CN107236025B - 与cd56分子特异性结合的多肽及其应用 - Google Patents

与cd56分子特异性结合的多肽及其应用 Download PDF

Info

Publication number
CN107236025B
CN107236025B CN201710206120.0A CN201710206120A CN107236025B CN 107236025 B CN107236025 B CN 107236025B CN 201710206120 A CN201710206120 A CN 201710206120A CN 107236025 B CN107236025 B CN 107236025B
Authority
CN
China
Prior art keywords
cell
polypeptide
polypeptides
tumour
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201710206120.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN107236025A (zh
Inventor
张雁
黄鸿兴
赵龙
汪华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGZHOU YIDAI PHARMACEUTICAL TECHNOLOGY Co Ltd
National Sun Yat Sen University
Original Assignee
GUANGZHOU YIDAI PHARMACEUTICAL TECHNOLOGY Co Ltd
National Sun Yat Sen University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUANGZHOU YIDAI PHARMACEUTICAL TECHNOLOGY Co Ltd, National Sun Yat Sen University filed Critical GUANGZHOU YIDAI PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority to CN201710206120.0A priority Critical patent/CN107236025B/zh
Priority to PCT/CN2017/099487 priority patent/WO2018176732A1/fr
Publication of CN107236025A publication Critical patent/CN107236025A/zh
Application granted granted Critical
Publication of CN107236025B publication Critical patent/CN107236025B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0619Neurons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0622Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201710206120.0A 2017-03-30 2017-03-30 与cd56分子特异性结合的多肽及其应用 Active CN107236025B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201710206120.0A CN107236025B (zh) 2017-03-30 2017-03-30 与cd56分子特异性结合的多肽及其应用
PCT/CN2017/099487 WO2018176732A1 (fr) 2017-03-30 2017-08-29 Polypeptide liant spécifiquement une molécule cd56 et son utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710206120.0A CN107236025B (zh) 2017-03-30 2017-03-30 与cd56分子特异性结合的多肽及其应用

Publications (2)

Publication Number Publication Date
CN107236025A CN107236025A (zh) 2017-10-10
CN107236025B true CN107236025B (zh) 2019-10-18

Family

ID=59983999

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710206120.0A Active CN107236025B (zh) 2017-03-30 2017-03-30 与cd56分子特异性结合的多肽及其应用

Country Status (2)

Country Link
CN (1) CN107236025B (fr)
WO (1) WO2018176732A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108912212B (zh) * 2018-06-28 2019-08-30 中山大学附属口腔医院 一种与cd105特异性结合的多肽及其应用
CN111840219A (zh) * 2020-08-13 2020-10-30 黄鸿兴 一种米诺地尔与西地那非联合的生发酊剂
CN112521479B (zh) * 2020-12-10 2022-04-15 中山大学附属口腔医院 一种与cd3特异性结合的多肽及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151578A1 (fr) * 2011-05-05 2012-11-08 Baylor Research Institute Récepteurs des transcrits de type immunoglobuline (ilt) en tant qu'antagonistes du cd8

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014052876A1 (fr) * 2012-09-28 2014-04-03 Immunogen Inc. Procédés pour augmenter l'efficacité d'une thérapie basée sur le cd56
CN105254717B (zh) * 2015-08-18 2018-08-24 中山大学 与cd34分子特异性结合的多肽及其应用
CN105254759A (zh) * 2015-10-26 2016-01-20 无锡傲锐东源生物科技有限公司 抗cd56蛋白单克隆抗体杂交瘤细胞及其产生的抗cd56单克隆抗体和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151578A1 (fr) * 2011-05-05 2012-11-08 Baylor Research Institute Récepteurs des transcrits de type immunoglobuline (ilt) en tant qu'antagonistes du cd8

Also Published As

Publication number Publication date
CN107236025A (zh) 2017-10-10
WO2018176732A1 (fr) 2018-10-04

Similar Documents

Publication Publication Date Title
CN106619515A (zh) 脂质体组合物及其用途
JP4806258B2 (ja) 脳移行活性を有するポリペプチド、およびその利用
CN107686520A (zh) 抗pd‑l1纳米抗体及其应用
CN107236025B (zh) 与cd56分子特异性结合的多肽及其应用
CN101942445B (zh) 核酸适体衍生物及其在制备药物载体中的应用
CN109789092A (zh) 抗原呈递细胞模拟支架及其制备和使用方法
CN105254717B (zh) 与cd34分子特异性结合的多肽及其应用
CN112386678B (zh) 多肽或其衍生物的应用
Zhang et al. Compatibility of neural stem cells with functionalized self-assembling peptide scaffold in vitro
CN102649818A (zh) 抗cd4蛋白的单克隆抗体及其活性片段及用途
CN108778328A (zh) 蛋白a结合多肽、抗epha2抗体及其使用方法
CN107109389A (zh) 具有修饰的轻链特异性的肉毒杆菌神经毒素及其生产方法
CN110312515A (zh) 新的抗血管生成细胞外囊泡
CN110072542A (zh) 在肿瘤的诊断和治疗中的fsh激素受体的配体
CN107353326A (zh) 结合pd‑1受体的非抗体结合蛋白及其应用
CN109718363A (zh) 预防、缓解或治疗阿尔茨海默病的肽及其应用
WO2003106640A2 (fr) Procedes et compositions de ciblage cellulaire
CN107236046A (zh) 一种重组人内皮抑素融合蛋白及其制备方法和应用
CN101824406B (zh) 重组β-内酰胺酶与RGD融合蛋白及其在医学中的应用
CN108912212B (zh) 一种与cd105特异性结合的多肽及其应用
CN102680272B (zh) 一种海胆多糖的提取、纯化及鉴定方法
CN107001483A (zh) 适合于神经元再生疗法的纳米抗体
CN113813375B (zh) 一种新型抗新冠病毒复合物的组成及其在防治冠状病毒感染疾病药物中的应用
RU2317097C2 (ru) Гетерокарпин, белок растительного происхождения, обладающий противораковыми свойствами
CN108276475A (zh) 一种鸡骨髓源树突状细胞靶向肽ah及其用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant