CN107206008A - 包括15‑hepe的组合物以及使用其治疗或预防纤维化的方法 - Google Patents

包括15‑hepe的组合物以及使用其治疗或预防纤维化的方法 Download PDF

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Publication number
CN107206008A
CN107206008A CN201580074543.0A CN201580074543A CN107206008A CN 107206008 A CN107206008 A CN 107206008A CN 201580074543 A CN201580074543 A CN 201580074543A CN 107206008 A CN107206008 A CN 107206008A
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CN
China
Prior art keywords
hepe
fibrosis
subject
composition
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580074543.0A
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English (en)
Chinese (zh)
Inventor
J·罗
K·杜菲
J·克莱麦克斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DS Biopharma Ltd
Original Assignee
DS Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DS Biopharma Ltd filed Critical DS Biopharma Ltd
Priority to CN202011279675.6A priority Critical patent/CN112245419A/zh
Publication of CN107206008A publication Critical patent/CN107206008A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580074543.0A 2014-12-02 2015-12-02 包括15‑hepe的组合物以及使用其治疗或预防纤维化的方法 Pending CN107206008A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011279675.6A CN112245419A (zh) 2014-12-02 2015-12-02 包括15-hepe的组合物以及使用其治疗或预防纤维化的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086535P 2014-12-02 2014-12-02
US62/086,535 2014-12-02
PCT/US2015/063488 WO2016090030A1 (en) 2014-12-02 2015-12-02 Compositions comprising 15-hepe and methods of treating or preventing fibrosis using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202011279675.6A Division CN112245419A (zh) 2014-12-02 2015-12-02 包括15-hepe的组合物以及使用其治疗或预防纤维化的方法

Publications (1)

Publication Number Publication Date
CN107206008A true CN107206008A (zh) 2017-09-26

Family

ID=56092410

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580074543.0A Pending CN107206008A (zh) 2014-12-02 2015-12-02 包括15‑hepe的组合物以及使用其治疗或预防纤维化的方法
CN202011279675.6A Pending CN112245419A (zh) 2014-12-02 2015-12-02 包括15-hepe的组合物以及使用其治疗或预防纤维化的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202011279675.6A Pending CN112245419A (zh) 2014-12-02 2015-12-02 包括15-hepe的组合物以及使用其治疗或预防纤维化的方法

Country Status (17)

Country Link
US (1) US10363235B2 (enExample)
EP (2) EP3226873B1 (enExample)
JP (2) JP6986445B2 (enExample)
KR (1) KR20170102879A (enExample)
CN (2) CN107206008A (enExample)
AU (2) AU2015358512B2 (enExample)
BR (1) BR112017011685A2 (enExample)
CA (1) CA2968980A1 (enExample)
ES (1) ES2900593T3 (enExample)
IL (2) IL252431B (enExample)
MA (1) MA41120A (enExample)
MX (2) MX382116B (enExample)
PH (1) PH12017501022B1 (enExample)
RU (2) RU2721555C2 (enExample)
SG (2) SG10202010594WA (enExample)
WO (1) WO2016090030A1 (enExample)
ZA (2) ZA201704463B (enExample)

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GB201301626D0 (en) * 2013-01-30 2013-03-13 Dignity Sciences Ltd Composition comprising 15-OHEPA and methods of using the same
CN105899485B (zh) 2013-11-15 2018-10-19 尊严科学有限公司 多不饱和羟基脂肪酸的药学上可接受的盐
US20150196521A1 (en) * 2014-01-10 2015-07-16 Dignity Sciences Limited Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
CN113893240A (zh) * 2015-01-16 2022-01-07 艾菲穆恩有限公司 包含15-hepe的组合物和其使用方法
CN113896628A (zh) 2015-05-13 2022-01-07 Ds生物制药有限公司 包含15-氧代-epa或15-氧代-dgla的组合物及其制备和使用方法
KR20180094516A (ko) * 2015-12-18 2018-08-23 애피뮨 리미티드 15-hepe를 포함하는 조성물 및 이를 사용하는 방법
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

Citations (2)

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US20140079631A1 (en) * 2011-03-25 2014-03-20 The Brigham And Women's Hospital, Inc. Anti-inflammatory particles
WO2014118097A1 (en) * 2013-01-30 2014-08-07 Dignity Sciences Limited Compositions comprising 15-ohepa and methods of using the same

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JP2000191525A (ja) 1998-12-25 2000-07-11 Nof Corp 皮膚外用剤組成物
WO2001049282A2 (en) * 2000-01-06 2001-07-12 Martek Biosciences Corporation Therapeutic preparations of highly unsaturated fatty acids
ATE504557T1 (de) 2000-02-16 2011-04-15 Brigham & Womens Hospital Aspirin-ausgelöste lipidmediatoren
JP2005179211A (ja) 2003-12-17 2005-07-07 Idemitsu Kosan Co Ltd 皮膚外用剤組成物
WO2005063231A2 (en) 2003-12-31 2005-07-14 Igennus Limited Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof
US20050239889A1 (en) 2004-04-26 2005-10-27 Jean Gosselin In vivo release of endogenous anti-microbial mediators by leukotriene B4 (LTB4) administration
WO2008021192A2 (en) * 2006-08-08 2008-02-21 Lipomics Technologies, Inc. Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof
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KR20180094516A (ko) 2015-12-18 2018-08-23 애피뮨 리미티드 15-hepe를 포함하는 조성물 및 이를 사용하는 방법

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WO2014118097A1 (en) * 2013-01-30 2014-08-07 Dignity Sciences Limited Compositions comprising 15-ohepa and methods of using the same

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Also Published As

Publication number Publication date
IL252431A0 (en) 2017-07-31
IL287983A (en) 2022-01-01
KR20170102879A (ko) 2017-09-12
PH12017501022B1 (en) 2022-02-16
EP3226873A1 (en) 2017-10-11
AU2015358512A1 (en) 2017-07-20
EP3988101A1 (en) 2022-04-27
JP2022031813A (ja) 2022-02-22
MA41120A (fr) 2017-10-10
PH12017501022A1 (en) 2017-11-27
MX2021005080A (es) 2021-06-15
RU2017122758A3 (enExample) 2019-06-13
BR112017011685A2 (pt) 2018-01-02
US10363235B2 (en) 2019-07-30
AU2015358512B2 (en) 2021-02-18
EP3226873B1 (en) 2021-10-27
RU2020115523A (ru) 2021-01-27
SG11201704495VA (en) 2017-06-29
US20160184252A1 (en) 2016-06-30
RU2017122758A (ru) 2019-01-09
ES2900593T3 (es) 2022-03-17
MX382116B (es) 2025-03-13
EP3226873A4 (en) 2018-08-08
CA2968980A1 (en) 2016-06-09
WO2016090030A1 (en) 2016-06-09
CN112245419A (zh) 2021-01-22
HK1245101A1 (zh) 2018-08-24
AU2021203189A1 (en) 2021-06-10
ZA201804380B (en) 2021-03-31
JP6986445B2 (ja) 2021-12-22
ZA201704463B (en) 2018-11-28
IL252431B (en) 2021-12-01
SG10202010594WA (en) 2020-12-30
RU2721555C2 (ru) 2020-05-20
JP2017536380A (ja) 2017-12-07
MX2017007000A (es) 2017-12-07

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Application publication date: 20170926

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