CN107375390A - A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood - Google Patents

A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood Download PDF

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Publication number
CN107375390A
CN107375390A CN201710739563.6A CN201710739563A CN107375390A CN 107375390 A CN107375390 A CN 107375390A CN 201710739563 A CN201710739563 A CN 201710739563A CN 107375390 A CN107375390 A CN 107375390A
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CN
China
Prior art keywords
oriental wormwood
squeezing
vacuum drying
fresh
drying powder
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Pending
Application number
CN201710739563.6A
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Chinese (zh)
Inventor
徐自升
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Individual
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Individual
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Priority to CN201710739563.6A priority Critical patent/CN107375390A/en
Publication of CN107375390A publication Critical patent/CN107375390A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood.The technique is cleaned, eluted after the harvesting of oriental wormwood medicinal material, and takes advantage of fresh squeezing, leaching concoction.The dregs of a decoction add water stirring, filtering squeezing.Gained concoction is concentrated under reduced pressure after merging, and is dried in vacuo, is vacuum-packed after crushing.Virgate Wormwood Herb medicine materical crude slice prepared by this method, remains the polarity in medicinal material and nonpolar active ingredient to greatest extent.Medicine materical crude slice is beneficial to accumulating, and convenient to adjust, quality controllable, curative effect is reliable, to ensureing that tcm clinical curative effect has great importance.The promotion and implementation of this law, will there are significant social effect and economic benefit.

Description

A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood
Technical field
The invention belongs to Chinese medicine manufacture field, more particularly to the processing technology of Chinese medicine capillaris tablet.
Background technology
Chinese medicine oriental wormwood is feverfew Artemisia capillarisArtemisia capillarisThunb. seedling.All herbal medicine, can Flu-prevention, control heatstroke, flu, headache body weight, stomachache, vomiting, fullness in chest, vapour lock food stagnation, infantile indigestion with food retention abdominal distension, diarrhoea, Under menorrhalgia, uterine bleeding band, the disease such as skin itching and oedema.Function is delivered in its radiating, is better than peppermint especially.
The processing mode of conventional capillaris tablet is:After harvesting, impurity is removed, is dried, directly packing storage and transport.This Dry oriental wormwood Hygienic Index can not be up to standard a bit, and medicinal material easily occurs and goes mouldy, so as to cause the decline of medical material quanlity and clinic The reduction of curative effect.Such prepared herbal medicine in small pieces ready for decoction, it is bulky, easily occur it is rotten and contaminated, quality it is difficult to ensure that, be unfavorable for adjustment and match somebody with somebody Just and ensure its clinical efficacy.
At present, in the market also has the manufactured granule pieces sale after extraction of oriental wormwood medicinal material.The preparation of granule pieces Journey, extraction not only time consumption and energy consumption, and do solvent because commonly using substantial amounts of water, the nonpolar active ingredient in medicinal material is difficult to be extracted Out.Further, since the oriental wormwood medicinal material of extraction is also to dry and by storage for a long time, therefore, the loss of active ingredient It is and very big.In order to ensure the clinic of oriental wormwood medicinal material is effective, steady quality, a kind of new capillaris tablet and its preparation technology Urgently develop.
The content of the invention
The invention discloses " a kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood ".This technique can be maximum The polarity and the nonpolar active ingredient that retain in oriental wormwood medicinal material of limit, avoid medicinal material from being processed and storage and transport process in existing medicine materical crude slice In the loss of caused active ingredient and the decline of medical material quanlity, reduce medicinal material by mould etc. pollution, to ensuring capillaris tablet Steady quality and clinical safety effectively have great importance.
To achieve these goals, the technical scheme is that:
Its herb is gathered in oriental wormwood picking time, is cleaned, after washing, takes advantage of fresh squeezing.In the dregs of a decoction after squeezing, 1 ~ 5 times of amount of addition Water, 5 ~ 30min is stirred, juice is taken with plate and frame filter press press filtration.The remaining dregs of a decoction press extracting juice again.Merge concoction three times, with 40 ~ 120 Mesh screen, obtain oriental wormwood concoction.By obtained oriental wormwood concoction be concentrated under reduced pressure under the conditions of 40 ~ 75 DEG C relative density for 1.05 ~ 1.30 medicinal extract, and 60 ~ 120 mesh sieves are crushed after it is dried in vacuo 4 ~ 8 hours in 40 ~ 70 DEG C, it is vacuum-packed, produces oriental wormwood It is fresh to squeeze vacuum drying powder decoction pieces.
On the label of product packaging bags, the name of an article in printing, medicinal part, planting site, medicine materical crude slice manufacturer, the date of manufacture, The information such as Contents of Main Components, meridian distribution of property and flavor, major function, usage and dosage, toxic side effect and contraindication.Oriental wormwood is enclosed in bag Thin layer differentiates collection of illustrative plates and/or efficient liquid phase characteristic spectrum, " identity card " as product.In addition, in the packaging bag of product, print There is Quick Response Code, former plant photo, medicinal material photo, medicine materical crude slice photo, character and the micro- mirror for obtaining product can be linked by scanning The information such as other feature.
The present invention is advantageous in that:
The oriental wormwood medicinal material of fresh collection, clean and directly squeezed after washing, filter, be concentrated under reduced pressure, being dried in vacuo, resulting powder Medicine materical crude slice, the active ingredient in medicinal material can be retained to greatest extent.This medicine materical crude slice volume compared to traditional medicine materical crude slice volume greatly Reduce, vacuum packaging so that prepared slice quality is more stable, is adjusted beneficial to accumulating and clinic, has very significant social effect And economic implications.
Embodiment
Embodiment 1
By the oriental wormwood medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 3 times The drinking water of amount, stir 20min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3 Secondary concoction merges, with 100 mesh sieve net filtrations.Filtrate decompression concentrates, and temperature is set as 65 DEG C.In medicinal extract relative density obtained by concentration For 1.15 when, be transferred in vacuum drying chamber, in 60 DEG C dry 8 hours, low-temperature grinding, moisture be not higher than 12%.
Embodiment 2
By the oriental wormwood medicinal material of fresh collection, clean, silt is washed with water, take advantage of using fresh herb squeezer pressure extracting juice.The gained dregs of a decoction add 5 times The drinking water of amount, stir 30min, plate and frame filter press pressure extracting juice.The remaining dregs of a decoction press extracting juice with squeezer again.By above-mentioned 3 Secondary concoction merges, with 80 mesh sieve net filtrations.Filtrate decompression concentrates, and temperature is set as 70 DEG C.In medicinal extract relative density obtained by concentration For 1.10 when, be transferred in vacuum drying chamber, in 65 DEG C dry 6 hours, low-temperature grinding, moisture be not higher than 12%.
Above example, only illustrate the technological thought of this invention, it is impossible to it is all whereby to limit protection scope of the present invention It is any change for being done on the basis of technical scheme according to technological thought proposed by the present invention, each falls within what the present invention protected Within the scope of.

Claims (2)

  1. A kind of 1. fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood, it is characterised in that:It is complete that its is gathered in oriental wormwood picking time Grass, clean, after washing, take advantage of fresh squeezing, the dregs of a decoction add the water of 1 ~ 5 times of amount, stir 5 ~ 30min, and plate and frame filter press press filtration takes juice, institute The surplus dregs of a decoction press extracting juice again, merge concoction three times, 40 ~ 120 mesh screens, obtain oriental wormwood concoction.
  2. A kind of 2. fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood according to claim 1, it is characterised in that:Will Obtained oriental wormwood concoction is concentrated under reduced pressure into the medicinal extract that relative density is 1.05 ~ 1.30 under the conditions of 40 ~ 75 DEG C, and by its in 40 ~ 70 DEG C vacuum drying 4 ~ 8 hours after crushed 60 ~ 120 mesh sieves, be vacuum-packed, produce oriental wormwood it is fresh squeeze vacuum drying powder decoction pieces.
CN201710739563.6A 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood Pending CN107375390A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710739563.6A CN107375390A (en) 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710739563.6A CN107375390A (en) 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood

Publications (1)

Publication Number Publication Date
CN107375390A true CN107375390A (en) 2017-11-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710739563.6A Pending CN107375390A (en) 2017-08-25 2017-08-25 A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of oriental wormwood

Country Status (1)

Country Link
CN (1) CN107375390A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596396A (en) * 2016-02-11 2016-05-25 徐自升 Freshly squeezed artemisia apiacea vacuum-dried powder decoction pieces and preparation technology thereof
CN105596417A (en) * 2016-02-11 2016-05-25 徐自升 Freshly squeezed herba periliae vacuum-dried powder decoction pieces and preparation technology thereof
CN105998133A (en) * 2016-07-23 2016-10-12 徐漫 Chinese lobelia freshly-squeezed vacuum drying powder decoction tablets and preparation process thereof
CN106109532A (en) * 2016-07-23 2016-11-16 徐自升 A kind of Flos Lonicerae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105596396A (en) * 2016-02-11 2016-05-25 徐自升 Freshly squeezed artemisia apiacea vacuum-dried powder decoction pieces and preparation technology thereof
CN105596417A (en) * 2016-02-11 2016-05-25 徐自升 Freshly squeezed herba periliae vacuum-dried powder decoction pieces and preparation technology thereof
CN105998133A (en) * 2016-07-23 2016-10-12 徐漫 Chinese lobelia freshly-squeezed vacuum drying powder decoction tablets and preparation process thereof
CN106109532A (en) * 2016-07-23 2016-11-16 徐自升 A kind of Flos Lonicerae is fresh squeezes vacuum drying powder decoction pieces and preparation technology thereof

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Application publication date: 20171124