CN1813804A - External-use ointment and its preparing method - Google Patents
External-use ointment and its preparing method Download PDFInfo
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- CN1813804A CN1813804A CNA2005101227102A CN200510122710A CN1813804A CN 1813804 A CN1813804 A CN 1813804A CN A2005101227102 A CNA2005101227102 A CN A2005101227102A CN 200510122710 A CN200510122710 A CN 200510122710A CN 1813804 A CN1813804 A CN 1813804A
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Abstract
The present invention discloses a kind of six spirits ointment for external application, including six spirits adhesive plaster, six spirits rubber plaster, six spirits babu preparation and six spirits ointment. It is made up by using six spirits pill powder as main medicine and adding matrix through a certain preparation process, and has the functions of clearing away heat and toxic material, relieving inflammation and stopping pain and can obtain good therapeutic effect for curing furuncle in children, large carbuncle, acute mastitis, innominate inflammatory swelling, herpes and mammitis, etc.
Description
One, technical field
The invention belongs to technical field of Chinese medicines, specifically relate to class external-use ointment and preparation method thereof.
Two, background technology
LIUSHEN WAN is a kind of Chinese medicine of enjoying great prestige a century, having won fame both at home and abroad, and is made up of Six-element Chinese medicines such as Moschus, has refreshing and detoxicating, the effect of anti-inflammatory analgetic.Be used for scarlet fever, laryngopharynx swelling and pain, acute throat trouble retropharyngeal abscess, single bilateral tonsillitis, children's's furuncle, carbuncle and ulcer furuncle, acute mastitis carbuncle on the back, innominate toxic swelling.In addition herpes zoster, phlebitis, leukemia, digestive tract tumor, mastitis also there is better therapeutic effect.It is as follows to describe its external method in the LIUSHEN WAN usage and dosage that the ministry standard WS3-B-3374 of Ministry of Health of the People's Republic of China is recorded: but external application is at the red swelling of the skin place, with ten several on ball, with cold boiled water or rice vinegar a little, contain to change in the food spoon and loose, around deposited the putting on the skin, every day, normal for several times guarantor was damp, till swollen moving back.To come to a head or worn mashedly as redness, and be sure not again to apply.This method use exist dosage inaccurate, use that inconvenience, moisture retention are poor, medicine become easily graininess be difficult for coating, crawling, absorption bad, skin produced stimulate and shortcomings such as anaphylaxis easily.
Application number is 01100171.2 patent documentation, discloses a kind of nanometer six Miraculous drug medicines; Application number is 200410062452.9 patent documentation, discloses a kind of LIUSHEN KOUQIANG BENGJIEPIAN and preparation method thereof.Yet these two inventions are all different with the present invention, these two invention described six refreshing medicines are formed and are different from the LIUSHEN WAN prescription that Ministry of Public Health ministry standard WS3-B-3374 is recorded, LIUSHEN WAN factory exclusively has because LIUSHEN WAN is only write out a prescription, and its complete prescription is from unexposed mistake.The LIUSHEN WAN powder that the present invention uses can obtain or directly obtain from LIUSHEN WAN manufacturer from commercially available LIUSHEN WAN, its effective ingredient is equal to commercially available LIUSHEN WAN fully, need not further to understand its effective ingredient and form, thereby make enforcement of the present invention can reach the suitability for industrialized production degree easily.
Plaster means that refinings such as medical material, edible vegetable oil and Plumbum preparatium or Hydrocerussitum (Ceruse) form creme, and the stand is applied to the external preparation of making on the back lining materials that supplies skin to stick.Plaster should meet the following requirements in production and duration of storage: (1) medical material should be suitably cataclasm, and it is fried withered to add the food plant by the method for stipulating under each kind item; The not anti-fried medical material of the light bubble of quality should treat that the fried extremely withered and yellow back of other medical materials adds.The medical material of volatile ingredient, mineral drug and valuable medicine should be ground into fine powder, are coated with preceding adding in the stand, and temperature is no more than 70 ℃.(2) preparation all should dry, no moisture absorption caking with Plumbum preparatium, official's powder.(3) the oil refining of exploding medicine adds Plumbum preparatium or official's powder to " dripping into pearl ", stirs and makes abundant mixing, the spray clear water.Plaster becomes to stick together, and puts in the clear water and floods.(4) mastic of plaster answers glossy exquisiteness, light, old tender appropriateness, stand to be coated with even, non-trimming breach, can be affixed on after heating on the skin and not move.Black plaster should pitch-black, no erythema; White plaster is answered HUANGBAI(sic), no white point.(5) plaster should airtight storage.
Emplastrum mean medicinal substances extract, medical material or and chemicals and suitable substrate and base material made for skin and sticked, can produce a class lamellar external preparation of part or general action.Comprise rubber-emplastrum, cataplasma and patch etc.
Rubber-emplastrum refer to medicinal substances extract or and substrate mixings such as chemicals and rubber after, coat the emplastrum of making on the back lining materials.The preparation method of rubber-emplastrum is used two kinds of solvent method and pressure sinterings more.Common solvent is gasoline, n-hexane, and substrate commonly used has rubber, thermoplastic rubber, Colophonium, rosin derivative, vaseline, lanoline and zinc oxide etc.
Cataplasma mean medicinal substances extract or and chemicals and suitable hydrophilic matrix mixing after, coat the emplastrum of making on the back lining materials.Substrate commonly used has carmethose, gelatin, glycerol and micropowder silica gel etc.
Cataplasma can add transdermal enhancer, wetting agent, antiseptic, anti-allergic agent, antioxidant in case of necessity.
Ointment means the semi-solid external preparation that medicinal substances extract, medical material fine powder and suitable substrate uniform mixing are made.That substrate commonly used is divided into is oil, water solublity and emulsion bases can add transdermal enhancer, wetting agent, antiseptic, anti-allergic agent, antioxidant in case of necessity.
Ointment can add transdermal enhancer, wetting agent, antiseptic, anti-allergic agent and antioxidant.
Make external preparation through LIUSHEN WAN is changed dosage form, comprise six refreshing plaster, six refreshing emplastrumes (rubber-emplastrum, cataplasma) and six refreshing ointment, can overcome the shortcoming of LIUSHEN WAN external fully.For the clinical external of LIUSHEN WAN provides convenience.
Three, summary of the invention
An object of the present invention is to provide that a class is easy to use, drug release rate is fast, onset is rapid, the external-use ointment of bioavailability height, preparation stabilization.
Another object of the present invention provides the preparation method of a class external-use ointment.
The present invention is implemented by the following technical programs:
One class external-use ointment, it is to be the unguentum of principal agent with the LIUSHEN WAN powder, and it comprises six refreshing plaster, six refreshing rubber-emplastrums, six refreshing cataplasmas and six refreshing ointment, and six refreshing plaster wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 100-600 part
Edible vegetable oil 1100-3500 part
Plumbum preparatium 100-1000 part or official's powder 500-3500 part;
Six refreshing rubber-emplastrums wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 20-200 part
Rubber 100-400 part
Colophonium or esterase or Foral 100-400 part
Lanoline 25-200 part and/or vaseline 10-100 part and/or liquid paraffin 5-50 part and/or vegetable oil 5-50 part
Zinc oxide and/or lithopone 150-500 part
Gasoline 300-1200 part;
Six refreshing cataplasmas wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 1-100 part
Hydrophillia Babu agent substrate 40-1000 part
Penetration enhancer 1-40 part
Additives 1-5 part;
Six refreshing ointment wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 1-200 part
Greasing base or water-soluble base or emulsion-type substrate 100-1000 part
Penetration enhancer 1-100 part
Wetting agent 1-50 part
Additives 1-50 part.
Described external-use ointment, the Hydrophillia Babu agent substrate that it is characterized in that described six refreshing cataplasmas is by hydrophilic cohesiveness substrate, cross-linking agent, wetting agent, filler, water is formed, and wherein hydrophilic cohesiveness substrate can be sodium carboxymethyl cellulose, gelatin, agar, sodium polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, polyacrylic acid monoethanol ammonium, polyacrylic acid diethanol ammonium, the polyacrylic acid triethanol ammonium, carboxymethyl starch, polyvinylpyrrolidone, polyvinyl alcohol, carbopol, Polyethylene Glycol, polyacrylic acid, arabic gum, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxy methocel, in the tragakanta one or more; Cross-linking agent can be one or both in aluminium hydroxide, aluminum chloride, aluminium potassium sulfate, aluminium carbonate, aluminum acetate, aluminum nitrate, magnesium hydroxide, magnesium aluminate, magnesium nitrate, the calcium chloride; Wetting agent can be one or more in glycerol, propylene glycol, mannitol, the sorbitol; Filler comprises one or more in zinc oxide, titanium dioxide, Kaolin, clay, Pulvis Talci, micropowder silica gel, calcium carbonate, kieselguhr, kaolin, the lithopone.
Described external-use ointment, wherein the greasing base of six refreshing ointment can be one or more in animal and plant fat, vaseline, paraffin, liquid paraffin, lanoline, Cera Flava, spermaceti and the silicone oil; Water-soluble base can be one or more in glycerol, gelatin, Polyethylene Glycol, carbomer, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium alginate and the sodium polyacrylate; The emulsifying agent of emulsion-type substrate can be that soda soap, three ethanol soap classes, fatty alcohol sulphuric acid (ester) sodium class, Polysorbate, hexadecanol, octadecanol, tristerin, stearic acid polyglycerin ester, fatty acid Pyrusussuriensis are smooth, among the peregelO, polyoxyethylene nonylphenol ether one or more.
Described external-use ointment, the six refreshing cataplasmas wherein and the penetration enhancer of six refreshing ointment can be one or more of azone, propylene glycol, dimethyl sulfoxide, menthol, Camphora, limonene and eucalyptole, fatty acid ester, oleic acid, linoleic acid, lauryl alcohol, sodium lauryl sulphate, Tween 80, carbamide, ethanol, salicylic acid and N monomethyl ketopyrrolidine, N one ethyl pyrrolidone.
Described external-use ointment, the wetting agent of six refreshing ointment wherein comprises one or more in glycerol, propylene glycol, mannitol, the sorbitol.
Described external-use ointment, the six refreshing cataplasmas wherein and the additives of six refreshing ointment are antioxidant, antiseptic and anti-allergic agent, and antioxidant wherein can be one or more in dibenzylatiooluene, malic acid, citric acid, sodium pyrosulfite, potassium metabisulfite, ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, alpha-tocopherol, ascorbic acid, α-tocopheryl acetate, the sodium ascorbate; Antiseptic wherein can be a kind of or several in parabens, quaternary ammonium salts, sorbic acid, chlorobutanol, benzoic acid, sodium benzoate, thimerosal, benzalkonium chloride, benzalkonium bromide, the hibitane; Anti-allergic agent wherein is selected from diphhydramine hydrochloride or chlorphenamine maleate.
The preparation method of external-use ointment, the preparation method of six refreshing plaster wherein is:
Getting vegetable oil 1100-3500 part puts in the pot, refining is to dripping into pearl with high heat, other gets Plumbum preparatium 100-1000 part or official's powder 500-3500 part adds in the vegetable oil, stir evenly, be soaked in cream in the water or water spray receipts cream, get cream and melt with slow fire, add LIUSHEN WAN powder 100-600 part, stir evenly, share on back lining materials, promptly.
The preparation method of six refreshing rubber-emplastrums wherein is:
Raw rubber 100-400 part is cut into the stick of suitable size, in rubber mixing machine, be smelt reticular film, and spread out put cold, reticular film is immersed in 300-1200 part gasoline, soaked 18～24 hours, to the complete swelling gel, with gel move into beat stir 3～4 hours in the cream bucket after, add vaseline 10-100 part and/or lanoline 25-200 part and/or Colophonium 100-400 part and/or vegetable oil 5-50 part successively, zinc oxide or lithopone 150-500 part are made substrate, add LIUSHEN WAN medicated powder 20-200 part again, continued stir about 4 hours, wait when becoming even cream to starch, filter, solvent is reclaimed in coating, the cutting lining, encapsulation, promptly.
The preparation method of six refreshing cataplasmas wherein is:
Hydrophilic cohesiveness substrate 10-400 part, cross-linking agent 10-200 part, wetting agent 10-200 part are added water dissolve in right amount, stir, add filler 10-200 part; stir; get Hydrophillia Babu agent substrate, add LIUSHEN WAN powder 1-100 part, stir; the degassing; coating, covered with protective film, cutting; encapsulation, promptly.
The preparation method of six refreshing ointment wherein has following four kinds:
Method for making a: with grease type substrate or water-soluble base 100-1000 part, grind well or heat and stir evenly, add LIUSHEN WAN powder 1-200 powder, grind well or stir evenly, promptly.
Method for making b: grease type substrate or water-soluble base 100-800 part and penetration enhancer 1-100 part and/or heat preserving agent and/or additives 1-5 part grind well, and add LIUSHEN WAN powder 1-200 part, grind well or stir evenly, promptly.
Method for making c: oily components 50-500 part is ground well or heating and melting, in addition LIUSHEN WAN powder 1-200 part and water-soluble component 50-500 part are ground well or stirs evenly, promptly.
Method for making d: additives 1-5 part, penetration enhancer 1-100 part, adding water mixes, add water-soluble base 100-500 part and grind well, other gets emulsifying agent 1-100 part and adds water and make dissolving in right amount, adds while stirring in the above-mentioned dispersion liquid, grind well, make empty ointment, get LIUSHEN WAN powder 1-200 part glycerol adding 2-200 part and water again and grind well in right amount, add in the ointment of above-mentioned sky, grind well, promptly.
Beneficial effect: through LIUSHEN WAN being changed the externally used paste that dosage form is made, have easy to use, rate of release is fast, onset is rapid, bioavailability is high, the characteristics of preparation stabilization, can overcome the shortcoming of LIUSHEN WAN external fully.Described external-use ointment, the particle size range of LIUSHEN WAN powder are 1nm～1000 μ m.
Four, the specific embodiment
Further specify the present invention below in conjunction with embodiment:
Example 1
Prescription: 300 parts in LIUSHEN WAN powder
3500 parts of Oleum sesami
1100 parts of Plumbum preparatium
Method for making: get edible Oleum sesami and put pot interior refining, add Plumbum preparatium, stir evenly, receive cream, cream is soaked in the water to dripping into pearl.Get cream and melt, add the LIUSHEN WAN fine powder, stir evenly, share on back lining materials, promptly get six refreshing plaster with slow fire.
Example 2
Prescription: 100 parts in LIUSHEN WAN powder
1100 parts of salad oils
1000 parts in official's powder
Method for making: get salad oil and put pot interior refining, add the powder of confiscating, stir evenly, receive cream, cream is soaked in the water to dripping into pearl.Get cream and melt, add the LIUSHEN WAN fine powder, stir evenly, share on back lining materials, promptly get six refreshing plaster with slow fire.
Example 3
Prescription: 200 parts in LIUSHEN WAN powder
3500 parts of Oleum Arachidis hypogaeae semen
1000 parts of Plumbum preparatium
Method for making: get Oleum Arachidis hypogaeae semen and put pot interior refining, add Plumbum preparatium, stir evenly, receive cream, cream is soaked in the water to dripping into pearl.Get cream and melt, add the LIUSHEN WAN fine powder, stir evenly, share on back lining materials, promptly get six refreshing plaster with slow fire.
Example 4
Prescription: 160 parts of 160 parts of Colophonium of 20 parts of rubber of LIUSHEN WAN powder
10 parts of 15 parts of liquid paraffin of 40 parts of vaseline of lanoline
450 parts in 200 parts of gasoline of zinc oxide
Method for making: rubber is cut into the stick of suitable size, in rubber mixing machine, is smelt reticular film, and spread out and put coldly, reticular film is immersed in an amount of gasoline, soaked 18～24 hours, to the complete swelling gel.With rubber cement move into beat stir 3～4 hours in the cream bucket after, add vaseline, lanoline, Colophonium, zinc oxide and liquid paraffin etc. successively and make substrate, add the LIUSHEN WAN powder again, continued stir about 4 hours, wait when becoming even cream to starch, filter, solvent is reclaimed in coating, the cutting lining, encapsulation promptly gets six refreshing rubber cream.
Example 5
Prescription: 300 parts in 230 parts of lithopone of 50 parts of rubber of LIUSHEN WAN powder
18 parts in 25 parts of vaseline of 245 parts of lanolines of esterase
700 parts in 8 parts of gasoline of liquid paraffin
Method for making: get rubber, esterase, lithopone, lanoline, vaseline, liquid paraffin etc. are made substrate by 4 belows of example method, add the LIUSHEN WAN fine powder, stir evenly, and make coating.Be coated with cream, cutting, the lid lining is cut into small pieces, and promptly gets six refreshing rubber cream.
Example 6
Prescription: 250 parts in 2750 parts of gelatin of 400 parts of Sorbitols of LIUSHEN WAN powder
10 parts of 150 parts of ethyl hydroxybenzoates of 20 parts of Kaolin of aluminium hydroxide
30 parts of 40 parts of polyvinylpyrrolidone K-90 of sodium polyacrylate
250 parts in 100 parts of water of 300 parts of azones of sodium carboxymethyl cellulose
Method for making: gelatin, Sorbitol, sodium polyacrylate, sodium carboxymethyl cellulose, aluminium hydroxide, polyvinylpyrrolidone K-90 is soluble in water, adding Kaolin, ethyl hydroxybenzoate, the azone of crossing 200 mesh sieves again stirs, getting the LIUSHEN WAN powder sneaks in the substrate, stir evenly, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 7
Prescription: 25 parts in 300 parts of gelatin of 30 parts of glycerol of LIUSHEN WAN powder
25 parts of 10 parts of sodium polyacrylate of 20 parts of methyl hydroxybenzoates of aluminium carbonate
150 parts in 20 parts of lithopone of sodium carboxymethyl cellulose
30 parts of N monomethyls of polyvinylpyrrolidone K-90 ketopyrrolidine 10g part
600 parts in water
Method for making: gelatin, glycerol, sodium polyacrylate, sodium carboxymethyl cellulose, aluminium carbonate, polyvinylpyrrolidone K-90 are dissolved in 600ml water by said ratio, add N monomethyl ketopyrrolidine, ethyl hydroxybenzoate, lithopone, LIUSHEN WAN powder again, stir, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 8
Prescription: 50 parts of 100 parts of polyvinyl alcohol of 150 parts of gelatin of LIUSHEN WAN
300 parts of 1250 parts of Kaolin of Sorbitol, 340 sodium polyacrylate
75 parts in 25 parts of tartaric acid of 1000 parts of Oleum Ricini of glycerol
125 parts of sodium carboxymethyl cellulose
Method for making: by said ratio that gelatin, glycerol, sodium polyacrylate, Oleum Ricini, Sorbitol, sodium carboxymethyl cellulose, polyvinyl alcohol heated and stirred is even, add tartaric acid, Kaolin, LIUSHEN WAN powder again, stir, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 9
Prescription: 30 parts of 120 parts of benzyl alcohol of 50 parts of Mentholums of LIUSHEN WAN
135 parts in 30 parts of gelatin of 60 parts of dimethyl sulfoxide of Camphora
100 parts in 50 parts of water of glycerol
Method for making: get gelatin, the G ﹠ W heated and stirred makes dissolving, mixing adds LIUSHEN WAN powder, Mentholum, Camphora, dimethyl sulfoxide, benzyl alcohol, stirs, and makes thick paste, coating, and the lid lining, section promptly gets six refreshing cataplasmas.
Example 10
Prescription: 25 parts in 300 parts of gelatin of 30 parts of glycerol of LIUSHEN WAN powder
30 parts of 10 parts of polyacrylic acid of 2 parts of disodium EDTAs of aluminium carbonate
10 parts of 30 parts of azones of 20 parts of lithopone of sodium carboxymethyl cellulose
600 parts in water
Method for making: by said ratio that gelatin, glycerol, polyacrylic acid, sodium carboxymethyl cellulose, disodium EDTA, aluminium carbonate is soluble in water, add LIUSHEN WAN powder, lithopone, azone again, stir, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 11
Prescription: 25 parts in 300 parts of gelatin of 20 parts of glycerol of LIUSHEN WAN powder
26 parts of 8 parts of sodium polyacrylate of 2 parts of dibenzylatiooluene of aluminium potassium sulfate
10 parts of 30 parts of azones of the 20 parts of micropowder silica gels in tragakanta
10 parts of 5 parts of tartaric acid 10g of dimethyl sulfoxide part diphhydramine hydrochlorides
580 parts in water
Method for making: gelatin, glycerol, sodium polyacrylate, tragakanta, tartaric acid, diphhydramine hydrochloride, aluminium potassium sulfate is soluble in water by said ratio, add LIUSHEN WAN powder, dibenzylatiooluene, micropowder silica gel, dimethyl sulfoxide, azone again, stir, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 12
Prescription: 37.5 parts of 30 parts of Mentholums of 20 parts of Camphoras of LIUSHEN WAN powder
136.5 parts of 91 parts of glycerol of 5 parts of gelatin of chlorphenamine maleate
Method for making: get the heating of gelatin, glycerol and make substrate, Camphora, Mentholum, chlorphenamine maleate, LIUSHEN WAN powder are added in the substrate of being made by gelatin glycerol successively, after stirring, coating, the lid lining, section promptly gets six refreshing cataplasmas.
Example 13
Prescription: 40 parts in 100 parts of Cera Flavas of 6 parts of Oleum Sesami of LIUSHEN WAN powder
Method for making: with the Oleum Sesami heating, add the Cera Flava fusing, in the impouring container, when the temperature of waiting is reduced to 60～70 ℃, add the LIUSHEN WAN powder, stir evenly, promptly get six refreshing ointment to condensation.
Example 14
Prescription: 9 parts of 87 parts of lanolines of 3 parts of vaseline of LIUSHEN WAN powder
Method for making: get vaseline and lanoline, after the heating in water bath fusion, add the LIUSHEN WAN powder, stir evenly, put coldly, promptly get six refreshing ointment.
Example 15
Prescription: 10 parts of 25 parts of liquid paraffin of 3 parts of stearic acid of LIUSHEN WAN powder
4 parts of 18 parts of triethanolamine of 25 parts of vaseline of glycerol
30 parts of ethyl hydroxybenzoates of 4 parts of water of azone are an amount of
Method for making: add the emulsifying agent triethanolamine after getting stearic acid, vaseline, liquid paraffin, azone heat fused, gauze filters out impurities, 80 ℃ of insulations.LIUSHEN WAN powder and glycerol, water are ground evenly, add the ethyl hydroxybenzoate stirring and make dissolving, 80 ℃ of insulations.Oil phase is added water, be stirred to Emulsion and form, fully grind well after reducing to room temperature, promptly get six refreshing ointment.
Example 16
Prescription: 80 parts of 10 parts of monoglycerides of 10 parts of stearic acid of LIUSHEN WAN powder
20 parts of 40 parts of paraffin oil of 20 parts of Arlacel-80s of Tween-80
1.5 parts of 6 parts of ethyl hydroxybenzoates of 10 parts of benzoic acid of laurocapram
80 parts of octadecanol
Method for making: get stearic acid, monoglyceride, octadecanol, Tween-80, paraffin oil, Arlacel-80 heating (80 ℃) makes fusion, 80 ℃ are incubated 30 minutes, when temperature is reduced to 40 ℃, add LIUSHEN WAN powder, laurocapram, benzoic acid, ethyl hydroxybenzoate, mixing promptly gets six refreshing ointment.
Example 17
Prescription: 600 parts of 400 parts of PEG400s of 30 parts of Macrogol 4000s of LIUSHEN WAN powder
Method for making: taking polyethylene glycol 4000 and PEG400 mix, and are heated to 65 ℃ in water-bath, stir, and are cooled to 55 ℃, add the LIUSHEN WAN powder, stir to condensation, promptly get six refreshing ointment.
Example 18
Prescription: 150 parts of 60 parts of glycerol of 30 parts of sodium carboxymethyl cellulose of LIUSHEN WAN powder
800 parts in 1 part of water of chlorobutanol
Method for making: get chlorobutanol and water and be made into aqueous solution for 100 parts, get sodium carboxymethyl cellulose and glycerol grinds well, add in 200 parts of hot water, place a few hours after, add the chlorobutanol aqueous solution, add other 500 parts of water, stir evenly, make substrate, add the LIUSHEN WAN powder, stir, promptly get six refreshing ointment.
Example 19
Prescription: 60 parts of 10 parts of glycerol of 40 parts of sodium carboxymethyl cellulose of LIUSHEN WAN powder
50 parts of 11 parts of ethanol of 40 parts of Tween-80s of propylene glycol
5 parts of 830 parts of diphhydramine hydrochlorides of 0.5 part of water of triethanolamine
Method for making: get sodium carboxymethyl cellulose, glycerol, propylene glycol, Tween-80, ethanol, triethanolamine, water, stir evenly, make substrate, add LIUSHEN WAN powder and diphhydramine hydrochloride, mixing promptly gets six refreshing ointment.
Example 20
Prescription: 100 parts of 15 parts of glycerol of 30 parts of carbomers of LIUSHEN WAN powder
22.5 parts of 1 part of triethanolamine of 30 parts of ethyl hydroxybenzoates of propylene glycol
801.5 parts in water
Method for making: get ethyl hydroxybenzoate, add propylene glycol and make dissolving, add water 600g again, stir evenly, add carbomer, the vacuum homogenizing grinds, and makes complete swelling, places, and is standby; Other gets triethanolamine and adds water 100g and make dissolving, adds while stirring in the above-mentioned carbomer dispersion liquid, and the vacuum homogenizing grinds, and makes into blank ointment, places, and is standby; Other gets the LIUSHEN WAN powder, and glycerol adding and water 101.5g grind to make fully and disperse, and add in the above-mentioned blank ointment, and the vacuum homogenizing grinds well, and promptly gets six refreshing ointment.
Example 21
Prescription: 100 parts of 30 parts of glycerol of 40 parts of hydroxypropyl celluloses of LIUSHEN WAN powder
2 parts of 15 parts of sorbic acid of 30 parts of dimethyl sulfoxide of propylene glycol
5 parts of 25 parts of chlorphenamine maleate of 10 parts of triethanolamine of citric acid
900 parts in water
Method for making: get sorbic acid, citric acid, chlorphenamine maleate, adding propylene glycol, dimethyl sulfoxide make dissolving, add water 600g again, stir evenly, and add hydroxypropyl cellulose, and the vacuum homogenizing grinds, and makes complete swelling, places, and is standby; Other gets triethanolamine, add water 100g makes dissolving, adds while stirring in the above-mentioned dispersion liquid, and the vacuum homogenizing grinds, and makes into blank ointment, places, standby; Other gets the LIUSHEN WAN powder, and glycerol adding and water 200g grind to make fully and disperse, and add in the above-mentioned blank ointment, and the vacuum homogenizing grinds well, and promptly gets six refreshing ointment.
Example 22
Prescription: 100 parts of 30 parts of glycerol of 40 parts of sodium carboxymethyl cellulose of LIUSHEN WAN powder
3 parts of 15 parts of sodium benzoate of 30 parts of dimethyl sulfoxide of propylene glycol
30 parts of 15 parts of polyoxyethylene sorbitan monoleates of sodium pyrosulfite
800 parts in water
Method for making: get sodium benzoate, sodium pyrosulfite, adding propylene glycol, dimethyl sulfoxide make dissolving, add water 600g again, stir evenly, add sodium carboxymethyl cellulose, the vacuum homogenizing grinds, make complete swelling, place, standby: other gets polyoxyethylene sorbitan monoleate, add water 100g makes dissolving, adds while stirring in the above-mentioned dispersion liquid, the vacuum homogenizing grinds, make into blank ointment, place, standby; Other gets the LIUSHEN WAN powder, and glycerol adding and water 100g grind to make and disperse fully to add in the above-mentioned blank ointment, and the vacuum homogenizing grinds well, and promptly gets six refreshing ointment.
Claims (10)
1. a class external-use ointment is characterized in that it is is the unguentum of principal agent with the LIUSHEN WAN powder, and it comprises six refreshing plaster, six refreshing rubber-emplastrums, six refreshing cataplasmas and six refreshing ointment, and six refreshing plaster wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 100-600 part
Edible vegetable oil 1100-3500 part
Plumbum preparatium 100-1000 part or official's powder 500-3500 part.
Six refreshing rubber-emplastrums wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 20-200 part
Rubber 100-400 part
Colophonium or esterase or Foral 100-400 part
Lanoline 25-200 part and/or vaseline 10-100 part and/or liquid paraffin 5-50 part and/or vegetable oil 5-50 part
Zinc oxide and/or lithopone 150-500
Gasoline 300-1200 part
Six refreshing cataplasmas wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 1-100 part
Hydrophillia Babu agent substrate 40-1000 part
Penetration enhancer 1-40 part
Additives 1-5 part
Six refreshing ointment wherein are made by following raw materials by weight percent:
LIUSHEN WAN powder 1-200 part
Greasing base or water-soluble base or emulsion-type substrate 100-1000 part
Penetration enhancer 1-100 part
Wetting agent 1-50 part
Additives 1-50 part.
2. external-use ointment according to claim 1, it is characterized in that wherein six refreshing cataplasma Hydrophillia Babu agent substrate are by hydrophilic cohesiveness substrate, cross-linking agent, wetting agent, filler, water is formed, and wherein hydrophilic cohesiveness substrate comprises sodium carboxymethyl cellulose, gelatin, agar, sodium polyacrylate, polyacrylic acid potassium, ammonium polyacrylate, polyacrylic acid monoethanol ammonium, polyacrylic acid diethanol ammonium, the polyacrylic acid triethanol ammonium, carboxymethyl starch, polyvinylpyrrolidone, polyvinyl alcohol, carbopol, Polyethylene Glycol, polyacrylic acid, arabic gum, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxy methocel, in the tragakanta one or more; Cross-linking agent comprises one or both in aluminium hydroxide, aluminum chloride, aluminium potassium sulfate, aluminium carbonate, aluminum acetate, aluminum nitrate, magnesium hydroxide, magnesium aluminate, magnesium nitrate, the calcium chloride; Wetting agent comprises one or more in glycerol, propylene glycol, mannitol, the sorbitol; Filler comprises one or more in zinc oxide, titanium dioxide, Kaolin, clay, Pulvis Talci, micropowder silica gel, calcium carbonate, kieselguhr, kaolin, the lithopone.
3. external-use ointment according to claim 1, the greasing base that it is characterized in that described six refreshing ointment comprises one or more in animal and plant fat, vaseline, paraffin, liquid paraffin, lanoline, Cera Flava, spermaceti and the silicone oil; Water-soluble base comprises one or more in glycerol, gelatin, Polyethylene Glycol, carbomer, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium alginate and the sodium polyacrylate; The emulsifying agent of emulsion-type substrate comprises that soda soap, three ethanol soap classes, fatty alcohol sulphuric acid (ester) sodium class, Polysorbate, hexadecanol, octadecanol, tristerin, stearic acid polyglycerin ester, fatty acid Pyrusussuriensis are smooth, among the peregel O, polyoxyethylene nonylphenol ether one or more.
4. external-use ointment according to claim 1, the substrate that it is characterized in that described six refreshing ointment also comprises one or more in penetration enhancer, wetting agent, the additives.
5. according to claim 1 or 4 described external-use ointments, the penetration enhancer that it is characterized in that described six refreshing cataplasmas and six refreshing ointment comprises one or more of azone, propylene glycol, dimethyl sulfoxide, menthol, Camphora, limonene and eucalyptole, fatty acid ester, oleic acid, linoleic acid, lauryl alcohol, sodium lauryl sulphate, Tween 80, carbamide, ethanol, salicylic acid and N monomethyl ketopyrrolidine, N one ethyl pyrrolidone.
6. external-use ointment according to claim 4, the wetting agent that it is characterized in that described six refreshing ointment comprises one or more in glycerol, propylene glycol, mannitol, the sorbitol.
7. according to claim 1 or 4 described external-use ointments, the six refreshing cataplasmas wherein and the additives of six refreshing ointment are antioxidant, antiseptic and anti-allergic agent.
8. external-use ointment according to claim 7 is characterized in that described antioxidant comprises one or more in dibenzylatiooluene, malic acid, citric acid, sodium pyrosulfite, potassium metabisulfite, ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, alpha-tocopherol, ascorbic acid, α-tocopheryl acetate, the sodium ascorbate;
Antiseptic comprises one or more in parabens, quaternary ammonium salts, sorbic acid, chlorobutanol, benzoic acid, sodium benzoate, thimerosal, benzalkonium chloride, benzalkonium bromide, the hibitane;
Anti-allergic agent is selected from diphhydramine hydrochloride or chlorphenamine maleate.
9. method for preparing claim 1 external-use ointment, wherein the preparation method of six refreshing plaster is:
Getting vegetable oil 1100-3500 part puts in the pot, refining is to dripping into pearl with high heat, other gets Plumbum preparatium 100-1000 part or official's powder 500-3500 part adds in the vegetable oil, stir evenly, be soaked in cream in the water or water spray receipts cream, get cream and melt with slow fire, add LIUSHEN WAN powder 100-600 part, stir evenly, share on back lining materials, promptly.
The preparation method of six refreshing rubber-emplastrums wherein is:
Raw rubber 100-400 part is cut into the stick of suitable size, in rubber mixing machine, be smelt reticular film, and spread out put cold, reticular film is immersed in 300-1200 part gasoline, soaked 18～24 hours, to the complete swelling gel, with gel move into beat stir 3～4 hours in the cream bucket after, add vaseline 10-100 part and/or lanoline 25-200 part and/or Colophonium 100-400 part and/or vegetable oil 5-50 part successively, zinc oxide and/or lithopone 150-500 part are made substrate, add LIUSHEN WAN powder 20-200 part again, continued stir about 4 hours, wait when becoming even cream to starch, filter, solvent is reclaimed in coating, the cutting lining, encapsulation, promptly;
The preparation method of six refreshing cataplasmas wherein is:
Hydrophilic cohesiveness substrate 10-400 part, cross-linking agent 10-200 part, wetting agent 10-200 part are added the suitable quantity of water dissolving, stir, add filler 10-200 part; stir; get Hydrophillia Babu agent substrate, add LIUSHEN WAN powder 1-100 part, stir; the degassing; coating, covered with protective film, cutting; encapsulation, promptly.
10. method for preparing the described external-use ointment of claim 1 is characterized in that the method for making of described six refreshing ointment is as follows:
Method for making a: with grease type substrate or water-soluble base 100-1000 part, grind well or heat and stir evenly, add LIUSHEN WAN powder 1-200 powder, grind well or stir evenly, promptly.
Method for making b: grease type substrate or water-soluble base 100-800 part and penetration enhancer 1-100 part and/or heat preserving agent and/or additives 1-5 part grind well, and add LIUSHEN WAN powder 1-200 part, grind well or stir evenly, promptly.
Method for making c: oily components 50-500 part is ground well or heating and melting, in addition LIUSHEN WAN powder 1-200 part and water-soluble component 50-500 part are ground well or stirs evenly, promptly.
Method for making d: additives 1-5 part, penetration enhancer 1-100 part, adding water mixes, add water-soluble base 100-500 part and grind well, other gets emulsifying agent 1-100 part and adds water and make dissolving in right amount, adds while stirring in the above-mentioned dispersion liquid, grind well, make empty ointment, get LIUSHEN WAN powder 1-200 part glycerol adding 2-200 part and water again and grind well in right amount, add in the ointment of above-mentioned sky, grind well, promptly.
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| CN100423750C (en) * | 2006-08-11 | 2008-10-08 | 林忠 | Dermatosis treating medicine |
| CN102091273A (en) * | 2011-03-09 | 2011-06-15 | 贺倩 | Gynecological lotion and preparation method thereof |
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| CN100423750C (en) * | 2006-08-11 | 2008-10-08 | 林忠 | Dermatosis treating medicine |
| CN102091273A (en) * | 2011-03-09 | 2011-06-15 | 贺倩 | Gynecological lotion and preparation method thereof |
| CN102091273B (en) * | 2011-03-09 | 2012-08-15 | 贺倩 | Gynecological lotion and preparation method thereof |
| JP5112573B1 (en) * | 2011-07-12 | 2013-01-09 | 株式会社フローラルミネラル研究所 | Mastitis prevention and treatment composition |
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| CN104606656A (en) * | 2015-01-23 | 2015-05-13 | 九寨沟天然药业集团有限责任公司 | Preparation process of traditional Chinese medicine rubber electuary medicine and paste |
| CN106265692A (en) * | 2015-05-22 | 2017-01-04 | 天津药物研究院有限公司 | A kind of transdermal formulation of enoxolone 30-amide derivatives and its production and use |
| CN108498548A (en) * | 2017-02-27 | 2018-09-07 | 上海雷允上药业有限公司 | Refreshing gel patch agent of one kind six and preparation method thereof |
| CN108498548B (en) * | 2017-02-27 | 2020-05-26 | 上海雷允上药业有限公司 | Liushen gel paste and preparation method thereof |
| CN107375894A (en) * | 2017-09-05 | 2017-11-24 | 申峰 | Treat outer emplastrum of Chinese medicine of neck-shoulder pain, lumbago and leg pain and preparation method thereof |
| CN107951866A (en) * | 2017-12-06 | 2018-04-24 | 北京茗泽中和药物研究有限公司 | Loxoprofen sodium patch |
| CN111466639A (en) * | 2020-05-06 | 2020-07-31 | 佳木斯大学 | Sustained-release medicine antiviral mask patch and preparation method thereof |
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| CN100459973C (en) | 2009-02-11 |
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Address after: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Patentee after: Leiyunshang Pharmaceutical Group Co. Ltd. Address before: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Patentee before: Leiyunshang Pharmaceutical Co., Ltd. |