CN100462096C - Medicine for enhancing human body immune function and treating Aids and its preparation method - Google Patents

Medicine for enhancing human body immune function and treating Aids and its preparation method Download PDF

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CN100462096C
CN100462096C CNB2005100880318A CN200510088031A CN100462096C CN 100462096 C CN100462096 C CN 100462096C CN B2005100880318 A CNB2005100880318 A CN B2005100880318A CN 200510088031 A CN200510088031 A CN 200510088031A CN 100462096 C CN100462096 C CN 100462096C
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radix
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CN1785407A (en
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杨勇
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Abstract

A Chinese medicine for improving human immunity and treating AIDS by nourishing human Qi, blood, vital essence and body fluid and suppressing and killing pathogenic microbes is prepared from 5 Chinese-medicinal materials including tortoise plastron, toad, ganoderma, klein cinguefoil herb, etc through extracting their active components by alcohol or decocting.

Description

A kind of medicine that improves human body immune function and treating Aids and preparation method thereof
Technical field the present invention relates to the medicine that a kind of raising immune function of human body, treatment acquired immune deficiency syndrome (AIDS) (AIDS) and HIV (human immunodeficiency virus) (HIV) carrier infect hepatitis A virus (HAV), herpes simplex virus, varicella zoster virus virus, tubercule bacillus, antibacterial, fungus, protozoons etc. such as (VZV).The invention still further relates to the preparation method of this medicine, belong to the field of Chinese medicines.
Since the background technology U.S. found acquired immune deficiency syndrome (AIDS) (AIDS) patient in 1981, lasted for two more than ten years, HIV sufferers increases with surprising rapidity, bring huge impact for the economic growth and social progress in the world, the medical sci-tech worker of various countries has developed many medicines that are used for the treatment of acquired immune deficiency syndrome (AIDS), but single because of acting on, can not be at the cause of disease, pathogenesis, regulate the function of human body on the whole, so can not fundamentally treat acquired immune deficiency syndrome (AIDS).
In numerous Drug therapy HIV sufferers, can not obtain under the situation of good result, the inventor is through research repeatedly, with the Chinese medical theory is guidance, the cause of disease according to acquired immune deficiency syndrome (AIDS), pathogenesis and clinical manifestation, dialectical prescription, through clinical experiment, finally found a kind of raising immune function of human body, suppress and kill multiple virus (comprising HIV (human immunodeficiency virus) (Human Immunodeficiency Virus)), antibacterial, tubercule bacillus, fungus, the oral medicinal herb medicine of protozoon etc., be used for the treatment of acquired immune deficiency syndrome (AIDS) (AIDS) and HIV carriers and infect hepatitis A virus (HAV), herpes simplex virus, virus such as varicella zoster virus (VZV), tubercule bacillus, fungus, antibacterial, disease due to the protozoon etc., thus the present invention finished.
Summary of the invention the purpose of this invention is to provide a kind of raising immune function of human body, suppresses and kills multiple virus, antibacterial, fungus, tubercule bacillus, protozoon etc., the Chinese medicine composition of treatment acquired immune deficiency syndrome (AIDS) (AIDS).
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The inventor is according to the method for syndrome differentiation of Chinese medicine, think that acquired immune deficiency syndrome (AIDS) (AIDS) belongs to the category of " science of epidemic febrile disease of Chinese medicine ", clinical characteristics (that is: have infectiousness) with " epidemic disease ", the distinguishing feature (that is: have poison very grave characteristic) that also has " poison ", so the invention people claims that HIV (human immunodeficiency virus) is " epidemic disease poison I ".
Acquired immune deficiency syndrome (AIDS) be disease also, not from the gas of human body, blood, cloudy, sun, its pathological changes does not go out the internal organs of human body, meridians, extremity, bones of the body collectively, non-six gas of acquired immune deficiency syndrome (AIDS) are felt, non-ly breathe and go into from mouth and nose, be by skin zone, passages through which vital energy circulates, channels is impaired, the chamber sexual intercourse, children's is the natural endowment deficiency, touch epidemic disease poison I and send out, it is careful and to touch poison gently with guarding rigidly of human righteousness to infect epidemic disease poison I, heavy, many, the widow has confidential relation, its morbidity must show gently, heavy, slow, anxious, epidemic disease poison I invades human body, promptly decoct the gas of human body, blood, smart, liquid, cause Kidney-Yin loss (that is: the immune system of destruction human body), imbalance of YIN and YANG, Kidney-Yin loss, healthy energy does not have the power of imperial heresy and infects pathogen (that is: wind, cold, summer-heat, wet, dry, fire, poison, epidemic disease), show as internal organs, meridians, extremity, the pathological changes of bones of the body collectively (that is: acquired immune deficiency syndrome (AIDS) (AIDS)).Its Therapeutic Method is " strengthening vital QI to eliminate pathogenic factors ", " set upright " and be training benefit people bromhidrosis, blood, essence, liquid (promptly improving immune function of human body), " eliminating evil " is exactly to dispel wind, cold, summer-heat, wet, dry, fiery, malicious, the heresy of epidemic disease (promptly suppress and kill pathogenic microorganisms such as various bacteria, virus, fungus, bacillus, protozoon), fundamentally regulate the function of human body, make equilibrium between yin and yang.
The inventor thinks according to a large amount of data and clinical experience: most HIV sufferers belong to " cloudy insufficiency of essence; pathogen is had a surplus ", so adopt medicine to be monarch with training benefit people bromhidrosis, blood, essence, liquid, to ward off medicines such as dirty, invigorating spleen and reinforcing stomach, dispelling wind, expelling summer-heat, promoting pus discharge and tissue regeneration strengthening, parasite killing, analgesic therapy be minister with having removing pathogenic heat from blood and toxic substance from the body, nourishing YIN and clearing away heat, blood stasis dispersing and deswelling, preventing the attack (or recurrence) of malaria counteracting toxic substances, pathogenic fire reducing dehumidifying, broken lumps in the chest and abdomen, circulation of qi promoting, the monarch and his subjects' compatibility treatment acquired immune deficiency syndrome (AIDS) (AIDS).
Medicine of the present invention makes up Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Carapax Trionycis, Radix Panacis Quinquefolii, Radix Astragali, Radix Ophiopogonis, Fructus Corni and Ganoderma lucidum seu Japonicum, makes each efficacy of drugs produce synergism, make bring about the desired sensation, blood, essence, liquid and mend, reach the effect of human body immunity improving function.Select for use Cornu Cervi Pantotrichum to be because Cornu Cervi Pantotrichum sweet-salty temperature, return Liver and kidney warp, kidney-Yang invigorating, fill blood, beneficial marrow, bone and muscle strengthening, arrogate to oneself especially and control asthenia weakness and emaciation, tired mind, dizzy.Select for use Carapax et Plastrum Testudinis to be because the Carapax et Plastrum Testudinis nature and flavor are salty sweet flat, return Liver and kidney warp, nourishing YIN for suppressing the hyperactive YANG, reinforcing the kidney to strengthen the bone, treatment deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, haematemesis, epistaxis, chronic cough seminal emission, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria.Select for use Carapax Trionycis to be because the Carapax Trionycis nature and flavor are salty flat, return liver spleen channel, replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving, treatment consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly, mass in the abdomen mass beside the umbilicus, infantile malnutrition.Selecting Radix Panacis Quinquefolii for use is because the cold of Radix Panacis Quinquefolii mildly bitter flavor, warp of GUIXIN lung kidney, lung benefiting the moon, clear asthenic fire, promoting the production of body fluid to quench thirst, control chronic cough of deficiency lung, lose blood, dry throat and mouth, deficiency-heat be tired of tired.Selecting Radix Astragali for use is because the sweet tepor of Radix Astragali, returns lung spleen channel, stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle and do not burst or burst and do not hold back for a long time.Selecting Radix Ophiopogonis for use is because the little bitter cold of Radix Ophiopogonis, returns lung stomach heart channel, nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid, controls dryness of the lung dry cough, haematemesis, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quench one's thirst, calentura Tianjin wound, dry mouth and throat, constipation.Select for use Fructus Corni to be because Fructus Corni acid tepor is gone into the Liver and kidney warp, invigorating the liver and kidney, arresting seminal emission gas, collapse, control soreness of waist and knee joint admittedly, dizzy, tinnitus, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shake rapid pulse.Select for use Ganoderma lucidum seu Japonicum to be because Ganoderma lucidum seu Japonicum property is sweet flat, nontoxic, the treatment asthenia, cough, asthma, insomnia, dyspepsia are good at protecting refreshing beneficial vital essence, sharp joint, hard muscles and bones especially.Select for use Bufo siccus, Radix Paeoniae Rubra, Cortex Moutan, Radix Scrophulariae, Rhizoma Coptidis, Rhizoma Belamcandae, Herba Artemisiae Annuae, Herba potentillae kleinianae, Radix Tetrastigmatis Hemsleyani, Flos Chrysanthemi Indici, Rhizoma Curcumae, Rhizoma valerianae latifoliae, Herba Pogostemonis He Gardenia to make up, can make each efficacy of drugs produce synergism, thereby can effectively kill epidemic disease poison I, dispel the heresy of wind, cold, summer-heat, wet, dry, fiery, malicious, epidemic disease, the compatibility monarch drug can fundamentally be treated acquired immune deficiency syndrome (AIDS), reach and set upright and do not stay heresy, eliminating evil and do not hinder positive purpose.Wherein select for use Bufo siccus to be because Bufo siccus is pungent in flavor and cool in property, poisonous, return that Yangming Channel , Po Disorder knot, row water are wet, removing toxic substances, parasite killing, analgesic therapy, arrogate to oneself and control furuncle, carbuncle on the back, carbuncle of yin nature scrofula, the malignant boil, mass in the abdomen hypochondriac lump, tympanites, edema, infantile malnutrition, and sharp in counteracting toxic substances.Selecting Radix Paeoniae Rubra for use is because the bitter cold of Radix Paeoniae Rubra nature and flavor, returns the liver spleen channel, clots absorbing, pain relieving, removing heat from blood, subsides a swelling, controls the hernia abdominal mass and gather stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion carbuncle.Select for use Cortex Moutan to be because the Cortex Moutan nature and flavor are arduous cool, GUIXIN, liver, kidney channel, heat clearing away, removing heat from blood, invigorate blood circulation, repercussive, control the pathogenic heat attacking blood system in febrile diseases, send out speckle, infantile convulsion, haematemesis, epistaxis, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, amenorrhea and mass in the abdomen.Select for use Radix Scrophulariae to be because the lung kidney channel is returned in the bitter salty cold of Radix Scrophulariae nature and flavor, nourishing YIN to lower pathogenic fire, relieving restlessness, detoxify, control the calentura excessive thirst, send out sleep peaceful, spontaneous sweating, Tianjin of speckle, hectic fever due to YIN-deficiency consumptive fever, night and hinder constipation, haematemesis, epistaxis, laryngopharynx swelling and pain, carbuncle scrofula.Select for use Rhizoma Coptidis to be because Rhizoma Coptidis nature and flavor bitter cold, GUIXIN liver stomach large intestine channel, pathogenic fire purging, dampness, detoxifcation, parasite killing, row pyretic toxicity when controlling, typhoid fever, intenseness of heat are vexed, feeling of fullness vomiting, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis, quench one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema.Select for use Rhizoma Belamcandae to be because Rhizoma Belamcandae nature and flavor bitter cold is poisonous, return the lung Liver Channel, pathogenic fire reducing, detoxifcation, loose blood, expectorant, control sore throat, pharyngalgia, cough with dyspnea, accumulation and obstruction of sputum, scrofula tuberculosis, malaria with splenomegaly, carbuncle sore tumefacting virus.Select for use Herba Artemisiae Annuae to be because the bitter little suffering of Herba Artemisiae Annuae nature and flavor is cold, return the liver and gall warp, heat clearing away, expelling summer-heat, remove and steam, control epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency, consumptive fever, malaria, jaundice, scabies, pruritus.Selecting Herba potentillae kleinianae for use is that heat-clearing and toxic substances removing is controlled infantile convulsion hyperpyrexia, malaria, cough, laryngalgia, arthralgia chiefly caused by damp pathogen, carbuncle tinea skin ulcer, erysipelas, prurigo because of the cold of Herba potentillae kleinianae nature and flavor toil.Select for use Radix Tetrastigmatis Hemsleyani to be because Radix Tetrastigmatis Hemsleyani is pungent in flavor and cool in property, heat-clearing and toxic substances removing, promoting blood circulation by removing wind is controlled hyperpyrexia convulsion, pneumonia, asthma, hepatitis, rheumatism, pharyngalgia, scrofula, carbuncle furuncle furuncle.Select for use Flos Chrysanthemi Indici to be because the lung Liver Channel is returned in the cold of Flos Chrysanthemi Indici nature and flavor toil, wind and heat dispersing, subduing swelling and detoxicating is controlled anemopyretic cold, pneumonia, diphtheria, gastroenteritis, furuncle carbuncle, aphtha, erysipelas, eczema, epidemic blisters.Selecting Rhizoma Curcumae for use is because Rhizoma Curcumae nature and flavor toil temperature, returns the liver spleen channel, circulation of qi promoting, removing blood stasis, removing food stagnancy, pain relieving, controls trusted subordinate's distending pain, lumps in the chest and abdomen, and dyspepsia does not disappear.Selecting Rhizoma valerianae latifoliae for use is because the Rhizoma valerianae latifoliae property and flavor of peppery and warm, returns lung stomach warp, circulation of qi promoting, cold expelling, invigorates blood circulation, controls the sun stroke abdominal distention, and vomiting is had loose bowels, lung qi edema, anemofrigid cold, consumptive disease are hindered cough.Select for use Herba Pogostemonis to be because the hot tepor of Herba Pogostemonis nature and flavor is returned lung taste warp, fast gas and in, ward off dirty, damp eliminating, the heat-damp in summer that cures cold, cold and heat, headache, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, malaria, dysentery, edema.Xuan Yong Gardenia Shi is sweet in flavor and cold in property Yin Wei Gardenia, and GUIXIN liver lung stomach warp, is controlled the calentura restlessness of asrhenia type and insomnia at heat clearing away, pathogenic fire purging, removing heat from blood, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, haematemesis, dysentery, hematuria, pathopyretic ulcer.
Selected the medicine of a large amount of sufferings, cool bitter cold in the crude drug of the present invention for use, impairment of the spleen evil stomach probably, thus with the Rhizoma valerianae latifoliae with hot using warming therapy, the flat system of Herba Pogostemonis, make and tremble with fear and imapirment of the spleen and stomach not, hot and not dry.
Select Bufo siccus, product that Rhizoma Belamcandae is poisonous in the crude drug of the present invention for use, clinical experience according to the inventor is thought, in the available crude drug of the present invention (as: Fructus Corni, Radix Ophiopogonis, Rhizoma Coptidis, the Herba potentillae kleinianae etc.) of the product restraint of Yin and detoxification, its toxicity is reduced and give full play to therapeutical effect.
Drug component consumption of the present invention also draws through a large amount of clinical empirical summaries of inventor, and each amounts of components all has better curative effect in the following weight parts scope:
Base stock of the present invention is:
1. the still unossified young horn of animal in deer family Cervus nippon Temminck Cervus nippon Temminck or Cervus elaphus linnaeus Cervus elaphus L, clear and bright back saw is got the 3rd year stag it " first planting young pilose antler ", filth on the flush away fine hair burns burnt fine hair, scraping with the ethanol lights, twine with the strap bundle, slowly infiltrate from the bottom with hot wine, run through to degree, cut into slices then, flatten, dry to fill, 1-5 parts, main product Jilin, Heilungkiang, the Inner Mongol;
2. the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray), the autumn and winter catch, and after killing, reject muscles, get its sternite, and clean, dry, 9-24 parts, main product Hubei, Anhui, Jiangsu, Zhejiang;
3. the carapace of Trionychidae animal Trionyx sinensis (Wiegmann) Amyda sinensis (Wiegmann), 3-JIUYUE is caught, catch after, after striking off Caput Trionycis, peeling carapace, scrape residual to the greatest extent meat, soak with clear water, clean, dry, 9-24 parts, main product Hubei, Anhui, Jiangsu, Zhejiang;
4. the root of Araliaceae Radix Panacis Quinquefolii panax quinquefolium L. is chosen the root in 3-6 years of growth, excavates autumn, removes branch, and palpus tail and earth dry, and 3-6 parts, the main product U.S., Canada, France;
5. the dry root of leguminous plant Radix Astragali Astragalusme mbranaceus (Fisch.) Bge or Inner Mongol Radix Astragali Asiragalus mongholicus Bge, excavate autumn, Ex-all earth and impurity, cut residual root head and hollow the greater, be soaked in water, pull out, run through back section in time and dry, 10-25 parts, the main product Inner Mongol, Shanxi, Jilin, Heilungkiang;
6. the tuber of liliaceous plant dwarf lilyturf 0phiopogon japonicus Ker-Gaw1 is chosen the Radix Ophiopogonis in the 3rd year in cultivation back, excavates when the Beginning of summer or Clear and Bright, Ex-all impurity and earth are soaked in water, and pull out, clean, dry, 9-18 parts, main product Zhejiang, Sichuan;
7. the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et zucc is plucked when fruit maturation reddens between 10 1 November, cleans, removes removal core and impurity, dry, and 6-18 parts, main product Shaanxi, Henan, Shanxi, Anhui;
8. the dry Herb of Polyporaceae plant Ganoderma Ganoderma japonicum (Fr.) Lloyd or Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganodermalucidum (Leyss.ex Fr.) Karst, take autumn, and Ex-all earth and impurity dry, 5-12 parts, main product Zhejiang, Jiangxi, Guangdong, Jilin;
9. Bufonidae animal Bufo siccus Bufo bufo garga rizans Cantor or Bufo melanostictus Melanostictus Schneider remove the dry all of a pawl, Xia Qiu catches, catch after, adopt Venenum Bufonis earlier, then Bufo siccus is killed, remove a pawl, dry, 3-9 parts, main product Tibet, Heilungkiang, Jilin, Hunan;
10. the dry root of ranunculaceae plant Radix Paeoniae (wild species) Paeonialactif loraPall or Paeonia obovata Maxim. paeoniaobovata Maxim or river Radix Paeoniae Rubra Paeonia veitchii Lynch, excavate autumn, remove stem and leaf, supporting root and fibrous root are cleaned earth, choose decontamination, be soaked in water to seven, most probably saturating, cut into slices, dry, 6-18 parts, main product Sichuan, Yunnan, Guizhou, Shanxi, Shaanxi;
The dry root bark of ranunculaceae peony Paeonia suffruticosa Andr. is selected the Paeonia suffruticosa in 3-5 years of cultivation, excavates at the beginning of autumn or spring, choose decontamination, remove core, clean, run through, cut into slices, dry, 5-12 parts, main product Anhui, Sichuan, Gansu, Shaanxi;
The dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl is excavated in the Beginning of Winter of around, removes stem, leaf, fibrous root, cleans earth, chooses clean impurity, removes removing LU, and clean and run through section, dry, 9-18 parts, main product Zhejiang, Sichuan, Hubei;
Figure C200510088031D00073
Ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch or Coptis deltoidea C.Y.Cheng et Hsiao Coptisdeltoidea C.Y.Cheng et Hsiao or coptis omeiensis Coptis omeiensis (Chen) C.Y.Cheng or Coptis teeta Coptis teetoidesC.Y.Cheng rhizome, gather between annual November, remove stem and leaf after excavating, fibrous root and earth, dry, hit rough bark, 4-12 parts, main product Sichuan, Guizhou, Shaanxi, Yunnan;
Irides Rhizoma Belamcandae Belamcanda chinensis (L.) DC. rhizome, excavate spring and autumn, chooses decontamination, and washing is clean, soaks slightly, and pull out, run through, cut into slices, dry, sieve and must consider to be worth doing, 3-10 parts, main product Hubei, Henan, Jiangsu, Anhui;
Figure C200510088031D00075
The herb of feverfew Herba Artemisiae Annuae Artemi sia apiacea Hance or Herba Artemisiae annuae Artemi sia annua L. before blooming summer, selects stem and leaf color green grass or young crops person, extract aerial parts, choose decontamination, remove undesirable root, dry in the shade, 5-18 parts, main product Liaoning, Hebei, Shandong, Shanxi;
Figure C200510088031D00076
The whole herb with root of rosaceous plant Herba potentillae kleinianae Potentilla Kleiniana Wight et Arn, gather summer, removes earth and impurity, dry, 6-15 parts, main product Guizhou, Hunan, Jiangxi, Zhejiang;
Figure C200510088031D00077
The dry root of vitaceae tetratigma hemsleyanum Tetrastigma hemsleyanum Diels et Gilg, excavate autumn, removes stem and leaf, fibrous root and impurity, dry, 3-12 parts, main product Hubei, Jiangxi, Fujian;
Figure C200510088031D00078
The head inflorescence of feverfew Herba Dendranthematis indici Chrysanthemum indicum L or HERBA CHRYSANTHEMI LAVANDULAEFOLII C.boreale Mak or lavandulaleaf dendranthema herb C.lavandulaefolium (Fisch.) Mak., spend autumn when blooming and gather, remove impurity, dry in the shade, 6-12 parts, main product Jiangsu, Guangxi, Guangdong, Sichuan;
Figure C200510088031D00081
Zingiberaceous plant Rhizoma Curcumae Curcumaz edoaria (Berg.) Rosc rhizome, excavate autumn, removes clean earth, and Ex-all feeler and impurity after cooking, are cut into slices, are dried, and 5-9 parts, main product Fujian, Guangxi, Guangdong, Sichuan;
Figure C200510088031D00082
Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae Valeriana jatamansii Jones or Valeriana Fauriei Briq. Valerianaofficinalis L.var.latifolia Miq rhizome, excavate 9-October, remove stem and leaf, clean, cut off fibrous root, cut into slices, dry, 3-10 parts, main product Shaanxi, Henan, Hubei, Guizhou;
Figure C200510088031D00083
The herb of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth or Herba Pogostemonis Agastacherugosa (Fisch.et Mey.) O.Ktze, gather between 6-July, choose decontamination, remove undesirable root and old stem, earlier leaf is taken, other puts, the stem water runs through, cutting, dry, then with leaf and even, dry 5-12 parts.Main product Heilungkiang, Jilin, Hubei, Sichuan;
Figure C200510088031D00084
The fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides EIIis is plucked when the fruit maturation skin is yellow between October, removes fruit stem and impurity, dry, and 8-18 parts, main product Jiangsu, Zhejiang, Anhui, Jiangxi.
Composition of raw materials of the present invention is preferably:
1. the still unossified young horn of animal in deer family Cervus elaphus linnaeus Cervus elaphus L, clear and bright back saw is got the 3rd year stag it " first planting young pilose antler ", filth on the flush away fine hair burns burnt fine hair with the ethanol lights, cleans, twine with the strap bundle, slowly infiltrate from the bottom with hot wine, run through to degree, cut into slices then, flatten, dry to fill, 3 parts, main product Jilin, Heilungkiang, the Inner Mongol;
2. the sternite of Testudinidae animal Testudinis Chinemys reelesii (Gray), the autumn and winter catch, and after killing, reject muscles, get its sternite, and clean, dry, 21 parts, main product Hubei, Anhui, Jiangsu, Zhejiang;
3. the carapace of Trionychidae animal Trionyx sinensis (Wiegmann) Amyda sinensis (Wiegmann), 3-JIUYUE is caught, catch after strike off Caput Trionycis, peel carapace, scrape residual to the greatest extent meat after, soak with clear water, clean, dry, 21 parts, main product Hubei, Anhui, Jiangsu, Zhejiang;
4. the dry root of Araliaceae Radix Panacis Quinquefolii panax quinquefolium L. is chosen the root in 3-6 years of growth, excavates autumn, removes branch, and palpus tail and earth dry, and 5 parts, the main product U.S., Canada, France;
5. the dry root of leguminous plant Inner Mongol Radix Astragali Astragalus mongholicus Bge., excavate autumn, Ex-all earth and impurity, cut residual root head and hollow the greater, be soaked in water, pull out, run through back section in time and dry, 20 parts, the main product Inner Mongol, Shanxi, Jilin, Heilungkiang;
6. the tuber of Radix Ophiopogonis liliaceous plant dwarf lilyturf Ophiopogon japonicus Ker-Gaw1 is chosen the Radix Ophiopogonis in the 3rd year in cultivation back, excavates when the Beginning of summer or Clear and Bright, Ex-all impurity and earth are soaked in water, and pull out, clean, dry, 16 parts, main product Zhejiang, Sichuan;
7. the drying and ripening sarcocarp of Fructus Corni Cornaceae plant Fructus Corni Cornus officinalis Sieb.et zucc, pluck when fruit maturation reddens between 10-November, clean, remove removal core and impurity, dry, 16 parts, main product Shaanxi, Henan, Shanxi, Anhui;
8. the dry Herb of Polyporaceae plant Ganoderma Ganoderma japonicum (Fr.) Lloyd, take autumn, and Ex-all earth and impurity dry, and 10 parts, main product Zhejiang, Jiangxi, Guangdong, Jilin;
9. Bufonidae animal Bufo siccus Bufo bufo gargarizans Cantor's is all, and Xia Qiu catches, catch after, adopt Venenum Bufonis earlier, then Bufo siccus is killed, remove a pawl, dry, 5 parts, main product Tibet, Jilin, Heilungkiang, Hunan;
10. the root of ranunculaceae plant Radix Paeoniae (wild species) Paeonia lactiflora Pall, excavate autumn, removes stem and leaf, and supporting root and fibrous root are cleaned earth, choose decontamination, and cut into slices, dry, 15 parts, main product Sichuan, Yunnan, Guizhou, Shanxi, Shaanxi;
Figure C200510088031D00091
The dry root bark of ranunculaceae peony Paeonia suffruticosa Andr is selected the Paeonia suffruticosa in 3-5 years of cultivation, excavates autumn, chooses decontamination, removes core, and clean, run through, cut into slices, dry, 10 parts, main product Anhui, Gansu, Shaanxi, Sichuan;
Figure C200510088031D00092
The dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl is excavated in the Beginning of Winter of around, removes stem, leaf, fibrous root, cleans earth, chooses clean impurity, removes removing LU, cleans, and runs through, and section is dried, and 15 parts, main product Zhejiang, Sichuan, Hubei;
Ranunculaceae plant coptis omeiensis Coptis omeiensis (Chen) C.Y.Cheng rhizome was gathered between annual November, removed stem and leaf after excavating, and fibrous root and earth dry, and hit rough bark, and 9 parts, main product Sichuan;
Irides Rhizoma Belamcandae Belamcanda chinensis (L.) DC. rhizome, excavate spring and autumn, chooses decontamination, and wash only, soak slightly, pull out, run through, cut into slices, dry, sieve and must consider to be worth doing, 9 parts, main product Hubei, Henan, Jiangsu, Anhui;
The dry herb of feverfew Herba Artemisiae Annuae Artemisia apiacea Hance before blooming summer, selects stem and leaf color green grass or young crops person, extracts aerial parts, chooses decontamination, removes undesirable root, dry in the shade, and 15 parts, main product Liaoning, Hebei, Shandong, Shanxi;
Figure C200510088031D00096
The whole herb with root of rosaceous plant Herba potentillae kleinianae Potentilla kleiniana Wight et Arn, gather summer, removes earth and impurity, dry, 12 parts, main product Guizhou, Hunan, Jiangxi, Zhejiang;
The dry root of vitaceae tetratigma hemsleyanum Tetrastigma hemsleyanum Diels et Gilg, excavate autumn, removes stem and leaf, fibrous root and impurity, dry, 10 parts, main product Hubei, Jiangxi, Fujian;
Figure C200510088031D00098
The head inflorescence of feverfew Herba Dendranthematis indici Chrysanthemum indicum L is spent when blooming and gather autumn, removes impurity, dry in the shade, and 10 parts, main product Jiangsu, Sichuan, Guangxi, Guangdong;
Zingiberaceous plant Rhizoma Curcumae Curcuma zedoaria (Berg.) Rosc rhizome, excavate autumn, removes clean earth and impurity, cuts into slices, dries, and removes feeler, and 8 parts, main product Fujian, Guangxi, Guangdong, Sichuan;
The dry rhizome of Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae Valeriana jatamansii Jones, excavate 9-October, removes stem and leaf, cleans, and cuts off fibrous root, and cut into slices, dry, 6 parts, main product Shaanxi, Henan, Hubei, Guizhou;
Figure C200510088031D000911
The dry herb of labiate Herba Pogostemonis Agastache rugosa (Fi sch.et Mey.) O.Ktze, gather between 6-July, choose decontamination, remove undesirable root and old stem, earlier leaf is taken, other puts, the stem water runs through, cutting, dry, then with leaf and even, dry, 10 parts, main product Heilungkiang, Jilin, Hubei, Sichuan;
The fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides EIIis is plucked when the fruit maturation skin is yellow between October, removes fruit stem and impurity, dries 15 parts, main product Jiangsu, Zhejiang, Anhui, Jiangxi.
The sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray) described in the present invention, the carapace of also available Testudinidae animal Testudinis Chinemys reevesii (Gray).
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example: these crude drug can be ground into coarse powder, extract with Different concentrations of alcohol, make extractum, dry, sterilize, be ground into impalpable powder, required various adjuvants when adding the preparation different dosage form are made any conventional peroral dosage form; Can be with Cornu Cervi Pantotrichum, Radix Panacis Quinquefolii, be ground into fine powder, Rhizoma valerianae latifoliae, Herba Pogostemonis are extracted volatile oil with steam distillation, all the other crude drug extract with Different concentrations of alcohol, make extractum, dry, as to be ground into impalpable powder and Cornu Cervi Pantotrichum, Radix Panacis Quinquefolii, pulverizing fine powder mixing is sterilized, and sprays into the volatile oil of Rhizoma valerianae latifoliae, Herba Pogostemonis extraction, add the required various adjuvants of preparation different dosage form, make any conventional peroral dosage form; Can be with Cornu Cervi Pantotrichum; Radix Panacis Quinquefolii; being ground into fine powder is used as medicine; Carapax et Plastrum Testudinis; Carapax Trionycis is made glue; be ground into fine powder; Rhizoma valerianae latifoliae; Herba Pogostemonis is extracted volatile oil with steam distillation; all the other crude drug extract with Different concentrations of alcohol; dry; be ground into impalpable powder and Cornu Cervi Pantotrichum; the fine powder mix homogeneously of Radix Panacis Quinquefolii pulverizing; add Carapax et Plastrum Testudinis again; Carapax Trionycis is made the broken fine powder of rubber powder; mix homogeneously; sterilization; spray into Rhizoma valerianae latifoliae; the volatile oil of Herba Pogostemonis extraction, required various adjuvants are made any routine dosage form for oral administration when adding the preparation different dosage form again, and these can not be used to limit protection scope of the present invention.
Medicine activity component of the present invention can obtain with following method:
A, with described weight proportion 1., 4. number crude drug sterilization, pulverize separately becomes fine powder, mix homogeneously is made fine powder 1;
B. with described weight proportion 2., 3., 5.- The sterilization of number crude drug, pulverize separately becomes coarse powder, use alcohol reflux, extracts temperature at 30-50 ℃, adds the alcohol reflux 3 hours that is equivalent to 5 times of amounts 50% of raw medicinal herbs for the first time, filtration; Add for the second time the alcohol reflux 2 hours that is equivalent to 3 times of amounts 70% of raw medicinal herbs, filter; Add the alcohol reflux 1 hour be equivalent to 2 times of amounts 85% of raw medicinal herbs for the third time, filter, merges three times ethanol extract, reclaiming ethanol, to be condensed into proportion be 1.30 extractum, in 40-50 ℃ of dryings down; Make dry extract 2;
C. with among the method B with the medicinal residues behind the ethanol extraction, decocted 1 hour with the pure water that is equivalent to 2.5 times of amounts of medicinal residues, filter, be condensed into proportion and be 1.40 extractum, the ethanol with 2 times of amounts 95% carries out precipitate with ethanol again, reclaims ethanol, be condensed into extractum, dry under 40-50 ℃, make dry extract 3;
D. merge fine powder 1, dry extract 2, dry extract 3, be ground into impalpable powder again, ultraviolet disinfection 1.5 hours.
The active component of medicine of the present invention can add various adjuvants required when preparing different dosage form, be prepared into any peroral dosage form commonly used as excipient, disintegrating agent, binding agent etc. with the method for Chinese medicinal of routine, as tablet, pill, capsule, oral liquid etc.
Medicine of the present invention has following beneficial effect: people's bromhidrosis is mended in training, blood, smart, liquid, invigorating spleen and reinforcing stomach, tonifying liver, lung moistening, the kidney invigorating, reinforcing the heart, the benefit marrow, the effect of brain-strengthening etc. (that is: the effect of raising immune function of human body), has removing pathogenic heat from blood and toxic substance from the body simultaneously, nourishing YIN and clearing away heat, blood stasis dispersing and deswelling, the preventing the attack (or recurrence) of malaria counteracting toxic substances, the pathogenic fire reducing dehumidifying, dirty Po lumps in the chest and abdomen is warded off in circulation of qi promoting, dispelling wind, expelling summer-heat, promoting pus discharge and tissue regeneration strengthening, effects such as parasite killing analgesic therapy (that is: suppress and kill multiple virus, antibacterial, fungus, tubercule bacillus, pathogenic microorganisms such as protozoon), can treat the malaria of plain edition and acquired immune deficiency syndrome (AIDS) (AIDS) patient and HIV (human immunodeficiency virus) (HIV) carrier, diphtheria, erysipelas, pneumonia, hepatitis A (HAV), hepatitis B (ABV), hepatitis C (ACV) etc., the outer tuberculosis of lung and lung, gastroenteritis, esophagitis, tonsillitis, oral candidiasis, pharyngolaryngitis, seborrheic dermatitis, prurigo, tinea, herpes simplex, herpes zoster, parotitis, urinary tract infection, lymphadenectasis, cirrhotic ascites, furuncle and phyma, tumor etc., regulate the function of human body on the whole, reach equilibrium between yin and yang.
The following beneficial effect of further setting forth medicine of the present invention by the clinical observation on the therapeutic effect test of the specific embodiment:
The 1 Drug therapy hepatitis A of the present invention clinical observation of test example.
1, physical data
Accept out-patient's 36 examples for medical treatment, male's 20 examples wherein, women's 16 examples, men and women's ratio is 5:4.8-20 years old 18 age example, 21-30 years old 10 example, 31-40 years old 5 example, 41-55 years old 3 example.Its middle school student 14 people, peasant 18 people, driver 3 people, workman 1 people.
2, diagnostic criteria
(1) tcm diagnosis standard
Eating and drinking without temperance is often arranged, and with the hepatitis contact history, companion's distension and fullness in the abdomen, indigestion and loss of appetite vomiting and nausea, limbs are stranded weight, yellowish body, icteric sclera, yellow urine.
(2) Western medicine diagnose standard
A, alanine aminotransferase (alanine aminotransferase ALT), aspartate amino transferase (aspartate aminotransferase AST) significantly raise.
B, anti-HAV-1gM, anti-HAV-1gA, anti-HAV-1gG, anti-HAVAg, HAV-RNA are all positive.
C, serum conjugated bilirubin (CB), total bilirubin (STB) increase.
3, Therapeutic Method
The active component of medicine of the present invention, " 0 " number capsule of packing into, oral 3 times of child every day, each 2, oral 3 times of adult every day, each 4, two weeks is 1 course of treatment, 2 courses of treatment of logotype.
4, efficacy assessment standard
Produce effects: distension and fullness in the abdomen, indigestion and loss of appetite vomiting and nausea, limbs are stranded weight, yellowish body, yellow urine transference cure after treating, and serum alanine aminotransferase (ALT), serum conjugated bilirubin (CB), aspartate amino transferase (AST), total bilirubin (STB) are reduced to normal level or HAV-1gM, anti-HAV-1gA, anti-HAVAg, HAV-RNA change feminine gender into.
Take a turn for the better: distension and fullness in the abdomen, indigestion and loss of appetite vomiting and nausea, the tired weight of limbs, yellowish body, icteric sclera, yellow urine symptom are obviously improved serum phenylalanine ammonia transferring enzyme (ALT), serum conjugated bilirubin (CB), aspartate amino transferase after treating
(AST), total bilirubin (STB) reduces.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (see Table 1 and table 2)
In a word, 3 middle of the month, with medicine activity component of the present invention treatment hepatitis A 36 examples, produce effects 30 examples as a result, 5 examples that take a turn for the better, invalid 1 example, obvious effective rate is 83.33%, and improvement rate is 13.88%, and total effective rate is 97.22%.
The phthisical clinical observation of test example 2 Drug therapys of the present invention
1, physical data
Accept out-patient's totally 30 examples for medical treatment, male's 21 examples wherein, women's 9 examples, men and women's ratio is 7:3.12-20 years old 8 age example, 21-30 years old 10 example, 31-40 years old 6 example, 41-50 years old 3 example, 51-60 years old 3 example.Peasant 16 people wherein, workman 4 people, student 8 people, cadre 2 people.
2, diagnostic criteria
(1) tcm diagnosis standard
Patient's initial stage is only felt fatigue and weak, dry cough, and inappetence, body is become thin gradually, and spitting of blood, hectic fever, flushed cheeks, night sweat can appear in seriously ill person.
(2) Western medicine diagnose standard
A, lesions position diminished breath sound or news and bronchial breathing sound and moist rale.
B, expectorant smear or cultivation tulase are positive more.
C, X line are taken the photograph the visible pulmonary of sheet tuberculose focus.
D, erythrocyte sedimentation rate increase piece, and tuberculin skin test presents strong positive.
3, Therapeutic Method
The active component of medicine of the present invention is loaded on " 0 " number capsule, and oral 3 times of child every day, each 2, oral 3 times of adult every day, each 4, two weeks is one and is journey, 3 courses of treatment of logotype.
4, efficacy assessment standard
Produce effects: the lunger is after treatment, and cardinal symptoms such as hectic fever, cough, spitting of blood, night sweat disappear, expectorant smear or cultivation tulase feminine gender, and the X line is taken the photograph sheet pulmonary tuberculose focus and is dwindled or calcification, and erythrocyte sedimentation rate reduces.
Take a turn for the better: inappetence, fatigue and weak, dry cough, emaciated physique, hectic fever, spitting of blood etc. are all obviously improved.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (see Table 3 and table 4)
In a word, three middle of the month, with invention Drug therapy pulmonary tuberculosis 30 examples, produce effects 18 examples as a result, 10 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 60%, and improvement rate is 33.33%, and total effective rate is 93.33%.
Test example 3 Drug therapy chickenpoxs of the present invention---the clinical observation that varicella zoster virus (VZV) infects
1, physical data
Accept out-patient's totally 32 examples for medical treatment, male's 20 examples wherein, women's 12 examples, men and women's ratio is 5:3.21-30 years old 6 age example, 31-40 years old 6 example, 41-50 years old 7 example, 51-65 years old 13 example, wherein, student 4 people, peasant 20 people, workman 8 people.
2, diagnostic criteria
(1) tcm diagnosis standard
From the beginning of the part patient heating is arranged earlier, asthenia, inappetence, and prodromes such as pars affecta skin burning sensation or neuralgia, but it is dermexanthesis person that absence of prodrome is also arranged, irregular erythema took place through 1-3 days affected parts, then the papulovesicle of the foxtail millet grain of most and cluster occur, become vesicle rapidly, assemble a place or number place to the Semen phaseoli radiati size, be arranged in band shape, vesicle often takes place in batch, and bunch interval is with normal skin, and the erythra pilosity is born in health one side, be no more than median line, but also the minority erythra can occur at the affected part offside sometimes, skin lesion is sent out well in the waist rib, chest, women's head-ornaments, cervical region also is found in extremity, pudendum and eye, nose, places such as mouth, pain is one of primary disease feature, and pain can be because of the age, site of pathological change, infringement weight and variant.
(2) Western medicine diagnose standard
The papulovesicle of the foxtail millet grain of majority and cluster to the Semen phaseoli radiati size appears in A, skin, becomes vesicle rapidly, assembles a place or number place, is arranged in band shape, and vesicle often takes place in batch, and bunch interval is with normal skin.
B, utilize polymerase chain reaction,PCR (PCR) technology, check VZV-DNA in the herpes juice.
3, Therapeutic Method
The active component of medicine of the present invention is loaded on " 0 " number capsule, and oral 3 times of child every day, each 2, oral 3 times of adult every day, each 4,7 days is a course of treatment, 4 courses of treatment of logotype.
4, efficacy assessment standard
Produce effects: chickenpox---herpes zoster (VZV) is after treatment, and drying forms a scab, decrustation, and pain disappears, no heating, asthenia, inappetence person.
Take a turn for the better: chickenpox---herpes zoster (VZV) is after treatment, and the decrustation time is very fast, and pain degree alleviates, and asthenia, inappetence are clearly better.
Invalid: as not reach the improvement standard.
5, therapeutic outcome (see Table 5 and table 6)
In a word, 1 middle of the month, with Drug therapy chickenpox of the present invention---the herpes zoster poison infects 32 examples, produce effects 28 examples as a result, and 3 examples that take a turn for the better, invalid 1 example, obvious effective rate is 87.5%, and improvement rate is 9.375%, and total effective rate is 96.87%.
Test example 4 inventors are to the patient of 5 routine HIV (human immunodeficiency virus) (HIV) carriers companion neck portion, oxter, inguinal lymph nodes enlargement, treat with medicine activity component of the present invention (being loaded on " 0 " number capsule), oral 3 times of every day, each oral 5, after 3 months, observed result, the lymph node of 3 routine patient's enlargements all disappears, and the lymph node of 2 routine patient's enlargements is clearly apparent to be dwindled.Tired, hectic fever sign disappears.
Further set forth the preparation method of medicine of the present invention by the following examples.
Medicine of the present invention adopts following raw medicaments in portion by weight:
1. the still unossified young horn of animal in deer family Cervus elaphus linnaeus Cervus elaphus L is 3 parts;
2. the dry sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray) is 21 parts;
3. the drying of Trionychidae animal Trionyx sinensis (Wiegmann) Amyda sinensis (Wiegmann) back of the body is 21 parts;
4. the dry root of Araliaceae Radix Panacis Quinquefolii panax.quin quefolium L. is 5 parts;
5. the dry root of leguminous plant Inner Mongol Radix Astragali Astragalus mongholicus Bge is 20 parts;
6. the exsiccant tuber of liliaceous plant dwarf lilyturf Ophiopogon japonicus Ker Gaw1 is 16 parts;
7. the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et Zucc is 16 parts;
8. the dry Herb of Polyporaceae plant Ganoderma Ganoderma japonicum (Fr.) Lloyd. is 10 parts;
9. after Bufonidae animal Bufo siccus Bufo bufo gargarizans Cantor. adopts Venenum Bufonis, remove a pawl dry all 5 parts;
10. the dry root of ranunculaceae plant Radix Paeoniae (wild species) Paeonia lactiflora Pall. is 15 parts;
10 parts of the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr;
Figure C200510088031D00142
15 parts of the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl;
Figure C200510088031D00143
9 parts of the dry rhizomes of ranunculaceae plant coptis omeiensis Coptis omeiensis (Chen) C.Y.Cheng;
9 parts of the dry rhizomes of irides Rhizoma Belamcandae Belamcanda chinensis (L.) DC.;
Figure C200510088031D00145
15 parts of the dry herbs of feverfew Herba Artemisiae Annuae Artemisia apiacea Hance.;
Figure C200510088031D00146
12 parts of the dry herbs of the band root of rosaceous plant Herba potentillae kleinianae Potentilla kleiniana Wight et Arn;
10 parts of the dry root of vitaceae tetratigma hemsleyanum Tetrastigma hemsleyanum Diels et Gilg;
Figure C200510088031D00148
10 parts of the dry capitulums of feverfew Herba Dendranthematis indici Chrysanthemum indicum L.;
Figure C200510088031D00149
8 parts of the dry rhizomes of zingiberaceous plant Rhizoma Curcumae Curcuma zedoaria (Berg.) Rosc;
6 parts of the dry rhizomes of Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae Valeriana jatamansii Jones.;
Figure C200510088031D001411
10 parts of the dry herbs of labiate Herba Pogostemonis Agastache rugosa (Fisch.et Mey.) O.Ktze;
Figure C200510088031D001412
15 parts of the dry mature fruits of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides EIIis.
The drop pill preparation of embodiment 1 medicine of the present invention
With above-mentioned weight proportion 1.-
Figure C200510088031D001413
The sterilization of number crude drug is ground into coarse powder, use alcohol reflux, extracts temperature and is controlled at 30-50 ℃, adds the alcohol reflux 3 hours that is equivalent to 6 times of amounts 50% of raw medicinal herbs for the first time, filtration; Add for the second time the alcohol reflux 2 hours that is equivalent to 4 times of amounts 70% of raw medicinal herbs, filter; Add the alcohol reflux 1 hour be equivalent to 3 times of amounts 85% of raw medicinal herbs for the third time, filter; Merge three times ethanol extract, reclaim ethanol, be condensed into extractum, dry under 40-50 ℃, be ground into impalpable powder, ultraviolet disinfection 1.5 hours adds Polyethylene Glycol and makes drop pill.
The capsule preparation of embodiment 2 medicines of the present invention
A, with above-mentioned 1., 4. number crude drug sterilization, pulverize separately becomes fine powder, mix homogeneously is made fine powder 1; B, with above-mentioned 2., 3., 5.-
Figure C200510088031D001414
The sterilization of number crude drug is ground into coarse powder, use alcohol reflux, extracts temperature and is controlled at 30-50 ℃, adds the alcohol reflux 3 hours that is equivalent to 5 times of amounts 50% of raw medicinal herbs for the first time, filtration; Add for the second time the alcohol reflux 2 hours that is equivalent to 3 times of amounts 70% of raw medicinal herbs, filter; Add the alcohol reflux 1 hour be equivalent to 2 times of amounts 85% of raw medicinal herbs for the third time, filter; Merge three times ethanol extract, reclaim ethanol, be condensed into proportion and be 1.30 extractum, in 40-50 ℃ dry down, make dry extract 2;
C. with among the step B with the medicinal residues behind the ethanol extraction, decocted 1 hour with the pure water that is equivalent to 2.5 times of amounts of medicinal residues, filter, be condensed into proportion and be 1.40 times extractum, the ethanol with 2 times of amounts 95% carries out precipitate with ethanol again, reclaims ethanol, be condensed into extractum, dry under 40-50 ℃, make dry extract 3;
D. merge fine powder 1, dry extract 2, dry extract 3, be ground into impalpable powder again, mix homogeneously, ultraviolet disinfection 1.5 hours, the snap fit capsule of packing into.
The preparation tablets of embodiment 3 medicines of the present invention
A. with above-mentioned 1., 4. number crude drug sterilization, pulverize separately becomes fine powder, mix homogeneously is made fine powder 1;
B. with above-mentioned 2., 3., 5.-
Figure C200510088031D00151
The sterilization of number crude drug is ground into coarse powder, use alcohol reflux, extracts temperature and is controlled at 30-50 ℃, adds the alcohol reflux 3 hours that is equivalent to 5 times of amounts 50% of raw medicinal herbs for the first time, filtration; Add for the second time the alcohol reflux 2 hours that is equivalent to 3 times of amounts 70% of raw medicinal herbs, filter; Add the alcohol reflux 1 hour be equivalent to 2 times of amounts 85% of raw medicinal herbs for the third time, filter; Merge 3 times ethanol extract, reclaim ethanol, be condensed into proportion and be 1.30 extractum, in 40-50 ℃ dry down, make dry extract 2;
C. with among the step B with the medicinal residues behind the ethanol extraction, decocted 1 hour with the pure water that is equivalent to 2.5 times of amounts of medicinal residues, filter, be condensed into proportion and be 1.40 extractum, the ethanol with 2 times of amounts 95% carries out precipitate with ethanol again, reclaims ethanol, be condensed into extractum,, make dry extract 3 in 40-50 ℃ of dryings;
D. merge fine powder 1, dry extract 2, dry extract 3 is ground into impalpable powder again, mix homogeneously, ultraviolet disinfection 1.5 hours adds lactose and makes filler, adds ethanol and makes wetting agent, and compacting is in flakes.
Table 1 hepatitis A observation of curative effect after treating
Figure C200510088031D00161
Table 2 hepatitis A is sign improvement in January situation after treating
Symptom Distension and fullness in the abdomen Indigestion and loss of appetite vomiting and nausea Limbs are stranded heavy Yellowish body Icteric sclera Yellow urine
Before the treatment (example) 22 20 26 12 32 30
Treatment back (example) 7 6 10 4 9 12
Total effective rate (%) 68.18 70 61.53 66.66 71.87 60
Table 3 pulmonary tuberculosis observation of curative effect after treating
Figure C200510088031D00162
Table 4 pulmonary tuberculosis 45 days signs after treating are improved situation
Symptom Inappetence Fatigue and weak Hectic fever Cough Night sweat Spitting of blood
Before the treatment (example) 18 20 23 28 24 9
Treatment back (example) 6 8 7 10 8 5
Total effective rate (%) 66.66 60 69.56 64.28 66.66 44.44
Table 5 chickenpox-herpes zoster observation of curative effect after treating
Table 6 chickenpox-herpes zoster is sign improvement in January situation after treating
Symptom Heating Asthenia Pain Inappetence
Before the treatment (example) 16 24 28 20
Treatment back (example) 4 9 6 8
Total effective rate (%) 75 62.5 78.57 60

Claims (3)

1. medicine for the treatment of hepatitis A, pulmonary tuberculosis, varicella zoster virus and acquired immune deficiency syndrome (AIDS), its feature is made by following raw medicaments in portion by weight:
1. the still unossified young horn of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus is 1-5 parts;
2. the dry sternite of Testudinidae animal Testudinis is 9-24 parts;
3. the dry carapace of Trionychidae animal Trionyx sinensis (Wiegmann) is 9-24 parts;
4. the dry root of Araliaceae Radix Panacis Quinquefolii is 3-6 parts;
5. the dry root of leguminous plant Radix Astragali or Inner Mongol Radix Astragali is 10-25 parts;
6. the dried root of liliaceous plant dwarf lilyturf is 9-18 parts;
7. the drying and ripening sarcocarp of Cornaceae plant Fructus Corni is 6-18 parts;
8. the dry Herb of Polyporaceae plant Ganoderma or Ganoderma lucidum (Leyss. Ex Fr.) Karst. is 5-12 parts;
9. Bufonidae animal Bufo siccus or Bufo melanostictus are adopted dry all 3-9 parts that remove a pawl behind the Venenum Bufonis;
10. the dry root of wild Radix Paeoniae of cohosh or Paeonia obovata Maxim. or river Radix Paeoniae Rubra is 6-18 parts;
Figure C200510088031C0002162719QIETU
5-12 parts of the dry root bark of cohosh Paeonia suffruticosa;
Figure C200510088031C0002162800QIETU
9-18 parts of the dry root of goatweed Radix Scrophulariae;
Figure C200510088031C0002162804QIETU
4-12 parts of the dry rhizomes of cohosh Rhizoma Coptidis or Coptis deltoidea C.Y.Cheng et Hsiao or coptis omeiensis or Coptis teeta;
Figure C200510088031C0002162808QIETU
3-10 parts of the dry rhizomes of irides Rhizoma Belamcandae;
Figure C200510088031C0002162813QIETU
5-18 parts of the dry herbs of feverfew Herba Artemisiae Annuae or Herba Artemisiae annuae;
Figure C200510088031C0002162826QIETU
6-15 parts of the dry herbs of the band root of rosaceous plant Herba potentillae kleinianae;
Figure C200510088031C0002162833QIETU
3-12 parts of the dry root of vitaceae tetratigma hemsleyanum;
Figure C200510088031C0002162842QIETU
6-12 parts of the dry capitulums of feverfew Herba Dendranthematis indici or HERBA CHRYSANTHEMI LAVANDULAEFOLII or lavandulaleaf dendranthema herb;
5-9 parts of the dry rhizomes of zingiberaceous plant Rhizoma Curcumae;
Figure C200510088031C000210
3-10 parts of the dry rhizomes of Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae or Valeriana Fauriei Briq.;
Figure C200510088031C000211
5-12 parts of the dry herbs of labiate Herba Pogostemonis or Herba Pogostemonis;
Figure C200510088031C000212
8-18 parts of the dry mature fruits of Maguireothamnus speciosus Fructus Gardeniae.
2. according to claim 1, a kind of medicine for the treatment of hepatitis A, pulmonary tuberculosis, varicella zoster virus and acquired immune deficiency syndrome (AIDS), wherein the consumption of each crude drug is:
1. the still unossified young horn of animal in deer family Cervus elaphus linnaeus is 3 parts;
2. the dry sternite of Testudinidae animal Testudinis is 21 parts;
3. the dry carapace of Trionychidae animal Trionyx sinensis (Wiegmann) is 21 parts;
4. the dry root of Araliaceae Radix Panacis Quinquefolii is 5 parts;
5. the dry root of leguminous plant Inner Mongol Radix Astragali is 20 parts;
6. the dried root of liliaceous plant dwarf lilyturf is 16 parts;
7. the drying and ripening sarcocarp of Cornaceae plant Fructus Corni is 16 parts;
8. the dry Herb of Polyporaceae plant Ganoderma is 10 parts;
9. after Bufonidae animal Bufo siccus is adopted Venenum Bufonis, remove a pawl dry all 5 parts;
10. the dry root of the wild Radix Paeoniae of cohosh is 15 parts;
Figure C200510088031C00031
10 parts of the dry root bark of cohosh Paeonia suffruticosa;
Figure C200510088031C00032
15 parts of the dry root of goatweed Radix Scrophulariae;
Figure C200510088031C00033
9 parts of the dry rhizomes of cohosh coptis omeiensis;
Figure C200510088031C00034
9 parts of the dry rhizomes of irides Rhizoma Belamcandae;
Figure C200510088031C00035
15 parts of the dry herbs of feverfew Herba Artemisiae Annuae;
Figure C200510088031C00036
12 parts of the dry herbs of the band root of rosaceous plant Herba potentillae kleinianae;
Figure C200510088031C00037
10 parts of the dry root of vitaceae tetratigma hemsleyanum;
Figure C200510088031C00038
10 parts of the dry capitulums of feverfew Herba Dendranthematis indici;
Figure C200510088031C00039
8 parts of the dry rhizomes of zingiberaceous plant Rhizoma Curcumae;
Figure C200510088031C000310
6 parts of the dry rhizomes of Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae;
Figure C200510088031C000311
10 parts of the dry herbs of labiate Herba Pogostemonis;
Figure C200510088031C000312
15 parts of the dry mature fruits of Maguireothamnus speciosus Fructus Gardeniae.
3. according to claim 1 or 2, a kind of medicine for the treatment of hepatitis A, pulmonary tuberculosis, varicella zoster virus and acquired immune deficiency syndrome (AIDS), available following method obtains:
A. with described weight proportion 1., 4. number crude drug sterilization, pulverize separately becomes fine powder, mix homogeneously is made fine powder 1;
B. with described weight proportion 2., 3., 5.-
Figure C200510088031C000313
The sterilization of number crude drug is ground into coarse powder, use alcohol reflux, and the extraction temperature is controlled at 30-50 0C adds for the first time the alcohol reflux 3 hours that is equivalent to 5 times of amounts 50% of raw medicinal herbs, filters; Add for the second time the alcohol reflux 2 hours that is equivalent to 3 times of amounts 70% of raw medicinal herbs, filter; Add the alcohol reflux 1 hour be equivalent to 2 times of amounts 85% of raw medicinal herbs for the third time, filter; Merge three times ethanol extract, reclaim ethanol, be condensed into proportion and be 1.30 extractum, in 40-50 ℃ dry down, make dry extract 2;
C. with the medicinal residues behind the ethanol extraction among the method B, decocted 1 hour, filter with the pure water that is equivalent to 2.5 times of amounts of medicinal residues, be condensed into proportion and be 1.40 extractum, the ethanol with 2 times of amounts 95% carries out precipitate with ethanol again, reclaims ethanol, be condensed into extractum, dry under 40-50 ℃, make dry extract 3;
D. merge fine powder 1, dry extract 2, dry extract 3, be ground into impalpable powder again, ultraviolet disinfection 1.5 hours.
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CN1112437A (en) * 1994-12-23 1995-11-29 徐衡德 Medicine for treating phthisis and its preparation
CN1318377A (en) * 2000-04-20 2001-10-24 卢忠 Hepatosis treating Chinese medicine

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Publication number Priority date Publication date Assignee Title
CN1112437A (en) * 1994-12-23 1995-11-29 徐衡德 Medicine for treating phthisis and its preparation
CN1318377A (en) * 2000-04-20 2001-10-24 卢忠 Hepatosis treating Chinese medicine

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