomer, 0.01 ~0.05 part of ethylparaben, it is stand-by；
Step 7, after load weighted stearic acid and vaseline are mixed, 80~85 DEG C are heated to, is slowly added under conditions of stirring Glycerine, polyethylene glycol, carbomer, ethylparaben, Chinese medicine composite extract medicinal extract is eventually adding, treats that temperature is reduced to after mixing 65~70 DEG C, stand cream, press mold, sealing, emplastrum outside the Chinese medicine of described treatment neck-shoulder pain, lumbago and leg pain is made.
6. the preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 5, it is characterised in that：Step 3~10min of medicinal herb grinder grinding time in 1, medicinal herb grinder 1.5~2.5kw of power, 5000~10000rad/ of rotating speed min。
7. the preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 5, it is characterised in that：Step 1~3min of medicinal herb grinder grinding time in 3, medicinal herb grinder 1.5~2.5kw of power, 5000~10000rad/min of rotating speed.
8. the preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 5, it is characterised in that：Step The density of Chinese medicine composite extract medicinal extract is 1.1~1.2g/ml in 5.
9. the preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 5, it is characterised in that：Step Weighed respectively according to parts by weight in 6 Chinese medicine composite extract medicinal extract made from 12 parts of step 5,20 parts of stearic acid, 7 parts Vaseline, 2 parts of glycerine, 2 parts of polyethylene glycol, 2 parts of carbomer, 0.03 part of ethylparaben are stand-by.
10. the preparation method of the outer emplastrum of Chinese medicine for the treatment of neck-shoulder pain, lumbago and leg pain according to claim 5, it is characterised in that：Step The substrate that cream is spread out in rapid 7 is non-woven fabrics, and press mold material is PP films, pack sealing.
CN201710790912.7A 2017-09-05 2017-09-05 Treat outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof Pending CN107375894A (en)

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