CN107184868A - It is a kind of being capable of effectively lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity - Google Patents

Abstract

One kind being capable of effective lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity, solve traditional slimming medicine action pathway single, the problem of side effect is obvious, Basic Theories of Chinese Medicine is combined with modern targeting preparation theory, fatty in food is absorbed from body is suppressed, suppress liver and utilize glucose synthctic fat, suppress fat cell using the glucose and the aspect of aliphatic acid synthctic fat three of intake to start with, and the increase of body fat cell volume is suppressed by the decomposition and indirect control fat cell synthctic fat for directly facilitating body fat, adipocyte number increase, three aspects intercept the root of obesity with two target spots；And modern medicine is combined, from promoting toxin excretion, stimulating three aspects of probiotics in nervous system, paraphyte, carry out endogenous regulation, strengthen immunity.

Description

It is a kind of being capable of effectively lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity

Technical field

The invention belongs to medicines and health protection technical field, it is related to a kind of by suppressing pancreatic lipase, suppressing intracellular Fatty synthesis, so as to effective lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity.

Background technology

The heat of chronic high intake exceedes the heat of body consumption, and unnecessary heat is just stored in body in the form of fat It is interior, the storage of body fat is exceeded arm's length standard.The mechanism that fat is accumulated in vivo is mainly：Fat, liver in food The fat that the fat of dirty middle utilization glucose synthesis, fat cell itself are synthesized using the glucose and aliphatic acid of intake.And fat Fat tissue is excessively to increase by two factors by the increase of body fat cell volume, adipocyte number to cause again.The maturation of the mankind The increase of adipocyte number, only can just occur when fat cell volume reaches to a certain degree.

At present, be nothing but on ways of preventing obesity move, go on a diet, acupuncture, drug therapy.

American Society of Sports Medicine's suggestion is daily with moderate strength duration exercises 30-60 minute, and movable energy expenditure is every time 300 card left and right, this is just more apparent to fitness and weight losing effect.But it is due to that obese patient's body weight is higher, due to bearing in motion Often there is the phenomenon of palpitation and short breath in weight, and motion is not omnipotent, without the sports events that effect is reached in easily saving.

Go on a diet by the intake for substantially reducing heat, and then consume fat, the short time can see effect of weight reducing, but save We can not be ignored for the harm that the zone of eclipse comes, and can such as cause not enough hypoglycemia, high-quality protein, various vitamins deficiencies, vivo protein The phenomenon that matter is consumed, basic metabolism declines, easily bounce-back etc. seriously endangers health.

Acupancture also has a certain curative effect, and research shows effectively to treat simple obesity, reduction cholesterol, low close Lipoprotein, triglyceride levels are spent, but Secondary Obesity is fat as caused by some diseases, passes through simple Acupancture It is invalid or short-acting, and the problematic person of bleeding constitution, inpatient with haematological diseases, clotting mechanism, because Acupancture is with silver Pin is directly pricked in subcutaneous stimulating acupoint, is also to injure to some blood coagulation disorders persons though pinprick is small, therefore these patients should not enter Any acupuncture and moxibustion therapy of row.

Drug therapy, including western medicine and treatment by Chinese herbs.Western medicine includes the medicine of appetite-suppressing, increase water discharge Medicine, increase WeiDongLi Capsule accelerate excretion medicine, mainly by appetite-suppressing maincenter, diuresis, excretion, suppress anabolism come The purpose of lowering blood-fat and reducing weight is reached, effect can be effective in the short time, but cures the symptoms, not the disease, only by being carried out in itself to disease Treatment, intercepted obesity source after could really lose weight, and the harm brought we can not also despise, such as Anorectic effect Alcohol Agent can trigger palpitaition, excited, dizzy, headache, insanity；Diuretics can cause vomiting, dizziness, drop in blood pressure；Drain medicine Dynamics is larger, has adverse reactions such as flatulence, watery stool, rectum discomfort etc..

The cause of disease of obesity is said in terms of the traditional Chinese medical science can be classified as four aspects：Native endowment, this inherent cause phase with modern medicine Seemingly, father and mother are fat, and fat probability is larger after general children adult；Overfeeding delicious food, influences the transporting of spleen, and essence of water and grain can not be changed For essence and blood, cream fat phlegm is turbid to be accumulated in internal, it is fat；Long-term depressive, the traditional Chinese medical science thinks liver controlling conveyance and dispersion, and happiness bar reaches, if Long-term mental depression, then liver-qi depression, so that depressed phlegm is solidifying or irritability is lost and dredged, taste are become estranged, raw in phlegm wet, then cause obesity； Sitting is crouched long, and temper transporting is powerless, cream fat cohesion, and obesity is formed.In summary, fat and individual physique, diet, work and rest, feelings The factors such as will are relevant, and main spleen liver is not relaxed, and phlegm is turbid, wet turbid, the fat delay that blood stasis is caused, so should start with from invigorating spleen and soothing liver, Fat-reducing purpose is reached by Li Shui, excreting dampness, dissolving stasis, defaecation, lipid-loweringing.Traditional Chinese medicine capable of reducing weight needs to carry out under the guidance of expert, it is impossible to Taking privately, may be damaged to body like that, can also cause fat-reducing effect unobvious.And enter using Chinese medicine merely The treatment of row obesity, patient compliance is not enough, takes effect slow, it is impossible to obtain good curative effect.

From the point of view of more than, fat-reducing is the activity intervened human normal physiological function, and regular fat-reducing can be serious Our body is injured, the symptoms such as osteoporosis, amnesia, gastroptosis, alopecia, anaemia are caused, finds and solves fat simultaneously The links problem of formation, effectively fat-reducing, are that fat-reducing market is one long-term while strengthening the Weight reducing compound of body immunity Target.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine composition of lowering blood-fat and reducing weight, by traditional theory of traditional Chinese medical science and modern medicine Be combined, use for reference targeting preparation raw material, from adipogenic mechanism it is several in terms of address problem of obesity：Suppress body Fatty in food is absorbed, suppress liver using glucose synthctic fat, suppress Portugal of the fat cell using intake Grape sugar and aliphatic acid synthctic fat, and by directly facilitate body fat decomposition and indirect control fat cell synthctic fat come Suppress increase, the adipocyte number increase of body fat cell volume.Body immunity is taken into account, Adipogenesis, fertilizer can solved While fat formation problem；Meanwhile, this composition is directed to the side effect of slimming drugs, has selected with improvement anaemia, has improved sleep Composition it is military, strengthen body immunity, reach the effect that righting is mutually promoted with eliminating evil, health slimming.

Monarch drug in a prescription is hawthorn, promoting blood circulation and removing blood stasis, promotes body fat to decompose, and reduces the volume of fat cell and reduces fat cell Quantity, for fat main crux；Another hawthorn contains flavone compound to be had to blood flow and central nervous system Adjustment effect, strengthen immunity simultaneously improves insomnia Anemia.

Ministerial drug is rhizoma alismatis, and excreting dampness row phlegm suppresses lipocyte proliferation, reduces adipocyte number；Black tea, suppresses fat and inhales Receive, promote lipid excretion, and it is fat that can easily prevent saccharide converted, reduces the volume of fat cell；Papillary, increases respectively Strong monarch drug in a prescription reduces the volume of fat cell and the effect for the quantity for reducing fat cell.Contain abundant flavonoids in another black tea Compound, with very strong antioxidation, can improve body immunity, prevention disease.Monarch drug in a prescription is aided in improve immunity of organisms.

Adjutant：Lotus leaf, cooling blood and hemostasis, containing alkaloid, effectively reduces fat, and strengthens monarch drug in a prescription lipolysis effect, simultaneously Absorption of the intestinal tissue to fat is prevented, intake is reduced；Chitosan, with fat combination, can reduce the absorption of fat, increase fat Excretion；Arabinose, suppresses the absorption of carbohydrate, prevents intake, prevents carbohydrate from absorbing and being synthesized in liver and fat cell Fat；Three is shared, and intake, liver cell and the fat cell synthctic fat of fat are prevented from source.Another chitosan, which has, to swash The biological effect of airframe systems living, arabinose can breed beneficial bacterium, promote the preferential adsorption and excretion fat of body enteron aisle The discharge of fat analyte, auxiliary ministerial drug improves immunity of organisms.

Make medicine：Coix seed, invigorating spleen and reinforcing stomach controls arthritis with fixed pain caused by dampness, sharp stomach, consumer edema, while having toxin expelling hydrofuge, strengthen immunity Effect.All medicines more than reconciling, reach effect of fat-reducing and strengthen immunity.

Seven kinds of the above, the effect of fat that disappears is played altogether, suppresses Adipogenesis, strengthen immunity.

1st, the formation of fat is suppressed

Hawthorn, slightly warm in nature is sour sweet, enters taste Liver Channel, and food digesting stomach fortifying is promoting blood circulation and removing blood stasis, convergence and dysentery.Overfeeding delicious food, can influence The transporting of spleen, cream fat phlegm is turbid to be accumulated in internal, and obesity is formed, and hawthorn can disappear meat stagnation, and it also has the work(of blood-activating and qi-promoting, Can Removing Blood Stasis without hindering new blood, play a part of stagnation resolvation and disappear fat, modern study hawthorn can increase the secretion of digestive ferment in stomach, promote Digestion, contained lipase can promote lipolysis, but also can reduce hyperlipidemia model animal T-CHOL, triglycerides, tool There is certain effect for reducing fat, reach the purpose of fat-reducing.Hawthorn energy prevention and cure of cardiovascular disease, with expansion blood vessel, increase coronary blood Flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, softening blood vessel, diuresis and calmness etc. are made With.Hawthorn energy hypotensive, can lightening heart load, improve myocardial blood supply, oxygen supply, have certain curative effect to uncomfortable in chest, palpitaition.Hawthorn because The secretion of enzyme can be increased, therefore digestion can be promoted, and the effect of tool stomach invigorating, tonifying spleen, beneficial lung.Flavonoids and Wei Sheng contained by hawthorn The materials such as plain C, carrotene can block and reduce the generation of free radical, strengthen the immunity of body.

2nd, suppress the formation of fat, suppress the absorption of fat

Lotus leaf, property hardship is flat, Return liver taste warp, with clearing away summerheat, sending up the lucid yang, effect of cooling blood and hemostasis.《Key to Diagnosis and Treatment》In Say:" lotus leaf takes it, makes us thin bad." Nuciferine in lotus leaf contains a variety of effectiveization fat alkaloids, can effectively decompose body In fat, Nuciferine can gather in the intestinal wall of human body, form one layer of fatty barrier film, and tissue fat absorbs, and has very strong Repel the function of grease, and then allow people to produce dislike to the food of greasy meat or fish, there is stronger effect of weight reducing and effect for reducing fat. Also contain a large amount of fibers in lotus leaf, promote the wriggling of large intestine, contribute to discharge toxins in body and superabundant fats, solve the tired of obesity Disturb.Meanwhile, lotus leaf also has effect of diuresis so that unnecessary fat and the discharge of retention electrolyte in vivo, people just reduces naturally.

3rd, adipocyte number increase is suppressed

Rhizoma alismatis, cold in nature, slightly sweet flavor returns kidney, bladder warp, and clearing damp and promoting diuresis expels the heat-evil treating stranguria.Rhizoma alismatis is longer than water-filling, and Li Shui effects are stronger, Kind excreting dampness row phlegm, changes turbid lipid-loweringing, and then lose weight.There is experiment to show rhizoma alismatis reduction serum total cholesterol and low-density lipoprotein effect Highly significant, and also studies have reported that, the rhizoma alismatis of various concentrations acts on Preadipocyte In Vitro, and cytoactive is reduced than normal group, Illustrate that rhizoma alismatis has and suppress lipocyte proliferation and apoptosis-induced effect, this is provided into one for the antiobesity action mechanism of rhizoma alismatis Walk theoretical foundation.

4th, the absorption of sugar is suppressed

Arabinose, arabinose mainly has two in the use function of food and pharmaceutical preparations, and one is that can suppress to hydrolyze disaccharide Enzyme, therefore suppress because intake sucrose caused by blood glucose rise；Two be the inhibitory action to disaccharide hydrolase because of arabinose, The sucrose not being decomposed in small intestine is decomposed by the microorganisms in large intestine and produce substantial amounts of organic acid, this organic acid is to liver Dirty synthctic fat has inhibitory action, along with inhibitory action of the arabinose in small intestine to absorption sucrose, so as to reduce in vivo The generation of new fats.Arabinose can also breed beneficial bacterium, promote HDL to be formed, and HDL can be with Low-density lipoprotein, triglycerides, cholesterol etc. are reduced, the street cleaner of blood vessel is described as, so arabinose is more satisfactory Diet food.

5th, suppress to absorb, suppress sugar and be converted into fat

Black tea, the Tea Polyphenols containing about 10%-20% or so, Tea Polyphenols can promote the metabolism of aliphatic acid, promote fat splitting, subtract The effect of few Fat Accumulation, while the absorption of fat can be suppressed, and with the effect for promoting lipid compounds to be discharged from excrement. Secondly, Tea Polyphenols suppression body prevents sugar from being converted into fat the absorption of carbohydrate.Black tea is formed through green tea fermentation, is also had The digestant effect of nourishing the stomach.Have research show black tea can make Abdominal Fat cell perimeter, equivalent diameter, area volume, Girth volume is substantially reduced.In summary, black tea has effects that good fat fat-reducing of dispelling.

Black tea, which has, improves body immunity, prophylactic effect.Black tea antimicrbial power is strong, and being gargled with black tea to prevent Caught a cold caused by viral, and prevent decayed tooth.Containing abundant flavone compound in black tea, with very strong antioxidation, Body immunity, prevention disease can be improved.

6th, chitosan, reduces the intake of fat

Chitosan easily with the lipoid substance in human body, such as triglycerides, aliphatic acid, bile acid and other sterols complexing, generation It is difficult, by the complex compound that hydrochloric acid in gastric juice is hydrolyzed and digestive system absorbs, so as to reduce absorption of the human body to high fat kind material, shell to be gathered Sugar is added in food as fat-removal agent, on the one hand can reduce absorption of the human body to lipid material, promote it to excrete, On the other hand absorbed energy can be effectively reduced because occurring complexing with the fat in food.Chitosan has activation Airframe systems, the series of biologic effect for mediating airframe systems, improve the systemic-function of phagocyte.Macrophage Surface is present The acceptor of bacterial polysaccharides, and chitosan is as the analog of bacterial polysaccharides, can stimulating expression of macrophage activation, produce following anti- Should：Promote its phagocytic function, strengthen its cooperative effect in other immune responses, so as to realize body to T cell, NK cells With the regulation of B cell, the cellullar immunologic response and humoral immune response of body are mediated.Therefore, chitosan has and body is exempted from Epidemic disease adjustment effect.

7th, coix seed, increases immunity, while aiding in clearing damp and promoting diuresis

Semen Coicis, claims " coix seed " in Chinese medicine,《Sheng Nong's herbal classic》Top grade is classified as, it can control arthritis with fixed pain caused by dampness, sharp stomach, and disappear water Swollen, invigorating spleen and reinforcing stomach, long term usage is made light of one's life by commiting suicide QI invigorating.Modern's stress is big, and the heart qi deficiency, eating and drinking without temperance, amount of exercise is few, the insufficiency of the spleen with overabundance of dampness. Should clearing damp, bushing again also wants strengthening the spleen and stomach, and non-Semen Coicis does not belong to.Fat in the traditional Chinese medical science, oedema can mean that Have in vivo wet.Aqueous can not flow with qi and blood, be trapped between human body cell, human body is expanded rapidly.Oedema is in this way, fertilizer Fat is also in this way, only degree has depth to have shallow.The extremely strong medicine of clearing damp or food can dispel these and be trapped in people The aqueous of body, also can just subside a swelling.So, Semen Coicis has good effect of weight reducing, can lose weight, and not wound body.

This research is come by exploring step by step.70 mouse are chosen, Normal group, model group, sun is randomly divided into Property control group, formula one group, formula two groups, formula three groups, formula four groups, every group 10.

Normal group：Distilled water gavage, 2ml/ days；

Model group：10% lard, 10% yolk powder, 80% normal diet is mixed, daily mouse feeding 15g；

Positive controls：Orlistat gavage, 60mg/kgd；

Formula group is to form bulk drug through water extraction concentration：

It is formulated one group：Haw thorn extract 0.18g g/kgd, Lotus Leafextract 0.18g g/kgd, Alisma extract 0.18g G/kgd, black tea extract 0.18g g/kgd, Semen Coicis extract 0.18g g/kgd, are dissolved in water gastric infusion, continuously Administration 2 months；

It is formulated two groups：Haw thorn extract 0.18g g/kgd, Lotus Leafextract 0.18g g/kgd, Alisma extract 0.18g G/kgd, black tea extract 0.18g g/kgd, Semen Coicis extract 0.18g g/kgd, chitosan 1.8g/kgd, L- Arabinose 1.8g/kgd, is dissolved in water gastric infusion, successive administration 2 months；

It is formulated three groups：Haw thorn extract 0.18g g/kgd, black tea extract 0.18g g/kgd, Semen Coicis extract 0.18g g/kgd, chitosan 1.8g/kgd, L-arabinose 1.8g/kgd are dissolved in water gastric infusion, successive administration 2 Month.

It is formulated four groups：Haw thorn extract 0.18g g/kgd, Lotus Leafextract 0.18g g/kgd, Alisma extract 0.18g g/kgd, chitosan 1.8g/kgd, L-arabinose 1.8g/kgd are dissolved in water gastric infusion, successive administration 2 Month.

Observe mouse weight and body fat weight in each group（Whole fat around mouse propagation device are taken, claim its weight）Change Change.

The mouse weight of table 1 compares (x ± s)

Group	N/ is only	Original body mass	Final body weight
				Normal group	10	20.32±0.71	30.35±0.96
Model group	10	19.85±0.81	40.16±0.72
				Positive controls	10	20.54±0.93	27.67±0.69
It is formulated one group	10	20.03±0.76	28.24±0.34
				It is formulated two groups	10	20.13±1.01	26.07±0.19
It is formulated three groups	10	19.83±1.08	26.37±0.29
				It is formulated four groups	10	20.64±0.94	27.54±0.28

Model group is compared with normal group, P<0.01；Positive controls and one group, two groups, three groups, four groups of formula and model group ratio Compared with * P<0.01.

As it can be seen from table 1 after each group original body mass no significant difference, treatment end, model control group with just Normal control group compares, and body weight is significantly raised, and four groups of positive controls and formula are compared with model group, and body weight is significantly reduced, and Four group body weight of formula reduce amplitude sizes：It is formulated one group>It is formulated four groups>It is formulated three groups>It is formulated two groups.

The comparison (x ± s) of the mouse body fat weight of table 2

Group	N/ is only	Body fat weight/g
			Normal group	10	0.35±0.006
Model group	10	0.76±0.009
			Positive controls	10	0.47±0.007
It is formulated one group	10	0.50±0.007
			It is formulated two groups	10	0.44±0.006
It is formulated three groups	10	0.46±0.005
			It is formulated four groups	10	0.47±0.005

Model group is compared with normal group, P<0.01；Positive controls and one group, two groups, three groups, four groups of formula and model group ratio Compared with * P<0.01.

From table 2 it can be seen that model control group is compared with Normal group, body fat weight is significantly raised, positive controls Compared with four groups of formula with model group, body fat weight is significantly reduced, and four group body weight reduction amplitude sizes of formula are：Formula Two groups>It is formulated three groups>It is formulated four groups>It is formulated one group.

Conclusion：Formula group has fat fat-reducing effect of dispelling well, and two groups of effects of formula are most obvious.

The beneficial effects of the present invention are：Basic Theories of Chinese Medicine is combined by the present composition with modern targeting preparation theory, From suppress body fatty in food is absorbed, suppresses liver using glucose synthctic fat, to suppress fat cell sharp Started with the glucose and the aspect of aliphatic acid synthctic fat three of intake, and by directly facilitating the decomposition and control indirectly of body fat Fat cell synthctic fat processed increases to suppress the increase of body fat cell volume, adipocyte number, three aspects and two target spots Intercept the root of obesity；And modern medicine is combined, from the excretion of promotion toxin, stimulate probiotics three in nervous system, paraphyte Aspect, carries out endogenous regulation, strengthen immunity.

The collocation of this research each component is reasonable, mutually promotes, thus can synthetically play stable equilibrium's regulation viscera function, Strengthen immunity, the effect for promoting lowering blood-fat and reducing weight.

Embodiment

The specific embodiment of the weight composition of many each raw materials of the Chinese medicine composition is given below：

Embodiment 1

30 parts of hawthorn, 15 parts of lotus leaf, 15 parts of rhizoma alismatis, 25 parts of chitosan, 55 parts of coix seed, 75 parts of black tea, 35 parts of L-arabinose.

Its preparation process is：1）30 parts of hawthorn is weighed, 15 parts of lotus leaf, 15 parts of rhizoma alismatis, 55 parts of coix seed is crushed, 5 times of amounts 75% ethanol, twice, return time is 2 hours, merges phegma twice for backflow, reclaims ethanol and obtains thick paste；2）By 50 parts of black tea powders Broken, with above-mentioned thick paste, chitosan, arabinose, 12.5 parts of starch, suitable quantity of water stir, are dried under reduced pressure, ultramicro grinding, powder The broken time is 18min, and temperature is 2 DEG C, crosses 1000 mesh sieves；3）Above-mentioned Ultramicro-powder is taken, is mixed with water, is pelletized, is dried, then is added 0.42 part of magnesium stearate, tabletting obtains tablet.

Embodiment 2

40 parts of hawthorn, 25 parts of lotus leaf, 25 parts of rhizoma alismatis, 15 parts of chitosan, 45 parts of coix seed, 70 parts of black tea, 25 parts of L-arabinose.

Its preparation process is：1）40 parts of hawthorn is weighed, 25 parts of lotus leaf, 25 parts of rhizoma alismatis, 45 parts of coix seed is crushed, and adds 8 times Purified water is measured, is extracted twice, extraction time is 2 hours, and merging filtrate is concentrated to give thick paste；2）By above-mentioned chitosan, arabinose Stir, be dried under reduced pressure with thick paste, ultramicro grinding, grinding time is 18min, temperature is 2 DEG C, crosses 1000 mesh sieves；3）Will be upper Ultramicro-powder is stated, is mixed with water, is pelletized, is dried, with 150 parts of mixings of black tea, is dispensed into nylon cloth pocket.

Embodiment 3

35 parts of haw thorn extract, 22 parts of Lotus Leafextract, 20 parts of Alisma extract, 20 parts of chitosan, 50 parts of Semen Coicis extract, 73 parts of black tea, 30 parts of L-arabinose.

Its preparation process is：1）Above-mentioned hawthorn is weighed, lotus leaf, rhizoma alismatis, coix seed is crushed, add 8 times of amount purified waters, carry Take twice, extraction time is 2 hours, and merging filtrate is concentrated to give thick paste；2）By the stirring of above-mentioned chitosan, arabinose and thick paste Uniformly, it is dried under reduced pressure, ultramicro grinding, grinding time is 18min, temperature is 2 DEG C, crosses 1000 mesh sieves；3）By above-mentioned Ultramicro-powder, plus Water is well mixed, and is pelletized, and is dried, and with 150 parts of mixings of black tea, loads capsule.

Embodiment 4

Weight losing function human feeding trial：

1 materials and methods

1.1 sample：Using the dosage and formulation of embodiment 2, twice daily, one bag every time.

1.2 study subject：Subject's male or female, overweight people, by physical examination, without the functions such as the obvious heart, liver, courage, kidney barrier Hinder.

1.2.1 subject's selection standard：Adult BMI >=30, or total fat percentage reach man>25%, female>30% from It is willing to subject.

1.2.2 exclusion standard：

1.2.2.1 merge intentionally, liver, the serious disease, mental patient such as kidney and hemopoietic system.

1.2.2.2 the article relevant with tested function is taken in a short time, has influence on the judgement person to result.

1.2.2.3 not by the edible tested material of regulation, it is impossible to which judging effect or data, umbra does not ring effect or security judges Person.

1.3 test method：Inclusive criteria will be met and ensures the volunteer of compatibility test, be randomly divided into test-meal group and Control group.Test-meal group is taken the sample of producer's offer with control group by recommended dose, is continuously taken 2 months.Do not change during experiment Become original eating habit, normal diet.

2 observation index：Efficiency index, tests in test-meal and starts and terminate each test once.

2.1 body weight and height：Emptying stool and urine, takes off one's shoes before determining, and test-meal forebody-afterbody resurveys timing and wears same clothes body Weight scale is determined.

2.2 bioelectrical impedance analysis：Determine human body body fat rate.

2.3 girth diameters are determined：

2.3.1 waistline：The abdomen girth of flat navel.

2.3.2 hip circumference：With the girth of both sides greater trochanter of femur level.

2.4 stratum corneum lipids are determined：Measurement site：

2.4.1 mid-point on the outside of right deltoid muscle lower edge arm.

2.4.2 right angulus inferior scapulae.

2.4.3 3cm by right navel.

2.4.4 right anterior superior spine.

2.4 experimental datas are counted：Statistical analysis is carried out with INSTAT softwares.

3 results

3.1 ordinary circumstance：Initial trial crowd test-meal group 50, control group 50.Before and after test-meal experiment, subject is spiritual, sleep Dormancy, diet, stool and urine situation no abnormality seen.Control group：Male/female is 15/35, and the age is 48.21 ± 11.36 years old：Test-meal group： Male/female is 15/35, and the age is 48.30 ± 11.51 years old.

3.3 efficiency observation indexs

3.3.1 body weight, body fat gross weight and fat percentage are determined

Body weight, body fat total amount and fat percentage measurement result (x ± s) before and after the test-meal of table 3

Test-meal group body fat gross weight and Rate of body lipid before test-meal with being compared P<0.05, compared P with control group<0.05.

Before experiment, control group and test-meal group body weight, body fat gross weight, Rate of body lipid level compare, and P values are all higher than 0.05, There is comparativity between pointing out two groups.Weight average declines 4.09kg, body fat gross weight before test-meal group subject relatively tests after experiment Averagely decline 4kg, Rate of body lipid averagely declines 3.69%.Body weight, which has no, after experiment substantially changes (P>0.05).Test-meal after experiment Group subject's body fat gross weight and Rate of body lipid have conspicuousness (P with comparing difference before control group and itself experiment<0.05).

3.3.2 subcutaneous fat thickness measuring-

Subcutaneous fat thickness measuring result (x ± s) before and after the test-meal of table 4

Subcutaneous fat thickness declines before test-meal group subject relatively tests after experiment, is reduced wherein at deltoid muscle under 3.94mm, omoplate Place, which reduces to reduce at by 3.99mm, navel, reduces 2.12mm at 2.66mm, bone spine.After experiment at test-meal group subject deltoid muscle and shoulder Place under shoulder blade, by navel place's subcutaneous fat thickness with being compared before testing and control group comparing difference has conspicuousness (P<0.05), ilium spine Locate subcutaneous fat thickness with control group comparing difference without conspicuousness (P>0.05).

3.3.3 girth diameter measurement result

Girth diameter measurement result (x ± s) before and after the test-meal of table 3

Waistline reduces 6.4cm before test-meal group subject relatively tests after experiment, and hip circumference reduces 3.86cm.Test-meal group subject after experiment Waistline has conspicuousness (P with comparing difference before control group and itself experiment<0.05), after experiment test-meal group subject hip circumference with compareing (the P that compares that there was no significant difference before group and itself experiment>0.05).

3.3.4 depigmentation rate：After the experiment of 2 months, control group has 1 subject to be taken because of interruption can not be sentenced by test product Disconnected effect is screened out；Test-meal group has 1 subject to be taken because of interruption can not be judged that effect is screened out by test product.Last efficiency test Crowd is according to group 49, test-meal group 49.It is shown in Table 5.

The depigmentation rate of table 5

Group	Control group	Test-meal group
			Before test-meal	50	50
Depigmentation number	1	1
			Depigmentation rate	2.04%	2.04%

4 brief summaries

Shown according to above human feeding trial result, at test-meal group body fat gross weight and Rate of body lipid, subject's deltoid muscle with Under omoplate place and navel side at subcutaneous fat thickness, the waistline of subject and control group have significant difference, according to《Health food Examine and assessment technique specification》Evaluation criterion is pointed out, and the Chinese medicine composition of this research has antiobesity action to human body.

Claims (2)

1. a kind of being capable of effectively lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity, it is characterised in that：The composition presses number Constitute and be：30-40 parts of haw thorn extract, 15-25 parts of Lotus Leafextract, 15-25 parts of Alisma extract, 15-25 parts of chitosan, the heart of a lotus seed 45-55 parts of seed of jog's tears extract, 70-75 parts of black tea, 25-35 parts of L-arabinose.

2. it is according to claim 1 it is a kind of can effectively lowering blood-fat and reducing weight, the Chinese medicine composition of strengthen immunity, its feature exists In：The composition is constituted by number：35 parts of haw thorn extract, 22 parts of Lotus Leafextract, 20 parts of Alisma extract, chitosan 20 parts, 50 parts of Semen Coicis extract, 73 parts of black tea, 30 parts of L-arabinose.