CN107233566A - 猪瘟‑猪圆环二联亚单位的疫苗及其制备方法和应用 - Google Patents
猪瘟‑猪圆环二联亚单位的疫苗及其制备方法和应用 Download PDFInfo
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- CN107233566A CN107233566A CN201710023628.7A CN201710023628A CN107233566A CN 107233566 A CN107233566 A CN 107233566A CN 201710023628 A CN201710023628 A CN 201710023628A CN 107233566 A CN107233566 A CN 107233566A
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Abstract
Description
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CN201710023628.7A CN107233566B (zh) | 2017-01-13 | 2017-01-13 | 猪瘟-猪圆环二联亚单位的疫苗及其制备方法和应用 |
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CN201710023628.7A CN107233566B (zh) | 2017-01-13 | 2017-01-13 | 猪瘟-猪圆环二联亚单位的疫苗及其制备方法和应用 |
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CN107233566A true CN107233566A (zh) | 2017-10-10 |
CN107233566B CN107233566B (zh) | 2022-05-27 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018233264A1 (zh) * | 2017-06-19 | 2018-12-27 | 普莱柯生物工程股份有限公司 | 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 |
CN109091669A (zh) * | 2018-09-19 | 2018-12-28 | 天康生物股份有限公司 | 猪瘟-圆环混合抗原的制备方法及其产品、猪瘟-圆环二联亚单位疫苗及其制备方法 |
CN110038124A (zh) * | 2019-05-13 | 2019-07-23 | 天康生物股份有限公司 | 猪瘟-猪传染性胸膜肺炎二联亚单位的疫苗及其制备方法和应用 |
CN112494643A (zh) * | 2020-12-09 | 2021-03-16 | 西安电子科技大学 | 一种猪csfv-pcv二联dna疫苗及其制备方法 |
CN113058032A (zh) * | 2021-03-22 | 2021-07-02 | 武汉科前生物股份有限公司 | 一种猪瘟、猪伪狂犬病和猪圆环病毒2型三联亚单位疫苗及其制备方法和应用 |
CN114230677A (zh) * | 2022-02-23 | 2022-03-25 | 北京中海生物科技有限公司 | 含有猪瘟E2和圆环病毒的Cap的重组蛋白及其制备方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160068575A1 (en) * | 2014-09-05 | 2016-03-10 | Chung Yuan Christian University | Novel recombinant baculovirus vector and uses thereof |
WO2017200484A1 (en) * | 2016-05-19 | 2017-11-23 | Temasek Life Sciences Laboratory Limited | Multivalent vaccines against major swine viral diseases |
-
2017
- 2017-01-13 CN CN201710023628.7A patent/CN107233566B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160068575A1 (en) * | 2014-09-05 | 2016-03-10 | Chung Yuan Christian University | Novel recombinant baculovirus vector and uses thereof |
WO2017200484A1 (en) * | 2016-05-19 | 2017-11-23 | Temasek Life Sciences Laboratory Limited | Multivalent vaccines against major swine viral diseases |
Non-Patent Citations (1)
Title |
---|
高珊: "猪圆环病毒 2 型 ORF2 基因与猪瘟病毒 E2 基因在奶山羊胎儿成纤维细胞中的表达与生物活性的鉴定,高珊,《爱学术》数据库猪圆环病毒 2 型 ORF2 基因与猪瘟病毒 E2 基因在奶山羊胎儿成纤维细胞中的表达与生物活性的鉴定", 《爱学术》 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018233264A1 (zh) * | 2017-06-19 | 2018-12-27 | 普莱柯生物工程股份有限公司 | 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 |
CN109091669A (zh) * | 2018-09-19 | 2018-12-28 | 天康生物股份有限公司 | 猪瘟-圆环混合抗原的制备方法及其产品、猪瘟-圆环二联亚单位疫苗及其制备方法 |
CN110038124A (zh) * | 2019-05-13 | 2019-07-23 | 天康生物股份有限公司 | 猪瘟-猪传染性胸膜肺炎二联亚单位的疫苗及其制备方法和应用 |
CN110038124B (zh) * | 2019-05-13 | 2023-04-14 | 天康生物股份有限公司 | 猪瘟-猪传染性胸膜肺炎二联亚单位的疫苗及其制备方法和应用 |
CN112494643A (zh) * | 2020-12-09 | 2021-03-16 | 西安电子科技大学 | 一种猪csfv-pcv二联dna疫苗及其制备方法 |
CN112494643B (zh) * | 2020-12-09 | 2022-07-12 | 西安电子科技大学 | 一种猪csfv-pcv二联dna疫苗及其制备方法 |
CN113058032A (zh) * | 2021-03-22 | 2021-07-02 | 武汉科前生物股份有限公司 | 一种猪瘟、猪伪狂犬病和猪圆环病毒2型三联亚单位疫苗及其制备方法和应用 |
CN113058032B (zh) * | 2021-03-22 | 2022-07-12 | 武汉科前生物股份有限公司 | 一种猪瘟、猪伪狂犬病和猪圆环病毒2型三联亚单位疫苗及其制备方法和应用 |
CN114230677A (zh) * | 2022-02-23 | 2022-03-25 | 北京中海生物科技有限公司 | 含有猪瘟E2和圆环病毒的Cap的重组蛋白及其制备方法和应用 |
CN114230677B (zh) * | 2022-02-23 | 2022-05-10 | 北京中海生物科技有限公司 | 含有猪瘟E2和圆环病毒的Cap的重组蛋白及其制备方法和应用 |
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