CN107375047A - Resveratrol cyclodextrin inclusion compound gel and its preparation method and application - Google Patents
Resveratrol cyclodextrin inclusion compound gel and its preparation method and application Download PDFInfo
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- CN107375047A CN107375047A CN201710532770.4A CN201710532770A CN107375047A CN 107375047 A CN107375047 A CN 107375047A CN 201710532770 A CN201710532770 A CN 201710532770A CN 107375047 A CN107375047 A CN 107375047A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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Abstract
The present invention relates to resveratrol cyclodextrin inclusion compound gel and its preparation method and application, the gel includes the raw material of following parts by weight：40 parts~60 parts of 0.3 part~4 parts of resveratrol, 3 parts~40 parts of cyclodextrin, 1 part~5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part~5 parts of bulk kelp extract powder, 1 part~5 parts of Sodium Hyaluronate and water；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%~1.2%.The resveratrol cyclodextrin inclusion compound gel of the present invention, resveratrol contain in cyclodextrin, add its uniformity in gel, improve the skin sense of the gel-type cosmetics containing resveratrol.The resveratrol cyclodextrin inclusion compound gel of the present invention has good anti-oxidation efficacy, facial oxygen radical can effectively be removed and promote cell metabolism, have and unfold wrinkle, the effect of desalinating microgroove, promote the effect of impaired skin reparation, while there is the efficiency that can strengthen moisturizing.
Description
Technical field
The present invention relates to beauty and skin care technical field, and in particular to a kind of resveratrol-cyclodextrin inclusion compound gel and its
Preparation method and application.
Background technology
Resveratrol is polyphenol compound, is mainly derived from the plants such as peanut, grape, giant knotweed, mulberry fruit.Resveratrol is
A kind of biological very strong natural polyphenol class material, also known as resvertrol, it is the chemopreventive agent of tumour, and it is small to reducing blood
Plate is assembled, prevention and treatment atherosclerosis, the chemopreventive agent of cardiovascular and cerebrovascular disease.Resveratrol is present in plant
Natural, it plays oxidation resistant mechanism of action and mainly removes or suppress free radical generation, suppresses lipid peroxy
Change, adjust anti-oxidant related enzyme activity etc., therefore, the beauty skin care products such as facial mask can be prepared with resveratrol, but it is not
Characteristic soluble in water determines the limitation for directly applying to gel-type facial mask, eye mask, if being directly mixed into gel-type with powdery
Facial mask, eye mask can make it that finished product is dry and astringent.
The content of the invention
It is an object of the present invention to propose a kind of resveratrol-cyclodextrin inclusion compound gel.
Resveratrol-cyclodextrin inclusion compound gel of the present invention, include the raw material of following parts by weight：Resveratrol 0.3
Part~4 parts, 3 parts~40 parts of cyclodextrin, 1 part~5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part~5 parts of bulk kelp extract powder, transparent
40 parts~60 parts of 1 part~6 parts of matter acid sodium and water；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%
~1.2%.
Resveratrol-cyclodextrin inclusion compound gel of the present invention, resveratrol are contained in cyclodextrin, add it solidifying
Uniformity in glue, improve the skin sense of the gel-type cosmetics containing resveratrol.Resveratrol-cyclodextrin of the present invention
Inclusion compound gel has good anti-oxidation efficacy, can effectively remove facial oxygen radical and promote cell metabolism,
With wrinkle is unfolded, the effect of desalinating microgroove, promote the effect of impaired skin reparation, while there is the efficiency that can strengthen moisturizing.
In addition, resveratrol according to the above embodiment of the present invention-cyclodextrin inclusion compound gel, can also have following attached
The technical characteristic added：
As the preferred embodiment of the present invention, described resveratrol-cyclodextrin inclusion compound gel, in addition to following weight
Measure the raw material of number：1 part~3 parts of butanediol, 1 part~2 parts of glycine betaine, 1 part~2 parts of allantoin, the hydrogenated castor of polyethylene glycol -40
1 part~5 parts of oil, 1 part~5 parts of the rilanit special of polyethylene glycol -60,1 part~3 parts of titanium dioxide, 1 part~3 parts of zinc oxide, chlorination
1 part~2 parts of calcium and 2 parts~4 parts of essence, 1 part~3 parts of flat Enteromorpha extract, 1 part~3 parts of Juniperus formosana algae extract.
As the preferred embodiment of the present invention, described resveratrol-cyclodextrin inclusion compound gel, including following weight
The raw material of number：It is 0.3 part of resveratrol, 3 parts of cyclodextrin, 5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 5 parts of bulk kelp extract powder, transparent
6 parts of matter acid sodium, 40 parts of water, 3 parts of butanediol, 2 parts of glycine betaine, 2 parts of allantoin, 5 parts of the rilanit special of polyethylene glycol -40, poly- second
4 parts of 5 parts of the rilanit special of glycol -60,3 parts of titanium dioxide, 3 parts of zinc oxide, 2 parts of calcium chloride and essence, flat Enteromorpha extract 3
Part, 3 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%.
As the preferred embodiment of the present invention, described resveratrol-cyclodextrin inclusion compound gel, including following weight
The raw material of number：It is 4 parts of resveratrol, 40 parts of cyclodextrin, 1 part of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part of bulk kelp extract powder, transparent
1 part of matter acid sodium, 60 parts of water, 1 part of butanediol, 1 part of glycine betaine, 1 part of allantoin, 1 part of the rilanit special of polyethylene glycol -40, poly- second
2 parts of 1 part of the rilanit special of glycol -60,1 part of titanium dioxide, 1 part of zinc oxide, 1 part of calcium chloride and essence, flat Enteromorpha extract 1
Part, 1 part of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 1.2%.
As the preferred embodiment of the present invention, described resveratrol-cyclodextrin inclusion compound gel, including following weight
The raw material of number：It is 2 parts of resveratrol, 21 parts of cyclodextrin, 3 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 3 parts of bulk kelp extract powder, transparent
3.5 parts of matter acid sodium, 50 parts of water, 2 parts of butanediol, 1.5 parts of glycine betaine, allantoin 1.5,35 parts of the rilanit special of polyethylene glycol -40,
3 parts of the rilanit special of polyethylene glycol -60,2 parts of titanium dioxide, 2 parts of zinc oxide, 1.5 parts of calcium chloride and 3 parts of essence, flat Enteromorpha carry
Take 2 parts of thing, 2 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.65%.
Further, the cyclodextrin be at least hydroxypropyl-β-cyclodextrin, piroxicam-beta-schardinger dextrin, sulphur butyl-β-
One kind in cyclodextrin and methyl-B-cyclodextrin.
It is another object of the present invention to the preparation method for proposing described resveratrol-cyclodextrin inclusion compound gel.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
S101：The Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 10 parts~20 parts water first
And stir, then be heated to 85 DEG C~95 DEG C and be incubated 40min~50min, it is then cooled to 68 DEG C~75 DEG C；
S102：The cyclodextrin is dissolved in and in the water of the cyclodextrin equivalent weight number and stirred, Ran Houjia
Enter the resveratrol, obtain the solution containing resveratrol-cyclodextrin inclusion compound, be then heated to 50 DEG C~68 DEG C；
S103：Surplus stock component is added in the remaining water and stirred；
S104：The obtained solution of the step S103 is added in the solution that the step S101 is obtained, stirs 25min
~35min, its temperature is then adjusted to 50 DEG C~68 DEG C, it is uniform to add the solution ＆ stir that the step S102 is obtained, then
Resveratrol-cyclodextrin inclusion compound gel is obtained after being cooled to room temperature
Another object of the present invention is to propose that described resveratrol-cyclodextrin inclusion compound gel is led in beauty and skin care
Application in domain.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Embodiments of the invention are described below in detail, the embodiment is exemplary, it is intended to for explaining the present invention, and
It is not considered as limiting the invention.
Embodiment 1
Embodiment 1 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
4 parts of veratryl alcohol, 40 parts of hydroxypropyl-β-cyclodextrin, 1 part of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part of bulk kelp extract powder, hyaluronic acid
1 part of sodium, 60 parts of water, 1 part of butanediol, 1 part of glycine betaine, 1 part of allantoin, 1 part of the rilanit special of polyethylene glycol -40, polyethylene glycol -
2 parts of 60 1 part of rilanit specials, 1 part of titanium dioxide, 1 part of zinc oxide, 1 part of calcium chloride and essence, 1 part of flat Enteromorpha extract, Juniperus formosana
1 part of algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 1.2%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 10 parts of water first and is stirred,
95 DEG C are heated to again and is incubated 50min, are then cooled to 75 DEG C.
(2) hydroxypropyl-β-cyclodextrin is added in 40 parts of the water and stirred, then add the white black false hellebore
Alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 68 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 25min, so
After adjust its temperature to 68 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
Embodiment 2
Embodiment 2 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
0.3 part of veratryl alcohol, 3 parts of piroxicam-beta-schardinger dextrin, 5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 5 parts of bulk kelp extract powder, hyalomitome
Sour 6 parts of sodium, 40 parts of water, 3 parts of butanediol, 2 parts of glycine betaine, 2 parts of allantoin, 5 parts of the rilanit special of polyethylene glycol -40, poly- second two
4 parts of 5 parts of the rilanit special of alcohol -60,3 parts of titanium dioxide, 3 parts of zinc oxide, 2 parts of calcium chloride and essence, 3 parts of flat Enteromorpha extract,
3 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 20 parts of water first and is stirred,
85 DEG C are heated to again and is incubated 50min, are then cooled to 68 DEG C.
(2) piroxicam-beta-schardinger dextrin is added in 3 parts of the water and stirred, then add the white lamb's-quarters
Reed alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 50 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 25min, so
After adjust its temperature to 50 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
Embodiment 3
Embodiment 3 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
2 parts of veratryl alcohol, 21 parts of Sulfobutyl ether β _ cyclodextrin, 3 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 3 parts of bulk kelp extract powder, hyaluronic acid
3.5 parts of sodium, 50 parts of water, 2 parts of butanediol, 1.5 parts of glycine betaine, allantoin 1.5,35 parts of the rilanit special of polyethylene glycol -40, poly- second
3 parts of 3 parts of the rilanit special of glycol -60,2 parts of titanium dioxide, 2 parts of zinc oxide, 1.5 parts of calcium chloride and essence, flat Enteromorpha extract 2
Part, 2 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.65%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 15 parts of water first and is stirred,
90 DEG C are heated to again and is incubated 45min, are then cooled to 72 DEG C.
(2) Sulfobutyl ether β _ cyclodextrin is added in 21 parts of the water and stirred, then add the white black false hellebore
Alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 59 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 30min, so
After adjust its temperature to 59 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
The methyl-B-cyclodextrin of embodiment 4
Embodiment 4 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
4 parts of veratryl alcohol, 40 parts of methyl-B-cyclodextrin, 1 part of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part of bulk kelp extract powder, Sodium Hyaluronate 1
Part, 60 parts of water, 1 part of butanediol, 1 part of glycine betaine, 1 part of allantoin, 1 part of the rilanit special of polyethylene glycol -40, polyethylene glycol -60
2 parts of 1 part of rilanit special, 1 part of titanium dioxide, 1 part of zinc oxide, 1 part of calcium chloride and essence, 1 part of flat Enteromorpha extract, Codiumfragile(sur.) Hariot.
1 part of extract；Wherein, the mass percent that the resveratrol accounts for the gel is 1.2%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 10 parts of water first and is stirred,
95 DEG C are heated to again and is incubated 40min, are then cooled to 75 DEG C.
(2) methyl-B-cyclodextrin is added in 40 parts of the water and stirred, then add the white black false hellebore
Alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 50 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 25min, so
After adjust its temperature to 50 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
Embodiment 5
Embodiment 5 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
0.3 part of veratryl alcohol, 3 parts of hydroxypropyl-β-cyclodextrin, 5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 5 parts of bulk kelp extract powder, hyaluronic acid
6 parts of sodium, 40 parts of water, 3 parts of butanediol, 2 parts of glycine betaine, 2 parts of allantoin, 5 parts of the rilanit special of polyethylene glycol -40, polyethylene glycol -
4 parts of 60 5 parts of rilanit specials, 3 parts of titanium dioxide, 3 parts of zinc oxide, 2 parts of calcium chloride and essence, 3 parts of flat Enteromorpha extract, Juniperus formosana
3 parts of algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 20 parts of water first and is stirred,
85 DEG C are heated to again and is incubated 50min, are then cooled to 68 DEG C.
(2) hydroxypropyl-β-cyclodextrin is added in 3 parts of the water and stirred, then add the white black false hellebore
Alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 50 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 25min, so
After adjust its temperature to 50 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
Embodiment 6
Embodiment 6 proposes a kind of resveratrol-cyclodextrin inclusion compound gel, includes the raw material of following parts by weight：In vain
2 parts of veratryl alcohol, 21 parts of piroxicam-beta-schardinger dextrin, 3 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 3 parts of bulk kelp extract powder, hyalomitome
It is sour 3.5 parts of sodium, 50 parts of water, 2 parts of butanediol, 1.5 parts of glycine betaine, allantoin 1.5,35 parts of the rilanit special of polyethylene glycol -40, poly-
3 parts of 3 parts of the rilanit special of ethylene glycol -60,2 parts of titanium dioxide, 2 parts of zinc oxide, 1.5 parts of calcium chloride and essence, the extraction of flat Enteromorpha
2 parts of thing, 2 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.65%.
The preparation method of described resveratrol-cyclodextrin inclusion compound gel, comprises the following steps：
(1) the Zou Bo Irish moss OK a karaoke club rubber powder and bulk kelp extract powder are added in 15 parts of water first and is stirred,
90 DEG C are heated to again and is incubated 45min, are then cooled to 72 DEG C.
(2) piroxicam-beta-schardinger dextrin is added in 21 parts of the water and stirred, then add the white lamb's-quarters
Reed alcohol, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 59 DEG C.
(3) surplus stock component is added in the remaining water and stirred.
(4) solution that the step (3) obtains is added in the solution that the step (1) obtains, stirs 30min, so
After adjust its temperature to 59 DEG C, it is uniform to add the solution ＆ stir that the step (2) obtains, then is cooled to after room temperature
To resveratrol-cyclodextrin inclusion compound gel.
Resveratrol-cyclodextrin inclusion compound gel of the present invention, resveratrol are contained in cyclodextrin, add it solidifying
Uniformity in glue, improve the skin sense of the gel-type cosmetics containing resveratrol.Resveratrol-cyclodextrin of the present invention
Inclusion compound gel has good anti-oxidation efficacy, can effectively remove facial oxygen radical and promote cell metabolism,
With wrinkle is unfolded, the effect of desalinating microgroove, promote the effect of impaired skin reparation.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, specific features, structure, material or the feature of description can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the different embodiments or example and the feature of different embodiments or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (8)
1. a kind of resveratrol-cyclodextrin inclusion compound gel, it is characterised in that include the raw material of following parts by weight：White black false hellebore
0.3 part~4 parts of alcohol, 3 parts~40 parts of cyclodextrin, 1 part~5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part~5 parts of bulk kelp extract powder,
40 parts~60 parts of 1 part~6 parts of Sodium Hyaluronate and water；Wherein, the mass percent that the resveratrol accounts for the gel is
0.09%~1.2%.
2. resveratrol according to claim 1-cyclodextrin inclusion compound gel, it is characterised in that also including following weight
The raw material of number：1 part~3 parts of butanediol, 1 part~2 parts of glycine betaine, 1 part~2 parts of allantoin, the rilanit special of polyethylene glycol -40
1 part~5 parts, 1 part~5 parts of the rilanit special of polyethylene glycol -60,1 part~3 parts of titanium dioxide, 1 part~3 parts of zinc oxide, calcium chloride
1 part~2 parts and 2 parts~4 parts of essence, 1 part~3 parts of flat Enteromorpha extract, 1 part~3 parts of Juniperus formosana algae extract.
3. resveratrol according to claim 1 or 2-cyclodextrin inclusion compound gel, it is characterised in that including following weight
The raw material of number：It is 0.3 part of resveratrol, 3 parts of cyclodextrin, 5 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 5 parts of bulk kelp extract powder, transparent
6 parts of matter acid sodium, 40 parts of water, 3 parts of butanediol, 2 parts of glycine betaine, 2 parts of allantoin, 5 parts of the rilanit special of polyethylene glycol -40, poly- second
4 parts of 5 parts of the rilanit special of glycol -60,3 parts of titanium dioxide, 3 parts of zinc oxide, 2 parts of calcium chloride and essence, flat Enteromorpha extract 3
Part, 3 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.09%.
4. resveratrol according to claim 1 or 2-cyclodextrin inclusion compound gel, it is characterised in that including following weight
The raw material of number：It is 4 parts of resveratrol, 40 parts of cyclodextrin, 1 part of Zou Bo Irish moss OK a karaoke clubs rubber powder, 1 part of bulk kelp extract powder, transparent
1 part of matter acid sodium, 60 parts of water, 1 part of butanediol, 1 part of glycine betaine, 1 part of allantoin, 1 part of the rilanit special of polyethylene glycol -40, poly- second
2 parts of 1 part of the rilanit special of glycol -60,1 part of titanium dioxide, 1 part of zinc oxide, 1 part of calcium chloride and essence, flat Enteromorpha extract 1
Part, 1 part of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 1.2%.
5. resveratrol according to claim 1 or 2-cyclodextrin inclusion compound gel, it is characterised in that including following weight
The raw material of number：It is 2 parts of resveratrol, 21 parts of cyclodextrin, 3 parts of Zou Bo Irish moss OK a karaoke clubs rubber powder, 3 parts of bulk kelp extract powder, transparent
3.5 parts of matter acid sodium, 50 parts of water, 2 parts of butanediol, 1.5 parts of glycine betaine, allantoin 1.5,35 parts of the rilanit special of polyethylene glycol -40,
3 parts of the rilanit special of polyethylene glycol -60,2 parts of titanium dioxide, 2 parts of zinc oxide, 1.5 parts of calcium chloride and 3 parts of essence, flat Enteromorpha carry
Take 2 parts of thing, 2 parts of Juniperus formosana algae extract；Wherein, the mass percent that the resveratrol accounts for the gel is 0.65%.
6. resveratrol according to claim 1 or 2-cyclodextrin inclusion compound gel, it is characterised in that the cyclodextrin is extremely
It is one kind in hydroxypropyl-β-cyclodextrin, piroxicam-beta-schardinger dextrin, Sulfobutyl ether β _ cyclodextrin and methyl-B-cyclodextrin less.
7. the preparation method of resveratrol-cyclodextrin inclusion compound gel described in any one of claim 1~6, it is characterised in that
Comprise the following steps：
S101：The Zou Bo Irish moss OK a karaoke club rubber powder and the bulk kelp extract powder are added in 10 parts~20 parts water first
And stir, then be heated to 85 DEG C~95 DEG C and be incubated 40min~50min, it is then cooled to 68 DEG C~75 DEG C；
S102：The cyclodextrin is dissolved in and in the water of the cyclodextrin equivalent weight number and stirred, then adds institute
Resveratrol is stated, obtains the solution containing resveratrol-cyclodextrin inclusion compound, is then heated to 50 DEG C~68 DEG C；
S103：Surplus stock component is added in the remaining water and stirred；
S104：The obtained solution of the step S103 is added in the solution that the step S101 is obtained, stirring 25min~
35min, its temperature is then adjusted to 50 DEG C~68 DEG C, it is uniform to add the solution ＆ stir that the step S102 is obtained, then will
It obtains resveratrol-cyclodextrin inclusion compound gel after being cooled to room temperature.
8. the answering in beauty and skin care field of resveratrol-cyclodextrin inclusion compound gel described in any one of claim 1~6
With.
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| CN111888325A (en) * | 2020-08-04 | 2020-11-06 | 瑞希(重庆)生物科技有限公司 | Carrageenan gel, pharmaceutical excipient and skin external preparation |
| EP3735960A1 (en) * | 2019-05-06 | 2020-11-11 | BHI Beauty & Health Investment Group Management GmbH | Cosmetic preparation comprising resveratrol |
| CN112203631A (en) * | 2018-05-25 | 2021-01-08 | 株式会社资生堂 | Deodorants and deactivators |
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Application publication date: 20171124 |