CN1824016A - Compound flowery knotweed and rehmannia preparation and its manufacturing method - Google Patents
Compound flowery knotweed and rehmannia preparation and its manufacturing method Download PDFInfo
- Publication number
- CN1824016A CN1824016A CN 200510134445 CN200510134445A CN1824016A CN 1824016 A CN1824016 A CN 1824016A CN 200510134445 CN200510134445 CN 200510134445 CN 200510134445 A CN200510134445 A CN 200510134445A CN 1824016 A CN1824016 A CN 1824016A
- Authority
- CN
- China
- Prior art keywords
- preparation
- active component
- medicine
- fructus
- soft capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating sore and limp loins and knees, headache, dizziness and poliosis, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of soreness of the waist and knees that is used for, it is dizzy to have a headache, the prescription of early whitening of beard and hair and preparation technology thereof.
Background technology:
Soreness of the waist and knees, it is dizzy to have a headache, and early whitening of beard and hair is clinical common sympton, and the traditional Chinese medical science is often taked enriching yin and nourishing kidney, crow palpus hair color, the means of strengthening bone and muscle are treated it, and evident in efficacy, and the compound fleece flower root-rehmannia root ball is that it represents medicine.But in the practice, because this medicine is the part medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, its pill that makes can be used for curing mainly soreness of the waist and knees, it is dizzy to have a headache, early whitening of beard and hair.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
100～858 parts of Radix Polygoni Multiflori Preparata 100～858 parts of Fructus Ligustri Lucidi of 50～429 portions of Radix Rehmanniae (processed with wine)
100～858 parts of Herba Ecliptaes
Preferably:
200 parts of Radix Polygoni Multiflori Preparata 200 parts of Fructus Ligustri Lucidi of 100 portions of Radix Rehmanniae (processed with wine)
200 parts of Herba Ecliptaes
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get Fructus Ligustri Lucidi, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get prescription residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Fructus Ligustri Lucidi beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of hard capsule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, and drying, mixing is filled and is promptly got hard capsule.
Filler described in the preparation of granule, hard capsule is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the blood tonification effect of losing blood property blood deficiency mice
30 of mices are divided 3 groups at random, blank group (normal saline), technology is 2. extractum group (0.78g/kg) of extractum group (0.23g/kg), technology 1., earlier with each group mice docking blood sampling, measure normocyte (RBC) counting and hemoglobin (Hb) content, every then Mus blood-letting 0.5ml causes acute bleeding, and lose blood back RBC counting and Hb content are measured in docking blood sampling for the second time after 24 hours.After this begin gastric infusion or isometric(al) normal saline.Every day 1 time is continuous 7 days.RBC counted and Fib content after administration was measured in the docking blood sampling once more in the 8th day after the administration, RBC and Hb value were the back minimizing value of losing blood after normal RBC and Hb value deducted respectively and lose blood, to deduct lose blood back RBC and Hb value respectively be value added after the administration for RBC and Hb value after the administration, the results are shown in Table 1 and table 2.
The influence of table 1 couple losing blood property blood deficiency mice RBC (x ± s, n=10)
| Group | RBC(1012/L) |
| Normally | After losing blood | The minimizing value | After the administration | Value added | |
| Matched group technology is 2. extractum group of extractum group technology 1. | 9.57±0.81 9.72±0.98 9.34±1.03 | 5.68±1.02 5.82±1.34 5.58±0.94 | 3.90±1.37 3.90±1.37 3.76±0.93 | 8.00±0.98 9.57±0.85 9.21±0.86 | 2.33±1.55 3.75±1.43 * 3.63±0.99 * |
The influence of table 2 couple losing blood property blood deficiency mice Hb (x ± s, n=10)
| Group | Hb(g/L) | ||||
| Normally | After losing blood | The minimizing value | After the administration | Value added | |
| Matched group technology is 2. extractum group of extractum group technology 1. | 135.6±12.5 135.5±12.7 129.9±14.4 | 82.5±17.3 80.8±18.6 77.5±13.0 | 53.1±10.3 54.7±18.8 52.4±12.9 | 111.6±19.9 133.7±11.2 124.7±12.3 | 29.1±19.8 52.9±20.4 * 47.2±11.7 * |
The result shows that after chmice acute was lost blood, RBC number and content of hemoglobin obviously reduced in the blood, and the extractum group can make the RBC number in the acute bleeding mice blood increase, and content of hemoglobin raises.
2, improve the experimentation of chronic renal insufficiency
2.1 method
Male rat, body weight is 200～230g, except that the normal control group, all the other treated animals adopt the Plant method, the most of excision of row 5/6 kidney is made and is given the plain particles feedstuff after the operation of chronic kidney hypofunction rat model modeling rat and freely drink water, be divided into 5 groups after 1 week at random, grouping sees Table 2, and the normal control group does not add any processing factor; 1 week beginning administration after all the other rat modelings, model control group (distilled water), benazepril group (10mg/kg), technology be extractum group (0.11g/kg) 1., and technology is extractum group (0.39g/kg) 2., gastric infusion.Weigh 1 per two weeks to adjust dosage, 8 weeks of the course of treatment.Observation index comprises ordinary circumstance (ergasia, chroma of hair, body weight etc.) and blood test.
2.2 result
2.2.1 ordinary circumstance
The performance of normal control treated animal is alert, and reaction is fast, the fur densification, and neat and glossy, diet is normal; Each treated animal lethargy after the modeling, movable slow, fur is fluffy, withered tarnish, inappetence.Wherein model control group is the most obvious, and the benazepril group is taken second place, and the extractum group is better than model control group and benazepril group.
2.2.2 renal function
After the modeling, model group rat blood serum creatinine, urine rope nitrogen are apparently higher than normal control group (P＜0.01), and after the treatment, benazepril group and extractum group serum Scr, Bun obviously descend.Although with normal group more variant (P＜0.01), but significantly be lower than model control group, the remaining kidney compensatory hypertrophy of modeling reserve group is obvious, with the normal group comparing difference highly significant (P＜0.01) is arranged, rat body weight then descends to some extent, especially obviously (compare P＜0.05 with normal group) with model group and benazepril group weight loss, each extractum group does not then relatively have significant difference with the normal control group; In addition, respectively organize kidney of rats weight/weight ratio after the modeling and obviously increase, highly significant (P＜0.01) is arranged with normal control group comparing difference.See table 3 for details.
The influence of table 3 pair chronic kidney hypofunction kidney of rats function (x ± s)
| Group | n | Bun(mmol/L) | Scr(μmol/L) | Kidney heavy (g) | Body weight (g) | Kidney weight/body weight (* 10 -3) |
| Normal control group model matched group technology is 2. extractum group benazepril group of extractum group technology 1. | 10 7 9 8 8 | 7.34±0.94 14.22±2.56 ** 10.99±2.71 **△ 11.04±0.99 **△ 10.51±1.74 **△ | 43.19±6.09 134.83±9.08 ** 74.57±13.86 **△△ 94.08±13.12 ** 90.27±13.81 ** | 0.33±0.06 0.95±0.25 ** 0.89±0.33 ** 0.82±0.32 ** 0.88±0.15 ** | 280.63±40.49 236.71±31.78 * 278.62±41.13 △ 288.28±34.99 △ 259.57±39.11 * | 1.19±0.29 4.07±1.09 ** 3.27±1.14 ** 2.97±0.76 **△ 3.41±0.36 ** |
Compare with normal group
*P＜0.01; Compare with model group,
△P＜0.05,
△ △P＜0.01
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment soreness of the waist and knees, it is dizzy to have a headache, the medicine of early whitening of beard and hair, and change preparation technology, can obviously strengthen its enriching yin and nourishing kidney, crow palpus hair color, clinical efficacies such as strengthening bone and muscle, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Polygoni Multiflori Preparata 143g Radix Rehmanniae 286g Fructus Ligustri Lucidi (processed with wine) 286g
Herba Ecliptae 286g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get Fructus Ligustri Lucidi, soaked 30 minutes earlier with 65% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get prescription residue medical material, decoct with water 3 times, each 1.5 hours, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Polygoni Multiflori Preparata 429g Radix Rehmanniae 858g Fructus Ligustri Lucidi (processed with wine) 858g
Herba Ecliptae 858g
PEG400 300g
Make 1000
Preparation method:
(1) get Fructus Ligustri Lucidi, soaked 30 minutes earlier with 65% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get prescription residue medical material, decoct with water 3 times, each 1.5 hours, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Polygoni Multiflori Preparata 350g Radix Rehmanniae 700g Fructus Ligustri Lucidi (processed with wine) 700g
Herba Ecliptae 700g
Make 1000g
Preparation method:
(1) getting Fructus Ligustri Lucidi beats powder and is used as medicine;
(2) get prescription residue medical material, decoct with water 3 times, each 1.5 hours, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 5.0g, dextrin 150.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of hard capsule of the present invention:
Prescription:
Radix Polygoni Multiflori Preparata 170g Radix Rehmanniae 340g Fructus Ligustri Lucidi (processed with wine) 340g
Herba Ecliptae 340g
Make 1000
Preparation method:
(1) getting Fructus Ligustri Lucidi beats powder and is used as medicine;
(2) get prescription residue medical material, decoct with water 3 times, each 1.5 hours, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 3.0g, mannitol 100.0g, granulation, drying adds magnesium stearate 3.0g, and mixing is filled, and promptly gets 1000 of capsules.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
100～858 parts of Radix Polygoni Multiflori Preparata 100～858 parts of Fructus Ligustri Lucidi of 50～429 portions of Radix Rehmanniae (processed with wine)
100～858 parts of Herba Ecliptaes.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
200 parts of Radix Polygoni Multiflori Preparata 200 parts of Fructus Ligustri Lucidi of 100 portions of Radix Rehmanniae (processed with wine)
200 parts of Herba Ecliptaes.
3, claim 1 or any one Chinese medicine preparation of 2 are various suitable dosage forms such as drop pill, soft capsule, granule, chewable tablet, mixture, hard capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Fructus Ligustri Lucidi, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get prescription residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Fructus Ligustri Lucidi beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of hard capsule is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, mixing is filled and is promptly got hard capsule.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Fructus Ligustri Lucidi, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get prescription residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Fructus Ligustri Lucidi beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134445 CN1824016A (en) | 2005-12-15 | 2005-12-15 | Compound flowery knotweed and rehmannia preparation and its manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134445 CN1824016A (en) | 2005-12-15 | 2005-12-15 | Compound flowery knotweed and rehmannia preparation and its manufacturing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1824016A true CN1824016A (en) | 2006-08-30 |
Family
ID=36934956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510134445 Pending CN1824016A (en) | 2005-12-15 | 2005-12-15 | Compound flowery knotweed and rehmannia preparation and its manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1824016A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336970B (en) * | 2008-08-18 | 2012-02-15 | 盛立新 | Chinese herbal medicine for treating and preventing poliosis and alopecia |
| CN102823856A (en) * | 2012-02-03 | 2012-12-19 | 山东师范大学 | Kidney-tonifying hair-blackening health food for women and preparation method thereof |
| CN103655903A (en) * | 2013-12-16 | 2014-03-26 | 青岛百瑞吉生物工程有限公司 | Chinese herba preparation for treating yellow hair |
| CN105411855A (en) * | 2015-12-24 | 2016-03-23 | 山东省化工研究院 | Medical dropping pill device and method for preparing brain strengthening and hair blacking dropping pills with same |
-
2005
- 2005-12-15 CN CN 200510134445 patent/CN1824016A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336970B (en) * | 2008-08-18 | 2012-02-15 | 盛立新 | Chinese herbal medicine for treating and preventing poliosis and alopecia |
| CN102823856A (en) * | 2012-02-03 | 2012-12-19 | 山东师范大学 | Kidney-tonifying hair-blackening health food for women and preparation method thereof |
| CN103655903A (en) * | 2013-12-16 | 2014-03-26 | 青岛百瑞吉生物工程有限公司 | Chinese herba preparation for treating yellow hair |
| CN103655903B (en) * | 2013-12-16 | 2016-01-27 | 卞佳林 | A kind of Chinese drugs agentia for the treatment of yellow hair |
| CN105411855A (en) * | 2015-12-24 | 2016-03-23 | 山东省化工研究院 | Medical dropping pill device and method for preparing brain strengthening and hair blacking dropping pills with same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1823992A (en) | Ginseny spleen invigorating preparation and its new preparation method | |
| CN1857562A (en) | Kidney invigorating hair restorer preparation its preparing process | |
| CN1824211A (en) | Lung clearing cough suppressing phlegm transforming medicinal preparation and its new preparation method | |
| CN1824215A (en) | Poria ovate attractylodes medicinal preparation and its new preparation method | |
| CN1824240A (en) | Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method | |
| CN1748774A (en) | Brain tonifying preparation and new preparing method | |
| CN1775253A (en) | Chinese hawthorn blood-pressure-reducing preparation, and new preparing method | |
| CN1775279A (en) | Gynaecologic formulation and new preparing method | |
| CN1824016A (en) | Compound flowery knotweed and rehmannia preparation and its manufacturing method | |
| CN1824018A (en) | Dual supplementation preparation of qi and blood and its making method | |
| CN1775264A (en) | Maiwei-dihuang preparation and new preparing method | |
| CN1748748A (en) | Little leaf deervetch herb preparation for pregnant woman and new preparing method | |
| CN1775247A (en) | Fleece-flower root and rhizoma rehmanniae preparation and new preparing method | |
| CN1775263A (en) | Qiju-dihuang preparation and new preparation method | |
| CN1824100A (en) | Medicinal preparation for treating cough and panting and its preparation method | |
| CN1824113A (en) | Postpartum laonurus medicinal preparation and its new preparation method | |
| CN1824241A (en) | Medicinal preparation and its new preparation method | |
| CN1824128A (en) | Semen locking medicinal preparation and its new preparation method | |
| CN1843440A (en) | Traditional Chinese medicine formulation and its novel preparation method | |
| CN1775244A (en) | Blood-cleaning detoxifying formulation and new preparing method | |
| CN1775248A (en) | Dried tangerine peel sputum-resolving preparation and new preparing method | |
| CN1775258A (en) | Womb-warming pregnancy-aiding preparation and new preparing method | |
| CN1824270A (en) | Middle-jiao regulating medicinal preparation and its new preparation method | |
| CN1824099A (en) | Diffusing-freeing lung rectifying medicinal preparation and its new preparation method | |
| CN1775238A (en) | Anti-inflammtory anti-dysentery preparation and new preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |