CN107334671A - A kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E - Google Patents
A kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E Download PDFInfo
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- CN107334671A CN107334671A CN201710520367.XA CN201710520367A CN107334671A CN 107334671 A CN107334671 A CN 107334671A CN 201710520367 A CN201710520367 A CN 201710520367A CN 107334671 A CN107334671 A CN 107334671A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E.Skin-moisturizing, skin water of the present invention is included as follows according to the component of mass percentage：Concentration is 1wt% pittosporum tobira flower essential oil 0.2%, and propane diols 2%, glycerine 2%, sodium hyaluronate 0.1%, sodium hydroxy methyl glycinate 0.5%, concentration is 0.1wt% Honegsukle flower P.E 1.5%, lactic acid 0.25% and water 93.45%.Skin-moisturizing, skin water of the present invention has desalination skin lines, pre- anti-aging, improves telangiectasis, alleviates red swelling of the skin by adding pittosporum tobira flower essential oil and Honegsukle flower P.E, available for improve and prevent skin aging and repair shine after skin and allergic skin.Skin-moisturizing, skin water of the present invention is without compositions such as heavy metal, alcohol, hormone, mineral oil, pigments, and formula is soft, and skin, which will not be produced, stimulates and bear.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of moisturizing profit containing pittosporum tobira flower essential oil and Honegsukle flower P.E
Skin water.
Background technology
Lotion is a kind of low viscosity, the extremely runny liquid skin care cosmetics as water, by it after facial cleansing
Add on skin, moisturizing, moisturizing, skin care, a kind of beauty and skin care of the effect of promotion skin physiology function can be played
Product.
Essential oil, person " liquid golden ", due to its distinctive natural characteristic and efficacy effect, in cosmetics field,
Obtain the favor of numerous consumers.Bioactive ingredients in pittosporum tobira flower essential oil can be releived with rapid osmotic hair follicle disinfecting, antimicrobial
Sensitive skin, and with suppression anti-aging effect of free radical；Honeysuckle contains OPC, double hydrogen ketone, polyphenol, string
The various active factors such as element, polypeptide and short chain fatty acids.At present there has been no by pittosporum tobira flower essential oil and honeysuckle combination lotion,
Such market is urgently developed.
The content of the invention
It is an object of the invention to the heavy metal of the lotion generally existing according to current market, hormone, alcohol, pigment etc.
Addition and caused by skin easy allergy the problems such as, and there has been no by the lotion of pittosporum tobira flower essential oil and honeysuckle combination, there is provided
A kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E, the moisturizing water constituent are pure natural raw material, without weight
Metal, alcohol, hormone, pigment, mineral oil etc., formula is soft, non-stimulated to skin.
Above-mentioned purpose of the present invention is achieved by the following technical programs：
A kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E, it is included as follows according to mass percent
The component of meter：Concentration is 1wt% pittosporum tobira flower essential oil 0.2%, and propane diols 2%, glycerine 2%, sodium hyaluronate 0.1%, methylol is sweet
Propylhomoserin sodium 0.5%, concentration are 0.1wt% Honegsukle flower P.E 1.5%, lactic acid 0.25% and water 93.45%；
Wherein, the preparation method of the pittosporum tobira flower essential oil comprises the following steps：
(1) take dry tobira 500g to crush, be transferred in the 5L fermentation tanks for having added 1500~2500g distilled water, add
0.5% beef extract, 1% peptone and 0.5% sodium chloride, and pH to 4.5~6.0 is adjusted with 1mol/L phosphate buffers, from
So ferment 36h, then high-temperature inactivation strain；
(2) step (1) products therefrom and 1.5~5.0g complex enzyme hydrolysis liquid are sufficiently mixed, 30 is digested at 42~60 DEG C
~50min；The complex enzyme hydrolysis liquid is cellulase, hemicellulase and pectase according to 3:1:1~5:1:2 mass ratio
The mixture of mixing, adds water to be configured to the complex enzyme hydrolysis liquid that mass percent is 0.3~0.9%, and pH is 4.5~6.0；
(3) step (2) products therefrom is isolated and purified using wiped-film still, obtains pittosporum tobira flower essential oil；
The preparation method of the Honegsukle flower P.E comprises the following steps：
(a) take new fresh honeysuckle 500g to crush, add 500~1500g distilled water, the complex enzyme hydrolysis liquid with 1.5~5.0g
It is sufficiently mixed, 30~50min is digested at 42~60 DEG C, centrifugation obtains digesting head product；The complex enzyme hydrolysis liquid is cellulose
Enzyme, hemicellulase and pectase are according to 3:1:1~5:1:The mixture of 2 mass ratio mixing, adds water to be configured to quality percentage
Than the complex enzyme hydrolysis liquid for 0.3~0.9%, pH is 4.5~6.0；
(b) product filtering will be digested obtained by step (a), filter residue is placed in water-bath and extracted, the volume ratio of filter residue and water
For 1：8~15, leaching liquor filter cleaner；It is repeated twice, merges leaching liquor；
(c) leaching liquor obtained by step (b) is subjected to constant flow filtering in sheet frame, then the rotary evaporation under 0.1MPa pressure
Concentration, is finally settled to 50g, obtains Honegsukle flower P.E.
The complex enzyme hydrolysis liquid that the present invention uses include cellulase (including endoglucanase, exoglucanase and β-
Glucan glycosides enzyme), hemicellulase and pectase, can be to the main component cellulose of tobira and honeysuckle, hemicellulose, fruit
The macromolecular substances such as glue are acted on, and realize its structural collapse, so that fragrance and functional component release are more complete, fragrance is more
Enriching is strongly fragrant.
The present invention is mainly entered using molecular distillation technique extraction pittosporum tobira flower essential oil, molecular distillation under conditions of high vacuum
The technology of row Liquid liquid Separation, its advantage are that the temperature of distillation is low, and the heated time of material is short and separation degree is high, particularly suitable for
Higher boiling, thermal sensitivity and readily oxidizable substance isolate and purify.Pittosporum tobira flower essential oil is heat-sensitive substance, using molecular distillation to its
Fragrance component retains preferably, while also can remove miscellaneous gas, makes the fragrance of pittosporum tobira flower essential oil purer, strong.
The preparation method of skin-moisturizing, skin water of the invention containing pittosporum tobira flower essential oil and Honegsukle flower P.E comprises the following steps：
(1) the pittosporum tobira flower essential oil that concentration is 1wt% and the Honegsukle flower P.E that concentration is 0.1wt% are weighed, is stirred,
Obtain the mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E；
(2) propane diols is weighed, adds the mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E obtained by step (1), stirring is extremely
Clear, obtain mixed material；
(3) other components are weighed, add mixed material obtained by step (2) after being dissolved with water while stirring, be again stirring for
Clear, obtain the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E.
Skin-moisturizing, skin water of the invention containing pittosporum tobira flower essential oil and Honegsukle flower P.E can use as daily lotion,
It is additionally operable to improve and prevents skin aging and repair skin and allergic skin after solarization.
Compared with prior art, the present invention has the advantages that：
(1) the skin-moisturizing, skin water of the invention containing pittosporum tobira flower essential oil and Honegsukle flower P.E is homogeneous, gently, to skin
Have no stimulation, rich in active components of plants, the raw material for being formulated selection is food grade materials and its extract, and product is pure natural
, without materials such as heavy metal, alcohol, hormone, mineral oil and pigments；
(2) present invention uses pittosporum tobira flower essential oil can be with rapid osmotic hair as one of raw material, bioactive ingredients therein
Capsule disinfecting, antimicrobial, sensitive skin of releiving, and with suppression anti-aging effect of free radical；
(3) present invention uses Honegsukle flower P.E honeysuckle contains the various active factor as one of raw material, these compositions
Can rapid osmotic skin, mutual induction between active cell, dredge facial microcirculation, promote the metabolism of skin；It can also reduce
Free radical, avoid skin from being damaged by free radical, skin is recovered original tight ness rating, unfold coarse groove, desalination so as to reach
The effect of microgroove；In addition, Honegsukle flower P.E also has immunosuppressive action, a variety of proinflammatory cytokines can be suppressed and reach suppression
Or the reaction that reduces inflammation.
Brief description of the drawings
Fig. 1 is that the lotion that different Honegsukle flower P.E additions are prepared contrasts to the inhibiting rate of hyaluronidase.
Fig. 2 is using the percutaneous water loss amount data of skin before and after lotion of the present invention.
Embodiment
The invention will be further described with reference to embodiments, but embodiment the present invention is not done it is any type of
Limit.
In following examples, unless otherwise instructed, used raw material is raw material on sale on the market, used side
Method is method well known to those skilled in the art.
Embodiment 1
Prepare the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E：
It is made up of the component as follows according to mass percentage：Concentration be 1wt% pittosporum tobira flower essential oil 0.2%, propane diols
2%, glycerine 2%, sodium hyaluronate 0.1%, sodium hydroxy methyl glycinate 0.5%, concentration is 0.1wt% Honegsukle flower P.E 1.5%,
Lactic acid 0.25% and water 93.45%.
Wherein, the preparation method of pittosporum tobira flower essential oil comprises the following steps：
(1) take dry tobira 500g to crush, be transferred in the 5L fermentation tanks for having added 2000g distilled water, add 0.5% N
Meat extract, 1% peptone and 0.5% sodium chloride, and pH to 5.0, spontaneous fermentation 36h are adjusted with 1mol/L phosphate buffers, so
High-temperature inactivation strain afterwards；
(2) step (1) products therefrom and 4.0g complex enzyme hydrolysis liquid are sufficiently mixed, 40min is digested at 50 DEG C；Complex enzyme
Solution liquid is cellulase, hemicellulase and pectase according to 3:1:The mixture of 1 mass ratio mixing, adds water to be configured to quality
Percentage be 0.6% complex enzyme hydrolysis liquid, pH 5.0；
(3) step (2) products therefrom is isolated and purified using wiped-film still, purification condition is：
Vapo(u)rizing temperature is 60~70 DEG C, and distillation pressure is 18~25Pa, and feed rate is 1.0~2.0ml/min, scrapes diaphragm plate rotating speed as 25
~40r/min, obtain pittosporum tobira flower essential oil；
The preparation method of Honegsukle flower P.E comprises the following steps：
(a) take new fresh honeysuckle 500g to crush, add 1000g distilled water, be sufficiently mixed with 3.0g complex enzyme hydrolysis liquid,
30min is digested at 50 DEG C, centrifugation obtains digesting head product；Complex enzyme hydrolysis liquid is that cellulase, hemicellulase and pectase are pressed
According to 5:1:The mixture of 2 mass ratio mixing, adds water to be configured to the complex enzyme hydrolysis liquid that mass percent is 0.6%, pH 4.5；
(b) product filtering will be digested obtained by step (a), filter residue is placed in water-bath and extracted, the volume ratio of filter residue and water
For 1:8~15, leaching liquor filter cleaner；It is repeated twice, merges leaching liquor；
(c) leaching liquor obtained by step (b) is subjected to constant flow filtering in sheet frame, then the rotary evaporation under 0.1MPa pressure
Concentration, is finally settled to 50g, obtains Honegsukle flower P.E.
Preparation process：
(1) the pittosporum tobira flower essential oil that concentration is 1wt% and the Honegsukle flower P.E that concentration is 0.1wt% are weighed, is stirred,
Obtain the mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E；
(2) propane diols is weighed, adds the mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E obtained by step (1), stirring is extremely
Clear, obtain mixed material；
(3) other components are weighed, add mixed material obtained by step (2) after being dissolved with water while stirring, be again stirring for
Clear, obtain the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E.
Experimental example 1
Hyaluronic acid (HA) is the composition that content is most in extracellular mechanism, proportion is maximum, has very strong water suction
Ability and adhesiveness, the secretion of controllable cell silver, therefore play important work in moisture of skin and elastic process is maintained
With.Hyaluronidase is the Specific lytic enzymes of hyaluronic acid, can be hydrolyzed the hyaluronic acid in skin, is inflammatory reaction
Effective enzyme, therefore hyaluronidase body outer suppressioning experiment is usually used in the evaluation index as material antiallergic activity.
Using dipotassium glycyrrhizinate as positive control, the Honegsukle flower P.E that the concentration of Different adding amount is 0.1wt% is distinguished
As the raw material of lotion, remaining component is constant, and only changing the addition of water makes total amount be 100%.The same embodiment of preparation process
1, its inhibition to hyaluronidase is determined, as a result such as Fig. 1.
As shown in Figure 1, when the Honegsukle flower P.E dosage that concentration is 0.1wt% reaches 1.5wt%, to hyaluronidase
Inhibiting rate reaches 85%, can play good inhibition, reduces the discomfort that inflammation is brought, and promotes Skin Cell new old generation
Thank.
Experimental example 2
Using normal human face as test object, using test skin of face before and after lotion made from embodiment 1 through water
Scattered vector contrast, such as Fig. 2.
As shown in Figure 2, it can obviously reduce the percutaneous moisture loss of skin using lotion made from the embodiment of the present invention 1
Amount, therefore lotion of the present invention has good moistening effect.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula carries out appropriate change and modification.Therefore, the invention is not limited in embodiment disclosed and described above, to this
Some modifications and changes of invention should also be as falling into the scope of the claims of the present invention.In addition, although this specification
In used some specific terms, but these terms are merely for convenience of description, do not form any restrictions to the present invention.
Claims (3)
1. a kind of skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E, it is characterised in that including as follows according to matter
Measure the component of percentage meter：Concentration be 1wt% pittosporum tobira flower essential oil 0.2%, propane diols 2%, glycerine 2%, sodium hyaluronate 0.1%,
Sodium hydroxy methyl glycinate 0.5%, concentration are 0.1wt% Honegsukle flower P.E 1.5%, lactic acid 0.25% and water 93.45%；
Wherein, the preparation method of the pittosporum tobira flower essential oil comprises the following steps：
(1) take dry tobira 500g to crush, be transferred in the 5L fermentation tanks for having added 1500~2500g distilled water, add 0.5%
Beef extract, 1% peptone and 0.5% sodium chloride, and adjust pH to 4.5~6.0, spontaneous fermentation with 1mol/L phosphate buffers
36h, then high-temperature inactivation strain；
(2) step (1) products therefrom and 1.5~5.0g complex enzyme hydrolysis liquid are sufficiently mixed, at 42~60 DEG C digest 30~
50min；The complex enzyme hydrolysis liquid is cellulase, hemicellulase and pectase according to 3:1:1~5:1:2 mass ratio mixing
Mixture, add water be configured to mass percent be 0.3~0.9% complex enzyme hydrolysis liquid, pH be 4.5~6.0；
(3) step (2) products therefrom is isolated and purified using wiped-film still, obtains pittosporum tobira flower essential oil；
The preparation method of the Honegsukle flower P.E comprises the following steps：
(a) take new fresh honeysuckle 500g to crush, add 500~1500g distilled water, it is abundant with 1.5~5.0g complex enzyme hydrolysis liquid
Mixing, digests 30~50min at 42~60 DEG C, and centrifugation obtains digesting head product；The complex enzyme hydrolysis liquid is cellulase, half
Cellulase and pectase are according to 3:1:1~5:1:The mixture of 2 mass ratio mixing, adds water to be configured to mass percent to be
0.3~0.9% complex enzyme hydrolysis liquid, pH are 4.5~6.0；
(b) product filtering will be digested obtained by step (a), filter residue is placed in water-bath and extracted, and the volume ratio of filter residue and water is 1:8
~15, leaching liquor filter cleaner；It is repeated twice, merges leaching liquor；
(c) leaching liquor obtained by step (b) is subjected to constant flow filtering in sheet frame, then rotary evaporation is dense under 0.1MPa pressure
Contracting, is finally settled to 50g, obtains Honegsukle flower P.E.
2. the preparation method of the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E described in claim 1, its feature
It is, comprises the following steps：
(1) the pittosporum tobira flower essential oil that concentration is 1wt% and the Honegsukle flower P.E that concentration is 0.1wt% are weighed, stirs, obtains
The mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E；
(2) propane diols is weighed, the mixture of pittosporum tobira flower essential oil and Honegsukle flower P.E obtained by step (1) is added, stirs to clarify
It is transparent, obtain mixed material；
(3) other components are weighed, step (2) gained mixed material is added after being dissolved with water while stirring, is again stirring for clarification
It is transparent, obtain the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E.
3. the skin-moisturizing, skin water containing pittosporum tobira flower essential oil and Honegsukle flower P.E described in claim 1 is in skin anti-aging and reparation
In application.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951776A (en) * | 2017-12-21 | 2018-04-24 | 湖南华莱生物科技有限公司 | A kind of long-acting skin-moisturizing, skin water of black tea and preparation method thereof |
| CN108553374A (en) * | 2018-06-26 | 2018-09-21 | 湖南御家化妆品制造有限公司 | Composition and application thereof in preparation of cosmetics with anti-inflammatory function |
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| CN108553374B (en) * | 2018-06-26 | 2021-06-04 | 湖南御家化妆品制造有限公司 | Composition and application thereof in preparation of cosmetics with anti-inflammatory function |
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Application publication date: 20171110 |