CN103041294B - A kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination and preparation method thereof - Google Patents
A kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination and preparation method thereof.A kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination, this Chinese medicine solid particle tablet is obtained by Chinese medicine solid particle compress tablet coating, described Chinese medicine solid particle obtains by comprising following weight percents composition mixing granulation: Rhizoma Curcumae volatile oil 2% ~ 10%, powdered Wuling mycelia in combination 10% ~ 40%, dry extract 10% ~ 40% prepared by Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis, other pharmaceutical adjuncts 10% ~ 75%; Described Rhizoma Curcumae volatile oil adopts saturated water solution method Yu β – cyclodextrin inclusion compound, the clathrate solid-liquid separation after enclose; Described clathrate is granulated after first mixing with powdered Wuling mycelia in combination, more obtained Chinese medicine solid particle tablet.Advantage of the present invention: eliminate drying process, decreases the loss of volatile oil, greatly shortens the process time, improves the retention rate of Rhizoma Curcumae volatile oil in finished product, ensure that drug quality and effectiveness.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly relate to a kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination and preparation method thereof.
Background technology
The application of traditional medicine volatile oil has long history, and the effectiveness of many traditional medicine volatile oils is early known to ancients.According to the chemical research of modern Chinese medicine, containing the Chinese crude drug One's name is legion of volatile oil, relate to the Chinese medicine of nearly all potency classes, as Herba Menthae, Radix Bupleuri, Herba Pogostemonis, Rhizoma Curcumae, Rhizoma Chuanxiong, Folium Perillae volatilization wet goods.The nature difference of traditional medicine volatile oil is comparatively large, is liquid at normal temperatures, more volatile, and character is unstable.The solid preparation that current oil content is high can select soft capsule or special hard capsule, but complicated process of preparation, product storage life is short, adopting containing volatile oil preparation is then very difficult based on dry extract.
Prior art: first the volatile oil beta-schardinger dextrin--water extracted in medical material is carried out enclose, solid-liquid separation, become moisture volatile oil clathrate compound; This moisture volatile oil clathrate compound adopts method of drying or less than the 50 DEG C dry 8-12 hour of Oven Method, powdered or granule; Powder former in medical material, dry extract etc. mix again, granulate; After again carrying out drying, make the solid preparation such as tablet, capsule further.
Chinese invention patent application (application number: 200510003035.1 applyings date: 2005-03-28) discloses Chinese medicine preparation of a kind of nourishing qi and blood and preparation method thereof, and it is prepared from primarily of the medical materials such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong and adjuvant.Which disclose Radix Angelicae Sinensis, Rhizoma Chuanxiong first prepares ethereal oil, adopt beta-cyclodextrin inclusion compound, then mix with dry extract.Although whether dry after the undeclared employing beta-cyclodextrin inclusion compound of this patent, mix with dry extract after enclose, Benexate Hydrochloride obviously needs drying, otherwise, cannot effectively mix after dry extract moisture absorption.
Chinese invention patent application (application number: the 201110121569.X applying date: 2011-05-12) discloses a kind of Chinese medicine preparation for the treatment of flu and preparation method thereof, and described Chinese medicine preparation is made up of 600 ~ 900 parts of Fructus Forsythiaes, 600 ~ 900 parts of Radix Bupleuri, 300 ~ 450 parts of Herba Ephedraes, 200 ~ 300 parts of Herba Pogostemonis, 200 ~ 300 portions of Cortex Cinnamomis and 200 ~ 300 parts of Radix Platycodoniss.Its preparation method Fructus Forsythiae, Herba Pogostemonis, Cortex Cinnamomi is extracted volatile oil respectively obtain mixture A; Fructus Forsythiae is extracted remaining medicinal residues and Herba Ephedrae after volatile oil, Radix Bupleuri, the active ingredient of Radix Platycodonis medical material united extraction, spraying dry makes powder B again; Then by mixture A and beta-cyclodextrin inclusion compound, obtained volatile oil pressed powder C; Finally powder B and powder C is mixed and load in softgel shell and get final product.This patent is also specify that volatile oil pressed powder C needs to carry out cold drying.
Chinese invention patent application (application number: 201010011610.3 applyings date: 2010-01-06) disclose a kind of treat infantile common cold series of Chinese and preparation technology and quality control method, they are prepared from by Chinese medicine Folium Isatidis, Radix Bupleuri, Radix Scutellariae, Herba Schizonepetae, Radix Platycodonis, Radix Glycyrrhizae and pharmaceutic adjuvant.This patent Radix Bupleuri volatile oil beta-cyclodextrin inclusion compound becomes clathrate, add Radix Platycodonis fine powder and volatile oil clathrate compound again then making Chinese medicine clear paste, mixing, obtain extraction extractum, add and be selected from dextrin, lactose, the one of sucrose or two kinds or three kinds as granulation adjuvant, carry out one-step palletizing, mixing, obtains children's and separates sense granule.It is dry that this patent also specify that clathrate needs under the condition of 50,60 DEG C in the description.
(application number is Chinese invention patent application: 200410081462.7) disclose a kind of pharmaceutical preparation containing volatile oil and preparation method thereof, the pharmaceutic adjuvant that it contains volatile oil and volatile oil can be solidified, wherein pharmaceutic adjuvant is the Polyethylene Glycol of mean molecule quantity more than 2500.The medicine key quality factors such as content and utilization rate of volatile oil is not evaluated in preparation method.
The Chinese invention patent application (application number: 200910100513.9 applyings date: 2009-07-09) of applicant's application discloses the pharmaceutical composition for the treatment of prostatitis, prostatic hyperplasia, and this pharmaceutical composition is prepared by the raw material of Chinese medicine comprising following weight parts proportioning: powdered Wuling mycelia in combination 60 ~ 100 parts, Rhizoma Curcumae 20 ~ 80 parts, Bulbus Fritillariae Thunbergii 20 ~ 80 parts, Rhizoma Alismatis 20 ~ 40 parts.This patent Rhizoma Curcumae extracts volatile oil beta-cyclodextrin inclusion compound, prepares volatile oil clathrate compound; The medicinal residues of Rhizoma Curcumae and Bulbus Fritillariae Thunbergii, Rhizoma Alismatis merge, and extract, extracting liquid filtering, is evaporated to clear paste, then adds ethanol, hold over night, filter, filtrate reduced in volume, dry obtained medical material dried cream powder; Get above-mentioned WULINGJUN Fen ﹑ medical material dried cream powder, volatile oil clathrate compound, mixing, obtains described pharmaceutical composition.The volatile oil clathrate compound that this patent relates to directly mixes with medical material dried cream powder, and it is also need to carry out drying.
Following shortcoming is all there is in each above-mentioned patent:
1, after the clathrate made after inclusion essential oil need first be dried to fine powder or granule, then granulate or process further after mixing with other extracts; Inclusion essential oil water content of matter high (40-60%) after dehydration, drying process temperature can not, more than 50 DEG C, need for up to 8-12 hours;
2, volatile oil clathrate compound dry run, have part volatile oil to overflow and partial loss, volatile oil reserved reduces, and causes certain contamination, and operator are uncomfortable;
If 3 process further again, the operations such as granulation, particle drying make the solid preparation such as tablet, capsule, then the volatile oil in these solid preparations retains and can reduce further, only has about 50%, affects medicine effectiveness and quality.
Summary of the invention
In order to solve above-mentioned technical problem, first object of the present invention is to provide a kind of Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination, said preparation decreases the loss of volatile oil content, greatly can shorten the process time, improve the retention rate of volatile oil in Chinese medicine preparation finished product, ensure that drug quality and effectiveness.Second object of the present invention is to provide a kind of above-mentioned Chinese medicine solid particle method for preparing tablet thereof.
In order to realize first above-mentioned object, present invention employs following technical scheme:
Contain a Chinese medicine solid particle tablet for Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination, this Chinese medicine solid particle tablet is obtained by Chinese medicine solid particle compress tablet coating, and described Chinese medicine solid particle obtains by comprising following weight percents composition mixing granulation:
Rhizoma Curcumae volatile oil 2% ~ 10%
Powdered Wuling mycelia in combination 10% ~ 40%
Dry extract 10% ~ 40% prepared by Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis
Other pharmaceutical adjuncts 10% ~ 75%;
Described Rhizoma Curcumae volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Rhizoma Curcumae volatile oil and β – cyclodextrin mass ratio are 1:4 ~ 10, the clathrate solid-liquid separation after enclose, not drying, and moisture is 35% ~ 50%; Described clathrate is granulated after first mix with powdered Wuling mycelia in combination, then the dry extract prepared with Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis, other pharmaceutical adjunct mixing granulations are dry obtain described in Chinese medicine solid particle tablet.
As preferably, this above-mentioned Chinese medicine solid particle is obtained by following weight percents composition mixing granulation:
Rhizoma Curcumae volatile oil 3% ~ 10%
Powdered Wuling mycelia in combination 15% ~ 35%
Dry extract 10% ~ 40% prepared by Rhizoma Curcumae, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis
Other pharmaceutical adjuncts 10% ~ 60%.
As further improvement, described Rhizoma Curcumae volatile oil is Yu the clathrate of β – cyclodextrin adopts saturated water solution method to prepare, Chinese crude drug volatile oil, β – cyclodextrin, water are than being 1:4 ~ 7:15 ~ 30, enclose temperature controls at 25 ~ 50 DEG C, mixing speed 60 ~ 120 revs/min, 2 ~ 5 hours response time.
As preferably, the raw material of Chinese medicine of described Chinese medicine solid particle is by following weight:
Powdered Wuling mycelia in combination 60 ~ 100 parts of Rhizoma Curcumae 20 ~ 80 parts
Bulbus Fritillariae Thunbergii 20 ~ 80 portions of Rhizoma Alismatis 20 ~ 40 parts.
As preferred again, the raw material of Chinese medicine of described Chinese medicine solid particle is by following weight:
Powdered Wuling mycelia in combination 70 ~ 90 parts of Rhizoma Curcumae 40 ~ 60 parts
Bulbus Fritillariae Thunbergii 40 ~ 60 portions of Rhizoma Alismatis 25 ~ 35 parts.
As preferably, other above-mentioned pharmaceutical adjuncts are selected from one or more combinations in filler, binding agent, disintegrating agent and lubricant.As preferred again, other above-mentioned pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and polyvidone.
In order to realize second above-mentioned object, present invention employs following technical scheme:
Prepare a method for the Chinese medicine solid particle tablet containing Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination, the method comprises the following steps:
1) Rhizoma Curcumae is prepared into Rhizoma Curcumae volatile oil;
2) Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis prepare dry extract;
3) Rhizoma Curcumae volatile oil beta-schardinger dextrin--water is carried out enclose, described Rhizoma Curcumae volatile oil is Yu β – cyclodextrin mass ratio is 1:3 ~ 10, and obtained the zedoary volatile oil clathrate wet by solid-liquid separation, its moisture is 35% ~ 50%;
4) be that 35% ~ 50% zedoary volatile oil clathrate and powdered Wuling mycelia in combination oscillating granulator premix are granulated by moisture;
5) above-mentioned granule mixed in advance, dry extract and other adjuvants being put granulator granulates dry, obtains granule, dries finishing control moisture 4.0% ~ 9.0%, obtained described solid particle;
6) granule of drying is added the lubricant of recipe quantity, mixing;
7) by mixed granulation, coating.
As further improvement, the solid-liquid separating method of described zedoary volatile oil clathrate is centrifugal filtration, filter press or decompress filter, the moist material obtained.
As further improvement, described zedoary volatile oil clathrate and powdered Wuling mycelia in combination premix are granulated 1 ~ 3 time, stainless steel mesh 10 ~ 30 order.
As further improvement, premix granule mixes with dry extract by described step 4), then adds the mixing of other adjuvants, carries out wet granulation or one-step palletizing.
As further improvement; the step of described wet granulation is as follows: in mixer-granulator, add binding agent carry out wet granular processed; paddle rotating speed 70 ~ 150 revs/min; fly cutter rotating speed 200 ~ 800 revs/min, runs 10 ~ 30 minutes, wet granular is placed in boiling drier; inlet temperature 45 ~ 85 DEG C; dry 5 ~ 30 minutes, obtain granule, control pellet moisture 4.0% ~ 9.0%.
As further improvement, the step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 DEG C, dry, moisture Control is 4.0% ~ 9.0%.
The present invention, owing to have employed above-mentioned technical scheme, adopts the mixed method of the zedoary volatile oil clathrate of undried and powdered Wuling mycelia in combination, dry extract, makes mixed material meet the needs of Chinese medicine preparation molding.Thus eliminate the volatile oil clathrate compound drying process that there is many drawbacks, decrease the loss of volatile oil content, greatly shorten the process time, improve the retention rate of Rhizoma Curcumae volatile oil in finished dosage form, ensure that drug quality and effectiveness.
Table 1 volatile oil clathrate compound that wets directly is granulated every the comparing of granulating after drying with volatile oil clathrate compound
The technique short time consumption that the technique of directly being granulated by the volatile oil clathrate compound that table 1 is wet is as seen granulated after drying than volatile oil clathrate compound shortens more than 8 times, and volatile oil utilization rate improves more than 30%, greatly reduce production cost, improve the utilization rate of volatile oil.
Detailed description of the invention
embodiment 1
The weight ratio of the composition of the present embodiment is: Oleum Curcumae 2.5%, powdered Wuling mycelia in combination 32%, dry extract 32%, other adjuvants 29.5%.
Containing the preparation method of the tablet of Oleum Curcumae, the method comprises the following steps:
1) Rhizoma Curcumae is extracted into volatile oil, Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Oleum Curcumae with weight ratio 50% dissolve with ethanol, in Oleum Curcumae: the ratio of beta-schardinger dextrin-=1:6 adds in saturated aqueous solution, stirring at room temperature 3 hours, mixing speed 100 revs/min, hold over night, removes supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet Oleum Curcumae clathrate and powdered Wuling mycelia in combination are placed in premix on rotary granulator to granulate;
4) mixed with other adjuvants such as dry extract, calcium hydrogen phosphate, microcrystalline Cellulose by above granule and be placed in high efficient mixed granulator, add binding agent, wet method makes soft material;
5) above-mentioned soft material is put in boiling drier, drying time 30min, inlet temperature 60 ~ 80 DEG C;
6) granule of drying is added the lubricant of recipe quantity, mixing;
7) by mixed granulation, coating.
embodiment 2
The weight ratio of the composition of the present embodiment is: Oleum Curcumae 3.5%, powdered Wuling mycelia in combination 35%, dry extract 28%, other adjuvants 33.5%.
Containing the preparation method of the tablet of Oleum Curcumae, the method comprises the following steps:
1) Rhizoma Curcumae is extracted into volatile oil, Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Oleum Curcumae with weight ratio 50% dissolve with ethanol, in Oleum Curcumae: the ratio of beta-schardinger dextrin-=1:6 adds in saturated aqueous solution, stirring at room temperature 3 hours, mixing speed 100 revs/min, hold over night, removes supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet Oleum Curcumae clathrate and powdered Wuling mycelia in combination are placed in premix on rotary granulator to granulate;
4) mixed with other adjuvants such as dry extract, calcium hydrogen phosphate, microcrystalline Cellulose by above granule and be placed in high efficient mixed granulator, add binding agent, wet method makes soft material;
5) above-mentioned soft material is put in boiling drier, drying time 30min, inlet temperature 60 ~ 80 DEG C;
6) granule of drying is added the lubricant of recipe quantity, mixing;
7) by mixed granulation, coating.
embodiment 3
The weight ratio of the composition of the present embodiment is: Oleum Curcumae 6.0%, powdered Wuling mycelia in combination 40%, dry extract 36%, other adjuvants 18.0%.
Containing the preparation method of the tablet of Oleum Curcumae, the method comprises the following steps:
1) Rhizoma Curcumae is extracted into volatile oil, Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Oleum Curcumae with weight ratio 50% dissolve with ethanol, in Oleum Curcumae: the ratio of beta-schardinger dextrin-=1:6 adds in saturated aqueous solution, stirring at room temperature 3 hours, mixing speed 100 revs/min, hold over night, removes supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet Oleum Curcumae clathrate and powdered Wuling mycelia in combination are placed in premix on rotary granulator to granulate;
4) mixed with other adjuvants such as dry extract, calcium hydrogen phosphate, microcrystalline Cellulose by above granule and be placed in high efficient mixed granulator, add binding agent, wet method makes soft material;
5) above-mentioned soft material is put in boiling drier, drying time 30min, inlet temperature 60 ~ 80 DEG C;
6) granule of drying is added the lubricant of recipe quantity, mixing;
7) by mixed granulation, coating.
Claims (7)
1. one kind contains the preparation method of the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination, it is characterized in that this Chinese medicine solid particle tablet is obtained by Chinese medicine solid particle compress tablet coating, described Chinese medicine solid particle comprises following weight percents composition mixing granulation and obtains:
Rhizoma Curcumae volatile oil 2% ~ 10%
Powdered Wuling mycelia in combination 10% ~ 40%
Dry extract 10% ~ 40% prepared by Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis
β – cyclodextrin;
Other pharmaceutical adjuncts 10% ~ 75%;
Described Rhizoma Curcumae volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Rhizoma Curcumae volatile oil and β – cyclodextrin mass ratio are 1:4 ~ 10, the clathrate solid-liquid separation after enclose, not drying, and moisture is 35% ~ 50%; Described clathrate is granulated after first mix with powdered Wuling mycelia in combination, then the dry extract prepared with Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis, other pharmaceutical adjunct mixing granulations are dry obtain described in Chinese medicine solid particle;
The method specifically comprises the following steps:
1) Rhizoma Curcumae is prepared into Rhizoma Curcumae volatile oil;
2) Rhizoma Curcumae residue, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis prepare dry extract;
3) Rhizoma Curcumae volatile oil beta-schardinger dextrin--water is carried out enclose, described Rhizoma Curcumae volatile oil is Yu β – cyclodextrin mass ratio is 1:4 ~ 10, and obtained the zedoary volatile oil clathrate wet by solid-liquid separation, its moisture is 35% ~ 50%;
4) be that 35% ~ 50% zedoary volatile oil clathrate and powdered Wuling mycelia in combination oscillating granulator premix are granulated by moisture;
5) above-mentioned granule mixed in advance, dry extract and other adjuvants being put granulator granulates dry, obtains granule, dries finishing control moisture 4.0% ~ 9.0%, obtained described Chinese medicine solid particle;
6) granule of drying is added the lubricant of recipe quantity, mixing;
7) by mixed granulation, coating;
describedthe solid-liquid separating method of zedoary volatile oil clathrate is centrifugal filtration, filter press or decompress filter, the moist material obtained; Zedoary volatile oil clathrate and powdered Wuling mycelia in combination premix are granulated 1 ~ 3 time, stainless steel mesh 10 ~ 30 order;
Premix granule mixes with dry extract by described step 5), then adds the mixing of other adjuvants, carries out wet granulation or one-step palletizing;
The step of described wet granulation is as follows: in mixer-granulator, add binding agent carry out wet granular processed, paddle rotating speed 70 ~ 150 revs/min, fly cutter rotating speed 200 ~ 800 revs/min, run 10 ~ 30 minutes, wet granular is placed in boiling drier, inlet temperature 45 ~ 85 DEG C, dry 5 ~ 30 minutes, obtain granule, control pellet moisture 4.0% ~ 9.0%; The step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 DEG C, dry, moisture Control is 4.0% ~ 9.0%.
2. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 1, is characterized in that this Chinese medicine solid particle is obtained by following weight percents composition mixing granulation:
Rhizoma Curcumae volatile oil 3% ~ 10%
Powdered Wuling mycelia in combination 15% ~ 35%
Dry extract 10% ~ 40% prepared by Rhizoma Curcumae, Bulbus Fritillariae Thunbergii and Rhizoma Alismatis
β – cyclodextrin;
Other pharmaceutical adjuncts 10% ~ 60%;
Above-mentioned each component sum is 100%.
3. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 1 and 2, it is characterized in that: Rhizoma Curcumae volatile oil is Yu the clathrate of β – cyclodextrin adopts saturated water solution method to prepare, Rhizoma Curcumae volatile oil, β – cyclodextrin, water are than being 1:4 ~ 10:15 ~ 30, enclose temperature controls at 25 ~ 50 DEG C, mixing speed 60 ~ 120 revs/min, 2 ~ 5 hours response time.
4. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 1, is characterized in that the raw material of Chinese medicine of Chinese medicine solid particle is by following weight:
Powdered Wuling mycelia in combination 60 ~ 100 parts of Rhizoma Curcumae 20 ~ 80 parts
Bulbus Fritillariae Thunbergii 20 ~ 80 portions of Rhizoma Alismatis 20 ~ 40 parts.
5. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 4, is characterized in that the raw material of Chinese medicine of Chinese medicine solid particle is by following weight:
Powdered Wuling mycelia in combination 70 ~ 90 parts of Rhizoma Curcumae 40 ~ 60 parts
Bulbus Fritillariae Thunbergii 40 ~ 60 portions of Rhizoma Alismatis 25 ~ 35 parts.
6. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 1, is characterized in that: other pharmaceutical adjuncts are selected from one or more combinations in filler, binding agent, disintegrating agent and lubricant.
7. a kind of preparation method containing the Chinese medicine solid particle tablet of Rhizoma Curcumae volatile oil and powdered Wuling mycelia in combination according to claim 6, is characterized in that: other described pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and polyvidone.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843454A (en) * | 2006-02-10 | 2006-10-11 | 浙江佐力药业股份有限公司 | Medicinal formulation for treating climacteric syndrome and its preparation method |
| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843454A (en) * | 2006-02-10 | 2006-10-11 | 浙江佐力药业股份有限公司 | Medicinal formulation for treating climacteric syndrome and its preparation method |
| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
Non-Patent Citations (4)
| Title |
|---|
| 毕殿洲主编.包合技术、制粒、片剂的制备.《药剂学》.2003,108-112、151-163、325-328. * |
| 王丽君等.莪术油- * |
| -环糊精包合物的制备工艺及稳定性的考察.《中草药》.2001,第32卷(第4期),314-316. * |
| 莪术挥发油的提取及β-环糊精包合物的研究;鲁继红等;《浙江中医药大学学报》;20060930;第30卷(第5期);469-471 * |
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