CN107250154A - 包含缺乏糖基化信号的经修饰的噬菌体g3p氨基酸序列的多肽 - Google Patents

包含缺乏糖基化信号的经修饰的噬菌体g3p氨基酸序列的多肽 Download PDF

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Publication number
CN107250154A
CN107250154A CN201580065696.9A CN201580065696A CN107250154A CN 107250154 A CN107250154 A CN 107250154A CN 201580065696 A CN201580065696 A CN 201580065696A CN 107250154 A CN107250154 A CN 107250154A
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China
Prior art keywords
seq
amino acid
polypeptide
amino acids
disease
Prior art date
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Pending
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CN201580065696.9A
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English (en)
Chinese (zh)
Inventor
R.克里什南
E.阿斯普
M.普罗希茨基
R.费希尔
F.J.卡尔
R.G.E.霍尔盖特
T.D.琼斯
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Clara Biosciences Ltd By Share Ltd
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Clara Biosciences Ltd By Share Ltd
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Publication of CN107250154A publication Critical patent/CN107250154A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1716—Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/14011—Details ssDNA Bacteriophages
    • C12N2795/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201580065696.9A 2014-12-03 2015-12-02 包含缺乏糖基化信号的经修饰的噬菌体g3p氨基酸序列的多肽 Pending CN107250154A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087052P 2014-12-03 2014-12-03
US62/087,052 2014-12-03
PCT/US2015/063476 WO2016090022A1 (en) 2014-12-03 2015-12-02 Polypeptides comprising a modified bacteriophage g3p amino acid sequence lacking a gylcosylation signal

Publications (1)

Publication Number Publication Date
CN107250154A true CN107250154A (zh) 2017-10-13

Family

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Family Applications (1)

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CN201580065696.9A Pending CN107250154A (zh) 2014-12-03 2015-12-02 包含缺乏糖基化信号的经修饰的噬菌体g3p氨基酸序列的多肽

Country Status (20)

Country Link
US (2) US10722551B2 (https=)
EP (1) EP3227313B1 (https=)
JP (2) JP6730988B2 (https=)
KR (1) KR20170085132A (https=)
CN (1) CN107250154A (https=)
AR (1) AR102890A1 (https=)
AU (1) AU2015358504A1 (https=)
BR (1) BR112017011530A2 (https=)
CA (1) CA2969128A1 (https=)
DK (1) DK3227313T3 (https=)
EA (1) EA201791212A1 (https=)
ES (1) ES2910017T3 (https=)
IL (1) IL252426A0 (https=)
MX (1) MX2017007059A (https=)
PH (1) PH12017501004A1 (https=)
PL (1) PL3227313T3 (https=)
PT (1) PT3227313T (https=)
SG (1) SG11201704427YA (https=)
TW (1) TW201632542A (https=)
WO (1) WO2016090022A1 (https=)

Cited By (1)

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CN112672755A (zh) * 2018-06-15 2021-04-16 普罗克拉拉生物科学股份有限公司 通用淀粉样蛋白相互作用基序(gaim)

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CA2857539C (en) 2011-11-29 2021-08-03 Neurophage Pharmaceuticals, Inc. Bacteriophage gene 3 protein compositions and use as amyloid binding agents
DK2906235T3 (en) 2012-10-02 2017-09-25 Proclara Biosciences Inc USE OF P3 OF BACTERIOPHAGIC FUSION PROTEINS AS AMYLOID BINDING AGENTS
AU2014274253B2 (en) 2013-05-28 2018-06-14 Proclara Biosciences, Inc. Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
BR112017011530A2 (pt) 2014-12-03 2018-03-13 Proclara Biosciences Inc polipeptídeos que compreendem uma sequência de aminoácidos g3p de bacteriófago modificada sem sinal de glicosilação
AU2023403257A1 (en) 2022-12-02 2025-06-12 Alzheon, Inc. Methods for treating neurodegenerative disorders with tramiprosate

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WO2014055515A1 (en) * 2012-10-02 2014-04-10 Neurophage Pharmaceuticals, Inc. Use of p3 of bacteriophage fusion proteins as amyloid binding agents
CN104093414A (zh) * 2011-11-29 2014-10-08 神经噬菌体制药股份有限公司 噬菌体的p3作为淀粉样蛋白结合剂的用途
CN105473153A (zh) * 2013-05-28 2016-04-06 神经噬菌体制药股份有限公司 包含具有减小的免疫原性的经修饰的噬菌体g3p氨基酸序列的多肽

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112672755A (zh) * 2018-06-15 2021-04-16 普罗克拉拉生物科学股份有限公司 通用淀粉样蛋白相互作用基序(gaim)

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WO2016090022A1 (en) 2016-06-09
PH12017501004A1 (en) 2017-12-18
ES2910017T3 (es) 2022-05-11
MX2017007059A (es) 2018-05-02
AU2015358504A8 (en) 2017-07-13
US11723951B2 (en) 2023-08-15
KR20170085132A (ko) 2017-07-21
JP2020073610A (ja) 2020-05-14
AU2015358504A1 (en) 2017-06-29
PL3227313T3 (pl) 2022-05-09
US10722551B2 (en) 2020-07-28
TW201632542A (zh) 2016-09-16
JP2017538407A (ja) 2017-12-28
WO2016090022A9 (en) 2016-08-25
IL252426A0 (en) 2017-07-31
US20210015895A1 (en) 2021-01-21
CA2969128A1 (en) 2016-06-09
JP6730988B2 (ja) 2020-07-29
SG11201704427YA (en) 2017-06-29
PT3227313T (pt) 2022-04-12
EP3227313A1 (en) 2017-10-11
BR112017011530A2 (pt) 2018-03-13
AR102890A1 (es) 2017-03-29
DK3227313T3 (da) 2022-04-19
WO2016090022A8 (en) 2017-06-22
EP3227313B1 (en) 2022-02-09
EA201791212A1 (ru) 2018-01-31
US20180207231A1 (en) 2018-07-26

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