CN107156154A - A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole - Google Patents
A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole Download PDFInfo
- Publication number
- CN107156154A CN107156154A CN201710387664.1A CN201710387664A CN107156154A CN 107156154 A CN107156154 A CN 107156154A CN 201710387664 A CN201710387664 A CN 201710387664A CN 107156154 A CN107156154 A CN 107156154A
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- CN
- China
- Prior art keywords
- epoxiconazole
- bactericidal composition
- benzene metsulfovax
- agent
- composition according
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention discloses a kind of bactericidal composition containing benzene metsulfovax and epoxiconazole, containing the active ingredient and suitable agricultural agent being made up of benzene metsulfovax and epoxiconazole, formulation is oil-suspending agent.The present invention is good to the crop fungal disease prevention effect such as take-all, banded sclerotial blight, and synergistic effect substantially, can reduce dosage between two medicaments, effectively reduction ecological disruption and environmental pollution, and to people and animals, beneficial organism, Environmental security.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, and in particular to the bactericidal composition of a kind of benzene metsulfovax and epoxiconazole.
Background technology
Benzene metsulfovax, (adopted name benthiavalicarb-isopropyl), chemical name [[(6- fluoro benzothiazoles-
2- yls)-ethylaminocarbonyl] -2- methyl-propyls] carbamic acid isopropyl ester, CAS accession number [177406-68-7], molecule
Formula：C18H24FN3O3S(381.46).Benzene metsulfovax are a kind of amino amino formate ester bactericide, are had to oomycetes good
Bactericidal activity, has good inhibiting effect at low concentrations to the sprouting of the formation sporangium of its sporangium, with high selectivity,
There is excellent prevention and treatment activity to Oomycete the germ such as late blight and downy mildew of various crop, and low toxicity, to ring
Border safety, and with very strong prevention, treatment, osmotically active, good lasting effect and rain wash resistance.
Epoxiconazole (English name：Epoxiconazole), chemical name (2RS, 3SR) -1- [3- (2- chlorphenyls) -2,3- oxygen
Bridge -2- (4- fluorophenyls) propyl group] -1H-1,2,4- triazoles, CAS accession number [106325-08-0], molecular formula：C17H13ClFN3O
(329.76).Epoxiconazole is a kind of triazole bactericidal agent, and it suppresses the synthesis of germ ergosterol, hinders the shape of germ cell membrane
Into, while all fourth matter enzymatic activitys of crop can be improved, suppression germ intrusion.To cereal crop such as damping-off, powdery mildew, eyeprint
Ten multiple diseases such as disease have good preventive and therapeutic effect, and can prevent and treat to the leaf spot on the crops such as peanut, beet, vegetables, in vain
The disease such as powder disease, rust and anthracnose, white rot on grape has good preventive effect, and absorbability is strong, the lasting period is splendid, and plant absorbs
Conduction is rapid, with protecting, treat and root out well activity.
The document report that benzene metsulfovax and epoxiconazole are not applied in combination in the prior art.
The content of the invention
To the selection pressure of pathogen during in order to reduce benzene metsulfovax and epoxiconazole exclusive use, it is to avoid drug-fast quick
Rise, the present invention proposes a kind of new type bactericide composition.The present invention enters two kinds of active ingredients of benzene metsulfovax and epoxiconazole
Row combination, it is high with bactericidal activity in actual use, the advantages of wide sterilization spectrum, while delaying the pathogen resistance to the action of a drug to produce and send out
Total dosage in exhibition, reduction unit area, obtains efficient, economic, environmental protection benefit.
Technical scheme is as follows
A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole, the wherein mass ratio of benzene metsulfovax and epoxiconazole are 50:1
~1:50.
Described bactericidal composition, benzene metsulfovax and the mass ratio of epoxiconazole preferably are 3：7.
Oil-suspending agent, aqueous suspension agent, the agricultural bactericidal agent aid of use can be made in described bactericidal composition, its formulation
Including wetting dispersing agent, emulsifying agent, bleeding agent, thickener, defoamer, oil phase carrier etc.；It is preferred that wetting dispersing agent, emulsification
The surfactants such as agent, bleeding agent are aliphatic acid polyethenoxy ether, disecoctylmaleate sodium sulfonate, fatty alcohol polyoxy second
One or more in alkene ether, aliphatic amine polyoxyethylene ether, polyethylene glycol 400 dioleic acid ester；It is preferred that thickener for xanthans,
One or both of attapulgite；It is preferred that defoamer be organic silicon defoamer；It is preferred that oil phase carrier be paraffin oil.
Described bactericidal composition, benzene metsulfovax and the active ingredient of epoxiconazole composition preferably account for the total matter of bactericidal composition
The 6%~50% of amount, most preferably the benzene metsulfovax and the active ingredient of epoxiconazole composition account for bactericidal composition gross mass
30%.
Application of the described bactericidal composition in the crop fungal diseases such as take-all, banded sclerotial blight are prevented and treated.
Benzene metsulfovax and epoxiconazole proportioning screening test design and result treatment are carried out with Wadley methods, are determined first
The EC of benzene metsulfovax and epoxiconazole50, according to its EC50The portfolio ratio of two medicaments is set by Wadley methods, and is increased according to Wadley
Index SR values are imitated, determines that two components are suitably matched, is then verified by the abundant methods of Sun Yun.
Test objective thing is wheat sharp eyespot, and experiment uses colony diameter method.Benzene metsulfovax, fluorine are prepared according to experimental design
Ring azoles pastille flat board, per ware 20ml, sets and compares (CK) without medicine flat board, often handle 3 repetitions.In preculture colony edge with taking
The mycelia block of 6mm diameters is moved on on different culture media flat board respectively, and 26 DEG C of culture 10d, control group grows to culture dish diameter 2/3
~3/4 measures colony diameter, and calculates growth inhibition ratio by following equation：
Mycelial growth inhibition rate is converted into suppression probit value (Y), drug concentration is converted into log concentration (X), by concentration
Logarithm is that abscissa, probit value are that ordinate makees toxicity regression straight line, tries to achieve benzene metsulfovax and epoxiconazole single dose and its mixture pair
The virulence regression equation of sheath blight fungus, and calculate EC50、EC90Value and correlation coefficient r value.
The interaction of mixture is evaluated according to Wadley methods, calculation formula is as follows：
EC50 (theoretical values)=(a+b)/(a/EC50a+b/EC50b), SR=EC50 (theoretical values)/EC50 (actual values)。
Wherein a, b are each component content ratios in mixture, and the effect of mixture is analyzed with SR values.SR≤0.5, then two kinds of medicines
Agent mixture has antagonism；SR=0.5~1.5, then two kinds of medicament mixtures have addition；SR >=1.5, then two kinds of medicament mixtures
There is synergistic effect.
The benzene metsulfovax of table 1 are with epoxiconazole single dose and its mixture to gaeumannomyces graminis toxicity test result
Toxicity test result of the data analysis for Pathogen of Take-all from table 1：
From the point of view of coefficient of synergism (SR), in benzene metsulfovax：Epoxiconazole=1:50、1:20、1:9、2：8、3:7、4:6、5:5、
6:4、7:3、8:2、9:1、20:1、50:In 1 mass ratio proportioning, 1:50、1:20、1:9、6:4、20:1、50:1 this 6 proportionings
Coefficient of synergism be less than 0.5, i.e. SR<0.5, illustrate that benzene metsulfovax match complex roles in Pathogen of Take-all with epoxiconazole with this 6,
Show antagonism；5:5、9:1 this 2 proportioning coefficient of synergism between 0.5 and 1.5, i.e., 0.5<SR<1.5, show
Summation action；2：8、3:7、4:6、7:3、8:The coefficient of synergism of 2 this 5 proportionings is more than 1.5, i.e. SR>1.5, show synergy work
With.
The benzene metsulfovax of table 2 are with epoxiconazole single dose and its mixture to wheat sharp eyespot toxicity test result
Toxicity test result of the data analysis to sheath blight fungus from table 2：
In terms of coefficient of synergism (SR), in benzene metsulfovax：Epoxiconazole=1:50、1:20、1:9、2：8、3:7、4:6、5:5、6:
4、7:3、8:2、9:1、20:1、50:In 1 mass ratio proportioning, 1:50、1:20、1:9、2:8、4:6、6:4、50:1 this 7 proportionings
Coefficient of synergism be less than 0.5, i.e. SR<0.5, illustrate that benzene metsulfovax match complex roles in sheath blight fungus with epoxiconazole with this 7,
Show antagonism；5:5、8:2、9:1、20:1 this 4 proportioning coefficient of synergism between 0.5 and 1.5, i.e., 0.5<SR<
1.5, show summation action；3:The coefficient of synergism of 7 this 1 proportionings is more than 1.5, i.e. SR>1.5, show synergistic effect.
The toxicity test result of Pathogen of Take-all, sheath blight fungus is considered from composite reagent, in combination with production and use
The compound proportion of many factors such as medicine cost, preferably benzene metsulfovax and epoxiconazole is 3:When 7, it is withered for Pathogen of Take-all and line
Germ has best inhibition, and Bactericidal composite composition formula is determined and according to each group dtex by the screening system of agricultural agent
Property optimized production process, embodiment is as follows：
Embodiment 1
The preparation method of 10% benzene metsulfovax epoxiconazole oil-suspending agent：By mass percentage.
Preparation method：According to formula, above component is weighed in proportion, ball mill ball milling is added 30 minutes, filters, is pumped into
Dispersion tank high speed shear is fully ground after 3 minutes through sand mill, and control solid constituent particle diameter is within 2 microns, grinding knot
Stirred after beam, produce suspending agent product.
Embodiment 2
The preparation method of 20% benzene metsulfovax epoxiconazole oil-suspending agent：By mass percentage.
Preparation method, be the same as Example 1.
Embodiment 3
The preparation method of 30% benzene metsulfovax epoxiconazole oil-suspending agent：By mass percentage.
Preparation method, be the same as Example 1.
Wheat sharp eyespot is carried out to embodiment and full rot field control effect is determined：
Embodiment is as follows：
Trial crops wheat is set：The ㎡ of plot area 20,4 repetitions, random alignment sets protection row between each processing.
Foliar spray processing is carried out respectively at early April, dispenser 2 times is spaced 7 days, 600 liters of per hectare, even spraying, separately
If spraying the blank control of clear water.Banded sclerotial blight disease index investigation is carried out before chemicals treatment, in being adjusted respectively before wheat ripe and harvested
Look into wheat sharp eyespot and full rot incidence.
Investigation method, classification, drug effect, which are calculated, is performed both by National Standard of the People's Republic of China《Farmland test of pesticide effectiveness criterion》.
The reagent agent experimental design of table 3 and result
Claims (6)
1. a kind of bactericidal composition containing benzene metsulfovax and epoxiconazole, it is characterised in that：In described bactericidal composition, benzene thiophene bacterium
The mass ratio of amine and epoxiconazole is 1：50~50：1.
2. bactericidal composition according to claim 1, it is characterised in that：It is preferred that benzene metsulfovax and epoxiconazole mass ratio
For 3：7.
3. the bactericidal composition according to claim any one of 1-2, it is characterised in that also helped comprising agriculturally acceptable
Agent, the weight/mass percentage composition of active component is 6-50%.
4. the bactericidal composition according to any one of claim 3, it is characterised in that described auxiliary agent includes wetting and dispersing
Agent, emulsifying agent, thickener, defoamer, bleeding agent, oil phase carrier.
5. bactericidal composition according to claim 4, it is characterised in that：The formulation that composition can be prepared into suspends for oil
Agent.
6. the bactericidal composition according to claim any one of 1-5 can be used for preventing and treating take-all, wheat sharp eyespot etc.
A variety of fungal diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710387664.1A CN107156154A (en) | 2017-05-27 | 2017-05-27 | A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710387664.1A CN107156154A (en) | 2017-05-27 | 2017-05-27 | A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole |
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| Publication Number | Publication Date |
|---|---|
| CN107156154A true CN107156154A (en) | 2017-09-15 |
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ID=59821014
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710387664.1A Pending CN107156154A (en) | 2017-05-27 | 2017-05-27 | A kind of bactericidal composition containing benzene metsulfovax and epoxiconazole |
Country Status (1)
| Country | Link |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103563923A (en) * | 2012-08-04 | 2014-02-12 | 南京华洲药业有限公司 | Bactericidal composition containing thifluzamide and epoxiconazole and application thereof |
-
2017
- 2017-05-27 CN CN201710387664.1A patent/CN107156154A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103563923A (en) * | 2012-08-04 | 2014-02-12 | 南京华洲药业有限公司 | Bactericidal composition containing thifluzamide and epoxiconazole and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张一宾: "杀菌剂苯噻菌胺酯（benthiavalicarb-isopropyl）的开发沿革", 《世界农药》 * |
| 马双寅等: "12.5%氟环唑悬浮剂防治小麦纹枯病", 《农业技术与装备》 * |
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Application publication date: 20170915 |
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