CN1985946A - New preparing process for lung heat clearing and phlegm resolving preparation - Google Patents
New preparing process for lung heat clearing and phlegm resolving preparation Download PDFInfo
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Abstract
The present invention relates to Chinese medicine composition and its preparation, and is especially one kind of Chinese medicine composition for treating couth due to lung-heat, phlegm dyspnea, phlegm acculation and lung-qi obstruction and its preparation process. The Chinese medicine composition is preferably prepared into granule and tablet.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind ofly be used for the cough due to lung-heat, abundant expectoration is done to breathe heavily prescription that accumulation and obstruction of sputum, lung qi are not smooth and preparation technology thereof.
Background technology:
The cough due to lung-heat, abundant expectoration is done to breathe heavily, and accumulation and obstruction of sputum, lung qi freely are not clinically to see symptom more, and the traditional Chinese medical science is often taked lowering the adverse-rising QI to resolve phlegm, and the means of relieving cough and asthma are treated it, and evident in efficacy.Lung clearing and phlegm eliminating pill is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly the cough due to lung-heat, abundant expectoration is done to breathe heavily, and accumulation and obstruction of sputum, lung qi are not smooth.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
30～120 parts of Arisaema Cum Bile (stir-baking with sand) 30～120 parts of Rhizoma Pinelliae Preparatum of 15～60 portions of Semen Armeniacae Amarums (stir-baking with sand)
15～60 parts of 30～120 parts of Bulbus Fritillariae Cirrhosaes of 30～120 parts of Radix Scutellariaes of Fructus Aurantii (parched) (wine is processed)
15～60 parts of 30～120 parts of Fructus Perillae Frutescentiss of 15～60 parts of Radix Platycodoniss of Herba Ephedrae (processing)
15～60 parts of Semen Trichosanthis 30～120 parts of Semen Raphanis of 30～120 parts of Pericarpium Citri Reticulataes (stir-fry)
15～60 parts in 30～120 portions of Radix Glycyrrhizaes of 15～60 parts of Poria of Flos Farfarae (processing).
Preferably:
60 parts of Arisaema Cum Bile (stir-baking with sand) 60 parts of Rhizoma Pinelliae Preparatum of 30 portions of Semen Armeniacae Amarums (stir-baking with sand)
30 parts of 60 parts of Bulbus Fritillariae Cirrhosaes of 60 parts of Radix Scutellariaes of Fructus Aurantii (parched) (wine is processed)
30 parts of 60 parts of Fructus Perillae Frutescentiss of 30 parts of Radix Platycodoniss of Herba Ephedrae (processing)
30 parts of Semen Trichosanthis 60 parts of Semen Raphanis of 60 parts of Pericarpium Citri Reticulataes (stir-fry)
30 parts in 60 portions of Radix Glycyrrhizaes of 30 parts of Poria of Flos Farfarae (processing).
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, soft extract, fluid extract and extractum.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get the Herba Ephedrae coarse powder, extract 2～5 times with 0.5～2% (v/v) sulphuric acid merceration, each 3～48h hour, filter, filtrate adding calcium hydroxide fine powder is transferred PH8～10, leaves standstill 20～60min sucking filtration, and filtrate decompression is condensed into thick paste, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
Above active component is the active constituents of medicine of preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pericarpium Citri Reticulatae, the Herba Ephedrae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of rectifying and hide agent, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Arisaema Cum Bile (stir-baking with sand) 36g Semen Armeniacae Amarum 72g Rhizoma Pinelliae Preparatum (stir-baking with sand) 72g
Fructus Aurantii (parched) 72g Radix Scutellariae (wine is processed) 72g Bulbus Fritillariae Cirrhosae 36g
Herba Ephedrae (processing) 36g Radix Platycodonis 72g Fructus Perillae Frutescentis 36g
Semen Trichosanthis 72g Pericarpium Citri Reticulatae 72g Semen Raphani (stir-fry) 36g
Flos Farfarae (processing) 36g Poria 72g Radix Glycyrrhizae 36g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get the Herba Ephedrae coarse powder, extract 3 times with 0.5% (v/v) sulphuric acid merceration, each 8h hour, filter, filtrate adding calcium hydroxide fine powder is transferred PH8～10, leaves standstill the 30min sucking filtration, and filtrate decompression is condensed into thick paste, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
(4) with above-mentioned gained active component mixing, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Arisaema Cum Bile (stir-baking with sand) 150g Semen Armeniacae Amarum 300g Rhizoma Pinelliae Preparatum (stir-baking with sand) 300g
Fructus Aurantii (parched) 300g Radix Scutellariae (wine is processed) 300g Bulbus Fritillariae Cirrhosae 150g
Herba Ephedrae (processing) 150g Radix Platycodonis 300g Fructus Perillae Frutescentis 150g
Semen Trichosanthis 300g Pericarpium Citri Reticulatae 300g Semen Raphani (stir-fry) 150g
Flos Farfarae (processing) 150g Poria 300g Radix Glycyrrhizae 150g
PEG400 300g
Make 1000
Preparation method:
(1) get the Herba Ephedrae coarse powder, extract 3 times with 0.5% (v/v) sulphuric acid merceration, each 8h hour, filter, filtrate adding calcium hydroxide fine powder is transferred PH8～10, leaves standstill the 30min sucking filtration, and filtrate decompression is condensed into thick paste, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
(4) with above-mentioned gained active component mixing, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Arisaema Cum Bile (stir-baking with sand) 150g Semen Armeniacae Amarum 300g Rhizoma Pinelliae Preparatum (stir-baking with sand) 300g
Fructus Aurantii (parched) 300g Radix Scutellariae (wine is processed) 300g Bulbus Fritillariae Cirrhosae 150g
Herba Ephedrae (processing) 150g Radix Platycodonis 300g Fructus Perillae Frutescentis 150g
Semen Trichosanthis 300g Pericarpium Citri Reticulatae 300g Semen Raphani (stir-fry) 150g
Flos Farfarae (processing) 150g Poria 300g Radix Glycyrrhizae 150g
Make 1000g
Preparation method:
(1) get Herba Ephedrae, Pericarpium Citri Reticulatae breaks into fine powder, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
(4) with above-mentioned gained active component mixing, add aspartame 5.0g, dextrin 250.0g, to granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Arisaema Cum Bile (stir-baking with sand) 75g Semen Armeniacae Amarum 150g Rhizoma Pinelliae Preparatum (stir-baking with sand) 150g
Fructus Aurantii (parched) 150g Radix Scutellariae (wine is processed) 150g Bulbus Fritillariae Cirrhosae 75g
Herba Ephedrae (processing) 75g Radix Platycodonis 150g Fructus Perillae Frutescentis 75g
Semen Trichosanthis 150g Pericarpium Citri Reticulatae 150g Semen Raphani (stir-fry) 75g
Flos Farfarae (processing) 75g Poria 150g Radix Glycyrrhizae 75g
Make 1000
Preparation method:
(1) get Herba Ephedrae, Pericarpium Citri Reticulatae breaks into fine powder, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
(4) with above-mentioned gained active component mixing, add aspartame 3.0g, mannitol 150.0g, granulation, drying adds magnesium stearate 3.0g, mixing, tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
30～120 parts of Arisaema Cum Bile (stir-baking with sand) 30～120 parts of Rhizoma Pinelliae Preparatum of 15～60 portions of Semen Armeniacae Amarums (stir-baking with sand)
15～60 parts of 30～120 parts of Bulbus Fritillariae Cirrhosaes of 30～120 parts of Radix Scutellariaes of Fructus Aurantii (parched) (wine is processed)
15～60 parts of 30～120 parts of Fructus Perillae Frutescentiss of 15～60 parts of Radix Platycodoniss of Herba Ephedrae (processing)
15～60 parts of Semen Trichosanthis 30～120 parts of Semen Raphanis of 30～120 parts of Pericarpium Citri Reticulataes (stir-fry)
15～60 parts in 30～120 portions of Radix Glycyrrhizaes of 15～60 parts of Poria of Flos Farfarae (processing).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
60 parts of Arisaema Cum Bile (stir-baking with sand) 60 parts of Rhizoma Pinelliae Preparatum of 30 portions of Semen Armeniacae Amarums (stir-baking with sand)
30 parts of 60 parts of Bulbus Fritillariae Cirrhosaes of 60 parts of Radix Scutellariaes of Fructus Aurantii (parched) (wine is processed)
30 parts of 60 parts of Fructus Perillae Frutescentiss of 30 parts of Radix Platycodoniss of Herba Ephedrae (processing)
30 parts of Semen Trichosanthis 60 parts of Semen Raphanis of 60 parts of Pericarpium Citri Reticulataes (stir-fry)
30 parts in 60 portions of Radix Glycyrrhizaes of 30 parts of Poria of Flos Farfarae (processing).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, soft extract, fluid extract and extractum.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get the Herba Ephedrae coarse powder, extract 2～5 times with 0.5～2% (v/v) sulphuric acid merceration, each 3～48h hour, filter, filtrate adding calcium hydroxide fine powder is transferred PH8～10, leaves standstill 20～60min sucking filtration, and filtrate decompression is condensed into thick paste, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
Above active component is the active constituents of medicine of preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pericarpium Citri Reticulatae, the Herba Ephedrae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get the Herba Ephedrae coarse powder, extract 2～5 times with 0.5～2% (v/v) sulphuric acid merceration, each 3～48h hour, filter, filtrate adding calcium hydroxide fine powder is transferred PH8～10, leaves standstill 20～60min sucking filtration, and filtrate decompression is condensed into thick paste, and is standby;
(2) get Semen Armeniacae Amarum (squeezing is deoiled), Fructus Aurantii, Radix Scutellariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Pericarpium Citri Reticulatae medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract.
Above active component is the active constituents of medicine of preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Pericarpium Citri Reticulatae, the Herba Ephedrae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165476 CN1985946A (en) | 2006-12-20 | 2006-12-20 | New preparing process for lung heat clearing and phlegm resolving preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610165476 CN1985946A (en) | 2006-12-20 | 2006-12-20 | New preparing process for lung heat clearing and phlegm resolving preparation |
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|---|---|
| CN1985946A true CN1985946A (en) | 2007-06-27 |
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| CN 200610165476 Pending CN1985946A (en) | 2006-12-20 | 2006-12-20 | New preparing process for lung heat clearing and phlegm resolving preparation |
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Cited By (4)
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| CN103652556A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Radix astragali, couchgrass root and rhizoma dioscoreae chewable tablets and preparation method |
| CN103735884A (en) * | 2014-01-28 | 2014-04-23 | 辽宁省中医药研究院 | Medicament for treating cough and preparation of medicament |
| CN104352980A (en) * | 2014-11-17 | 2015-02-18 | 孙静 | Cooperative application of traditional Chinese medicines in acupuncture and moxibustion therapy for preventing phthisis |
| CN104547361A (en) * | 2015-01-16 | 2015-04-29 | 昆明中药厂有限公司 | Medicine composition as well as preparation method, preparation and application thereof |
-
2006
- 2006-12-20 CN CN 200610165476 patent/CN1985946A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103652556A (en) * | 2013-12-11 | 2014-03-26 | 罗永祺 | Radix astragali, couchgrass root and rhizoma dioscoreae chewable tablets and preparation method |
| CN103735884A (en) * | 2014-01-28 | 2014-04-23 | 辽宁省中医药研究院 | Medicament for treating cough and preparation of medicament |
| CN103735884B (en) * | 2014-01-28 | 2016-07-06 | 辽宁省中医药研究院 | A kind of medicine treating cough and preparation thereof |
| CN104352980A (en) * | 2014-11-17 | 2015-02-18 | 孙静 | Cooperative application of traditional Chinese medicines in acupuncture and moxibustion therapy for preventing phthisis |
| CN104547361A (en) * | 2015-01-16 | 2015-04-29 | 昆明中药厂有限公司 | Medicine composition as well as preparation method, preparation and application thereof |
| CN104547361B (en) * | 2015-01-16 | 2018-05-18 | 昆明中药厂有限公司 | A kind of pharmaceutical composition and preparation method thereof, preparation and application |
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