KR101236946B1 - Cosmetic Composition Comprising Naturalplant Extract for Alleviating Atopic Dermatitis - Google Patents

Abstract

The present invention relates to a cosmetic composition for alleviating atopic dermatitis comprising a vegetable extract, wherein the composition is selected from the group consisting of roundle, mackmundong, triticale, lemon balm, sage, evening primrose, lavender, rosemary and chamomile Contains vegetable extract as an active ingredient.
The cosmetic composition for atopic dermatitis relief according to the present invention can alleviate the itch caused by atopic dermatitis and improve the antibacterial, moisturizing and immune function of the skin, and thus can be effectively applied to the prevention and improvement treatment of atopic dermatitis.

Description

Cosmetic composition for atopic dermatitis alleviation comprising a vegetable extract {Cosmetic Composition Comprising Naturalplant Extract for Alleviating Atopic Dermatitis}

The present invention relates to a cosmetic composition for atopic dermatitis alleviation comprising a vegetable extract.

People (0.5% -1% of the world's population, 5-10% of children) suffer from atopic dermatitis, which is a very itchy eczema that occurs in people with atopic dermatitis. Atopic dermatitis is a genetic disease that has not yet been reliably identified for the cause of it. It is known that the onset and deterioration of environmental factors are largely involved. In addition, dry skin, the characteristics of skin itching easier than normal people, infections caused by bacteria, viruses, fungi, emotional factors, environmental factors seems to be caused by a combination of each other.

Several compositions have been proposed as a method for treating dry skin and itching of atopic dermatitis, but all of these compositions are pharmaceutical compositions, most of which contain steroid preparations or antibiotics as active ingredients. There is a fear that serious side effects such as bloating and increasing thickness of the stratum corneum or causing dilating are caused. In addition, the conventional atopic dermatitis treatment agent is prepared by adding a chemical to the ointment base, which is usually effective for skin diseases, there is a problem that side effects may occur in the skin that does not use natural ingredients to cause a sensitive reaction to the drug, In addition, even if atopic diseases were treated using existing atopy treatments, the recurrences are frequently recurred, which is difficult to cure.

An object of the present invention for solving the above problems is to provide an atopic dermatitis improving effect and excellent sustainability of the effect, to provide a cosmetic composition for atopic dermatitis relief comprising a natural plant extract safe to the human body.

Another object of the present invention to provide a topical dermatitis for atopic dermatitis relief comprising the cosmetic composition for atopic dermatitis relief.

Still another object of the present invention is to provide atopic dermatitis relief cosmetics comprising the cosmetic composition for atopic dermatitis relief.

According to an aspect of the present invention,

The present invention relates to a cosmetic composition for alleviating atopic dermatitis, comprising as an active ingredient a single or two or more vegetable extracts selected from the group consisting of roundles, macmundong, triticale, lemon balm, sage, evening primrose, lavender, rosemary and chamomile.

The vegetable extract may be included in an amount of 0.01 to 10 parts by weight based on 100 parts by weight of the composition.

The vegetable extract is round (1-3): Mcmundong (1-3): three hundred seconds (1-3): lemon balm (1-3): sage (1-3): evening primrose (1-3): lavender ( 1 to 3): Rosemary (1 to 3): Chamomile (1 to 3 times by weight).

The vegetable extract is extracted using 3 to 10 times the amount of purified water, lower alcohol having 1 to 2 carbon atoms, propylene glycol, ethyl acetate or butylene glycol solvent, or a mixed solvent thereof, based on the dry weight of the plant. Can be.

The cosmetic composition for alleviating atopic dermatitis may further include at least one additive selected from the group consisting of oil, water, surfactants, moisturizers, thickeners, chelating agents, pigments, preservatives and fragrances.

According to another aspect of the present invention,

It relates to atopic dermatitis relief skin external preparations comprising the cosmetic composition for atopic dermatitis relief.

Another aspect of the invention,

It relates to atopic dermatitis relief cosmetics comprising the cosmetic composition for atopic dermatitis relief.

The cosmetics may be one or more selected from the group consisting of essences, whitening creams, lotions, emulsions, packs, general cosmetics, skin milks, creams, serums, cosmetic soaps, softening cosmetics, medicinal cosmetics, hair toes and systemic cleansers.

The cosmetic composition for atopic dermatitis relief according to the present invention is excellent in inhibiting atopic dermatitis, antimicrobial activity and immunomodulatory effect and is effective in preventing and improving atopic dermatitis.

The cosmetic composition for atopic dermatitis relief according to the present invention is safe and non-irritating to the human body, and excellent in skin penetration, compared to the atopic therapeutic agent consisting of conventional chemicals.

Cosmetic composition for atopic dermatitis relief according to the present invention is excellent in the therapeutic effect of atopic dermatitis and excellent in the persistence of the effect can lower the recurrence rate of atopic dermatitis.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily practice.

The present invention provides a cosmetic composition for atopic dermatitis relief.

The cosmetic composition for atopic dermatitis alleviation is excellent in antibacterial and moisturizing power and immunity to reduce the symptoms caused by atopic diseases and inflammatory diseases, and lower the risk of recurrence of the skin disease.

The cosmetic composition for atopic dermatitis alleviation includes a natural vegetable extract as an active ingredient.

The natural botanical extract is a natural extract or essential oil extracted from the plant, and has excellent atopic dermatitis suppression, antibacterial, and immunomodulatory effects, and little irritation to the mucous membranes of the human body, especially the skin, eyes, and eyes.

The natural plant extracts may include herbal extracts or herbal extracts.

Oriental Medicine  extract

The herbal extract may comprise an extract of roundle, mammundong or three hundred seconds.

Polygonatum odoratum there is . pluriflorum ) is a perennial herb belonging to the family Liliaceae, and early spring young leaves and root stems are used for food, and in autumn, they are used for nourishing, tonic, and antipyretic.

Ophiophogon japonicus belongs to the Ophiopogoneae of the Liliaceae family, and the root muscle contains sugars (sucrose, fructose) and ρ-sitosterol-steroidal saponin to help lung function, relieve limb pain, neuralgia, rheumatism and cough. It is also effective in calming and cooling phlegm and reducing fever.

The three hundred seconds ( Saururus chinensis ) is a perennial herb that belongs to more than three hundred years, and contains ingredients such as querchithrin, isoquerchithrine, and flavonoids, which have excellent anti-inflammatory and anticancer effects, and provide excellent anti-inflammatory effect due to its strong bactericidal and detoxifying effects. do.

Herbal extract

The herbal extract may include extracts of lemon balm, sage, evening primrose, lavender, rosemary or chamomile.

The lemon balm ( Melissa officinalis ) is a perennial herb belonging to the Lamiaceae, with detoxification, virus prevention, skin soothing effect and sensitive skin softening, regulating skin sebum production and reducing skin trouble, which is effective in antibacterial, sterilizing and astringent action. have.

The sage ( Salvia officinalis ) is a perennial herb belonging to the Lamiaceae and has a sterilizing and disinfecting effect such as water supply, antiseptic, antibacterial, and anti-inflammatory, and is excellent as an anti-inflammatory agent of various inflammations and soothes the skin and keeps the skin moist.

The evening primrose ( Oenothera odorata ) is a biennial plant belonging to the family Pinaceae, improves blood circulation, inhibits the body's inflammatory response and inflammation-causing substances, and has excellent effects on atopic dermatitis and other dermatitis.

Lavender ( Lavandula officinalis ) is an evergreen perennial herb of Lamiaceae and has a soothing and healing action, cell regeneration and antibacterial and bactericidal effects, and is effective in various dermatitis including atopic dermatitis.

The rosemary ( Rosmarinus officinalis ) has an excellent effect of soothing and converging skin, has a bactericidal and antibacterial effect, and has an excellent skin soothing effect by preventing skin aging.

The chamomile ( Anthemis nobilis ) is very low toxicity, suitable for sensitive skin, dry and damaged skin and effective for most skin diseases, has a softening, moisturizing and skin soothing function. In addition, there is an anti-inflammatory, antibacterial action and skin recovery effect, it is effective in normalizing the skin of capillaries and dry and itchy skin.

The natural plant extract may include a single or two or more extracts selected from the group consisting of roundle, makmundong, three hundred seconds, lemon balm, sage, evening primrose, lavender, rosemary and chamomile. Preferably it may include one or more extracts from the herbal extracts and one or more extracts from the herbal extracts, more preferably a mixed extract of roundle, mackmundong, triticale, lemon balm, sage, evening primrose, lavender, rosemary and chamomile It may include.

The blending ratio of each component of the natural plant extract may be 1 to 3 weight ratio (w / w). For example, roundle (1-3): McMoon-dong (1-3): Three hundred seconds (1-3): Lemon balm (1-3): Sage (1-3): Evening primrose (1-3): Lavender ( 1-3): rosemary (1-3): chamomile (1-3 weight ratio (w / w)).

The natural plant extract may be a concentrated liquid extract or a dry powder thereof. In addition, it may be an essential oil of the hub.

The liquid extract is about 1 to 25 times, preferably 3 to 10 times the amount of purified water, a polar solvent such as a lower alcohol having 1 to 2 carbon atoms, and propylene glycol after washing and drying the herbs and herbs, respectively. , Ethyl acetate, butylene glycol solvent, or a mixed solvent thereof. Preferably, purified water and ethanol mixture containing 50% to 99% by weight of ethanol, or 30% to 99% by weight of propylene glycol It can be extracted using a mixture of purified water and propylene glycol contained in%.

By using the mixed solvent or a single solvent, reflux cooling extraction for 1 hour to 24 hours, preferably 10 hours to 20 hours, filtration under reduced pressure and concentration to obtain the liquid extract.

The essential oil is about 1 hour to 24 hours, preferably 10 hours to 20 hours, using the purified water of about 1 to 30 times, preferably 5 to 15 times the dry weight of the herb after washing and drying the herbs, respectively. Aroma distilled water is obtained by distillation for distillation over time, and the essential oil component can be separated therefrom.

The liquid extract may be extracted alone by extracting the desired herbal medicine / herbs alone, the extract may be mixed in the above-mentioned ratio, or may be extracted by mixing the desired herbal medicine / herbs in the above-mentioned ratio. The essential oil is similar to the mixing method of the liquid extract.

The cosmetic composition for alleviating atopic dermatitis may include 0.01 to 10 parts by weight of the natural vegetable extract based on 100 parts by weight of the composition. If the content of the natural vegetable extract is less than 0.01 parts by weight, the vegetable extract may not provide efficacy as an active ingredient, and if it exceeds 10 parts by weight, the effect of inhibiting and alleviating atopic dermatitis is saturated and no further enhancement of the effect may be obtained.

The cosmetic composition for atopic dermatitis alleviation is a variety of additives, for example, water-soluble components used in general atopic dermatitis alleviating cosmetic composition, skin external preparations, etc., in addition to the natural vegetable extract, as necessary, within the range that does not reduce the effect of the present invention, It may include one or more selected from powder components, oils, surfactants, moisturizers, viscosity modifiers, chelating agents, preservatives, antioxidants, fragrances, pigments and the like. In addition, the atopic dermatitis may further include additives used, and in particular, ceramides (Ceramides), moisturizers or lipids (Lipids), etc., which are frequently used in the atopic skin treatments, or steroids such as hydrocortisone (Hydrocortisone) ), Vitamin A derivatives such as Retunyl palmitate or Tocopherol, or other plant extracts, can be formed into liposomes using known lecithin, or N-stearoyl-phytosphingosine. In combination with (N-Stearoyl-phytosphingosine) may be possible.

The present invention is the formulation of the cosmetic composition for atopic dermatitis relief essence, whitening cream, lotion, emulsion, pack, general cosmetics, skin milk, cream, serum, cosmetic soap, softening cosmetics, medicinal cosmetics, hair tonic, systemic cleanser, oil It may be a dermatitis-relieving cosmetics, such as gels and skin external preparations for alleviating dermatitis.

Hereinafter, the present invention will be described in more detail with reference to Examples. This is for the purpose of illustrating the present invention, and thus the scope of the present invention is not limited thereto.

Example  1: 1 to 12: natural vegetable extract preparation

After grinding 600g each of roundle, macmundong, three hundred seconds, lemon balm, sage, evening primrose, and lavender into particles of about 50 mesh, and cooling them under reflux for 10 hours in a 70% ethanol solution of 5 times the weight of each, filter paper The extract extracted by filtration with a (10 μm filter) was concentrated under reduced pressure to obtain each extract of the present invention. In addition, the plants can be obtained by extracting in the same manner using a 50% propylene glycol aqueous solution solvent.

Rosemary and chamomile were each obtained by washing and drying 1 Kg of each, followed by distillation with 15 times the weight of purified water for 15 hours by distillation, and then separating the essential oil components of the upper layer after cooling.

Example
One Composition herbal Extract composition ratio
(Weight ratio) 1-1 Round One 1-2 McMundong One 1-3 Three hundred seconds One 1-4 Lemon balm One 1-5 sage One 1-6 Evening primrose One 1-7 lavender One 1-8 Rosemary One 1-9 Chamomile One 1-10 Round: Mangmun-dong: 300 seconds: Lemon Balm: Sage: Evening Primrose: Lavender 1: 1: 1: 1: 1: 1: 1 1-11 Rosemary: Chamomile 1: 1 1-12 Round: Malmundong: 300 seconds: Lemon balm: Sage: Evening primrose: Lavender: Rosemary: Chamomile 1: 1: 1: 1: 1: 1: 1: 1: 1

Experimental Example : Skin through human experiment Moisturizing  Measure

The skin moisturizing power was compared with respect to the extract obtained in Example 1. Skin moisturizing ability was measured in 10 20-30 normal adults. The test method is as follows. The skin conductivity of the subject was measured using a corneometer (CM 820 Courage + Khazaka, Cologne, Germany) under constant temperature and humidity conditions (24 ℃, 40% humidity) before starting the application As a default, nine sites were arbitrarily selected and the uncoated site, 1-12 of Example 1, was applied, and the change in skin conductivity after 2, 4, and 8 hours was measured to evaluate the skin moisturizing effect of the sample. The amount of water changed compared to the initial value was calculated using the following equation, and the results are shown in Table 2.

Moisture Growth Rate M (Moisturization) = ((Mt = i-Mt = 0 / Mt = 0) x 100

Mt = i: Moisture content measured at t = i hours

Mt = 0: Moisture measured before the start of the test at the unapplied area (t = 0)

Example
One Skin moisture growth rate 2 hours 4 hours 8 hours 1-1 60 42 35 1-2 57 39 33 1-3 55 38 33 1-4 62 44 40 1-5 61 42 36 1-6 60 41 35 1-7 59 41 34 1-8 57 39 33 1-9 58 39 34 1-10 82 65 61 1-11 85 67 64 1-12 90 79 68

As shown in Table 2, it can be confirmed that the skin moisturizing power of the vegetable extract according to the present invention is excellent, in particular, it can be confirmed that the skin moisture increase rate of Example 1-12 is the most effective.

Experimental Example  2: anti-inflammatory effect using macrophages

For the extract obtained in Example, the effect of inhibiting iNOS activity was measured to compare the effect on anti-inflammatory. Macrophages (RAW 264.7) were dispensed into 24 well culture dishes at a concentration of 8 × 10 ⁵ cells / ml. Medium was used DMEM (Dubelcco's Modified Eagle Medium, sigma, USA) containing 10% bovine serum. After 24 hours of dispensing, the cells were replaced with fresh DMEM medium, and 10 μl of LPS (Lipopolysaccharide, sigma, USA), 1 μg / ml, and test samples were added to each concentration, followed by incubation in a 37 ° C., 5% CO ₂ incubator for 24 hours. After incubation, 100 μl of the supernatant and 100 μl of Griess' reagent for nitrite (Fluka, USA) were reacted, and then absorbance was measured at 570 nm using ELISA (Enzyme Linked Immuno System Assay, TECAN, Austria). To confirm cell viability, the supernatant of the cultured cells was removed and washed again with 200 μl of 5% PBS (Phosphate buffer saline), followed by washing with 0.25 mg / ml MTT (3- [4,5-dimethylthiazole-2-yl]-. After adding 1 ml of 2,5-diphenyl-tetrazolium bromide, Sigma, USA) solution for 4 hours, MTT was removed and 1 ml of DMSO (Dimethylsufoxide) was added and dissolved, and the absorbance was measured at 570 nm. iNOS activity rate (% yield) and cell survival rate (%) are shown in Table 3.

Configuration % yield Cell survival rate (%) 50 µg / ml 100 µg / ml 50 µg / ml 100 µg / ml LPS 100 100 Example 1-1 93.28 68.78 101.25 105.23 Examples 1-2 92.68 67.44 102.89 104.36 Example 1-3 97.11 59.35 99.87 101.01 Example 1-4 98.72 62.58 98.78 99.56 Examples 1-5 92.66 59.11 102.54 101.77 Examples 1-6 91.18 58.28 100.85 100.12 Example 1-7 92.54 86.32 98.54 99.55 Examples 1-8 90.78 87.98 103.54 105.68 Example 1-9 87.15 65.24 99.12 101.58 Example 1-10 85.89 52.44 98.87 100.24 Example 1-11 90.72 88.69 95.24 98.11 Example 1-12 68.05 37.40 100.87 104.78 Indomethacin 25.75 108.27

Table 3 is a result of measuring the anti-inflammatory effect on the extract obtained in Example 1 or a mixture thereof. As a result, Example 1-12, which is a mixture of all the natural plant extract components presented in the present invention, showed 62.6% of iNOS activity inhibitory effect.

Experimental Example  3: of the present composition in atopic patients with itching and erythema As a cosmetic  effect

Based on Experimental Examples 1 and 2, Examples 1-12, which are most effective, were treated to 30 patients with atopic dermatitis accompanying itching, erythema and inflammation for 4 weeks. The results were classified into three stages according to the symptoms of atopic dermatitis. As for the evaluation method, the subjects evaluated on the 5-point satisfaction scale and compared the questionnaire evaluation for symptom relief such as itching and visually confirmed erythema and rash before treatment, and the results on the 5-point satisfaction scale are shown in Table 4.

Skin symptoms Skin hypoallergenic Keratin skin improvement effect Itching effect Anti-inflammatory effect weakness 4.0 4.5 4.5 4.8 usually 4.0 4.3 4.3 4.5 Severe 3.8 4.0 4.2 4.2

As shown in Table 4, most of the subjects showed satisfactory response to the effect of the composition on each symptom of atopic dermatitis, and are particularly effective in reducing the number of scratches and inflammation due to the improvement of itching. appear. It was confirmed that there was a significant decrease in erythema, rash and the like visually confirmed.

Preparation of Formulations Containing Vegetable Extracts

Example  2: Cosmetics Emulsion

In the conventional cosmetic emulsion composition shown in Table 5 below, the extract obtained in Example 1 or a mixture thereof is prepared at 5.0 wt%. Phase B shown in Table 5 was dissolved by heating to 80 ° C, and phase A was also dissolved by heating to 80 ° C with purified water. After completely dissolved, the above-mentioned A phase was introduced into the above-mentioned B phase and emulsified while stirring well with a homomixer, and then the C phase was introduced into the above-mentioned B phase and neutralized. After cooling said phase B to 45 degreeC, phase D was put and stirred in said phase B, and the cosmetic emulsion was prepared.

Formulation (wt%) Raw material name Example 1 1-1 1-2 1-3 1-4 1-5 1-6 1-7 1-8 1-9 One-
10 One-
11 One-
12 D extract 5 5 5 5 5 5 5 5 5 5 5 5 A Monostearine
Polyoxyethylene sorbitan 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Cetanol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sorbitan monosulfate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Cetostearyl alcohol 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Stearic acid 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Dimethicone 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Cetyl octanoate 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 B glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Carbomer 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 C Triethanolamine 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Purified water Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance system 100 100 100 100 100 100 100 100 100 100 100 100

Example  3: lotion manufacturer

Example 1-12 5.0 wt% extract, glycerin 5.0 wt%, 1,3-butylene glycol 5.0 wt%, hyaluronic acid 0.2 wt%, polyoxyethylene hydrogenated castor oil 0.15 wt%, ethanol 5.0 wt%, preservative 0.1 wt% %, Proper amount of perfume and residual amount of purified water were mixed to prepare a lotion.

Example  4: essence manufacturer

Example 1-12 5.0 wt% extract, cetostearyl alcohol 2.0 wt%, self-emulsifying monostearic acid 1.5 wt%, dimethicone 3.0 wt%, monostearate sorbitan 0.5 wt%, stearic acid 1.0 wt%, mineral oil 5.0 wt% %, Jojoba oil 2.0 wt%, monostearic acid polyethylene glycol 7.0 wt%, glycerin 3.0 wt%, 1,3-butylene glycol 3.0 wt%, carbomer 0.15 wt%, triethanolamine 0.2 wt%, appropriate amount of preservative, perfume And the remaining amount of purified water were mixed to prepare an essence.

Example  5: lotion manufacturer

Example 1-12 5.0 wt% extract, cetostearyl alcohol 2.0 wt%, self-emulsifying monostearic acid 1.5 wt%, dimethicone 3.0 wt%, monostearate sorbitan 0.5 wt%, stearic acid 1.0 wt%, mineral oil 5.0 wt% %, Jojoba oil 2.0 wt%, monostearic acid polyethylene glycol 7.0 wt%, glycerin 3.0 wt%, 1,3-butylene glycol 5.0 wt%, carbomer 0.2 wt%, triethanolamine 0.3 wt%, appropriate amount of preservative, perfume And a residual amount of purified water were mixed to prepare a lotion.

Example  6: cream manufacturer

Example 1-12 7.0 wt% extract, cetostearyl alcohol 4.0 wt%, self-emulsifying monostearic acid 3.0 wt%, dimethicone 5.0 wt%, monostearate sorbitan 2.0 wt%, stearic acid 3.0 wt%, mineral oil 5.0 wt% %, Jojoba oil 4.0 wt%, monostearic acid polyethylene glycol 7.0 wt%, glycerin 5.0 wt%, 1,3-butylene glycol 5.0 wt%, carbomer 0.3 wt%, triethanolamine 0.4 wt%, appropriate amount of preservative, perfume And a residual amount of purified water were mixed to prepare a cream.

Cosmetic composition for atopic dermatitis relief according to the present invention can be effectively applied to prevent and improve atopic dermatitis because it contains a vegetable extract excellent in moisture retention, anti-inflammatory effect and the degree of itching relief of atopic dermatitis.

Claims (8)

Roundles, lemon balm and evening primrose; And
Macmundong, three hundred seconds, sage, lavender, rosemary and chamomile Atopy dermatitis relief cosmetic composition comprising at least one vegetable extract selected from the group consisting of active ingredients. The method of claim 1,
The vegetable extract is a cosmetic composition for atopic dermatitis relief, characterized in that it comprises 0.01 to 10 parts by weight with respect to 100 parts by weight of the composition. The method of claim 1,
The vegetable extract is round (1-3): Mcmundong (1-3): three hundred seconds (1-3): lemon balm (1-3): sage (1-3): evening primrose (1-3): lavender ( 1 to 3 ratio): Rosemary (1 to 3): chamomile (1 to 3 times weight ratio) a cosmetic composition for atopic dermatitis relief, characterized in that consisting of the ratio. The method of claim 1,
The vegetable extract is prepared by using 3 to 10 times the amount of purified water, lower alcohol having 1 to 2 carbon atoms, propylene glycol, ethyl acetate or butylene glycol solvent, or a mixed solvent thereof, based on the dry weight of the plant. Cosmetic composition for atopic dermatitis alleviation, characterized in that the extraction. The method of claim 1,
The atopic dermatitis relief composition further comprises at least one additive selected from the group consisting of oil, water, surfactants, moisturizers, thickeners, chelating agents, pigments, preservatives and fragrances. A topical dermatitis for atopic dermatitis relief comprising the cosmetic composition for atopic dermatitis alleviation of claim 1. Cosmetics for atopic dermatitis relief comprising the cosmetic composition for atopic dermatitis relief of claim 1. The method of claim 7, wherein
The cosmetics are one or more selected from the group consisting of essences, whitening creams, lotions, emulsions, packs, general cosmetics, skin milks, creams, serums, cosmetic soaps, softening cosmetics, medicinal cosmetics, hair tonics and systemic cleansers. Cosmetics for the treatment of atopic dermatitis.