CN107210181B - 在触发碎裂能量的同时迅速扫描宽四极rf窗 - Google Patents

在触发碎裂能量的同时迅速扫描宽四极rf窗 Download PDF

Info

Publication number
CN107210181B
CN107210181B CN201680008552.4A CN201680008552A CN107210181B CN 107210181 B CN107210181 B CN 107210181B CN 201680008552 A CN201680008552 A CN 201680008552A CN 107210181 B CN107210181 B CN 107210181B
Authority
CN
China
Prior art keywords
ion
precursor
trace
value
precursor ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680008552.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN107210181A (zh
Inventor
N·G·布卢姆菲尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CN107210181A publication Critical patent/CN107210181A/zh
Application granted granted Critical
Publication of CN107210181B publication Critical patent/CN107210181B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/06Electron- or ion-optical arrangements
    • H01J49/062Ion guides
    • H01J49/063Multipole ion guides, e.g. quadrupoles, hexapoles
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN201680008552.4A 2015-02-05 2016-01-29 在触发碎裂能量的同时迅速扫描宽四极rf窗 Active CN107210181B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112603P 2015-02-05 2015-02-05
US62/112,603 2015-02-05
PCT/IB2016/050483 WO2016125061A1 (en) 2015-02-05 2016-01-29 Rapid scanning of wide quadrupole rf windows while toggling fragmentation energy

Publications (2)

Publication Number Publication Date
CN107210181A CN107210181A (zh) 2017-09-26
CN107210181B true CN107210181B (zh) 2019-11-01

Family

ID=56563519

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680008552.4A Active CN107210181B (zh) 2015-02-05 2016-01-29 在触发碎裂能量的同时迅速扫描宽四极rf窗

Country Status (6)

Country Link
US (1) US10079137B2 (ja)
EP (1) EP3254298B1 (ja)
JP (1) JP6698668B2 (ja)
CN (1) CN107210181B (ja)
CA (1) CA2975963A1 (ja)
WO (1) WO2016125061A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3586354A4 (en) * 2017-02-22 2020-12-16 DH Technologies Development Pte. Ltd. PHYSICAL ISOLATION OF ADDUCTS AND OTHER COMPLICATING FACTORS IN PREVIOUS ION SELECTION FOR IDA
WO2019012589A1 (ja) * 2017-07-10 2019-01-17 株式会社島津製作所 質量分析装置、質量分析方法、及び質量分析用プログラム
CN109828068B (zh) * 2017-11-23 2021-12-28 株式会社岛津制作所 质谱数据采集及分析方法
EP3575797A1 (en) * 2018-06-01 2019-12-04 Fundació Centre de Regulació Genòmica Improvements in mass spectrometry

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102017058A (zh) * 2008-05-15 2011-04-13 塞莫费雪科学(不来梅)有限公司 Ms/ms数据处理
US8237106B2 (en) * 2006-05-10 2012-08-07 Micromass Uk Limited Mass spectrometer
CN103109346A (zh) * 2010-11-08 2013-05-15 Dh科技发展私人贸易有限公司 用于通过质谱分析快速筛选样本的系统及方法
CN103109345A (zh) * 2010-09-15 2013-05-15 Dh科技发展私人贸易有限公司 产物离子光谱的数据独立获取及参考光谱库匹配
CN103282997A (zh) * 2010-12-29 2013-09-04 Dh科技发展私人贸易有限公司 用于触发用于数据获取的相关频谱的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
EP1502280B1 (en) * 2002-04-29 2013-09-04 MDS Inc., doing business as MDS Sciex Broad ion fragmentation coverage in mass spectrometry by varying the collision energy
GB0427632D0 (en) * 2004-12-17 2005-01-19 Micromass Ltd Mass spectrometer
US7541575B2 (en) * 2006-01-11 2009-06-02 Mds Inc. Fragmenting ions in mass spectrometry
JP5194212B2 (ja) * 2006-12-26 2013-05-08 ブリガム・ヤング・ユニバーシティ 血清プロテオミクスシステムと関連する方法
JP5111123B2 (ja) * 2008-01-16 2012-12-26 株式会社日立製作所 質量分析計及び質量分析方法
JP5112557B2 (ja) * 2009-02-19 2013-01-09 株式会社日立ハイテクノロジーズ 質量分析システム
KR101114228B1 (ko) * 2009-06-01 2012-03-05 한국기초과학지원연구원 데이터 비의존성 분석법과 데이터 의존성 분석법을 복합화한 단백질 분석방법
US8481926B2 (en) * 2009-09-04 2013-07-09 Dh Technologies Development Pte. Ltd. Method, system and apparatus for filtering ions in a mass spectrometer
EP2513946B1 (en) * 2009-12-18 2018-02-14 DH Technologies Development Pte. Ltd. Method of processing ions
WO2013171556A1 (en) 2012-05-18 2013-11-21 Dh Technologies Development Pte. Ltd. Modulation of instrument resolution dependant upon the complexity of a previous scan
GB201208961D0 (en) * 2012-05-18 2012-07-04 Micromass Ltd 2 dimensional MSMS
WO2014096915A1 (en) * 2012-12-20 2014-06-26 Dh Technologies Development Pte. Ltd. Compound identification using multiple spectra at different collision energies
JP5997650B2 (ja) * 2013-04-15 2016-09-28 株式会社日立ハイテクノロジーズ 分析システム
GB201308765D0 (en) * 2013-05-15 2013-06-26 Electrophoretics Ltd Mass Tag Reagents
WO2014195785A1 (en) 2013-06-06 2014-12-11 Dh Technologies Development Pte. Ltd. Improved data quality after demultiplexing of overlapping acquisition windows
EP3304382A4 (en) * 2015-05-29 2019-07-17 Waters Technologies Corporation TECHNIQUES FOR PROCESSING SPECTRAL MASS DATA

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8237106B2 (en) * 2006-05-10 2012-08-07 Micromass Uk Limited Mass spectrometer
CN102017058A (zh) * 2008-05-15 2011-04-13 塞莫费雪科学(不来梅)有限公司 Ms/ms数据处理
CN103109345A (zh) * 2010-09-15 2013-05-15 Dh科技发展私人贸易有限公司 产物离子光谱的数据独立获取及参考光谱库匹配
CN103109346A (zh) * 2010-11-08 2013-05-15 Dh科技发展私人贸易有限公司 用于通过质谱分析快速筛选样本的系统及方法
CN103282997A (zh) * 2010-12-29 2013-09-04 Dh科技发展私人贸易有限公司 用于触发用于数据获取的相关频谱的方法

Also Published As

Publication number Publication date
CN107210181A (zh) 2017-09-26
CA2975963A1 (en) 2016-08-11
US20180012742A1 (en) 2018-01-11
JP6698668B2 (ja) 2020-05-27
US10079137B2 (en) 2018-09-18
EP3254298A4 (en) 2018-10-31
WO2016125061A1 (en) 2016-08-11
JP2018504607A (ja) 2018-02-15
EP3254298A1 (en) 2017-12-13
EP3254298B1 (en) 2023-10-18

Similar Documents

Publication Publication Date Title
CN103109346B (zh) 用于通过质谱分析快速筛选样本的系统及方法
CN107210181B (zh) 在触发碎裂能量的同时迅速扫描宽四极rf窗
US9472387B2 (en) Systems and methods for identifying precursor ions from product ions using arbitrary transmission windowing
CN109643635A (zh) 用于在扫描swath数据中识别前体及产物离子对的系统及方法
CN105190828B (zh) 在重叠采集窗的多路分用之后改进数据质量
JP6158965B2 (ja) Srmアッセイにおけるバックグラウンド干渉の決定のためのtof−msmsデータの可変xic幅の使用
CN105869981A (zh) 用于在串联质谱分析中使用可变质量选择窗宽度的系统及方法
CN107092769A (zh) 用于在串联质谱分析中使用交错窗宽度的系统及方法
US20110315870A1 (en) Systems and methods for analyzing substances using a mass spectrometer
CN109643633B (zh) 自动化质谱库保留时间校正
JP2021511627A (ja) Msms信頼度を改良するためのdm−swath取り込み
CN106341983A (zh) 优化光谱数据的方法
CN105051526B (zh) 质量分析装置
CN104024845B (zh) 智能本底数据采集及减除
Morelli et al. Automatic procedure for mass and charge identification of light isotopes detected in CsI (Tl) of the GARFIELD apparatus
US11650208B2 (en) Deconvolving isobaric reporter ion ratios
CN104798174B (zh) 用于使用多个光谱以不同碰撞能量进行化合物识别的系统、方法及设备
CN107148572A (zh) 用于选择离子进行离子碎裂的方法和系统
CN114616645A (zh) 利用正交碎裂方法的质量分析-swath方法
CN108375643A (zh) 通过色谱重建检测低含量lcms组分
JP2023546822A (ja) Ms/msによる定量的分析のためのグループ検出を管理するための高分解能検出
JP2020085912A (ja) イオン種の質量を判定するためのシステムおよび方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant