CN1360898A - Prepn of Baoxinning tablet as angiocardiopathy treating medicine - Google Patents
Prepn of Baoxinning tablet as angiocardiopathy treating medicine Download PDFInfo
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- CN1360898A CN1360898A CN 00120626 CN00120626A CN1360898A CN 1360898 A CN1360898 A CN 1360898A CN 00120626 CN00120626 CN 00120626 CN 00120626 A CN00120626 A CN 00120626A CN 1360898 A CN1360898 A CN 1360898A
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- dry extract
- rhizoma zingiberis
- zingiberis recens
- angiocardiopathy
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Abstract
The present invention is preparation process of Baoxingning tablet as angiocardiopathy treating medicine. The medicine is prepared by mixing ginger extractum, red sage extractum, Chinese angelica extractum, bitter orange extractum and notoginseng powder and tableting the mixture powder.
Description
What the present invention relates to is preparation method to Baoxinning tablet as angiocardiopathy treating medicine.
Preparation has blood circulation promoting and blood stasis dispelling and promoting the circulation of QI to relieve pain function and the medicine that can be used for treating cardiovascular diseases such as angina pectoris, arrhythmia and coronary heart disease is protected the peaceful conventional method of the heart, be with raw material components such as Radix Salviae Miltiorrhizae dry extract, Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract and Radix Notoginseng fine powders, with the raw material Rhizoma Zingiberis Recens is decocted with water after concentrated aqueous solution mix after, granulation again, drying and tabletting form.Because use therein is the aqueous solution of Rhizoma Zingiberis Recens, the consumption during preparation is difficult for accurately, and the later stage when carrying out dried required time longer relatively, energy consumption is also higher relatively.
Given this, the objective of the invention is provides a kind of and can help making the consumption of each raw material components more accurate for addressing the above problem, and the method for preparing Baoxinning tablet as angiocardiopathy treating medicine that can help enhancing productivity and/or cutting down the consumption of energy.
The preparation method of the said Baoxinning tablet as angiocardiopathy treating medicine of the present invention, be to be that raw material components is made equally with Radix Salviae Miltiorrhizae dry extract, Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract, Rhizoma Zingiberis Recens and Radix Notoginseng powder, Rhizoma Zingiberis Recens in the wherein said raw material is for after being made into dry extract earlier, mixes with other component and suppresses in flakes.
What the method for making of above-mentioned Rhizoma Zingiberis Recens dry extract can adopt is, Rhizoma Zingiberis Recens was respectively decocted 1 hour with the water of 5 times of weight respectively, merge twice decoction liquor and be the filter media of 0.175 millimeter (～80 order), be condensed into after proportion is 1.18-1.25 with the aperture, dry again and make powdery.During pharmacy, this Rhizoma Zingiberis Recens dry extract can be converted to medicine and stipulate to use behind the required Rhizoma Zingiberis Recens raw material consumption.Wherein prepare the used raw material of Rhizoma Zingiberis Recens dry extract and can be dried ginger slice, also can be fresh Rhizoma Zingiberis.Though the dried in the preparation do not repel can be as the case may be with need in the drying of various ways at present and/or crushing treatment method, select, suggestion is good to adopt the spray drying mode, can directly prepare to be the required powdery product of pharmacy.
Except that traditional conventional method, can also adopt the method for following recommendation when the preparation medicine guarantor heart is peaceful; To place fully mix homogeneously of agitating device by Radix Salviae Miltiorrhizae dry extract, Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract, Rhizoma Zingiberis Recens dry extract and the Radix Notoginseng powder of medicine ormal weight, and after 95% ethanol that adds solid gross weight 1/3 makes soft material, make to be the granule of 0.991 millimeter (16 order) sieve by the aperture, remove ethanol in being heated to be 30 ℃～40 ℃, continue to be warming up to≤be dried to moisture content less than 4% under 60 ℃ of conditions, by aperture～0.9 millimeter (～18 order) sieve granulate, more in the usual way be all even sheet that is pressed into of mix lubricant such as magnesium stearate of its weight 1%.
Since in the said method of the present invention to medicine the Rhizoma Zingiberis Recens in raw materials used anticipated the form that is processed into its dry extract, be convenient to form the standard quality standard that to unify to grasp and control execution, not only easy to use, and be easy to accurately convert its use amount in medicine.On the other hand, after in medication preparation, each raw material being made soft material with 95% ethanol and granulating, also be easy to the later dried operation and the grasp of controlling index thereof, and help energy savings.
Below by specific embodiment foregoing of the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is confined to following example.
In the present embodiment, first preparation Rhizoma Zingiberis Recens dry extract: after getting the Rhizoma Zingiberis decoction pieces and weighing, water with 5 times of weight respectively decocted 1 hour respectively, filter with 0.175 millimeter (80 order) sieve in aperture after merging twice decoction liquor, after being condensed into proportion and being 1.20～1.25 fluid extract, it is standby to make its dry extract with conventional spray drying process, it can be converted to the Rhizoma Zingiberis Recens consumption that is equivalent to medicine regulation content during pharmacy and use.
To conform to quality requirements and the Radix Salviae Miltiorrhizae dry extract of specified volume ratio; Radix Angelicae Sinensis dry extract; Fructus Aurantii dry extract and above-mentioned Rhizoma Zingiberis Recens dry extract and Radix Notoginseng powder place fully mix homogeneously of agitator; and 95% ethanol that is incorporated as total weight of solids 1/3 is made soft material with conventional method; pass through 0.991 millimeter (16 order) the sieve series grain in aperture in oscillating granulator; put aeration-drying in the drying room; remove the humidity of ethanol generation prior to 35 ℃～40 ℃ hot blasts after; the continuation intensification is dried to moisture content and is lower than 4% under≤60 ℃; cross aperture～0.9 millimeter (～18 order) sieve granulate; the mix lubricant such as magnesium stearate with its weight 1% are even in the usual way after weighing, and the compacting of content and conventional method is in flakes and outer sugar coating in accordance with regulations.
Claims (6)
1. the preparation method of Baoxinning tablet as angiocardiopathy treating medicine, with Radix Salviae Miltiorrhizae dry extract, Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract, Rhizoma Zingiberis Recens and Radix Notoginseng powder is that raw material components is made, it is characterized in that Rhizoma Zingiberis Recens in the raw material for after being made into dry extract earlier, mix with other component again and suppress in flakes.
2. the preparation method of Baoxinning tablet as angiocardiopathy treating medicine as claimed in claim 1, the method for making that it is characterized in that said Rhizoma Zingiberis Recens dry extract is, Rhizoma Zingiberis Recens was respectively decocted 1 hour with the water of 5 times of weight respectively, merge twice decoction liquor and be 0.175 millimeter filter media with the aperture, be condensed into after proportion is 1.18-1.25, dry again and make powdery, be converted to the required Rhizoma Zingiberis Recens consumption of medication preparation and use.
3. the preparation method of Baoxinning tablet as angiocardiopathy treating medicine as claimed in claim 2, it is characterized in that preparing the used raw material of Rhizoma Zingiberis Recens dry extract is dried ginger slice.
4. the preparation method of Baoxinning tablet as angiocardiopathy treating medicine as claimed in claim 2, it is characterized in that preparing the used raw material of Rhizoma Zingiberis Recens dry extract is new fresh ginger-chip.
5. the preparation method of Baoxinning tablet as angiocardiopathy treating medicine as claimed in claim 2, the drying when it is characterized in that preparing the Rhizoma Zingiberis Recens dry extract is for directly to be made for the required pulverulence of pharmacy in the spray drying mode.
6. end the preparation method of one of 5 described Baoxinning tablet as angiocardiopathy treating medicine as claim 1, it is characterized in that Radix Salviae Miltiorrhizae dry extract with requirement, Radix Angelicae Sinensis dry extract, Fructus Aurantii dry extract, Rhizoma Zingiberis Recens dry extract and Radix Notoginseng powder place fully mix homogeneously of agitating device, and after 95% ethanol that adds solid gross weight 1/3 makes soft material, make to be the granule of 0.991 mm sieve by the aperture, in be heated to be remove ethanol below 40 ℃ after, continue to heat up and under≤60 ℃ of conditions, be dried to moisture content less than 4%, by aperture～0.9 mm sieve granulate, in blocks with the magnesium stearate mix homogeneously and the compacting that are its weight 1% again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00120626 CN1360898A (en) | 2000-12-26 | 2000-12-26 | Prepn of Baoxinning tablet as angiocardiopathy treating medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00120626 CN1360898A (en) | 2000-12-26 | 2000-12-26 | Prepn of Baoxinning tablet as angiocardiopathy treating medicine |
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| Publication Number | Publication Date |
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| CN1360898A true CN1360898A (en) | 2002-07-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00120626 Pending CN1360898A (en) | 2000-12-26 | 2000-12-26 | Prepn of Baoxinning tablet as angiocardiopathy treating medicine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535890A (en) * | 2015-12-31 | 2016-05-04 | 吉林修正药业新药开发有限公司 | Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof |
| CN107375882A (en) * | 2017-08-08 | 2017-11-24 | 郑州韩都药业集团有限公司 | A kind of preparation method for protecting the peaceful particle of the heart |
| CN107468654A (en) * | 2017-08-08 | 2017-12-15 | 郑州韩都药业集团有限公司 | One kind protects the peaceful particle of the heart |
-
2000
- 2000-12-26 CN CN 00120626 patent/CN1360898A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535890A (en) * | 2015-12-31 | 2016-05-04 | 吉林修正药业新药开发有限公司 | Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof |
| CN105535890B (en) * | 2015-12-31 | 2019-03-29 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating cardiovascular disease |
| CN107375882A (en) * | 2017-08-08 | 2017-11-24 | 郑州韩都药业集团有限公司 | A kind of preparation method for protecting the peaceful particle of the heart |
| CN107468654A (en) * | 2017-08-08 | 2017-12-15 | 郑州韩都药业集团有限公司 | One kind protects the peaceful particle of the heart |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |