CN107149579B - Cream containing plant composition with oil control and acne inhibition effects - Google Patents
Cream containing plant composition with oil control and acne inhibition effects Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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Abstract
The invention discloses a cream containing a plant composition with the effects of controlling oil and inhibiting acne; aiming at providing a cream which can effectively inhibit excessive secretion of grease and astringe pores so as to inhibit pox from happening, has no toxic or side effect and has no irritation to skin, and the technical key points are as follows: the cream mainly comprises the following components in percentage by mass: 1-6% of plant composition, 0.05-0.1% of o-cymene-5-alcohol, 2-6% of babassu seed oil glyceryl polyether-8 esters, 1-5% of macadamia nut oil, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.01-0.1% of sodium hyaluronate and 82.5-95.84% of matrix, wherein the plant composition is prepared by compounding collard extracting solution, basil leaf extracting solution and peanut seed coat extracting solution; belongs to the field of cosmetics.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to cream containing a plant composition with oil control and acne inhibition effects and a preparation method of the cream.
Background
The acne is a chronic inflammatory dermatosis of the pilosebaceous gland caused by various factors, the exuberant oil secretion is one of important causes, and the inhibition of the acne by oil control is a practical and feasible method.
Oil control refers to adjusting the amount of oil secreted by the skin, and the existing oil control methods mainly adopt facial cleansing or use of oil control skin care products. Wherein, only the oil control in the physical sense is realized by cleaning the face, only the transient oil control effect can be achieved, and the problem of oil and acne growth is not fundamentally solved.
The oil control skin care products on the market at present realize the purpose of controlling or regulating sebum secretion by adding various plant extracts, but the oil control and acne inhibition effect is still not obvious and can be reflected after long-term use.
The performance of oil control products prepared by blending different plant extracts is greatly different. Therefore, the problem to be solved in the art is to select which plant extracts to compound, and to safely apply the obtained plant composition to the skin care product to achieve a better oil control effect, so as to further achieve the purpose of inhibiting the occurrence of pox.
Disclosure of Invention
In view of the above problems, the present invention aims to provide a cream which uses natural ingredients as functional raw materials, can effectively inhibit excessive secretion of oil and fat and astringe pores, thereby inhibiting pox, and has no toxic or side effect and no irritation to skin.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a cream containing a plant composition with the effects of controlling oil and inhibiting acne mainly comprises the following components in percentage by mass:
the plant composition is prepared by compounding a collard extracting solution, a basil leaf extracting solution and a peanut seed coat extracting solution.
The weight ratio of the collard extracting solution to the basil leaf extracting solution to the peanut seed coat extracting solution is 5-8: 1.5-4.5: 0.5-1.5.
Preferably, the cream mainly comprises the following components in percentage by mass:
in the plant composition, the compounding proportion of the collard extracting solution, the basil leaf extracting solution and the peanut seed coat extracting solution is 6: 3: 1.
preferably, the cream containing the plant composition with the oil control and acne suppression effects is prepared by taking dried lupulus as a raw material, performing reflux extraction on the dried lupulus by using 70-80% ethanol water solution, performing reduced pressure concentration on the extract to obtain an extract, mixing the extract with water, and performing decolorization on the mixture to obtain the lupulus extract, wherein the polyphenol content in 1g of the lupulus extract is 0.1-0.2 mg/g.
Preferably, the cream containing the plant composition with the oil control and acne suppression effects is obtained by extracting the extract of the collard according to the following method: pulverizing herba Centellae, adding 10-30ml of extraction solvent into per gram of herba Centellae, extracting with 70-80% ethanol water solution at 70-80 deg.C under reflux for 30-60min, concentrating the extractive solution at 40-50 deg.C under reduced pressure to obtain extract with concentration ratio of 1: 1.1-1.3, mixing the extract with water, decolorizing with macroporous adsorbent resin, and eluting with ethanol water solution with volume ratio of water to ethanol of 8:1 to obtain herba Lespedezae Cuneatae extract.
Preferably, the cream containing the plant composition with the oil-controlling and acne-suppressing effects is prepared by taking dried basil leaves as a raw material, performing microwave extraction on the basil leaves through distilled water, filtering and centrifuging to obtain the basil leaf extract, wherein the polyphenol content in 1g of the basil leaf extract is 0.5-1.2 mg/g.
Preferably, the cream containing the plant composition with the oil-controlling and acne-inhibiting effects is obtained by extracting the basil leaf extract according to the following method: pulverizing basil leaves, adding 20-40ml of distilled water into each gram of basil leaves, extracting for 10-30min under the condition of microwave power of 400-.
Preferably, the cream containing the plant composition with the oil control and acne suppression effects is prepared by taking dried peanut seeds as a raw material, mixing the dried peanut seeds with a nitrogen-filled and oxygen-discharged 60-80% ethanol solution, performing microwave extraction and centrifugation under the protection of nitrogen to obtain the peanut seed coat extract, wherein the polyphenol content in 1g of the peanut seed coat extract is 0.1-0.5 mg/g.
Preferably, the cream containing the plant composition with the oil control and acne suppression effects is obtained by extracting the peanut seed coat extract according to the following method: pulverizing peanut seed coats, mixing uniformly by using a 60-80% ethanol solution as an extraction solvent according to the proportion of 10-15ml of the extraction solvent per gram of the peanut seed coats, adding into an extraction tube, carrying out accelerated extraction for 70-100s at 50-70 ℃ under the protection of nitrogen and at the microwave power of 500-700W, repeating for 1-3 times, combining extraction liquid, and centrifuging to obtain the peanut seed coat extraction liquid.
The preparation method of the cream comprises the steps of mixing the main components in the formula with the conventional base in the field, and adopting the conventional cream preparation method in the field to prepare the cream.
The matrix of the invention consists of bisabolol, tocopheryl acetate, bioglycan-1, allantoin, butanediol, water, phenoxyethanol/ethylhexyl glycerol and essence, and the sum of the mass percentages of the components is 82.5-95.84%.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
according to the invention, the oil control and acne suppression effects of a plurality of plant extracting solutions are carefully researched, the collard, the basil leaves and the peanut seed coats are selected as raw materials, the collard extracting solution, the basil leaf extracting solution and the peanut seed coat extracting solution are respectively prepared by a specific process, and the three extracting solutions are compounded according to a specific ratio to obtain the plant composition.
Wherein:
the collard is a herbal plant of Rosaceae cloaca, also called cloaca, is rich in tannin, salicylic acid, flavonoid and plant polyphenol, and has effects of mildly astringing pores and regulating oily skin lipid, and has effects of inhibiting lipoxygenase-5 activity, i.e. anti-inflammatory, tranquilizing and relieving inflamed and allergic skin; in addition, the product has broad-spectrum free radical scavenging function, has good inhibition effect on elastase, and can be used for resisting wrinkle and aging.
Herba Ocimi is annual herb of Ocimum of Labiatae, also called Ocimum basilicum, herba Menthae etc., contains volatile oil 0.02-0.04%, main components are ocimene, 1, 8-cineole, linalool, methyl piperitol etc., and non-volatile components are beta-sitosterol, daucosterol, stigmasterol and glucoside thereof; the flavone includes kaempferol, apigenin, quercetin and glycosides thereof; the phenolic acid is rosmarinic acid. Research shows that the basil leaf extracting solution has better inhibiting effect on staphylococcus aureus, bacillus subtilis, aspergillus niger and pityrosporum orbiculare and can also effectively inhibit the activity of 5 alpha-reductase.
The peanut seed coat is also named as peanut red coat, peanut red coat and the like, has sweet taste, slight bitter taste and mild property, has the effects of stopping bleeding, dissipating blood stasis and reducing swelling, is a main medicine for treating anemia and hemorrhage, has the curative effects of tonifying kidney and nourishing stomach, moistening lung to arrest cough, tonifying middle-jiao and Qi, clearing intestine and expelling toxin, and is recorded in books of compendium of materia medica and Chinese pharmacopoeia and the like. Modern pharmacological research also shows that the peanut red skin has a hemostatic effect, the peanut seed coat extract is extracted from the outer layer of the peanut kernel brown red thin skin, is rich in polyphenol hydroxyl compounds including tannin, gallic acid, catechin, anthocyanidin, chlorogenic acid, ferulic acid and the like, and has the effects of resisting oxidation, resisting dissolution of fibrin, resisting inflammation, blocking saccharification reaction, inhibiting bacteria, preventing whelk, seborrheic dermatitis and the like.
The plant composition is used as an active ingredient, and the plant composition is synergistic with three ingredients, namely o-cymene-5-alcohol, babassu seed oil glyceryl polyether-8 esters and macadamia nut oil, so that the cream which is scientific and precise in formula, free of toxic and side effects and free of irritation to skin is obtained, and the cream can effectively inhibit excessive secretion of grease and astringe pores, and therefore, the occurrence of acnes is inhibited. Wherein:
the o-cymene-5-alcohol is used as a broad-spectrum bactericide, has effects on bacteria, yeast, fungi, viruses and the like, can be used as an anti-acne agent to a certain extent, does not contain harmful substances such as halogen, heavy metal, hormone and the like, can absorb ultraviolet rays with specific wavelength, and has the capability of inhibiting oxidation.
The babassu seed oil glyceryl polyether-8 esters can obviously improve the activity of superoxide dismutase (SOD) in erythrocytes, delay the aging of organisms, keep moisture and improve the skin protection capability. Meanwhile, the production of anaphylactic substance (leukotriene hydrochloride) and intermediate platelet aggregation activation factor (PAF) is obviously reduced, and the rosmarinic acid contained in the extract has the activities of oxidation resistance, anticoagulation, antibiosis, antiphlogosis, antivirus and the like, and also has strong oxidation resistance and inhibits anaphylactic reaction.
Macadamia nut seed oil is extracted from macadamia nut, contains components similar to sebum, can relieve dryness, prevent skin moisture loss, and has good ductility, good permeability, mildness and no irritation.
Drawings
FIG. 1 shows the change of the fat-suppressing rate with time for each test sample.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following embodiments, but the present invention is not limited thereto, and any limited number of modifications made by anyone within the scope of the present invention are still within the scope of the present invention.
It should be noted that the raw materials used in the technical scheme provided by the present invention, except for the specific description, are prepared by conventional means or purchased through commercial channels.
Example 1 preparation of extract solution of Alchemia lineata, extract solution of Ocimum basilicum leaf and extract solution of peanut seed coat
In this example, the collard, basil leaves and peanut seed coat were dried to a moisture content of 5-10%, and then the collard extract, basil leaf extract and peanut seed coat extract were prepared according to the following methods, respectively:
the collard extracting solution is extracted by the following method: pulverizing 10g of herba Centellae, adding 200ml of 75% ethanol water solution, heating and reflux-extracting at 80 deg.C for 40min, concentrating the extractive solution at 45 deg.C under reduced pressure to obtain extract with concentration ratio of 1: 1.2, mixing the extract with water, decolorizing with macroporous adsorbent resin, and eluting with ethanol water solution with volume ratio of water to ethanol of 8:1 to obtain herba Lespedezae Cuneatae extract. The content of polyphenol in 1g of the extract of the kalium is 0.1 mg/g.
The basil leaf extract is extracted by the following method: pulverizing 10g folium Ocimi Pilosi, adding 300ml distilled water, extracting under microwave power of 500W for 20min, filtering, centrifuging at 3000r/min for 5min, and collecting supernatant to obtain folium Ocimi Pilosi extract. The basil leaf extract extracted by the method has the polyphenol content of 1.2mg/g in every 1g of basil leaf extract. The peanut seed coat extracting solution is obtained by extracting according to the following method: pulverizing 10g of peanut seed coat, adding 150ml of 60% ethanol solution, mixing, adding into an extraction tube, performing accelerated extraction at 50 deg.C under 600W for 100s under nitrogen protection, repeating for 1-3 times, mixing extractive solutions, and centrifuging to obtain extractive solution of peanut seed coat. The content of polyphenol in the peanut seed coat extract extracted according to the method is 0.45mg/g per 1g of peanut seed coat extract.
Example 2 preparation of a botanical composition having oil control and pox suppression efficacy
The extract of the collard, the extract of the basil leaf and the extract of the peanut seed coat, which are prepared in example 1, were mixed in a ratio of 6: 3: 1, and uniformly mixing.
Mixing 6g of the prepared collard extracting solution, 3g of the basil leaf extracting solution and 1g of the peanut seed coat extracting solution, and compounding to obtain 10g of the plant composition with the oil control and acne suppression effects.
Example 3A composition is prepared by extracting Trifolium mexicana, Ocimum basilicum leaves and peanut seed coats by atomization
In this example, the collard, basil leaf and peanut seed coat were dried to a moisture content of 5-10% and then the compositions were prepared separately as follows:
1) respectively pulverizing herba Alternantherae sessilis, folium Ocimi and testa Arachidis Hypogaeae, weighing 60kg of herba Alternantherae powder, 30kg of folium Ocimi powder and 10kg of testa Arachidis Hypogaeae powder, mixing, and sieving with 40-80 mesh sieve to obtain mixed particles;
2) adding 50-70% of ethanol into the mixed particles according to the mass ratio of the mixed particles to the solvent of 1:5-20 to obtain a suspension;
3) atomizing the suspension obtained in the step 2) by using an atomizer, naturally settling liquid mist to recover suspension, collecting the suspension, and keeping the temperature at 25-35 ℃;
4) filtering the suspension obtained in the step 3) to obtain clear liquid and residues;
5) heating the clear liquid obtained in the step 4), and separating out ethanol to obtain the plant composition.
Example 4 inhibition of 5 alpha-reductase assay
The oil content of the skin is one of the most important physiological indexes of the facial skin, and the normal and healthy skin is smooth, fine and elastic. And the skin grease is excessively secreted or excessively secreted, which not only affects the beauty, but also can cause various diseases of the skin.
The effect of sebum regulation is currently reflected by the detection of the inhibitory effect of 5 alpha-reductase.
The 5 alpha-reductase catalyzes and converts testosterone T into dihydrotestosterone under the participation of reduced coenzyme II, and if a 5 alpha-reductase inhibitor exists, the reaction process can be inhibited to a certain extent. Because the reduced coenzyme II has characteristic absorption at the wavelength of 340nm, the characteristic absorption of the oxidized coenzyme II generated after the reaction at the wavelength of 340nm disappears. The ultraviolet spectrophotometer is used for determination, and whether a certain substance has an inhibition effect on the 5 alpha-reductase or not and the size of the inhibition effect can be reflected.
Repeated experiments prove that the 5 alpha-reductase catalytic reaction system with the total volume of 100 mu L is established. Components of the reaction system the amounts (μ L) of the reagents used are shown in Table 1.
TABLE 1
Determination of blank control: adding testosterone T, 5 alpha-reductase, phosphate buffer (pH 7.4) and reduced coenzyme II into a reaction tube, mixing, measuring absorbance, incubating at 37 deg.C for 60min, measuring absorbance, deducting blank reduced background value of reduced coenzyme II, and measuring blank reduced value delta A0＝0.066。
Determination of the inhibitory Effect: adding testosterone T, 5 alpha-reductase, inhibitor, phosphate buffer (pH 7.4) and reduced coenzyme II into a reaction tube, mixing, measuring absorbance, incubating at 37 ℃ for 60min, measuring absorbance, subtracting blank reduced background value of reduced coenzyme II, and measuring inhibitor reduced value (delta An). The results are shown in Table 2.
And judging whether the activity of the enzyme is inhibited or not by taking finasteride as a positive drug, and preliminarily calculating the inhibition rate. The formula is I (%) ═(ΔA0－ΔAn)/ΔA0X 100%. The calculation results are shown in Table 2.
TABLE 2
Remarking: the extract solutions of collard, basil leaf and peanut seed coat in tables 1 and 2 were each the extract solutions prepared in example 1; composition a is the botanical composition provided in example 2; composition B was the botanical composition provided in example 3 (with a test dose of 10 g).
As can be seen from the results in table 2, the individual plant extracts of lupulus, basil leaves and peanut seed coat, composition a and composition B, which were prepared in example 1 of the present invention, all had different degrees of inhibition of 5 α -reductase, but the inhibition rate of composition a was close to that of the positive control finasteride, indicating that the individual plant extracts of lupulus, basil leaves and peanut seed coat, which were prepared by a specific process, were as follows: 3: 1, has good synergistic effect on the inhibition of 5 alpha-reductase.
Example 5 orthogonal assay
The compounding proportion of three functional components of the collard, the basil leaf and the peanut seed coat is determined by adopting a three-factor three-level orthogonal test.
Table 3 orthogonal test protocol table
TABLE 4 results of orthogonal experiments
The above test combinations were prepared by combining the extracts of the factors in table 3 at the levels indicated.
From the results in table 4, it can be seen that the extracts of lupulus, basil leaf and peanut seed coat all had an effect on the inhibition rate of 5 α -reductase, with the extract of lupulus having the greatest effect on the inhibition rate, followed by the extract of basil leaf; the optimal compound ratio determined by the invention is 6g of the extract of the collard, 3g of the extract of the basil leaf and 1g of the extract of the peanut seed coat, namely A3B3C2Is the best combination.
That is, the extract of the lupulus, the extract of the basil leaf and the extract of the peanut seed coat which are prepared by the specific process according to the invention are mixed according to the ratio of 6: 3: 1, the plant composition prepared by uniformly mixing the components in the weight ratio has the best effect of inhibiting 5 alpha-reductase.
To better illustrate the beneficial effects of the present invention, the present invention gives the cream formulations of examples 6-8 and comparative examples 1-3 (see table 5) and they were subjected to efficacy verification tests:
TABLE 5
The cream of examples 6-8 and comparative examples 1-3 were prepared by mixing the ingredients of the respective example formulations with art-recognized adjuvants and using art-recognized methods of cream preparation.
The base in example 8 is completely consistent with the base in the creams of comparative examples 1 to 3, and no synergistic effect is brought, and it is worth explaining that the influence factors of the base can be ignored in the efficacy verification test.
Oil control effect verification test
1. The test population: the selected subjects with skin characteristics of oily skin, mild and moderate whelk skin were 50 persons in total, aged 18-40 years, and randomly divided into 5 groups of 10 persons each.
2. Test samples:
(1) the cream of example 8 and the creams of comparative examples 1 to 3.
(2) Oil control creams are commonly commercially available.
3. The test method comprises the following steps:
before testing, each group of subjects cleans the face, then a tested area and a blank control area are selected on the forehead, the oil content of the two areas is tested by a skin oil tester SM815, and the average value is obtained after 3-5 times of testing, and is recorded as the initial oil content of an experimental group and the initial oil content of a blank group.
After each group of testees use the test samples, testing the oil content at 0.5h, 1h, 2h and 4h, taking an average value after testing for 3-5 times, and recording the oil content of the experimental group and the oil content of the blank group.
The measured values were counted and the change law of the oil content of the skin was analyzed, and the specific results are shown in table 6, respectively. Wherein the content of the first and second substances,
the oil increase rate is (oil content-initial oil content)/initial oil content.
The relative increase rate of the oil (i.e. the fat-inhibiting rate) is (experimental group oil content-blank group oil content)/blank group oil content. The smaller the value, the more significant the fat-suppressing effect of the test sample with respect to the blank sample.
TABLE 6
The results in Table 6 show that the cream of example 8 has a better skin oil reduction than the commercial oil control cream and the creams of comparative examples 1-3, indicating that the plant composition has a synergistic effect in inhibiting oil secretion with o-cymene-5-ol, babassu seed oil glyceryl polyether-8 esters, and macadamia nut seed oil.
(II) test for verifying effects of inhibiting excessive secretion of fats and oils and astringing pores
1. The test population: subjects with skin characteristics of oily skin, mild and moderate whelk skin were selected for a total of 140 persons, aged 18-40 years, and randomly divided into 7 groups of 20 persons each.
2. Test samples:
(1) the creams of examples 6-8 and the creams of comparative examples 1-3.
(2) Oil control creams are commonly commercially available.
3. The test method comprises the following steps:
after the test samples are used for 28 days, the use feeling evaluation of the test samples in 1-10 minutes aiming at the two aspects of skin gloss reduction and pore shrinkage is carried out on the test samples, wherein 6-10 minutes are marked, 3-6 minutes are marked, and less than 3 minutes are not marked, and the average scoring result is shown in table 7.
TABLE 7
From the results in table 7, it can be seen that examples 6 to 8 all have the effects of inhibiting excessive secretion of fats and oils and astringing pores, and the evaluation effect of the cream of example 8 is obviously better than that of the commercially available oil control cream and the creams of comparative examples 1 to 3, which shows that the plant composition has the obvious effects of inhibiting excessive secretion of fats and oils and astringing pores by synergizing with three components, namely o-cymene-5-ol, babassu seed oil glyceryl polyether-8 esters and macadamia nut seed oil.
(III) verification test of acne-suppressing Effect
1. The test population: subjects with skin characteristics of oily skin, mild and moderate whelk skin were selected for a total of 140 persons, aged 18-40 years, and randomly divided into 7 groups of 20 persons each.
2. Test samples:
(1) the creams of examples 6-8 and the creams of comparative examples 1-3.
(2) Oil control creams are commonly commercially available.
3. The test method comprises the following steps:
the test samples were used by the subjects in each group after cleansing every morning and evening, and after 28 days of use, the subjects evaluated the acne suppression effect, and the evaluation results were counted by the number of people, as shown in table 8.
TABLE 8
As can be seen from the results in Table 8, the evaluation effect of the cream in example 8 is obviously better than that of the commercially available oil control cream and the creams in comparative examples 1 to 3, which shows that the plant composition has a synergistic effect with three components of o-cymene-5-ol, babassu seed oil glyceryl polyether-8 esters and macadamia nut seed oil, and has an obvious effect of inhibiting pox.
(IV) keratinocyte cytotoxicity verification test
5% CO at 37 ℃2Was performed in a humid environment using pork corneocytes monolayer (corneal stromal cells) in contact with the creams prepared in examples 6-8. Measurements were made after 10 minutes, 1 hour, and 4 hours, respectively. The results show that the creams prepared in examples 6 to 8 do not cause cytotoxicity.
In conclusion, the lupulus extractive solution, the basil leaf extractive solution and the peanut seed coat extractive solution are prepared by a specific process, the three extractive solutions are compounded to obtain the plant composition, the plant composition is taken as an active ingredient, and the plant composition is synergized with three components, namely o-cymene-5-alcohol, babassu seed oil glyceryl polyether-8 esters and macadamia nut seed oil, so that the cream which is scientific and rigorous in formula, free of toxic and side effects and free of irritation to skin is obtained, and can effectively inhibit excessive secretion of grease and astringe pores, and accordingly acne is inhibited.
Claims (5)
1. The cream containing the plant composition with the oil control and acne suppression effects is characterized by comprising the following components in percentage by mass:
1-6% of plant composition
0.05-0.1% of o-cymene-5-ol
2-6% of babassu seed oil glycerol polyether-8 esters
1-5% of macadamia nut seed oil
0.1 to 0.3 percent of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer
0.01 to 0.1 percent of sodium hyaluronate
82.5-95.84% of matrix;
the plant composition comprises a collard extracting solution, a basil leaf extracting solution and a peanut seed coat extracting solution; the compounding proportion of the collard extracting solution, the basil leaf extracting solution and the peanut seed coat extracting solution is 5-8 by weight according to the dry weight of the raw materials of the collard, the basil leaf and the peanut seed coat: 1.5-4.5: 0.5-1.5;
the extract of the collard takes dry collard as a raw material, the dry collard is subjected to reflux extraction by 70-80% of ethanol water solution, and is concentrated into an extract under reduced pressure, the extract is mixed with water and is decolorized to obtain the extract of the collard, and the polyphenol content in 1g of the extract of the collard is 0.1-0.2 mg/g;
the basil leaf extracting solution is obtained by taking dried basil leaves as a raw material, performing microwave extraction on the basil leaves by using distilled water, filtering and centrifuging, wherein the polyphenol content in 1g of basil leaf extracting solution is 0.5-1.2 mg/g;
the peanut seed coat extracting solution is prepared by mixing dried peanut seed coats serving as a raw material with a nitrogen-filled and oxygen-removed 60-80% ethanol solution, performing microwave extraction and centrifugation under the protection of nitrogen, wherein the polyphenol content in 1g of the peanut seed coat extracting solution is 0.1-0.5 mg/g.
2. The cream containing the plant composition with the oil-controlling and pox-inhibiting effects as claimed in claim 1, wherein said extract of collard is obtained by extracting according to the following method: pulverizing herba Centellae, adding 10-30ml of extraction solvent into per gram of herba Centellae, extracting with 70-80% ethanol water solution at 70-80 deg.C under reflux for 30-60min, concentrating the extractive solution at 40-50 deg.C under reduced pressure to obtain extract with concentration ratio of 1: 1.1-1.3, mixing the extract with water, decolorizing with macroporous adsorbent resin, and eluting with ethanol water solution with volume ratio of water to ethanol of 8:1 to obtain herba Lespedezae Cuneatae extract.
3. The cream containing the plant composition with the oil-controlling and pox-inhibiting effects as claimed in claim 1, wherein said basil leaf extract is obtained by extracting according to the following method: pulverizing basil leaves, adding 20-40ml of distilled water into each gram of basil leaves, extracting for 10-30min under the condition of microwave power of 400-.
4. The cream containing the plant composition with the oil-controlling and acne-suppressing effects as claimed in claim 1, wherein the peanut seed coat extract is obtained by extracting according to the following method: pulverizing peanut seed coats, mixing uniformly by using a 60-80% ethanol solution as an extraction solvent according to the proportion of 10-15ml of the extraction solvent per gram of the peanut seed coats, adding into an extraction tube, carrying out accelerated extraction for 70-100s at 50-70 ℃ under the protection of nitrogen and at the microwave power of 500-700W, repeating for 1-3 times, combining extraction liquid, and centrifuging to obtain the peanut seed coat extraction liquid.
5. The cream containing plant composition with the effects of controlling oil and suppressing pox according to claim 1, characterized in that the matrix consists of bisabolol, tocopheryl acetate, bioglycan-1, allantoin, butylene glycol, water, phenoxyethanol/ethylhexyl glycerin and essence, and the sum of the mass percentages of the components is 82.5-95.84%.
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| CN109806194A (en) * | 2017-11-22 | 2019-05-28 | 广州慕可生物科技有限公司 | A kind of blemish clearing gel and preparation method thereof |
| CN109925234A (en) * | 2017-12-18 | 2019-06-25 | 广州宏韵医药科技股份有限公司 | A kind of exploitation and its application of oil-control MASQUE APAISANT HYDRATANT liquid |
| CN113018237B (en) * | 2021-03-12 | 2022-07-26 | 福州东艺善秀商业有限公司 | Natural, safe and efficient acne removing gel and preparation method thereof |
| CN114010562A (en) * | 2021-11-29 | 2022-02-08 | 广州兰蝶生物科技有限公司 | Oil-control acne-removing composition and preparation method thereof |
| CN114796047A (en) * | 2022-04-20 | 2022-07-29 | 广州市科能化妆品科研有限公司 | Anti-dandruff composition, application of anti-dandruff composition, shampoo and preparation method of shampoo |
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