CN107149579A - A kind of creams for pressing down acne effect plant composition containing oil-control - Google Patents
A kind of creams for pressing down acne effect plant composition containing oil-control Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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Abstract
The invention discloses a kind of creams for pressing down acne effect plant composition containing oil-control；Aim to provide one kind can effectively oil-control excessive secretion and convergence pore, so as to suppress small pox, have no toxic side effect, and to the creams of no skin irritation, technical points：The creams mainly include the component of following mass percents：The oily esters 2 6% of glycerin polyether 8 of plant composition 1 6%, the alcohol 0.05 0.1% of o cymenes 5, Babassu seed, Queensland nut seed oil 1 5%, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers 0.1 0.3%, Sodium Hyaluronate 0.01 0.1%, matrix 82.5 95.84%, the plant composition are formed by the careless extract extract solution of the garment or robe made of feathers, sweet basil leaf extract extract solution and peanut seed capsule extract extract solution compounding；Belong to cosmetic field.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of to press down the creams of acne effect plant composition containing oil-control and be somebody's turn to do
The preparation method of creams.
Background technology
Small pox is pilosebaceous follicle chronic inflammatory skin caused by many factors, and vigorous fat secretion is one of them
Major incentive, it is a kind of method of practicable to suppress small pox by oil-control.
Oil-control refers to the oil quantity for adjusting skin secretion, and existing oil control method mainly using cleaning face or uses control
Oil skin care products.Wherein, it is only the oil-control in physical significance by cleaning face, can only achieve of short duration oil-control effect, not
There is the problem of fundamentally solving fuel-displaced long acne.
Oil-control skin-protection product on the market realizes control or regulation sebum secretion by adding various plants extract at present
Purpose, but oil-control suppression acne effect still not substantially, it is necessary to which being used for a long time to embody.
The performance difference of the oil-control product of different plant extracts interworkings is larger.Therefore, which plant extract selected
Thing is compounded, and being applied to obtained plant composition safety in skin care item to reach more preferable oil-control effect, is entered
And the generation for suppressing small pox is realized, it is this area urgent problem to be solved.
The content of the invention
In view of the above-mentioned problems, it is an object of the invention to provide one kind using natural component as Effect raw material, can effectively suppress
Grease excessive secretion and convergence pore, so as to suppress small pox, have no toxic side effect and to the creams of no skin irritation.
To solve above technical problem, the technical scheme that the present invention is provided is such：
A kind of creams for pressing down acne effect plant composition containing oil-control, component that the creams mainly include and the component
Mass percent is as follows：
The plant composition is formed by the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution compounding.
The weight proportion of the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution is 5-8：1.5-4.5：
0.5-1.5。
It is preferred that, the component and the mass percent of the component that the creams mainly include are as follows：
In the plant composition, the compound proportion of garment or robe made of feathers grass extract solution, sweet basil leaf extract and peanut seed capsule extract solution
To be converted in terms of raw material garment or robe made of feathers grass, sweet basil leaf and the dry weight of peanut seed capsule, weight proportion is 6：3：1.
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the careless extract solution of the garment or robe made of feathers is with dry
Dry garment or robe made of feathers grass is raw material, through 70-80% ethanol water refluxing extractions, and is concentrated under reduced pressure into medicinal extract, then medicinal extract is mixed with water
Polyphenol content is 0.1-0.2mg/g in the careless extract solution of the garment or robe made of feathers through decolourizing to obtain after conjunction, the careless extract solution of every 1 gram of garment or robe made of feathers.
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the careless extract solution of the garment or robe made of feathers be by
Extract what is obtained according to following methods：After taking garment or robe made of feathers grass meal broken, the ratio of 10-30ml Extraction solvents is added in every gram of garment or robe made of feathers grass, with
70-80% ethanol waters are Extraction solvent, the heating and refluxing extraction 30-60min under the conditions of 70-80 DEG C, by extract solution in 40-
Medicinal extract is concentrated under reduced pressure under conditions of 50 DEG C, cocnentration factor is 1：1.1-1.3, then take medicinal extract mixed with water after through macroporous absorbent resin
Decolourize, then with the volume ratio of water and ethanol be 8:1 ethanol water elution, produces the careless extract solution of the garment or robe made of feathers.
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the sweet basil leaf extract is with dry
Dry sweet basil leaf is raw material, through distilled water Microwave Extraction and filter, the sweet basil leaf extract that centrifugal treating is obtained, every 1 Crow is strangled
Polyphenol content is 0.5-1.2mg/g in leaf extract.
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the sweet basil leaf extract be by
Extract what is obtained according to following methods：After sweet basil leaf is crushed, the ratio of 20-40ml distilled water is added in every gram of sweet basil leaf, micro-
10-30min is extracted under wave power 400-600W, is filtered, is centrifuged 5-6min under conditions of rotating speed 3000-5000r/min, take
Clear liquid, produces sweet basil leaf extract.
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the peanut seed capsule extract solution with
Dry peanut seed capsule is raw material, after being mixed through the 60-80% ethanol solutions with nitrogen charging deoxygenation, under the protection of nitrogen, microwave
It is 0.1-0.5mg/ to extract polyphenol content in the peanut seed capsule extract solution that simultaneously centrifugal treating is obtained, every 1 gram of peanut seed capsule extract solution
g。
It is preferred that, a kind of above-mentioned creams for pressing down acne effect plant composition containing oil-control, the peanut seed capsule extract solution is
Extract what is obtained in accordance with the following methods：After peanut seed capsule is crushed, in the ratio of every gram of peanut seed capsule 10-15ml Extraction solvent,
Using 60-80% ethanol solution as Extraction solvent, it is added to after being well mixed in extracting tube, under nitrogen protection, in microwave power
To accelerate extraction 70-100s at 500-700W, 50-70 DEG C of temperature, repeat 1-3 times, combining extraction liquid, centrifuged peanut kind
Skin extract solution.
The preparation method of creams of the present invention is adopted for the key component in inventive formulation is mixed with this area conventional substrate
It is made with the conventional creams preparation method in this area.
The matrix of the present invention is by bisabolol, tocopherol acetate, biological carbohydrate gum -1, allantoin, butanediol, water, benzene oxygen
Ethanol/Sensiva SC50, essence composition, the mass percent sum of each component is 82.5-95.84%.
Compared with prior art, the technical scheme that the present invention is provided has the advantages that：
The present invention is conscientiously studied oil-control suppression acne effect of numerous plant extraction liquids, selectes garment or robe made of feathers grass, sweet basil leaf
With peanut seed capsule as raw material, the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut are prepared by specific technique respectively
Kind of skin extract solution, and three kinds of extract solutions are compounded in specific proportions obtain plant composition.
Wherein：
Garment or robe made of feathers grass belongs to herbaceous plant, also known as duck's-foot for rose family duck's-foot, rich in tannic acid tannin, salicylic acid, flavonoids
With plant polyphenol etc., mainly there is gentle convergence pore, the grease of Oily is adjusted, and lipoxidase -5 is lived
Property have suppression, i.e., can the calm skin for relaxing inflammation and allergy with anti-inflammatory；In addition, also disappear with wide spectrum free radical
Except function, there is preferable inhibition to elastoser, available for crease-resistant and anti-ageing.
Sweet basil is labiate Ocimum annual herb plant, also known as hair sweet basil, Lan Xiang etc., 0.02- containing volatile oil
0.04%, main component is ocimenum, 1, 8-Cineole, linalool, estragole etc., non-volatile component have cupreol,
Daucosterol, stigmasterol and its glucosides；Flavones has Kaempferol, apiolin, quercetin and its glycoside；Phenolic acid has Rosmarinic acid etc..Grind
Study carefully and show, sweet basil leaf extract has preferable suppression to staphylococcus aureus, bacillus subtilis, aspergillus niger, pityrosporum furfur
Make and use, and can also effectively suppress the activity of 5α-reductase.
Peanut seed capsule also known as the red skin of peanut red coat, peanut, peanut-skin red etc., sweet, slight bitter are mild-natured, have hemostasis stasis, disappear
The key agents for treating anaemia and haemorrhage the effect of swollen, have concurrently tonifying kidney and nourishing stomach, moisten the lung and relieve the cough, tonifying middle-Jiao and Qi, detoxicating intestine
Curative effect,《Compendium of Materia Medica》With《Pharmacopoea Chinensis》Deng on the books in book.Modern pharmacological research also indicates that peanut red coat has only
Blood is acted on, and peanut seed capsule extract solution is extracted by the reddish brown thin skin of shelled peanut outer layer, rich in polyphenol hydroxyl compound, including list
Rather, gallic acid, catechin, anthocyanidin, chlorogenic acid, forulic acid etc., with anti-oxidant, antifibrin dissolving, anti-inflammatory, resistance
Hinder the effect of saccharification reaction, antibacterial, prevention whelk, fat leakage property dermatitis etc..
The present invention is using plant composition as active component, with o- cymene -5- alcohol, the oily ester of glycerin polyether -8 of Babassu seed
The oily three kinds of composition Synergistics of class, Queensland nut seed, obtain that scientific formulation is rigorous, have no toxic side effect and to no skin irritation
Creams, the creams can effectively oil-control excessive secretion and convergence pore, so as to suppress small pox.Wherein：
O- cymene -5- alcohol has effect as a kind of broad-spectrum germicide to bacterium, saccharomycete, fungi, virus etc.,
Can be at some extent as anti-acne agent, and itself is without harmful substances such as halogen, heavy metal, hormones, can be with
The ultraviolet of specific wavelength is absorbed, while having the ability for suppressing to aoxidize.
The Babassu seed oil esters of glycerin polyether -8 can significantly improve superoxide dismutase in red blood cell (SOD) vigor,
To delaying body aging, moisturizing improves skin protective capacities.It can make to cause the material white three of allergy dilute small with intermediate blood simultaneously
The yield of plate aggegation activation factor (PAF) is significantly reduced, wherein not only having inoxidizability, anticoagulation containing Alecrim acid, resisting
Bacterium anti-inflammatory, antiviral isoreactivity, but also with very strong inoxidizability, suppress allergic reaction.
Queensland nut seed oil extract is from macadamia, and ingredient is similar to sebum, can alleviate drying, prevent skin
Water loss, ductility is good, and permeability is good, does not stimulate gently.
Brief description of the drawings
Fig. 1 is that each test specimen suppression fat rate changes with time situation.
Embodiment
With reference to embodiment, technical scheme is described in further detail, but not constituted pair
Any limitation of the present invention, the modification of anyone limited number of time made within the scope of the present invention, still the present invention's
Within protection domain.
It should be noted that the raw material employed in the technical scheme that the present invention is provided, unless otherwise specified, by normal
Rule means are prepared or bought by commercial channel.
The preparation of the garment or robe made of feathers of embodiment 1 grass extract solution, sweet basil leaf extract and peanut seed capsule extract solution
Garment or robe made of feathers grass, sweet basil leaf and peanut seed capsule drying to water content 5-10% in the present embodiment, then in accordance with the following methods
The careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution are prepared respectively：
The careless extract solution of the garment or robe made of feathers is extracted in accordance with the following methods to be obtained：After taking 10g garment or robe made of feathers grass meals broken, 200ml is added
75% ethanol water, extract solution is concentrated under reduced pressure by the heating and refluxing extraction 40min under the conditions of 80 DEG C under conditions of 45 DEG C
Into medicinal extract, cocnentration factor is 1：1.2, then take medicinal extract to be decolourized after being mixed with water through macroporous absorbent resin, then with the volume of water and ethanol
Than for 8:1 ethanol water elution, produces the careless extract solution of the garment or robe made of feathers.The careless extract solution of the obtained garment or robe made of feathers, every 1 are extracted in the method
Polyphenol content is 0.1mg/g in the careless extract solution of gram garment or robe made of feathers.
The sweet basil leaf extract is extracted in accordance with the following methods to be obtained：After 10g sweet basil leafs are crushed, 300ml is added
Distilled water, extracts 20min under microwave power 500W, filtering, centrifuges 5min under conditions of rotating speed 3000r/min, takes supernatant
Liquid, produces sweet basil leaf extract.Obtained sweet basil leaf extract is extracted in the method, and polyphenol in leaf extract is strangled in every 1 Crow
Content is 1.2mg/g.The peanut seed capsule extract solution is extracted in accordance with the following methods to be obtained：After 10g peanut seed capsules are crushed,
150ml 60% ethanol solution is added, is added to after being well mixed in extracting tube, under nitrogen protection, is in microwave power
Accelerate extraction 100s under 600W, temperature 50 C, repeat 1-3 times, combining extraction liquid, centrifuged extract solution produces peanut kind
Skin extract solution.Extracting polyphenol content in obtained peanut seed capsule extract solution, every 1 gram of peanut seed capsule extract solution in the method is
0.45mg/g。
Embodiment 2 has the preparation of the plant composition of oil-control suppression acne effect
The careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and the peanut seed capsule extract solution that embodiment 1 is prepared are according to 6：3：1
Part by weight be well mixed.
The careless extract solution 6g of the above-mentioned garment or robe made of feathers prepared, sweet basil leaf extract 3g and peanut seed capsule extract solution 1g are mixed
The plant composition that there is 10g oil-control to press down acne effect is obtained after compounding.
Composition is made by being atomized to extract in garment or robe made of feathers grass, sweet basil leaf and peanut seed capsule by embodiment 3
Garment or robe made of feathers grass, sweet basil leaf and peanut seed capsule drying to water content 5-10% in the present embodiment, then in accordance with the following methods
Composition is prepared respectively：
1) garment or robe made of feathers grass, sweet basil leaf and peanut seed capsule are crushed respectively, weighs garment or robe made of feathers grass meal end 60kg, sweet basil leaf powder 30kg
With peanut seed capsule powder 10kg, mix, cross 40-80 sieve meshes, obtain hybrid fine particles；
2) it is 1 by the mass ratio of hybrid fine particles and solvent:5-20,50-70% ethanol is added into hybrid fine particles, obtains mixed
Suspension；
3) using atomizer by step 2) obtained suspension is atomized, and liquid mist natural subsidence reverts to suspension, collects mixed
Suspension, keeping temperature is 25-35 DEG C；
4) by step 3) obtained suspension filtered, and obtains clear liquid and residue；
5) by step 4) obtained clear liquid heated, isolates ethanol, obtain plant composition.
Embodiment 4 suppresses 5α-reductase experiment
The fat content of skin is one of mostly important physical signs of skin of face, and the skin of normal health should be light
It is sliding, fine and smooth, and high resilience.And skin oil and fat hypersecretion or very few, not only influence attractive in appearance or even many of skin can be triggered
Plant disease.
At present by detecting that the inhibition of 5α-reductase can react the effect that sebum is adjusted.
5α-reductase in the presence of reduced Coenzyme II by testosterone T catalyzed transitions be protona, if in the presence of 5 α-also
Reductase inhibitor, can just suppress this course of reaction to a certain extent.Because reduced Coenzyme II has feature at 340nm wavelength
Absorb, participate in the oxidized coenzyme Ⅱ characteristic absorption disappearance at 340nm wavelength generated after reaction.Entered with ultraviolet specrophotometer
Row is determined, and certain material can be reflected to whether inhibited and inhibitory action the size of 5α-reductase.
Through repetition test, the 5α-reductase catalystic converter system that cumulative volume is 100 μ L is established.Each composition reaction system
Each reagent dosage (μ L) is shown in Table 1.
Table 1
The measure of blank control：Testosterone T, 5α-reductase, phosphate buffer (pH=7.4), also are added in reaction tube
Determined after prototype codehydrogenase Ⅱ, mixing and absorbance is determined after absorbance, 37 DEG C of constant-temperature incubation 60min, deduct reduced Coenzyme II empty
It is white to decline background values, measure blank drop-out value Δ A0=0.066.
The measure of inhibitory action：Testosterone T, 5α-reductase, inhibitor, phosphate buffer (pH=are added in reaction tube
7.4) determined after, reduced Coenzyme II, mixing and absorbance is determined after absorbance, 37 DEG C of constant-temperature incubation 60min, deduct reduced form auxiliary
The blank of enzyme II declines background values, measures inhibitor drop-out value (Δ An).Measurement result is shown in Table 2.
Using Finasteride as positive drug, judge whether the activity of enzyme is suppressed, and the size of primary Calculation inhibiting rate.Calculate
Formula is I (%)=(Δ A0- Δ An)/Δ A0× 100%.Result of calculation is shown in Table 2.
Table 2
Remarks：The careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution in Tables 1 and 2 are embodiment 1
Each extract solution of middle preparation；Composition A is the plant composition that provides in embodiment 2；Composition B is offer in embodiment 3
Plant composition (wherein test consumption be 10g).
Garment or robe made of feathers grass, sweet basil leaf and the single plant of peanut seed capsule made from the embodiment of the present invention 1 it can be seen from the result of table 2
Thing extract solution, composition A, composition B have different degrees of inhibitory action, but composition A inhibiting rate to 5α-reductase
Close to positive control Finasteride, show the careless extract solution of the garment or robe made of feathers, the sweet basil leaf extract prepared by specific technique
With peanut seed capsule extract solution according to 6：3：The plant composition that 1 part by weight compounding is obtained, in 5α-reductase inhibitory action
With good synergy.
The orthogonal test of embodiment 5
Using Three factors-levels orthogonal test, answering for garment or robe made of feathers grass, sweet basil leaf and three kinds of functional components of peanut seed capsule is determined
With ratio.
The orthogonal test scheme table of table 3
The orthogonal experiments of table 4
Above-mentioned each test combinations are to be compounded the extract solution of each factor in table 3 according to the level.
As seen from the results in Table 4, the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution are to 5α-reductase
Inhibiting rate has an impact, and wherein influence of the careless extract solution of the garment or robe made of feathers to inhibiting rate is maximum, is secondly sweet basil leaf extract；Institute of the present invention
The optimum compound proportion of determination is the careless extract solution 6g of the garment or robe made of feathers, sweet basil leaf extract 3g, peanut seed capsule extract solution 1g, i.e. A3B3C2For most
Good combination.
That is, the careless extract solution of the garment or robe made of feathers that the present invention is prepared by specific technique, sweet basil leaf extract and
Peanut seed capsule extract solution is according to 6：3：The suppression 5α-reductase of the well mixed plant composition prepared of 1 part by weight
Best results.
In order to better illustrate beneficial effects of the present invention, the present invention provides embodiment 6-8 and comparative example 1-3 creams are matched somebody with somebody
Side's (being shown in Table 5), and efficacy validation experiment is carried out to them：
Table 5
The preparation method of embodiment 6-8 and comparative example 1-3 creams be by the component in respective Example formulations with
This area customary adjuvant mixing, is made using the conventional creams preparation method in this area.
Matrix in embodiment 8 and comparative example 1-3 creams is completely the same, does not bring the effect of Synergistic, is worth
Illustrate, the influence factor of matrix can be ignored in efficacy validation experiment.
(1) oil-control compliance test result test
1. the crowd of experiment：Selection skin characteristic is Oily, subject totally 50 people of slight and moderate whelk skin,
Age 18-40 Sui, it is randomly divided into 5 groups, every group of 10 people.
2. test specimen：
(1) creams of embodiment 8 and comparative example 1-3 creams.
(2) common commercially available oil-control creams.
3. test method：
Before test, first allow every group of subject's cleaning facial, then select tested region and blank control region in forehead, then
The fat content in above-mentioned two region is tested with skin oil and fat tester SM815, tests 3-5 times and averages, be designated as experimental group
Originate fat content and blank group starting fat content.
Every group of subject is used after test specimen, and fat content is tested in 0.5h, 1h, 2h, 4h, is tested 3-5 times and is averaged
Value, record experimental group fat content and blank group fat content.
The numerical value measured is counted, the fat content changing rule of analyzing skin, concrete outcome is shown in Table 6 respectively.Wherein,
Grease increment rate=(fat content-starting fat content)/starting fat content.
Grease relative increase rate (pressing down fat rate)=(experimental group fat content-blank group fat content)/blank group grease
Content.The value is smaller, illustrates that test specimen is more obvious with respect to blank sample suppression fat effect.
Table 6
The result of table 6 shows that the skin oil and fat content minimizing effect of the creams of embodiment 8 is superior to commercially available oil-control creams
And comparative example 1-3 creams, illustrate plant composition and o- cymene -5- alcohol, the oily esters of glycerin polyether -8 of Babassu seed, Australia
There is synergistic function in terms of oil-control secretion in the oily three kinds of compositions of continent nut seed.
(2) oil-control excessive secretion and convergence pore compliance test result test
1. the crowd of experiment：Selection skin characteristic is Oily, the subject totally 140 of slight and moderate whelk skin
People, age 18-40 Sui, is randomly divided into 7 groups, every group of 20 people.
2. test specimen：
(1) embodiment 6-8 creams and comparative example 1-3 creams.
(2) common commercially available oil-control creams.
3. test method：
Test specimen is used after the daily morning and evening face cleaning of above each group subject, after 28 days, skin is directed to test sample
The glossy reduction of skin and pore shrink two aspects and use feeling evaluation are carried out within 1-10 divides, and wherein 6-10 points are obvious for effect,
3-6 points general for effect, and less than 3 points are that average score the results are shown in Table shown in 7 without positive effect.
Table 7
Embodiment 6-8 is respectively provided with the effect of oil-control excessive secretion and convergence pore it can be seen from the result of table 7,
And the evaluation effect of the creams of embodiment 8 is substantially better than commercially available oil-control creams and comparative example 1-3 creams, illustrates plant group
Compound and o- cymene -5- alcohol, the oily esters of glycerin polyether -8 of Babassu seed, the oily three kinds of composition Synergistics of Queensland nut seed,
Effect in terms of oil-control excessive secretion and convergence pore is obvious.
(3) acne compliance test result test is pressed down
1. the crowd of experiment：Selection skin characteristic is Oily, the subject totally 140 of slight and moderate whelk skin
People, age 18-40 Sui, is randomly divided into 7 groups, every group of 20 people.
2. test specimen：
(1) embodiment 6-8 creams and comparative example 1-3 creams.
(2) common commercially available oil-control creams.
3. test method：
Test specimen is used after the daily morning and evening face cleaning of above each group subject, after 28 days, subject is to suppression acne effect
Use feeling evaluation is carried out, evaluation result is counted, is specifically shown in Table 8 per capita.
Table 8
It can be seen from the result of table 8 evaluation effect of the creams of embodiment 8 be substantially better than commercially available oil-control creams and
Comparative example 1-3 creams, illustrate that plant composition and o- cymene -5- alcohol, the oily esters of glycerin polyether -8 of Babassu seed, Australia are hard
Fruit seed three kinds of composition Synergistics of oil, it is obvious in the effect for suppressing small pox.
(4) horn cell cytotoxicity checking test
Contain 5%CO at 37 DEG C2Wet environment under carry out, use pork individual layer horn cell (keratocyte) with it is real
The creams that a 6-8 prepares are applied to be contacted.Measured respectively after 10 minutes, 1 hour, 4 hours.As a result show to implement
The creams that example 6-8 is prepared do not cause cytotoxicity.
In summary, the present invention first passes through specific technique and prepares the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and flower
Non-hibernating eggs skin extract solution, plant composition is obtained by these three extract solutions compounding, then using the plant composition as active component, with o-
The oily esters of glycerin polyether -8 of cymene -5- alcohol, Babassu seed, the oily three kinds of composition Synergistics of Queensland nut seed, obtain formula section
Learn it is rigorous, have no toxic side effect, to the creams of no skin irritation, the creams effectively oil-control excessive secretion and can restrain hair
Hole, so as to suppress small pox.
Claims (10)
1. it is a kind of containing oil-control press down acne effect plant composition creams, it is characterised in that the component that the creams mainly include with
And the mass percent of each component is as follows：
The plant composition is formed by the careless extract solution of the garment or robe made of feathers, sweet basil leaf extract and peanut seed capsule extract solution compounding.
2. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 1, it is characterised in that the plumage
The weight proportion of clothing grass extract solution, sweet basil leaf extract and peanut seed capsule extract solution is 5-8：1.5-4.5：0.5-1.5.
3. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 1, it is characterised in that the breast
The component and the mass percent of the component that frost mainly includes are as follows：
In the plant composition, garment or robe made of feathers grass extract solution, the compound proportion of sweet basil leaf extract and peanut seed capsule extract solution are to roll over
The dry weight meter of raw material garment or robe made of feathers grass, sweet basil leaf and peanut seed capsule is counted as, weight proportion is 6：3：1.
4. according to a kind of any described creams for pressing down acne effect plant composition containing oil-control of claims 1 to 3, its feature exists
In the careless extract solution of the garment or robe made of feathers, for raw material, through 70-80% ethanol water refluxing extractions, and is depressurized dense with dry garment or robe made of feathers grass
Shorten medicinal extract into, then the careless extract solution of the garment or robe made of feathers through decolourizing to obtain after medicinal extract is mixed with water, polyphenol contains in the careless extract solution of every 1 gram of garment or robe made of feathers
Measure as 0.1-0.2mg/g.
5. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 4, it is characterised in that the plumage
Clothing grass extract solution is extracted in accordance with the following methods to be obtained：After taking garment or robe made of feathers grass meal broken, add 10-30ml by every gram of garment or robe made of feathers grass and extract
The ratio of solvent, using 70-80% ethanol waters as Extraction solvent, the heating and refluxing extraction 30-60min under the conditions of 70-80 DEG C,
Extract solution is concentrated under reduced pressure into medicinal extract under conditions of 40-50 DEG C, cocnentration factor is 1：1.1-1.3, then take after medicinal extract mixes with water
Decolourized through macroporous absorbent resin, then with the volume ratio of water and ethanol be 8:1 ethanol water elution, produces garment or robe made of feathers grass extraction
Liquid.
6. according to a kind of any described creams for pressing down acne effect plant composition containing oil-control of claims 1 to 3, its feature exists
In, the sweet basil leaf extract using dry sweet basil leaf as raw material, through distilled water Microwave Extraction and filter, centrifugal treating is obtained
Sweet basil leaf extract, it is 0.5-1.2mg/g that polyphenol content in leaf extract is strangled in every 1 Crow.
7. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 6, it is characterised in that sieve
Le leaf extract is extracted in accordance with the following methods to be obtained：After sweet basil leaf is crushed, 20-40ml distillations are added by every gram of sweet basil leaf
The ratio of water, extracts 10-30min under microwave power 400-600W, filtering, under conditions of rotating speed 3000-5000r/min from
Heart 5-6min, takes supernatant, produces sweet basil leaf extract.
8. according to a kind of any described creams for pressing down acne effect plant composition containing oil-control of claims 1 to 3, its feature exists
In the peanut seed capsule extract solution is mixed using dry peanut seed capsule as raw material through the 60-80% ethanol solutions with nitrogen charging deoxygenation
Afterwards, under the protection of nitrogen, the peanut seed capsule extract solution that microwave abstracting and centrifugal treating are obtained, every 1 gram of peanut seed capsule extract solution
Middle polyphenol content is 0.1-0.5mg/g.
9. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 8, it is characterised in that the flower
Non-hibernating eggs skin extract solution is extracted in accordance with the following methods to be obtained：After peanut seed capsule is crushed, carried by every gram of peanut seed capsule 10-15ml
The ratio of solvent is taken, using 60-80% ethanol solution as Extraction solvent, is added to after being well mixed in extracting tube, nitrogen protection
Under, accelerate extraction 70-100s in the case where microwave power is 500-700W, 50-70 DEG C of temperature, repeat 1-3 times, combining extraction liquid, warp
Centrifugation obtains peanut seed capsule extract solution.
10. a kind of creams for pressing down acne effect plant composition containing oil-control according to claim 1, it is characterised in that described
Matrix is sweet by bisabolol, tocopherol acetate, biological carbohydrate gum -1, allantoin, butanediol, water, Phenoxyethanol/ethylhexyl
Oil, essence composition, the mass percent sum of each component is 82.5-95.84%.
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