CN107207404A - 化合物、其分离方法、合成方法及用途 - Google Patents

化合物、其分离方法、合成方法及用途 Download PDF

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Publication number
CN107207404A
CN107207404A CN201680007999.XA CN201680007999A CN107207404A CN 107207404 A CN107207404 A CN 107207404A CN 201680007999 A CN201680007999 A CN 201680007999A CN 107207404 A CN107207404 A CN 107207404A
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China
Prior art keywords
alkyl
halogenated
compound
methanol
aryl
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CN201680007999.XA
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CN107207404B (zh
Inventor
段震文
郭树仁
李雪梅
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Beijing Peking University WBL Biotech Co Ltd
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Beijing Peking University WBL Biotech Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/12—Preparation of carboxylic acid esters from asymmetrical anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明涉及新化合物、其分离方法、合成方法及用途，经活性实验证明该化合物具有HMG‑CoA还原酶抑制作用；另外还涉及其衍生物。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201680007999.XA 2015-02-04 2016-01-27 化合物、其分离方法、合成方法及用途 Active CN107207404B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510058282.5A CN105985244A (zh) 2015-02-04 2015-02-04 化合物、其分离方法、合成方法及用途
CN2015100582825 2015-02-04
PCT/CN2016/072306 WO2016124087A1 (zh) 2015-02-04 2016-01-27 化合物、其分离方法、合成方法及用途

Publications (2)

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CN107207404A true CN107207404A (zh) 2017-09-26
CN107207404B CN107207404B (zh) 2021-07-13

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CN201510058282.5A Pending CN105985244A (zh) 2015-02-04 2015-02-04 化合物、其分离方法、合成方法及用途
CN201680007999.XA Active CN107207404B (zh) 2015-02-04 2016-01-27 化合物、其分离方法、合成方法及用途

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Country Status (9)

Country Link
US (1) US10099998B2 (zh)
EP (1) EP3255031B1 (zh)
JP (1) JP6686032B2 (zh)
KR (1) KR102160471B1 (zh)
CN (2) CN105985244A (zh)
AU (1) AU2016214849B2 (zh)
MY (1) MY188671A (zh)
SG (1) SG11201706353WA (zh)
WO (1) WO2016124087A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2666459T3 (es) 2011-12-26 2018-05-04 Beijing Peking University Wbl Biotech Co., Ltd Derivado de esterol, procedimiento de preparación y finalidad del mismo
CN112964812A (zh) * 2021-02-05 2021-06-15 山东省产品质量检验研究院 一种检测乳制品中8种甜味剂的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
CN1318063A (zh) * 1998-09-18 2001-10-17 莱克制药与化学公司 得到高纯度HMG－CoA还原酶抑制剂的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5559140A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component
JPS56154439A (en) * 1980-04-30 1981-11-30 Sankyo Co Ltd Ml-236c derivative
JPS59137443A (ja) * 1983-01-27 1984-08-07 Akira Endo ジヒドロモナコリンｌカルボン酸の金属塩およびアルキルエステルならびにその製造法
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
CN102617533B (zh) * 2011-02-01 2014-08-27 北京北大维信生物科技有限公司 一种从红曲中分离的化合物、其制备方法及用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
CN1318063A (zh) * 1998-09-18 2001-10-17 莱克制药与化学公司 得到高纯度HMG－CoA还原酶抑制剂的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARUO IWABUCHI等: "Studies on Drug Metabolism Using Liquid Chromatography/Mass Spectrometry : Comparison of Three Liquid Chromatographic/Mass Spectrometric Interfaces", 《BIOLOGICAL MASS SPECTROMETRY》 *

Also Published As

Publication number Publication date
US10099998B2 (en) 2018-10-16
JP2018505884A (ja) 2018-03-01
KR20170134344A (ko) 2017-12-06
US20180022688A1 (en) 2018-01-25
KR102160471B1 (ko) 2020-09-29
AU2016214849B2 (en) 2020-05-07
EP3255031A1 (en) 2017-12-13
EP3255031B1 (en) 2021-09-29
CN107207404B (zh) 2021-07-13
SG11201706353WA (en) 2017-09-28
JP6686032B2 (ja) 2020-04-22
WO2016124087A1 (zh) 2016-08-11
CN105985244A (zh) 2016-10-05
AU2016214849A1 (en) 2017-08-24
MY188671A (en) 2021-12-22
EP3255031A4 (en) 2018-09-26

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