CN103040786B - Capsule of solid traditional Chinese medicine particles and preparation method of capsule - Google Patents
Capsule of solid traditional Chinese medicine particles and preparation method of capsule Download PDFInfo
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Abstract
The invention relates to a capsule of solid traditional Chinese medicine particles and the preparation method of the capsule. The capsule of solid traditional Chinese medicine particles comprises solid particles and a casing of the capsule, wherein the solid particles are formed by mixing and pelletizing the following ingredients according to weight percentage: 2 to 10 percent of Chinese medicine volatile oil, 10 to 40 percent of one or more of the Chinese medicine raw powder and zymophyte mycelium powder, 10 to 40 percent of Chinese medicine dry extract, and 10 to 75 percent of other pharmaceutical adjuncts; the Chinese medicine volatile oil and Beta-cyclodextrin are in clathration by adopting the method of saturated aqueous solution, and then solid-liquid separation is performed on clathrate compound after clathration; and the solid particles are made by firstly mixing the clathration compound and then pelletizing. The invention has the following advantages: a drying procedure is eliminated, the loss of the volatile oil is reduced, the process time is shortened greatly, the retention rate of the volatile oil in finished products of preparation of Chinese medicine is improved, and the quality and the effectiveness of medicine are ensured.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly relate to capsule of a kind of Chinese medicine solid particle containing volatile oil and preparation method thereof.
Background technology
The application of traditional medicine volatile oil has long history, and the effectiveness of many traditional medicine volatile oils is early known to ancients.According to the chemical research of modern Chinese medicine, containing the Chinese crude drug One's name is legion of volatile oil, relate to the Chinese medicine of nearly all potency classes, as Herba Menthae, Radix Bupleuri, Herba Pogostemonis, Rhizoma Curcumae, Rhizoma Chuanxiong, Folium Perillae volatilization wet goods.The nature difference of traditional medicine volatile oil is comparatively large, is liquid at normal temperatures, more volatile, and character is unstable.The solid preparation that current oil content is high can select soft capsule or special hard capsule, but complicated process of preparation, product storage life is short, adopting containing volatile oil preparation is then very difficult based on dry extract.
Prior art: first the volatile oil beta-schardinger dextrin--water extracted in medical material is carried out enclose, solid-liquid separation, become moisture volatile oil clathrate compound; This moisture volatile oil clathrate compound adopts method of drying or less than the 50 DEG C dry 8-12 hour of Oven Method, powdered or granule; Powder former in medical material, dry extract etc. mix again, granulate; After again carrying out drying, make the solid preparation such as tablet, capsule further.
Chinese invention patent application (application number: 200510003035.1 applyings date: 2005-03-28) discloses Chinese medicine preparation of a kind of nourishing qi and blood and preparation method thereof, and it is prepared from primarily of the medical materials such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong and adjuvant.Which disclose Radix Angelicae Sinensis, Rhizoma Chuanxiong first prepares ethereal oil, adopt beta-cyclodextrin inclusion compound, then mix with dry extract.Although whether dry after the undeclared employing beta-cyclodextrin inclusion compound of this patent, mix with dry extract after enclose, Benexate Hydrochloride obviously needs drying, otherwise, cannot effectively mix after dry extract moisture absorption.
Chinese invention patent application (application number: the 201110121569.X applying date: 2011-05-12) discloses a kind of Chinese medicine preparation for the treatment of flu and preparation method thereof, and described Chinese medicine preparation is made up of 600 ~ 900 parts of Fructus Forsythiaes, 600 ~ 900 parts of Radix Bupleuri, 300 ~ 450 parts of Herba Ephedraes, 200 ~ 300 parts of Herba Pogostemonis, 200 ~ 300 portions of Cortex Cinnamomis and 200 ~ 300 parts of Radix Platycodoniss.Its preparation method Fructus Forsythiae, Herba Pogostemonis, Cortex Cinnamomi is extracted volatile oil respectively obtain mixture A; Fructus Forsythiae is extracted remaining medicinal residues and Herba Ephedrae after volatile oil, Radix Bupleuri, the active ingredient of Radix Platycodonis medical material united extraction, spraying dry makes powder B again; Then by mixture A and beta-cyclodextrin inclusion compound, obtained volatile oil pressed powder C; Finally powder B and powder C is mixed and load in softgel shell and get final product.This patent is also specify that volatile oil pressed powder C needs to carry out cold drying.
Chinese invention patent application (application number: 201010011610.3 applyings date: 2010-01-06) disclose a kind of treat infantile common cold series of Chinese and preparation technology and quality control method, they are prepared from by Chinese medicine Folium Isatidis, Radix Bupleuri, Radix Scutellariae, Herba Schizonepetae, Radix Platycodonis, Radix Glycyrrhizae and pharmaceutic adjuvant.This patent Radix Bupleuri volatile oil beta-cyclodextrin inclusion compound becomes clathrate, add Radix Platycodonis fine powder and volatile oil clathrate compound again then making Chinese medicine clear paste, mixing, obtain extraction extractum, add and be selected from dextrin, lactose, the one of sucrose or two kinds or three kinds as granulation adjuvant, carry out one-step palletizing, mixing, obtains children's and separates sense granule.It is dry that this patent also specify that clathrate needs under the condition of 50,60 DEG C in the description.
(application number is Chinese invention patent application: 200410081462.7) disclose a kind of pharmaceutical preparation containing volatile oil and preparation method thereof, the pharmaceutic adjuvant that it contains volatile oil and volatile oil can be solidified, wherein pharmaceutic adjuvant is the Polyethylene Glycol of mean molecule quantity more than 2500.The medicine key quality factors such as content and utilization rate of volatile oil is not evaluated in preparation method.
The Chinese invention patent application (application number: 200910100513.9 applyings date: 2009-07-09) of applicant's application discloses the pharmaceutical composition for the treatment of prostatitis, prostatic hyperplasia, and this pharmaceutical composition is prepared by the raw material of Chinese medicine comprising following weight parts proportioning: powdered Wuling mycelia in combination 60 ~ 100 parts, Rhizoma Curcumae 20 ~ 80 parts, Bulbus Fritillariae Thunbergii 20 ~ 80 parts, Rhizoma Alismatis 20 ~ 40 parts.This patent Rhizoma Curcumae extracts volatile oil beta-cyclodextrin inclusion compound, prepares volatile oil clathrate compound; The medicinal residues of Rhizoma Curcumae and Bulbus Fritillariae Thunbergii, Rhizoma Alismatis merge, and extract, extracting liquid filtering, is evaporated to clear paste, then adds ethanol, hold over night, filter, filtrate reduced in volume, dry obtained medical material dried cream powder; Get above-mentioned WULINGJUN Fen ﹑ medical material dried cream powder, volatile oil clathrate compound, mixing, obtains described pharmaceutical composition.The volatile oil clathrate compound that this patent relates to directly mixes with medical material dried cream powder, and it is also need to carry out drying.
Following shortcoming is all there is in each above-mentioned patent:
1, after the clathrate made after inclusion essential oil need first be dried to fine powder or granule, then granulate or process further after mixing with other extracts.Inclusion essential oil water content of matter high (40-60%) after dehydration, drying process temperature can not, more than 50 DEG C, need for up to 8-12 hours;
2, volatile oil clathrate compound dry run, have part volatile oil to overflow and partial loss, volatile oil reserved reduces, and causes certain contamination, and operator are uncomfortable;
If 3 process further again, the operations such as granulation, particle drying make the solid preparation such as tablet, capsule, then the volatile oil in these solid preparations retains and can reduce further, only has about 50%, affects medicine effectiveness and quality.
Summary of the invention
In order to solve above-mentioned technical problem, an object of the present invention is to provide a kind of capsule of Chinese medicine solid particle, said composition decreases the loss of volatile oil content, greatly can shorten the process time, improve the retention rate of volatile oil in Chinese medicine preparation finished product, ensure that drug quality and effectiveness.Another object of the present invention is to provide a kind of preparation method adopting the capsule of above-mentioned Chinese medicine solid particle.
In order to realize first above-mentioned object, present invention employs following technical scheme:
A capsule for Chinese medicine solid particle, the capsule of this Chinese medicine solid particle comprises solid particle and capsule shell, and described solid particle obtains by comprising following weight percents composition mixing granulation:
Chinese crude drug volatile oil 2% ~ 10%
In the former powder of Chinese crude drug and fermentation mycelium powder one or more 10% ~ 40%
Chinese crude drug dry extract 10% ~ 40%
Other pharmaceutical adjuncts 10% ~ 75%;
Described Chinese crude drug volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Chinese crude drug volatile oil and β – cyclodextrin mass ratio are 1:4 ~ 7, the clathrate solid-liquid separation after enclose, not drying, and moisture is 35% ~ 50%; First with the former powder of Chinese crude drug and fermentation mycelium one or more granulate after mixing described clathrate, then obtain described solid particle with described Chinese crude drug dry extract, other pharmaceutical adjunct mixing granulation dryings.
As preferably, above-mentioned solid particle is obtained by following weight percents composition mixing granulation:
Chinese crude drug volatile oil 3% ~ 10%
In the former powder of Chinese crude drug and fermentation mycelium powder one or more 15% ~ 35%
Chinese crude drug dry extract 10% ~ 40%
Other pharmaceutical adjuncts 10% ~ 60%.
As further improvement, described Chinese crude drug volatile oil is Yu the clathrate of β – cyclodextrin adopts saturated water solution method to prepare, Chinese crude drug volatile oil, β – cyclodextrin, water are than being 1:4 ~ 7:15 ~ 30, enclose temperature controls at 25 ~ 50 DEG C, mixing speed 60 ~ 120 revs/min, 2 ~ 5 hours response time.
As preferably, above-mentioned Chinese medicinal solid granule composition adopts the preparation of fermentation mycelium powder.
As preferably, above-mentioned Chinese crude drug volatile oil is selected from one or more combinations in Rhizoma Curcumae, Radix Bupleuri, Rhizoma Chuanxiong, Herba Pogostemonis and Folium Perillae volatile oil.
As preferably, the former powder of above-mentioned Chinese crude drug is selected from one or more combinations in Radix Ginseng, Radix Panacis Quinquefolii, Cordyceps and Radix Notoginseng.
As preferably, above-mentioned fermentation mycelium is selected from one or more combinations in ganoderma lucidum powder, fermented Cordyceps powder, powdered Wuling mycelia in combination or Coriolous Dersicolor (Fr.) Quel mycopowder.
As preferably, other above-mentioned pharmaceutical adjuncts are selected from one or more combinations in filler, binding agent, disintegrating agent and lubricant.As preferred again, other above-mentioned pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and polyvidone.
In order to realize second above-mentioned object, present invention employs following technical scheme:
Prepare a method for the capsule of above-mentioned Chinese medicine solid particle, the method comprises the following steps:
1) Chinese crude drug is prepared into Chinese crude drug volatile oil and Chinese crude drug dry extract;
2) Chinese crude drug volatile oil beta-schardinger dextrin--water is carried out enclose, described Chinese crude drug volatile oil is Yu β – cyclodextrin mass ratio is 1:3 ~ 10, and obtained the Chinese crude drug volatile oil clathrate compound wet by solid-liquid separation, its moisture is 35% ~ 50%;
3) be that one or more of 35% ~ 50% Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug and fermentation mycelium powder body are granulated with oscillating granulator premixs by moisture;
4) above-mentioned granule mixed in advance, Chinese crude drug dry extract and other adjuvants being put granulator granulates dry, obtains granule, dries finishing control moisture 4.0% ~ 9.0%, obtained described solid particle;
5) above-mentioned solid particle is filled in capsule shells.
As further improvement, described Chinese crude drug volatile oil clathrate compound adopts saturated water solution method preparation, and volatile oil, β – cyclodextrin, water are than being 1:4 ~ 7:15 ~ 30, and enclose temperature controls at 25 ~ 50 DEG C, mixing speed 60 ~ 120 revs/min, 2 ~ 5 hours response time.
As further improvement, the solid-liquid separating method of described Chinese crude drug volatile oil clathrate compound is centrifugal filtration, filter press or decompress filter, the moist material obtained.
As further improvement, described Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug or fermentation mycelium premix are granulated 1 ~ 3 time, stainless steel mesh 10 ~ 30 order.
As further improvement, premix granule mixes with Chinese crude drug dry extract by described step 3), then adds the mixing of other adjuvants, carries out wet granulation or one-step palletizing.
As further improvement, the step of described wet granulation is as follows: in mixer-granulator, add binding agent carry out wet granular processed, paddle rotating speed 70 ~ 150 revs/min, fly cutter rotating speed 200 ~ 800 revs/min, runs 10 ~ 30 minutes.Wet granular is placed in boiling drier, inlet temperature 45 ~ 85 DEG C, dry 5 ~ 30 minutes, obtains granule, control pellet moisture 4.0% ~ 9.0%.
As further improvement, the step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 DEG C, dry, moisture Control is 4.0% ~ 9.0%.
The present invention, owing to have employed above-mentioned technical scheme, adopts the mixed method of the volatile oil clathrate compound of undried and the former powder of medical material, dry extract, makes mixed material meet the needs of Chinese medicine preparation molding.Thus eliminate the volatile oil clathrate compound drying process that there is many drawbacks, decrease the loss of volatile oil content, greatly shorten the process time, improve the retention rate of volatile oil in Chinese medicine preparation finished product, ensure that drug quality and effectiveness.
Table 1 volatile oil clathrate compound that wets directly is granulated every the comparing of granulating after drying with volatile oil clathrate compound
The technique short time consumption that the technique of directly being granulated by the volatile oil clathrate compound that table 1 is wet is as seen granulated after drying than volatile oil clathrate compound shortens more than 8 times, and volatile oil utilization rate improves more than 30%, greatly reduce production cost, improve the utilization rate of volatile oil.
Detailed description of the invention
embodiment 1
The weight ratio of the composition of the present embodiment is: Oleum Curcumae 2.5%, powdered Wuling mycelia in combination 36%, Chinese medicine dry extract 32%, other adjuvants 29.5%.
Containing the preparation method of the capsule of Oleum Curcumae, the method comprises the following steps:
1) Rhizoma Curcumae is extracted into volatile oil, other Chinese medicine extraction make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Oleum Curcumae with weight ratio 50% dissolve with ethanol, in Oleum Curcumae: the ratio of beta-schardinger dextrin-=1:6 adds in saturated aqueous solution, stirring at room temperature 3 hours, mixing speed 100 revs/min, hold over night, removes supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet Oleum Curcumae clathrate and powdered Wuling mycelia in combination are placed in premix on rotary granulator to granulate;
4) mixed with other adjuvants such as Chinese medicine dry extract, calcium hydrogen phosphate, microcrystalline Cellulose by above granule and be placed in high efficient mixed granulator, add binding agent, wet method makes soft material;
5) above-mentioned soft material is put in boiling drier, drying time 30min, inlet temperature 60 ~ 80 DEG C;
6) granule of drying is added the lubricant of recipe quantity, mixing, filled capsules.
embodiment 2
The weight ratio of the composition of the present embodiment is: Rhizoma Chuanxiong oil: 3%, fermented Cordyceps powder 35%, Chinese medicine dry extract 25%, other adjuvants 37%.
Containing the preparation method of the capsule of Rhizoma Chuanxiong oil, the method comprises the following steps:
1) Rhizoma Chuanxiong is extracted into volatile oil, and other Chinese medicine extraction make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Rhizoma Chuanxiong oil with weight ratio 50% dissolve with ethanol, in Oleum Curcumae: the ratio of beta-schardinger dextrin-=1:5 adds in saturated aqueous solution, 25 DEG C are stirred 5 hours, and hold over night, removes supernatant, bottom precipitation decompress filter, for subsequent use;
3) wet Oleum Curcumae clathrate and fermented Cordyceps powder are placed in premix on oscillating granulator to granulate;
4) adjuvants such as above granule and Chinese medicine dry extract, pregelatinized Starch, microcrystalline Cellulose are added in Fluidbedgranulatingdrier; Spray into binding agent, inlet temperature 70 DEG C, temperature of charge controls at 50 ± 5 DEG C, and dry, moisture Control is below 6%;
5) dry granule is added lubricant, mixing, filled capsules.
embodiment 3
The weight ratio of the composition of the present embodiment is: Folium Perillae volatile oil: 1.5%, ganoderma lucidum powder: 30%, Chinese medicine dry extract: 30%, other adjuvants 38.5%.
Containing the preparation method of the capsule of perilla oil, the method comprises the following steps:
1) Rhizoma Chuanxiong is extracted into volatile oil, and other Chinese medicine extraction make dry extract;
2) inclusion essential oil: get beta-schardinger dextrin-and be mixed with saturated aqueous solution, get Rhizoma Chuanxiong volatile oil with weight ratio 50% dissolve with ethanol, in Folium Perillae volatile oil: the ratio of beta-schardinger dextrin-=1:10 adds in saturated aqueous solution, stirring at room temperature 1.5 hours, hold over night, take down supernatant, bottom precipitation vacuum filtration, for subsequent use;
3) wet perilla oil clathrate and ganoderma lucidum powder are placed in premix on oscillating granulator to granulate;
4) above granule is mixed homogeneously with filler with Chinese medicine dry extract, other adjuvants, be placed in method rolling pelletizer, make wet granular;
5) above-mentioned granule is put in boiling drier, inlet temperature 65 DEG C, control temperature of charge at 50 ± 5 DEG C, dry 30min, dry Grain size controlling moisture 4.0% ~ 9.0%;
6) granule of drying is added lubricant, mixing, filled capsules.
Claims (7)
1. a capsule for Chinese medicine solid particle, is characterized in that the capsule of this Chinese medicine solid particle comprises solid particle and capsule shell, and described solid particle obtains by comprising following weight percents composition mixing granulation:
Chinese crude drug volatile oil 2% ~ 10%
In the former powder of Chinese crude drug and fermentation mycelium powder one or more 10% ~ 40%
Chinese crude drug dry extract 10% ~ 40%
Other pharmaceutical adjuncts 10% ~ 75%;
Described Chinese crude drug volatile oil adopts saturated water solution method and β – cyclodextrin inclusion compound, and Chinese crude drug volatile oil and β – cyclodextrin mass ratio are 1:4 ~ 7, the clathrate solid-liquid separation after enclose, not drying, and moisture is 35% ~ 50%; First with the former powder of Chinese crude drug and fermentation mycelium one or more granulate after mixing described clathrate, then obtain described solid particle with described Chinese crude drug dry extract, other pharmaceutical adjunct mixing granulation dryings; Other pharmaceutical adjuncts are selected from one or more in pregelatinized Starch, microcrystalline Cellulose, calcium hydrogen phosphate, hydroxypropyl cellulose and polyvidone.
2. the capsule of a kind of Chinese medicine solid particle according to claim 1, it is characterized in that: Chinese crude drug volatile oil is Yu the clathrate of β – cyclodextrin adopts saturated water solution method to prepare, Chinese crude drug volatile oil, β – cyclodextrin, water are than being 1:4 ~ 7:15 ~ 30, enclose temperature controls at 25 ~ 50 DEG C, mixing speed 60 ~ 120 revs/min, 2 ~ 5 hours response time.
3. the capsule of a kind of Chinese medicine solid particle according to claim 1, is characterized in that: Chinese crude drug volatile oil is selected from one or more combinations in Rhizoma Curcumae, Radix Bupleuri, Rhizoma Chuanxiong, Herba Pogostemonis and Folium Perillae volatile oil; The former powder of Chinese crude drug is selected from one or more combinations in Radix Ginseng, Radix Panacis Quinquefolii, Cordyceps and Radix Notoginseng; Described fermentation mycelium powder is selected from one or more combinations in ganoderma lucidum powder, fermented Cordyceps powder, powdered Wuling mycelia in combination or Coriolous Dersicolor (Fr.) Quel mycopowder.
4. prepare a method for the capsule of a kind of Chinese medicine solid particle described in claim 1 ~ 3 any one claim, it is characterized in that the method comprises the following steps:
1) Chinese crude drug is prepared into Chinese crude drug volatile oil and Chinese crude drug dry extract;
2) Chinese crude drug volatile oil beta-schardinger dextrin--water is carried out enclose, described Chinese crude drug volatile oil is Yu β – cyclodextrin mass ratio is 1:4 ~ 7, and obtained the Chinese crude drug volatile oil clathrate compound wet by solid-liquid separation, its moisture is 35% ~ 50%;
3) be that one or more of 35% ~ 50% Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug and fermentation mycelium powder body are granulated with oscillating granulator premixs by moisture;
4) above-mentioned granule mixed in advance, Chinese crude drug dry extract and other adjuvants being put granulator granulates dry, obtains granule, dries finishing control moisture 4.0% ~ 9.0%, obtained described solid particle;
5) above-mentioned solid particle is filled in capsule shells.
5. the preparation method of the capsule of a kind of Chinese medicine solid particle according to claim 4, is characterized in that: the solid-liquid separating method of Chinese crude drug volatile oil clathrate compound is centrifugal filtration, and filter press or decompress filter, obtain moist material; Chinese crude drug volatile oil clathrate compound and the former powder of Chinese crude drug or fermentation mycelium premix are granulated 1 ~ 3 time, stainless steel mesh 10 ~ 30 order.
6. the preparation method of the capsule of a kind of Chinese medicine solid particle according to claim 4, is characterized in that: premix granule mixes with Chinese crude drug dry extract by step 4), then adds the mixing of other adjuvants, carries out wet granulation or one-step palletizing.
7. the preparation method of the capsule of a kind of Chinese medicine solid particle according to claim 6, it is characterized in that: the step of described wet granulation is as follows: in mixer-granulator, add binding agent carry out wet granular processed, paddle rotating speed 70 ~ 150 revs/min, fly cutter rotating speed 200 ~ 800 revs/min, runs 10 ~ 30 minutes, wet granular is placed in boiling drier, inlet temperature 45 ~ 85 DEG C, dry 5 ~ 30 minutes, obtain granule, control pellet moisture 4.0% ~ 9.0%; The step of described one-step palletizing is as follows: control temperature of charge at 50 ± 5 DEG C, dry, moisture Control is 4.0% ~ 9.0%.
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| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
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| CN101596303A (en) * | 2009-07-09 | 2009-12-09 | 浙江佐力药业股份有限公司 | Pharmaceutical composition of treatment prostatitis, prostatic hyperplasia and preparation method thereof and preparation |
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| Title |
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| 含挥发油类中药材低温吸附干燥新技术;徐娓等;《中成药》;20051031;第27卷(第10期);全文 * |
| 莪术挥发油的提取及包合工艺研究;杨敏等;《时珍国医国药》;20081231;第19卷(第6期);全文 * |
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