CN107137369A - 一种止嗽丸及其制备方法和应用 - Google Patents

一种止嗽丸及其制备方法和应用 Download PDF

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CN107137369A
CN107137369A CN201710420460.3A CN201710420460A CN107137369A CN 107137369 A CN107137369 A CN 107137369A CN 201710420460 A CN201710420460 A CN 201710420460A CN 107137369 A CN107137369 A CN 107137369A
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戴文健
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NANJING JINGYUN CHEMICAL Co Ltd
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NANJING JINGYUN CHEMICAL Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/10—Preparation or pretreatment of starting material
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Abstract

本发明公开了一种止嗽丸，由下述原料药提取制备而成：制紫菀100g、白前100g、荆芥100g、甘草50g、制百部50g、桔梗100g、陈皮50g，现发现其能治疗皮肤瘙痒。

Description

一种止嗽丸及其制备方法和应用
技术领域
本发明涉及医药领域，尤其涉及一种止嗽丸及其制备方法和应用。
背景技术
止嗽丸，记载于卫生部标准(标准编号：WS3-B-0039-89)，处方为制紫菀100g、白前100g、荆芥100g、甘草50g、制百部50g、桔梗100g、陈皮50g，制备方法为：以上七味，荆芥、桔梗、陈皮、甘草粉碎成细粉，过筛；混匀，其余紫菀等三味，加水煎煮二次，第一次3小时，第二次2小时，合并煎液，滤过，静置，取上清液浓缩至相对密度为1.15～1.20(50℃)的清膏，与上述粉末混合制丸，低温干燥，打光，即得，功能与主治为止嗽去痰，疏风理肺。用于风邪犯肺咳嗽咽痒，痰不易咯出者，目前还没有本发明超微粉碎后制备成蜜丸和治疗皮肤瘙痒的文献报道。
发明内容
发明目的：本发明的目的在于提供一种止嗽丸及其制备方法和应用。
技术方案：一种止嗽丸，由下述原料药提取制备而成：制紫菀100g、白前100g、荆芥100g、甘草50g、制百部50g、桔梗100g、陈皮50g，其特征在于，制备方法为：以上六味，采用气流粉碎机进行超微粉碎，气流粉碎机的气流压力为1000-1200kPa，进料速度为160-200r﹒min-1，分级频率为30-40Hz，粉碎时间为40-50min，得到超微粉碎物，混匀，每100g加炼蜜50-60g制成小蜜丸，在微波250w热风40℃的条件下微波干燥15分钟、热风干燥2小时，包活性炭衣，即得丸剂。
所述止嗽丸在制备治疗皮肤瘙痒药物中的应用。
有益效果：提取后制备成蜜丸，减少病人服用量，而且能治疗皮肤瘙痒。
具体实施方式
实施例1：取制紫菀100g、白前100g、荆芥100g、甘草50g、制百部50g、桔梗100g、陈皮50g，其特征在于，制备方法为：以上六味，采用气流粉碎机进行超微粉碎，气流粉碎机的气流压力为1000-1200kPa，进料速度为160-200r﹒min-1，分级频率为30-40Hz，粉碎时间为40-50min，得到超微粉碎物，混匀，每100g加炼蜜50-60g制成小蜜丸，在微波250w热风40℃的条件下微波干燥15分钟、热风干燥2小时，包活性炭衣，即得丸剂。
实施例2：本发明对4-氨基吡啶(4-AP)诱发小鼠舔体反应模型的止痒作用研究
实验药物：按实施例1方法制备。
实验过程：取体重20-25g小鼠45只，随机分为正常对照组、模型对照组、本发明组，共3组，每组15只，雌雄各半。本发明组给予本发明口服，剂量为0.1g/10g小鼠，正常对照组、模型对照组灌胃等重量的生理盐水。连续给药3天后，将除正常对照组外的所有小鼠皮下注射浓度为0.01％的4-氨基吡啶(4-AP)，给药剂量1mg/kg。给药完毕后，将鼠分别放入鼠笼内，30s左右小鼠即出现反复扭头舔两侧背部的行为，即舔体反应。以小鼠连续舔体至出现短暂停顿作为舔体一次计算，记录给4-AP后30分钟内小鼠的舔体次数。以舔体次数作为衡量止痒作用的指标。比较组间差异性。
本发明对4-氨基吡啶(4-AP)诱发小鼠舔体反应模型止痒效果
实验结果表明，与模型组相比，本发明对4-氨基吡啶(4-AP)诱发小鼠舔体反应模型止痒作用的均有显著性差异,说明本发明能治疗皮肤瘙痒。

Claims (2)

1.一种止嗽丸，由下述原料药提取制备而成：制紫菀100g、白前100g、荆芥100g、甘草50g、制百部50g、桔梗100g、陈皮50g，其特征在于，制备方法为：以上六味，采用气流粉碎机进行超微粉碎，气流粉碎机的气流压力为1000-1200kPa，进料速度为160-200r﹒min-1，分级频率为30-40Hz，粉碎时间为40-50min，得到超微粉碎物，混匀，每100g加炼蜜50-60g制成小蜜丸，在微波250w热风40℃的条件下微波干燥15分钟、热风干燥2小时，包活性炭衣，即得丸剂。
2.如权利要求1所述止嗽丸在制备治疗皮肤瘙痒药物中的应用。
CN201710420460.3A 2017-06-07 2017-06-07 一种止嗽丸及其制备方法和应用 Withdrawn CN107137369A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110624069A (zh) * 2018-06-05 2019-12-31 朱嘉斌 一种治疗咳嗽的中药配方及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403130A (zh) * 2002-09-04 2003-03-19 谢亚苏 止嗽袋泡茶及制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403130A (zh) * 2002-09-04 2003-03-19 谢亚苏 止嗽袋泡茶及制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110624069A (zh) * 2018-06-05 2019-12-31 朱嘉斌 一种治疗咳嗽的中药配方及其制备方法

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