CN107375882A - A kind of preparation method for protecting the peaceful particle of the heart - Google Patents
A kind of preparation method for protecting the peaceful particle of the heart Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000002245 particle Substances 0.000 title claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 60
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- 239000000843 powder Substances 0.000 claims abstract description 36
- 239000006071 cream Substances 0.000 claims abstract description 22
- 241000234314 Zingiber Species 0.000 claims abstract description 21
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 21
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 13
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- 229910052708 sodium Inorganic materials 0.000 claims abstract description 13
- 239000011734 sodium Substances 0.000 claims abstract description 13
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 11
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- 239000000811 xylitol Substances 0.000 claims abstract description 11
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
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- 239000012141 concentrate Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 2
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- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 3
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- HYXITZLLTYIPOF-UHFFFAOYSA-N Tanshinone II Natural products O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)=CO2 HYXITZLLTYIPOF-UHFFFAOYSA-N 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- AZEZEAABTDXEHR-UHFFFAOYSA-M sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-2-sulfonate Chemical compound [Na+].C12=CC=C(C(CCC3)(C)C)C3=C2C(=O)C(=O)C2=C1OC(S([O-])(=O)=O)=C2C AZEZEAABTDXEHR-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
A kind of preparation method for protecting the peaceful particle of the heart, belongs to technical field of medicine, consisting of：0.15 0.17 parts of Radix Salviae Miltiorrhizae dry extract, 0.07 0.09 parts of Radix Angelicae Sinensis dry extract, 0.07 0.09 parts of Fructus Aurantii dry extract, 0.5 0.7 parts of ginger dry cream, 0.09 0.15 parts of Radix Notoginseng powder, 0.1 2.0 parts of Steviosin, 0.15 1.5 parts of 18 parts of xylitol, 0.2 ~ 0.7 part of Sodium Hydroxymethyl Stalcs and beta cyclodextrin.First by the red sage root, Radix Angelicae Sinensis and Fructus Aurantii by technical process such as drying, crushing, alcohol extracting, filtering, concentration, dryings, medicinal extract extract is obtained, ginger is then obtained into dry cream extract by water extraction, filtering, concentration, drying etc., make adhesive with ethanol, pelletized.Present invention improves over traditional formulation, expands using crowd, greatly improves the utilization rate of Chinese medicine, preferably plays and protects the peaceful pharmacological action of the heart and clinical efficacy.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of preparation method for protecting the peaceful particle of the heart.
Background technology
It is rather pure Chinese medicinal preparation to protect the heart, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, can effectively improve systema cariovasculare functional, is current
The ideal medicament of the illnesss such as clinical treatment angina pectoris, arrhythmia cordis, coronary heart disease.
Its side is made up of the red sage root, pseudo-ginseng, Radix Angelicae Sinensis, Fructus Aurantii, ginger.Red sage root promoting blood circulation, stasis-dispelling and pain-killing, relieving restlessness that clears away heart-fire, are used in side
For monarch drug in a prescription；Chinese angelica blood supplementing, promoting blood circulation and relieve pain, pseudo-ginseng dissipate stasis of blood hemostasis, detumescence ding-tong, Fructus Aurantii regulating the flow of QI to ease the stomach is stagnant with row, and three medicines are minister；
Associated with ginger, can defend with battalion, adjust all medicines, think that assistant makes.The prescription five tastes, compatibility is precise and appropriate, play altogether it is promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain it
Effect.Side reaction is low, steady quality, curative for effect.
Wherein the red sage root is one of China's tradition parts of generic medicinal plants, can therefrom extract tanshinone and danshinolic acid, and this two
Kind composition is to protect the active ingredient that clinical efficacy activity is maximum in the peaceful particle of the heart.Research shows that they all have significant simultaneously
Pharmacological action.Due to the disease incidences such as angiocarpy steeply rise and Chinese patent drug and health products using the red sage root as primary raw material
Exploitation, makes red sage root demand increase with annual 5% speed.But to natural resources of Chinese medicinal materials excessively and unordered exploitation, cause it is conventional in
Herb resource can not meet demand gradually, and in limited resource, improving the utilization rate of Chinese herb can not urgently treat.
The content of the invention
Based on above-mentioned purpose, the present invention provides a kind of preparation method for protecting the peaceful particle of the heart, can not only sufficiently extract the red sage root
In active ingredient, and preferably play protect the peaceful particle of the heart pharmacological action and clinical efficacy, applicability is stronger, using crowd
Scope is wider.
Based on above-mentioned purpose, the present invention adopts the following technical scheme that：
A kind of preparation method for protecting the peaceful particle of the heart, comprises the following steps：
（1）Prepare Radix Salviae Miltiorrhizae dry extract：The red sage root is ground into coarse powder, is put into percolate pot, addition concentration is 95v%, gross weight is red
Join the ethanol of 10 ~ 12 times of coarse powder weight, dipping to its diacolation and is collected until finishing after 24 hours with 1 ~ 3mL/min flow velocity
First time percolate, then toward concentration is added in percolate pot is 50 ~ 75v%, gross weight is 10 ~ 12 times of raw material meal weight
Ethanol, to its diacolation and collected with 1 ~ 3mL/min flow velocity until finish to obtain second of percolate；Add 5 ~ 6 times of weights of the dregs of a decoction
The water of amount carries out 2 ~ 3h of decoction to the remaining dregs of a decoction in percolate pot, and filtering, filtrate merges with above-mentioned percolate, is concentrated and dried, produces；
（2）Prepare Radix Angelicae Sinensis dry extract：75 ~ 95v% the alcohol refluxs for adding 8 ~ 10 times of weight of Radix Angelicae Sinensis extract 2 ~ 3 times, every time 6 ~ 8h,
Merging filtrate, concentrate, spray drying, produce；
（3）Prepare Fructus Aurantii dry extract：Fructus Aurantii is ground into coarse powder, is put into percolate pot, addition concentration is 95v%, gross weight is trifoliate orange
The ethanol of 10 ~ 12 times of shell coarse powder weight, dipping to its diacolation and are collected up to finishing after 24 hours with 1 ~ 3mL/min flow velocity,
Percolate is collected, concentration, 80 mesh is dry, pulverize into and produces；
（4）Prepare ginger dry cream：The decocting that 8 ~ 10 weight are added into ginger is boiled 2 ~ 3 times, and 2 ~ 3h, is filtered, merging filtrate every time,
Concentration, spray drying, is produced；
（5）Pseudo-ginseng is ground into fine powder, crosses 100 mesh sieves；
（6）Steviosin, xylitol, Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin are broken to 80 mesh fine powders；
（7）Prepare each raw material by following weight parts：Radix Salviae Miltiorrhizae dry extract 0.15-0.17 parts, Radix Angelicae Sinensis dry extract 0.07-0.09 parts, trifoliate orange
Shell dry extract 0.07-0.09 parts, ginger dry extract 0.5-0.7 parts, Radix Notoginseng powder 0.09-0.15 parts, Steviosin 0.1-2.0 parts, wood
Sugar alcohol 1-8 parts, 0.2 ~ 0.7 part of Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin 0.15-1.5 parts；
（8）Make adhesive with ethanol, by step（7）Various raw materials mix, pelletized according to existing method of granulating.
Preferably, step（7）In the composition of each raw material be：0.167 part of Radix Salviae Miltiorrhizae dry extract, 0.083 part of Radix Angelicae Sinensis dry extract, trifoliate orange
0.083 part of shell dry extract, 0.625 part of ginger dry cream, 0.1 part of Radix Notoginseng powder, 0.15 part of Steviosin, 3.5 parts of xylitol, methylol form sediment
0.65 part of 0.45 part of powder sodium and beta-schardinger dextrin.
The present invention is improved on the basis of original prescription technique, improves the utilization of the traditional Chinese medicine ingredients especially red sage root
Rate, and granule is made into, make patient compliance more preferable, more conducively the middle-older patient of dysphagia.
Embodiment
Technical scheme is described in further detail below in conjunction with specific embodiment, but the protection model of the present invention
Enclose and be not limited thereto.
Embodiment 1
A kind of preparation method for protecting the peaceful particle of the heart, comprises the following steps：
（1）The preparation of Radix Salviae Miltiorrhizae dry extract：Red sage root 1494.7kg is taken, is ground into coarse powder, is put into percolate pot, is made with 95v% ethanol molten
Agent（Total amount is 10 times of red sage root weight）, soak 24 hours, carry out diacolation, to its diacolation and collected straight with 3mL/min flow velocity
To finishing to obtain first time percolate；75v% ethanol as solvent is used again（Total amount is 10 times of red sage root weight）, diacolation is carried out, with
3mL/min flow velocity is to its diacolation and collects until finishing to obtain second of percolate；The water of 6 times of weight of the dregs of a decoction is added to percolate pot
The interior remaining dregs of a decoction carry out decoction 2h, and filtering, filtrate merges with above-mentioned percolate, be concentrated into relative density for 1.08 ~ 1.12 it is clear
Cream, spray drying, obtains 180.4kg Radix Salviae Miltiorrhizae dry extracts；
（2）The preparation of Radix Angelicae Sinensis dry extract：Radix Angelicae Sinensis 311kg is taken, adds the 75v% ethanol of 8 times of Radix Angelicae Sinensis weight, refluxing extraction 2 times, every time 6
Hour, merge extract solution, filtering, filtrate decompression is condensed into the clear cream that relative density is 1.10 ~ 1.25, spray drying, obtained
89.6kg Radix Angelicae Sinensis dry extracts；
（3）The preparation of Fructus Aurantii dry extract：Take Fructus Aurantii 541.1kg, be ground into coarse powder, be put into percolate pot, addition concentration be 95v%,
Gross weight be 10 times of Fructus Aurantii coarse powder weight ethanol, dipping 24 hours after, with 3mL/min flow velocity to its diacolation and collect until
Finish, collect percolate, be concentrated under reduced pressure into the clear cream that relative density is 1.10 ~ 1.25, be dried under reduced pressure, obtain 89.6kg Fructus Aurantiis and do
Medicinal extract, it is ground into 80 mesh and produces；
（4）The preparation of ginger dry cream：Ginger 675kg is taken, adds 8 times of weight of water, decoction is secondary, 2 hours every time, collecting decoction, mistake
Filter, filtrate are concentrated into the clear cream that relative density is 1.10 ~ 1.20, spray drying, produced；
（5）Pseudo-ginseng is ground into fine powder, crosses 100 mesh sieves；
（6）Steviosin, xylitol, Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin are broken to 80 mesh fine powders；
（7）Prepare each raw material by following weight parts：0.167 part of Radix Salviae Miltiorrhizae dry extract, 0.083 part of Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract
0.083 part, 0.625 part of ginger dry cream, 0.1 part of Radix Notoginseng powder, 0.15 part of Steviosin, 3.5 parts of xylitol, Sodium Hydroxymethyl Stalcs 0.45
0.65 part of part and beta-schardinger dextrin；
（8）Make adhesive, step with 95v% ethanol（7）Each raw material mix, pelletized according to existing granulation technique.
Embodiment 2
A kind of preparation method for protecting the peaceful particle of the heart, comprises the following steps：
（1）The preparation of Radix Salviae Miltiorrhizae dry extract：Red sage root 2989.4kg is taken, is ground into coarse powder, is put into percolate pot, is made with 95v% ethanol molten
Agent（Total amount is 12 times of red sage root weight）, soak 24 hours, carry out diacolation, to its diacolation and collected straight with 1mL/min flow velocity
To finishing to obtain first time percolate；50v% ethanol as solvent is used again（Total amount is 10 times of red sage root weight）, diacolation is carried out, with
1mL/min flow velocity is to its diacolation and collects until finishing to obtain second of percolate；The water of 5 times of weight of the dregs of a decoction is added to percolate pot
The interior remaining dregs of a decoction carry out decoction 3h, and filtering, filtrate merges with above-mentioned percolate, be concentrated into relative density for 1.08 ~ 1.12 it is clear
Cream, spray drying, obtains 360.7kg Radix Salviae Miltiorrhizae dry extracts；
（2）The preparation of Radix Angelicae Sinensis dry extract：Radix Angelicae Sinensis 622.1kg is taken, adds the 95v% ethanol of 10 times of Radix Angelicae Sinensis weight, refluxing extraction 2 times, often
Secondary 8 hours, merge extract solution, filtering, filtrate decompression is condensed into the clear cream that relative density is 1.10 ~ 1.25, spray drying, obtained
179.3kg Radix Angelicae Sinensis dry extract；
（3）The preparation of Fructus Aurantii dry extract：Fructus Aurantii 1082.2kg is taken, is ground into coarse powder, is put into percolate pot, adding concentration is
95v%, the ethanol that gross weight is 12 times of Fructus Aurantii coarse powder weight, dipping to its diacolation and are received after 24 hours with 1mL/min flow velocity
Collection collects percolate, is concentrated under reduced pressure into the clear cream that relative density is 1.10 ~ 1.25, is dried under reduced pressure, obtains up to finishing
179.3kg Fructus Aurantii dry extracts, it is ground into 80 mesh and produces；
（4）The preparation of ginger dry cream：Ginger 1350kg is taken, adds 10 times of weight of water to decoct secondary, 3 hours every time, collecting decoction, mistake
Filter, filtrate are concentrated into the clear cream that relative density is 1.10 ~ 1.20, spray drying, produced；
（5）Pseudo-ginseng is ground into fine powder, crosses 100 mesh sieves；
（6）Steviosin, Sodium Hydroxymethyl Stalcs, xylitol and beta-schardinger dextrin are broken to 80 mesh fine powders；
（7）Prepare each raw material by following weight parts：0.15 part of Radix Salviae Miltiorrhizae dry extract, 0.09 part of Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract
0.07 part, 0.7 part of ginger dry extract, 0.09 part of Radix Notoginseng powder, 2.0 parts of Steviosin, 1 part of xylitol, 0.7 part of Sodium Hydroxymethyl Stalcs and
0.15 part of beta-schardinger dextrin；
（8）Make adhesive, step with 95v% ethanol（7）Each raw material mix, pelletized according to existing granulation technique.
Embodiment 3
A kind of preparation method for protecting the peaceful particle of the heart, comprises the following steps：
（1）The preparation of Radix Salviae Miltiorrhizae dry extract：Red sage root 1024.7kg is taken, is ground into coarse powder, is put into percolate pot, is made with 95v% ethanol molten
Agent（Total amount is 11 times of red sage root weight）, soak 24 hours, carry out diacolation, to its diacolation and collected straight with 2mL/min flow velocity
To finishing to obtain first time percolate；60v% ethanol as solvent is used again（Total amount is 10 times of red sage root weight）, diacolation is carried out, with
2mL/min flow velocity is to its diacolation and collects until finishing to obtain second of percolate；The water of 6 times of weight of the dregs of a decoction is added to percolate pot
The interior remaining dregs of a decoction carry out decoction 3h, and filtering, filtrate merges with above-mentioned percolate, be concentrated into relative density for 1.08 ~ 1.12 it is clear
Cream, spray drying, obtains 123.7kg Radix Salviae Miltiorrhizae dry extracts；
（2）The preparation of Radix Angelicae Sinensis dry extract：Radix Angelicae Sinensis 214.4kg is taken, adds the 75v% ethanol of 8 times of Radix Angelicae Sinensis weight, refluxing extraction 2 times, often
Secondary 6 hours, merge extract solution, filtering, filtrate decompression is condensed into the clear cream that relative density is 1.10 ~ 1.25, spray drying, is made
61.8kg produce；
（3）The preparation of Fructus Aurantii dry extract：Take Fructus Aurantii 374.8kg, be ground into coarse powder, be put into percolate pot, addition concentration be 95v%,
Gross weight be 11 times of Fructus Aurantii coarse powder weight ethanol, dipping 24 hours after, with 2mL/min flow velocity to its diacolation and collect until
Finish, collect percolate, be concentrated under reduced pressure into the clear cream that relative density is 1.10 ~ 1.25, be dried under reduced pressure, obtain 62.1kg Fructus Aurantiis and do
Medicinal extract, it is ground into 80 mesh and produces；
（4）The preparation of ginger dry cream：Ginger 371kg is taken, adds 9 times of weight of water to decoct secondary, 2 hours every time, collecting decoction, mistake
Filter, filtrate are concentrated into the clear cream that relative density is 1.10 ~ 1.20, spray drying, produced；
（5）Pseudo-ginseng is ground into fine powder, crosses 100 mesh sieves；
（6）Steviosin, xylitol, Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin are broken to 80 mesh fine powders；
（7）Prepare each raw material by following weight parts：0.17 part of Radix Salviae Miltiorrhizae dry extract, 0.07 part of Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract
0.09 part, 0.5 part of ginger dry extract, 0.15 part of Radix Notoginseng powder, 0.1 part of Steviosin, 8 parts of xylitol, 0.2 part of Sodium Hydroxymethyl Stalcs and
1.5 parts of beta-schardinger dextrin；
（8）Make adhesive, step with 95v% ethanol（7）Each raw material mix, pelletized according to existing granulation technique.
Usage of the present invention is oral, dosage：One time 5 grams, three times per day, or follow the doctor's advice and cut down according to the circumstance by the state of an illness, major function：It is living
Blood stagnation resolvation, promoting qi circulation and relieving pain.For angina pectoris, arrhythmia cordis, improve coronary heart disease symptom etc..
The peaceful particle of the heart is protected to the embodiment of the present invention 1, carries out Accelerated stability test investigation, wherein the condition of investigation is 40 ± 2
DEG C, relative humidity 75 ± 5%；Investigation standard：（1）Character：This product is the particle of sepia；Sweet, slight bitter.（2）Differentiate 1：According to point
Light photometry determines, and has absorption maximum at 281 ± 3nm wavelength.（3）Differentiate 2：In test sample chromatogram, respectively with compareing
On the medicinal material red sage root, the chromatogram of Fructus Aurantii and Radix Angelicae Sinensis and the corresponding position of reference substance chromatogram, show the spot of same color.（4）Content：This
Product every are containing Radix Salviae Miltiorrhizae dry extract with tanshinone IIA（C19H18O3）Calculate, 1.2mg must not be less than.
The stability that table 1 protects the peaceful granule of the heart accelerates to investigate result
As can be seen from the above table, by 6 months stability accelerate investigate experiment, embodiment protect the peaceful particle of the heart appearance character compared with
To be stable, content still conforms to provide, other indexs also all meet the requirements, and it is that a kind of quality is highly stable to illustrate granule of the present invention
Formulation.Embodiment 2 accelerates investigation suitable with the result of embodiment 1 with embodiment 3 through overstability.
Clinical therapeutic efficacy：
Dosage regimen, the patient that selection voluntarily receives reagent amount to 150, wherein for the medicine compareed（It is existing commercially available
BAOXINNING JIAONANG and BaoXin Ningtablet）Totally 100,50 are protected the peaceful particle of the heart using the embodiment of the present invention 1, by following bases for estimation pair
Curative effect is investigated, and the results are shown in Table 2 to 5.
The main judgment basis of curative effect is as follows.
1）For angina pectoris effect：
It is excellent：Angina pectoris is alleviated quickly, good：Angina pectoris has been alleviated, in：Angina pectoris is slightly alleviated, poor：After one course for the treatment of of medication,
Angina pectoris is not alleviated substantially.
2）For arrhythmia cordis effect：
It is excellent：Arrhythmia cordis is alleviated quickly, good：Arrhythmia cordis has been alleviated, in：Arrhythmia cordis is slightly alleviated, poor：One treatment of medication
Cheng Hou, arrhythmia cordis are not alleviated substantially.
3）Improve coronary heart disease symptom effect：
It is excellent：Coronary heart disease symptom has and largely improved, good：Coronary heart disease symptom makes moderate progress, in：Coronary heart disease symptom slightly improves,
Difference：After one course for the treatment of of medication, coronary heart disease symptom does not improve substantially.
4）The mouthfeel compliance of patient：
It is excellent：It is good in taste, easily swallow clothes；It is good：Mouthfeel is general, is easier to swallow；In：Mouthfeel is general, can swallow, poor：Mouthfeel
It is poor, swallow difficulty.
Table 2 is used for angina pectoris effect observation
Table 3 is used for arrhythmia cordis effect observation
Table 4 is used to improve coronary heart disease symptom effect observation
Table 5 is used for mouthfeel compliance effect observation
The investigation result of table 2 to 5 shows：The embodiment of the present invention 1 protects the peaceful particle of the heart and is used for angina pectoris, arrhythmia cordis and improves coronary disease
Disease symptoms etc., effect are better than control group, and wherein mouthfeel compliance more has a clear superiority.It is peaceful to implement guarantor's heart made from 2 and embodiment 3
It is suitable that particle passes through the effect of same experiment and embodiment 1, and mouthfeel compliance is higher than control group.
Claims (2)
1. a kind of preparation method for protecting the peaceful particle of the heart, it is characterised in that comprise the following steps：
（1）Prepare Radix Salviae Miltiorrhizae dry extract：The red sage root is ground into coarse powder, is put into percolate pot, addition concentration is 95v%, gross weight is red
Join the ethanol of 10 ~ 12 times of coarse powder weight, dipping to its diacolation and is collected until finishing after 24 hours with 1 ~ 3mL/min flow velocity
First time percolate, then toward concentration is added in percolate pot is 50 ~ 75v%, gross weight is 10 ~ 12 times of raw material meal weight
Ethanol, to its diacolation and collected with 1 ~ 3mL/min flow velocity until finish to obtain second of percolate；Add 5 ~ 6 times of weights of the dregs of a decoction
The water of amount carries out 2 ~ 3h of decoction to the remaining dregs of a decoction in percolate pot, and filtering, filtrate merges with above-mentioned percolate, is concentrated and dried, produces；
（2）Prepare Radix Angelicae Sinensis dry extract：75 ~ 95v% the alcohol refluxs for adding 8 ~ 10 times of weight of Radix Angelicae Sinensis extract 2 ~ 3 times, every time 6 ~ 8h,
Merging filtrate, concentrate, spray drying, produce；
（3）Prepare Fructus Aurantii dry extract：Fructus Aurantii is ground into coarse powder, is put into percolate pot, addition concentration is 95v%, gross weight is trifoliate orange
The ethanol of 10 ~ 12 times of shell coarse powder weight, dipping to its diacolation and are collected up to finishing after 24 hours with 1 ~ 3mL/min flow velocity,
Percolate is collected, concentration, 80 mesh is dry, pulverize into and produces；
（4）Prepare ginger dry cream：The decocting that 8 ~ 10 weight are added into ginger is boiled 2 ~ 3 times, and 2 ~ 3h, is filtered, merging filtrate every time,
Concentration, spray drying, is produced；
（5）Pseudo-ginseng is ground into fine powder, crosses 100 mesh sieves；
（6）Steviosin, xylitol, Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin are broken to 80 mesh fine powders；
（7）Prepare each raw material by following weight parts：Radix Salviae Miltiorrhizae dry extract 0.15-0.17 parts, Radix Angelicae Sinensis dry extract 0.07-0.09 parts, trifoliate orange
Shell dry extract 0.07-0.09 parts, ginger dry extract 0.5-0.7 parts, Radix Notoginseng powder 0.09-0.15 parts, Steviosin 0.1-2.0 parts, wood
Sugar alcohol 1-8 parts, 0.2 ~ 0.7 part of Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin 0.15-1.5 parts；
（8）Make adhesive with ethanol, by step（7）Various raw materials mix, pelletized.
2. the preparation method of the peaceful particle of the heart is protected as claimed in claim 1, it is characterised in that step（7）In the composition of each raw material be：
0.167 part of Radix Salviae Miltiorrhizae dry extract, 0.083 part of Radix Angelicae Sinensis dry extract, 0.083 part of Fructus Aurantii dry extract, 0.625 part of ginger dry cream, Radix Notoginseng powder
0.65 part of 0.1 part, 0.15 part of Steviosin, 3.5 parts of xylitol, 0.45 part of Sodium Hydroxymethyl Stalcs and beta-schardinger dextrin.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638865A (en) * | 2019-08-20 | 2020-01-03 | 广西万寿堂药业有限公司 | Traditional Chinese medicine composition containing oldenlandia and preparation method thereof |
| CN110755590A (en) * | 2019-11-24 | 2020-02-07 | 江苏黄河药业股份有限公司 | Heart protecting capsule and preparation method thereof |
| CN115531507A (en) * | 2021-12-17 | 2022-12-30 | 吉林省正和药业集团股份有限公司 | Baoxinning tablet and preparation method thereof |
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| CN1361422A (en) * | 2000-12-26 | 2002-07-31 | 四川巴中普瑞制药有限公司 | Test method of angiocardiopathy treating medicine Baoxinning |
| CN1360898A (en) * | 2000-12-26 | 2002-07-31 | 四川巴中普瑞制药有限公司 | Prepn of Baoxinning tablet as angiocardiopathy treating medicine |
| CN105535890A (en) * | 2015-12-31 | 2016-05-04 | 吉林修正药业新药开发有限公司 | Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1361422A (en) * | 2000-12-26 | 2002-07-31 | 四川巴中普瑞制药有限公司 | Test method of angiocardiopathy treating medicine Baoxinning |
| CN1360898A (en) * | 2000-12-26 | 2002-07-31 | 四川巴中普瑞制药有限公司 | Prepn of Baoxinning tablet as angiocardiopathy treating medicine |
| CN105535890A (en) * | 2015-12-31 | 2016-05-04 | 吉林修正药业新药开发有限公司 | Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638865A (en) * | 2019-08-20 | 2020-01-03 | 广西万寿堂药业有限公司 | Traditional Chinese medicine composition containing oldenlandia and preparation method thereof |
| CN110755590A (en) * | 2019-11-24 | 2020-02-07 | 江苏黄河药业股份有限公司 | Heart protecting capsule and preparation method thereof |
| CN115531507A (en) * | 2021-12-17 | 2022-12-30 | 吉林省正和药业集团股份有限公司 | Baoxinning tablet and preparation method thereof |
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