CN104958695A - Method for preparing depression-relieving and soothing tablets - Google Patents
Method for preparing depression-relieving and soothing tablets Download PDFInfo
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Abstract
The invention discloses a method for preparing depression-relieving and soothing tablets. The method includes a first step, preparing raw materials; a second step, extracting alcohol; a third step, collecting extracts; a fourth step, preparing extract powder; a fifth step, granulating the extract powder; a sixth step, compressing tablets. The method has the advantages that anti-depression effects can be realized by water-soluble components and fat-soluble components in herbal medicine in prescription; the ethyl alcohol with certain concentration is used as an extract solvent, accordingly, the water-soluble components and the fat-soluble components with the anti-depression effects in the prescription can be comprehensively extracted, and the method can be used for producing the depression-relieving and soothing tablets on a large scale during industrial mass production.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to the preparation method of satisfactory of a kind of resolving depression.
Background technology
The modern life, the sickness rate of depression is high, and the reason of morbidity is various, the reason such as stress, diet, sleep allow people occur depressed, pessimistic, lack the symptom such as initiative, severe patient there will be world-weary, suicidal tendency.Drug therapy of the prior art generally adopts chemical drugs and Chinese patent medicine, chemical drugs targeted is strong, but side effect is large, especially a lot of potential hazard is not easily discovered in a short time, after experience updates, chemical drugs is constantly improved in therapeutic effect and side effect, but cannot avoid the appearance of other side effect in clinical treatment process.
Meanwhile, along with Chinese medicine is more and more widely known by the people, the medication theory of Chinese medicine is also in the concern being constantly subject to people, treatment by Chinese herbs depression starts as this field institute parent looks at, though without depression name of disease in China's traditional medicine, relevant record is all had in successive dynasties Chinese medicine document, as " melancholia " " globus hystericus " " dirty dry " " Bulbus Lilii syndrome " etc., the medication consideration of Chinese medicine Cure of depression is different from chemical drugs, Chinese medicine thinks the cause of disease system depression of liver-QI of depression, lose and to reach and the mind is gradually hindered in tune, belong to a kind of comprehensive disease, therefore treatment by Chinese herbs depression tool is used to have very great significance, its safety, effectively, the advantages such as medical expense is low all become the first-selection of more and more patient, and preparation can the Chinese medicine method of Cure of depression also be that existing market is badly in need of, have Chinese medicine production only and move towards commercial production road, multifarious people can be benefited.
The patent No. is that the medicine of 201110405141.8 1 kinds of Cure of depressions and preparation method and application thereof disclose preparation method, because the extracting method adopted in this patent is percolation, but this extracting method Extraction solvent volume used is large, operating time is long, is unfavorable for the application of industrial mass production.
Summary of the invention
1. invent the technical problem that will solve
The object of the invention is to overcome above-mentioned technical deficiency, provide the preparation method of satisfactory of a kind of resolving depression, the water soluble ingredient of the plant amedica in the method prescription and liposoluble constituent all have the effect of antidepressant effect, and adopt certain density ethanol more comprehensively can extract in prescription the water solublity and liposoluble constituent with antidepressant effect as Extraction solvent, relative to permeating extraction, reflux, extract, saves extraction time more, improves extraction efficiency and can be mass-produced in industry is produced greatly.
2. technical scheme
For achieving the above object, technical scheme provided by the invention is:
The preparation method that resolving depression is satisfactory, comprises step as follows:
Step one: raw material prepares: Radix Salviae Miltiorrhizae, Radix Bupleuri, Rhizoma Coptidis, Radix Curcumae, Radix Polygalae, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Lapis Chloriti;
Step 2: alcohol extraction: the raw material in step one is mixed and adds the alcoholic solution that concentration is 60%-80%, extract 3 times, each alcohol steep time is 1 ~ 1.5h, after lixiviate completes, extracting solution is crossed 200 mesh screen, abandons filtering residue;
Step 3: receive cream: filtrate reduced in volume step 2 obtained to relative density is the extractum of 1.2-1.25;
Step 4: prepare extract powder: use spraying dry extractum, sterilization treatment after dry, and cross 80 orders with top sieve, obtain dry extract;
Step 5: granulate: add microcrystalline Cellulose and 5 ‰ carboxymethyl starch sodium in dry extract, mixture is added after carrying out mix homogeneously in mixer, add 95% ethanol in the mixture and make soft material as wetting agent, soft material is put into granulation machine and granulate, the particle drying process after obtained;
Step 6: tabletting: the granule obtained in step 5 is pressed into plain sheet.
Further technical scheme, the raw material in step one according to parts by weight is: Radix Salviae Miltiorrhizae 20 ~ 40 parts, Radix Bupleuri 4 ~ 8 parts, Rhizoma Coptidis 2 ~ 4 parts, Radix Curcumae 8 ~ 12 parts, Radix Polygalae 4 ~ 8 parts, Rhizoma Acori Graminei 4 ~ 8 parts, Os Draconis 8 ~ 12 parts, Concha Ostreae 8 ~ 12 parts, Lapis Chloriti 8 ~ 12 parts.
Further technical scheme, in step 2, the temperature of alcohol steep is 65-75 DEG C.
Further technical scheme, in step 3, the condition of concentrating under reduced pressure is: vacuum is-0.06--0.08MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C.
Further technical scheme, the machine models that in step 4, spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier.
Further technical scheme, the condition of described G-5 Highspeedcentrifugingandsprayingdrier is: the relative density of spraying is 1.2-1.25, charging rate 25-30ml/min, inlet temperature 160-170 DEG C, leaving air temp 80-90 DEG C.
Further technical scheme, pellet moisture obtained in step 5 controls 4-8%, adds in spiral vortex type shaking screen and cross 16 mesh sieves after particle drying process, not by what sieve, returns to granulation machine and granulates.
Further technical scheme, in step 5, the interpolation of microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract.
Further technical scheme, in step 6, tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 40-60N, and tablet machine rotating speed is 30-40 turns/min, and tablet machine pressure is set to 50-60KN.
3. beneficial effect
Adopt technical scheme provided by the invention, compared with prior art, there is following beneficial effect:
The raw material used in the preparation method step one of 1, satisfactory of a kind of resolving depression of the present invention, its water soluble ingredient and liposoluble constituent all have the effect of antidepressant effect.
Adopt the ethanol of 60%-80% more comprehensively can extract in raw material the water solublity and liposoluble constituent with antidepressant effect as Extraction solvent in the preparation method step 2 of 2, satisfactory of a kind of resolving depression of the present invention, first permeating extraction generally can carry out immersion 24h to medical material, then carry out seepage pressure effects, extract consuming time longer; And this research carries out reflux, extract, 3 times, each 1.5h, shortens extraction time greatly, improves extraction efficiency and is highly suitable for industrial scale production.
In step 2, the temperature of alcohol steep is 65-75 DEG C, and this is because salvianolic acid B is unstable at relatively high temperatures, and experimental results demonstrate according to the application, the peak area obtaining the salvianolic acid B in extracting solution within the scope of this is maximum.
In the preparation method step 3 of 3, satisfactory of a kind of resolving depression of the present invention, filtrate reduced in volume to relative density is the extractum of 1.2-1.25, the extract powder that obtains of spraying under this relative density condition is better, be easy to granulate without caking, the extract powder that when relative density is excessive, spraying is obtained easily lumps, and not easily granulates.
In step 3, the condition of concentrating under reduced pressure is: vacuum is-0.06--0.08MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C, experimental results demonstrate by the application, concentrated under this concentrating under reduced pressure condition, greatly can shorten concentration time, improve concentrated speed fast.
Adopt the object of the sieve of more than 80 orders to be that the dry extract obtained is carried out process of sieving in the preparation method step 4 of 4, satisfactory of a kind of resolving depression of the present invention, obtain thinner dry extract, be easy to granulate.
The machine models that in step 4, spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier, condition is: the relative density of spraying is 1.2-1.25, charging rate 25-30ml/min, inlet temperature 160-170 DEG C, leaving air temp 80-90 DEG C, experimental results demonstrate by the application, uses the advantage of hig h-speed centrifugal spray drying to be: rate of drying is fast, can the advantage such as convection drying powdered, and the dry extract that this obtains under this condition is without glutinous wall phenomenon, and the powder obtained carefully and evenly.
What the wetting agent in the preparation method step 5 of 5, satisfactory of a kind of resolving depression of the present invention was selected is ethanol, and do not select water as wetting agent, this granulates because water is applicable to the extract powder that medicine itself has certain viscosity, and when using water as wetting agent, baking temperature used is too high, for thermo-labile, the medicine of meeting water perishable or water-soluble should not be applied.And the medicine itself in the application must keep dry inviscid, all for having more strongly adherent medicine, after the chance water such as some traditional Chinese medicinal extract powder or starch slurry, easily lump, not easily make granule; Or easily cause rotten medicine when heat drying; Or medicine dissolubility in water is large, make granulation procedure difficulty; Or it is too hard after particle drying, tabletting produces piebaldism, disintegrate is over time limit, therefore ethanol all should be adopted to make wetting agent for above medicine, when this experimentation shows to use water as wetting agent, the soft material obtained easily lumps, and with ethanol as the soft material that can obtain good quality during wetting agent, is easy to granulate.Drawing through great many of experiments, according to the ethanol below 90% and 90% carry out soft material processed carry out tabletting time, the soft material obtained easily lumps, not easily granulate, and obtained tablet surface is rough, and when adopting 100% alcohol granulation tabletting, the tablet obtained is easily loose, therefore adopts 95% ethanol as wetting agent in the present invention.
Pellet moisture obtained in step 5 controls 4-8%, in conjunction with the method for the raw material selected in the application and preparation, if finally find that in the granule obtained, moisture is too high, and easily caking, sticking in tableting processes; And the granule moisture level obtained is too low, then easily there is loose pieces, sliver phenomenon in obtained tablet; But it is smooth pellet moisture to be controlled tablet surface obtained within the scope of this, and hardness is moderate.
Add after particle drying process in step 5 in spiral vortex type shaking screen and cross 16 mesh sieves; by sieve; return to granulation machine to granulate; this is owing to having certain requirement to the particle diameter of obtained granule in tableting processes; if obtained grain diameter is excessive; then easily there is piebaldism in tablet surface; if strictly control granular size in pelletization; granule is crossed 16 mesh sieve process; can not only be economized in raw materials cost; also greatly can reduce the disqualification rate in tabletting, ensure that the tablet surface obtained is uniform and smooth, without piebaldism phenomenon simultaneously.
In step 5, the interpolation of microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract, experiment proves, add the hygroscopicity that microcrystalline Cellulose can improve dry extract, and the amount of adding microcrystalline Cellulose is through and adds not commensurability experimental result and draw, result display is added according to this ratio and is made dry extract have stronger hygroscopicity.
In the preparation method step 6 of 6, satisfactory of a kind of resolving depression of the present invention, tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 40-60N, tablet machine rotating speed is 30-40 turns/min, tablet machine pressure is set to 50-60KN, by experimental results demonstrate, the tablet obtained under this regulation can meet the requirement of Chinese Pharmacopoeia to tablet preferably, and the disintegration of tablet time limit obtained under this defined terms is moderate, and surface uniform is smooth.
Detailed description of the invention
For understanding content of the present invention further, the present invention is described in detail for embodiment.
embodiment 1
The preparation method that resolving depression is satisfactory, comprises step as follows:
Step one: raw material prepares: Radix Salviae Miltiorrhizae 40 parts, Radix Bupleuri 8 parts, Rhizoma Coptidis 4 parts, Radix Curcumae 12 parts, Radix Polygalae 8 parts, Rhizoma Acori Graminei 8 parts, Os Draconis 12 parts, Concha Ostreae 12 parts, Lapis Chloriti 12 parts;
Step 2: alcohol extraction: the raw material in step one is mixed and adds the alcoholic solution that concentration is 80%, extract 3 times, each alcohol steep time is 1.5h, and the temperature of lixiviate is 75 DEG C, after lixiviate completes, extracting solution is crossed 200 mesh screen, abandons filtering residue;
Step 3: receive cream: filtrate reduced in volume step 2 obtained to relative density is the extractum of 1.25, and the condition of concentrating under reduced pressure is: vacuum is-0.08MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C;
Step 4: prepare extract powder: use spraying dry extractum, sterilization treatment after dry, and cross 80 orders with top sieve, obtain dry extract; The machine models that spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier, and the relative density of spraying is 1.25, charging rate 30ml/min, inlet temperature 170 DEG C, leaving air temp 90 DEG C;
Step 5: granulate: add microcrystalline Cellulose and 5 ‰ carboxymethyl starch sodium in dry extract, the ratio that microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract is added, again mixture is added after carrying out mix homogeneously in mixer, add 95% ethanol in the mixture and make soft material as wetting agent, soft material is put into granulation machine to granulate, the particle drying process after obtained; Obtained pellet moisture controls 8%, adds in spiral vortex type shaking screen and cross 16 mesh sieves after particle drying process, not by what sieve, returns to granulation machine and granulates;
Step 6: tabletting: the granule obtained in step 5 is pressed into plain sheet; Tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 60N, and tablet machine rotating speed is 40 turns/min, and tablet machine pressure is set to 60KN.
Embodiment 2
The preparation method that resolving depression is satisfactory, comprises step as follows:
Step one: raw material prepares: Radix Salviae Miltiorrhizae 20 parts, Radix Bupleuri 4 parts, Rhizoma Coptidis 2 parts, Radix Curcumae 8 parts, Radix Polygalae 4 parts, Rhizoma Acori Graminei 4 parts, Os Draconis 8 parts, Concha Ostreae 8 parts, Lapis Chloriti 8 parts;
Step 2: alcohol extraction: the raw material in step one is mixed and adds the alcoholic solution that concentration is 60%, extract 3 times, each alcohol steep time is 1h, and the temperature of lixiviate is 65 DEG C, after lixiviate completes, extracting solution is crossed 200 mesh screen, abandons filtering residue;
Step 3: receive cream: filtrate reduced in volume step 2 obtained to relative density is the extractum of 1.2, and the condition of concentrating under reduced pressure is: vacuum is-0.06MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C;
Step 4: prepare extract powder: use spraying dry extractum, sterilization treatment after dry, and cross 80 orders with top sieve, obtain dry extract; The machine models that spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier, and the relative density of spraying is 1.2, charging rate 25ml/min, inlet temperature 160 DEG C, leaving air temp 80 DEG C;
Step 5: granulate: add microcrystalline Cellulose and 5 ‰ carboxymethyl starch sodium in dry extract, the ratio that microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract is added, again mixture is added after carrying out mix homogeneously in mixer, add 95% ethanol in the mixture and make soft material as wetting agent, soft material is put into granulation machine to granulate, the particle drying process after obtained; Obtained pellet moisture controls 4%, adds in spiral vortex type shaking screen and cross 16 mesh sieves after particle drying process, not by what sieve, returns to granulation machine and granulates;
Step 6: tabletting: the granule obtained in step 5 is pressed into plain sheet; Tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 40N, and tablet machine rotating speed is 30 turns/min, and tablet machine pressure is set to 50KN.
embodiment 3
The preparation method that resolving depression is satisfactory, comprises step as follows:
Step one: raw material prepares: Radix Salviae Miltiorrhizae 30 parts, Radix Bupleuri 6 parts, Rhizoma Coptidis 3 parts, Radix Curcumae 10 parts, Radix Polygalae 6 parts, Rhizoma Acori Graminei 6 parts, Os Draconis 10 parts, Concha Ostreae 10 parts, Lapis Chloriti 10 parts;
Step 2: alcohol extraction: the raw material in step one is mixed and adds the alcoholic solution that concentration is 70%, extract 3 times, each alcohol steep time is 1.25h, and the temperature of lixiviate is 70 DEG C, after lixiviate completes, extracting solution is crossed 200 mesh screen, abandons filtering residue;
Step 3: receive cream: filtrate reduced in volume step 2 obtained to relative density is the extractum of 1.23, and the condition of concentrating under reduced pressure is: vacuum is-0.07MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C;
Step 4: prepare extract powder: use spraying dry extractum, sterilization treatment after dry, and cross 80 orders with top sieve, obtain dry extract; The machine models that spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier, and the relative density of spraying is 1.23, charging rate 27ml/min, inlet temperature 165 DEG C, leaving air temp 85 DEG C;
Step 5: granulate: add microcrystalline Cellulose and 5 ‰ carboxymethyl starch sodium in dry extract, the ratio that microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract is added, again mixture is added after carrying out mix homogeneously in mixer, add 95% ethanol in the mixture and make soft material as wetting agent, soft material is put into granulation machine to granulate, the particle drying process after obtained; Obtained pellet moisture controls 6%, adds in spiral vortex type shaking screen and cross 16 mesh sieves after particle drying process, not by what sieve, returns to granulation machine and granulates;
Step 6: tabletting: the granule obtained in step 5 is pressed into plain sheet; Tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 50N, and tablet machine rotating speed is 35 turns/min, and tablet machine pressure is set to 55KN.
Claims (9)
1. a preparation method for satisfactory of resolving depression, is characterized in that, comprise step as follows:
Step one: raw material prepares: Radix Salviae Miltiorrhizae, Radix Bupleuri, Rhizoma Coptidis, Radix Curcumae, Radix Polygalae, Rhizoma Acori Graminei, Os Draconis, Concha Ostreae, Lapis Chloriti;
Step 2: alcohol extraction: the raw material in step one is mixed and adds the alcoholic solution that concentration is 60%-80%, extract 3 times, each alcohol steep time is 1 ~ 1.5h, after lixiviate completes, extracting solution is crossed 200 mesh screen, abandons filtering residue;
Step 3: receive cream: filtrate reduced in volume step 2 obtained to relative density is the extractum of 1.2-1.25;
Step 4: prepare extract powder: use spraying dry extractum, sterilization treatment after dry, and cross 80 orders with top sieve, obtain dry extract;
Step 5: granulate: add microcrystalline Cellulose and 5 ‰ carboxymethyl starch sodium in dry extract, mixture is added after carrying out mix homogeneously in mixer, add 95% ethanol in the mixture and make soft material as wetting agent, soft material is put into granulation machine and granulate, the particle drying process after obtained;
Step 6: tabletting: the granule obtained in step 5 is pressed into plain sheet.
2. the preparation method of satisfactory of a kind of resolving depression according to claim 1, it is characterized in that, the raw material in step one according to parts by weight is: Radix Salviae Miltiorrhizae 20 ~ 40 parts, Radix Bupleuri 4 ~ 8 parts, Rhizoma Coptidis 2 ~ 4 parts, Radix Curcumae 8 ~ 12 parts, Radix Polygalae 4 ~ 8 parts, Rhizoma Acori Graminei 4 ~ 8 parts, Os Draconis 8 ~ 12 parts, Concha Ostreae 8 ~ 12 parts, Lapis Chloriti 8 ~ 12 parts.
3. the preparation method of satisfactory of a kind of resolving depression according to claim 1, is characterized in that, in step 2, the temperature of alcohol steep is 65-75 DEG C.
4. the preparation method of satisfactory of a kind of resolving depression according to claim 1, is characterized in that, in step 3, the condition of concentrating under reduced pressure is: vacuum is-0.06--0.08MPa, and steam pressure is not more than 0.04MPa, and temperature is 70 DEG C.
5. the preparation method of satisfactory of a kind of resolving depression according to claim 1, is characterized in that, the machine models that in step 4, spraying dry uses is G-5 Highspeedcentrifugingandsprayingdrier.
6. the preparation method of satisfactory of a kind of resolving depression according to claim 5, it is characterized in that, the condition of described G-5 Highspeedcentrifugingandsprayingdrier is: the relative density of spraying is 1.2-1.25, charging rate 25-30ml/min, inlet temperature 160-170 DEG C, leaving air temp 80-90 DEG C.
7. the preparation method of satisfactory of a kind of resolving depression according to claim 1; it is characterized in that, pellet moisture obtained in step 5 controls 4-8%, adds in spiral vortex type shaking screen and cross 16 mesh sieves after particle drying process; not by what sieve, return to granulation machine and granulate.
8. the preparation method of satisfactory of a kind of resolving depression according to claim 1, is characterized in that, in step 5, the interpolation of microcrystalline Cellulose adds 1.25Kg microcrystalline Cellulose according to every 3Kg dry extract.
9. the preparation method of satisfactory of a kind of resolving depression according to claim 1, is characterized in that, in step 6, tabletting specification is that the tablet weight variation of every sheet controls
+5%, sheet hardness is 40-60N, and tablet machine rotating speed is 30-40 turns/min, and tablet machine pressure is set to 50-60KN.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266514A (en) * | 2016-08-22 | 2017-01-04 | 南京海昌中药集团有限公司 | A kind of preparation method of Bulbus Lilii Rhizoma Anemarrhenae electuary |
| CN115778997A (en) * | 2022-12-28 | 2023-03-14 | 江苏海洋大学 | Preparation method and quality detection method of Qibang granules |
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| CN102416148A (en) * | 2011-12-08 | 2012-04-18 | 南京海昌中药集团有限公司 | Medicine for treating depression, and preparation method and application thereof |
| KR101318330B1 (en) * | 2011-05-24 | 2013-10-15 | 원광대학교산학협력단 | Pharmaceutical composition and functional food having anti-depressant activity, and preparation method of the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101318330B1 (en) * | 2011-05-24 | 2013-10-15 | 원광대학교산학협력단 | Pharmaceutical composition and functional food having anti-depressant activity, and preparation method of the same |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266514A (en) * | 2016-08-22 | 2017-01-04 | 南京海昌中药集团有限公司 | A kind of preparation method of Bulbus Lilii Rhizoma Anemarrhenae electuary |
| CN115778997A (en) * | 2022-12-28 | 2023-03-14 | 江苏海洋大学 | Preparation method and quality detection method of Qibang granules |
| CN115778997B (en) * | 2022-12-28 | 2023-10-27 | 江苏海洋大学 | Preparation method and quality detection method of astragalus root and burdock granules |
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Application publication date: 20151007 |
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