CN107126379A - Oil control and acne removal composition and its application - Google Patents

Oil control and acne removal composition and its application Download PDF

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Publication number
CN107126379A
CN107126379A CN201710343782.2A CN201710343782A CN107126379A CN 107126379 A CN107126379 A CN 107126379A CN 201710343782 A CN201710343782 A CN 201710343782A CN 107126379 A CN107126379 A CN 107126379A
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Prior art keywords
acne
removal composition
oil control
control
skin
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CN107126379B (en
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戴跃锋
康文术
何广文
颜少慰
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Syoung Cosmetics Manufacturing Co Ltd
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HUNAN YUJIA COSMETICS MANUFACTURING Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/87Polyurethanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26Aluminium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29Titanium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/413Nanosized, i.e. having sizes below 100 nm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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Abstract

The present invention relates to a kind of oil control and acne removal composition and its application, the oil control and acne removal composition includes the component of following parts by weight:2 25 parts of soluble polyurethane, 5 25 parts of kaolin, 15 parts of titanium dioxide, 3 10 parts of DPG, 0.1 1 parts of zinc pyrrolidone carboxylate, 15 parts of anti-acne active matter.Above-mentioned oil control and acne removal composition uses aqueous polyurethane for film-forming components; selection DPG is used as coalescents; prepare the mud film containing polyurethane; kaolin passes through outside absorption grease oil-control; capriloyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract and pyrrolidones strong acid zinc are by suppressing 5 alpha-reductases; oil-control is secreted, and is effectively suppressed for the propionibacterium acnes of small pox flesh, effectively repairs the acne that oily skin is grown.

Description

Oil control and acne removal composition and its application
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of oil control and acne removal composition and its application.
Background technology
Facial mask market has become that China's daily use chemicals industry is fastest-rising one of to segment market at present, is sold according to Nelson Data, more than 21.9%, 2015 year conservative sales volume of continuous three annual compound growth rate in -2014 years 2012 facial mask market reaches To 30,000,000,000.Facial mask development it is closely bound up with effect soon, facial mask can be with the big problem of comprehensively solve skin 5:Moisturizing, oil-control is beautiful In vain, antiallergic and anti-aging, Deacne pack.
And everyday skincare is often just for which part problem, it is impossible to comprehensively quick to improve skin condition.Facial mask is utilized The of short duration time of skin part is covered in, air and the pollution in the external world is temporarily isolating, skin temperature and expansion pore is improved, promotes Sweat gland secretion and metabolism, promote skin oxygen content to rise.Moisture in facial mask gos deep into skin cuticula, it is become soft It is soft, increase elasticity;Mud film is due to the dirt in adhesion skin surface and pore, metabolite and crosses many greases of sauce etc., and its is clear Remove.
Tear-pull facial mask is a kind of facial mask for being applied to and forming a tunic after exsiccation on the face.It can make facial skin temperature body Height, so as to stimulate circulation and metabolism.After facial mask is dried, dirt in pore is brought out by way of tearing and reached Remove effect of dead skin.
Earliest tearing facial mask is powdered, is risen using natural polymer thickener and porous absorption diatomite in formula To synergy, one layer of fine and close close membrane is formed after magnesia and calcium sulfate drying.
Main using polyvinyl alcohol as primary raw material in another g., jelly-like tearing facial mask, formula, the PVOH aqueous solution is saturating It is bright and stably, one layer of hyaline membrane uniformly closed is formed after drying.But ethanol and polyalcohol adding proportion can influence to gather in formula The rate of drying of vinyl alcohol, polyvinyl alcohol, which needs to be slowly stirred for a long time, can just be completely dissolved.
Traditional tearing facial mask, because the damage of " tearing " to skin in itself is very big, easily causes skin pore thick, skin The symptoms such as allergy, while the facial mask moisturizing ability of this type is poor.
Containing abundant mineral matter in Conventional mud facial mask, there is anti-inflammatory, sterilize, remove grease, suppress acne and shrink hair The effect in hole.These mineral matters and trace element can also supplement the nutrients for skin, reach the purpose of maintenance skin.In skin when using The mud film of closing is formed on skin, with certain deep moisturizing, maintenance skin recovers cell viability, removes effect of cutin.
The main component of mud cream type facial mask is solid powder, surfactant and high molecular polymer.Solid powder is usual For kaolin, silica gel and clay;Surfactant in formula there is dispersing solid to act on, and high molecular polymer rises suspending stabilized Effect, the two micella formed plays synergistic function to the year of clay mask and stability, but traditional mud film shortcoming just It is to be relatively difficult to cleaning, it is poor to consumer experience.
Oily skin is easily caused acne, and 80% teenager is perplexed by acne problems, and paint is to cause in puberty Hormone it is disorderly.Skin doctor is gone to carry out in the patient of diagnosis and treatment, oiliness, acne liability skin problem account for 20%.
Oily skin is to perplex the problem of many people, and it is present in face, head, top of cleavage and the back of the body etc. this A little body parts often seen by people.Oily will not bring any aesthetic feeling:It is often thought of as fearful human communication disorders But be wilfully so noticeable again.It makes one to be difficult to stand and is sometimes also possible to cause that can not ignore to ask at heart Topic.
Existing mud cream type facial mask function is single, it is impossible to meet the demand of many effects of consumer.
The content of the invention
Based on this, it is an object of the invention to provide a kind of oil control and acne removal composition.
Specific technical scheme is as follows:
A kind of oil control and acne removal composition, includes the component of following parts by weight:
In wherein some embodiments, oil control and acne removal composition includes the component of following parts by weight:
In wherein some embodiments, the anti-acne active matter includes the component of following mass percent:
Decoyl glycine 22.5-27.5%
Methyl amimoacetic acid 7-9.5%
Ceylon cassia tree bark extract 2.5-3.5%
Remaining is water.
In wherein some embodiments, the active matter of the soluble polyurethane is polyurethane -35, and its active quantities is 43-48wt%.
In wherein some embodiments, the kaolinic particle diameter is 4000-6000 mesh.
In wherein some embodiments, the particle diameter of the titanium dioxide is 80-120nm.
It is a further object of the present invention to provide the application of above-mentioned oil control and acne removal composition.
Application of the above-mentioned oil control and acne removal composition in skin care item.
In wherein some embodiments, the skin care item are facial mask.
In wherein some embodiments, the facial mask is tear-pull mud film.
It is a further object of the present invention to provide a kind of facial mask.
A kind of facial mask, including above-mentioned oil control and acne removal composition.
Above-mentioned oil control and acne removal composition uses soluble polyurethane for film-forming components, by selecting kaolin and titanium dioxide Combination, final optimization pass selects DPG as coalescents, and the mud film containing polyurethane of preparation forms soft in hydration status Film, gently easily can be peeled off from skin surface, will not be minimally invasive caused by tearing is to skin, and can be adapted to sensitive skin, solution The problem of common mud film of having determined is difficult to clean.Mud film prepared by above-mentioned oil control and acne removal composition, can be widely applied to facial mask, neck Film, hand film, pin film, pleura, anal membrane;Above-mentioned facial mask is constituted using aqueous polyurethane on the basis of tearing mud film, using kaolin Oil-control, deep layer cleaning are adsorbed, while by forming polyurethane mantle, solving mud mask and blocking pore, it is difficult to the skill of cleaning Art difficult point, and being peeled off by tearing, the mechanism for being conducive to dead skin to remove, the prevention advantageously grown in oily skin acne and Nursing.Capriloyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract and pyrrolidines are also added in above-mentioned oil control and acne removal composition Ketone strong acid zinc, kaolin passes through outside absorption grease oil-control, capriloyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract and pyrrole Pyrrolidone strong acid zinc is effectively suppressed by suppressing 5α-reductase, oil-control secretion for the propionibacterium acnes of small pox flesh, Effectively repair the acne that oily skin is grown.
Tear-pull cosmetics are to use polymerizable compound film forming agent, and film forming agent is often applied to as main active In approved product and molded product, it can be in hair fiber formation layer of transparent, firm film, so as to keep hair Fixed effect.Meanwhile, it can also improve skin care item, anti-Sai product, the water proofing property of color make-up product, fastness and durability.
At present, the film forming agent of in the market mainly has 2 kinds:Polyvinylpyrrolidone (Kollidone 90F or second Vinyl pyrrolidone/vinyl acetate base co-polymer) film forming agent and carboxylic acid resin (acrylate polymer or acrylate/propylene Amide copolymer) film forming agent.
Such film forming agent has the disadvantages that:
1) carboxylic acid resin and vinyl pyrrolidone product easily bring sticky sense to skin;
2) polymer mechanical performance of film forming on skin or hair is difficult to grasp, it is generally the case that film forming is highly brittle;
3) in hair styling product, carboxylic acid resin and vinylpyrrolidone copolymer generally require to add solvent, because This copolymer is difficult dissolving in production technology, especially for the hair styling product or aqueous product of low volatile organic Middle application is very limited.
On the one hand, consumer, which increasingly chases after to worship, can bring the cosmetics of natural effect (tight such as without the sticky sense of skin Sense etc.);On the other hand, the cosmetic industry headed by the U.S. starts to follow limitation of the legislations of environmental protection to product formula, that is, limits The content of VOC.
Above-mentioned oil control and acne removal composition uses soluble polyurethane film forming agent, and the dipropyl two of film forming is contributed to by selection Alcohol, and mineral matter soil carry out formulation ratio optimum organization, and the mud film finally prepared can be applied in consumer's use habit Facial mask custom is drying and forming-film in 15-20 minutes, uses water spray so that the mantle hydration stress formed shrinks so that the film is light The gentle stripping skin of pine, solves the problem of mud Membrane cleaning is difficult, is pleased to consumer, entertaining is experienced using the skin care of mud film.
1 membrane formation mechanism
The aqueous polyurethane dispersion of use (HMW polyurethane is dispersed in water).Emulsifying agent is added into polyurethane Chain, to keep the stability of dispersion, by isocyanates with containing active hydrogen compound (such as polyalcohol, makrolon and Polyester) react so that polyurethane chain is closed.
The various characteristics of polyurethane depend on its segmented structure, the aqueous polyurethane dispersion that the application is used, by low Molecular weight component (isocyanates and solubilizer) constitute segment be hard segment, by high molecular weight component (polyalcohol it is amorphous Rubbery state) constitute segment be soft chain segment.The combination of hard and soft chain segment determines the mechanical performance of thin polymer film.
The soluble polyurethane that the application is used is a kind of water-based dispersion, without 1-METHYLPYRROLIDONE (NMP) or Ethanol equal solvent, also without antiseptic, can be adapted to prepare sensitive group cosmetics.
2 film forming procedures
Tradition prepares tearing facial mask and uses polyvinyl alcohol film forming agent, to obtain preferable properties of product, i.e. skin surface shape Into continuous thin polymer film, drying time is fast, is easily peeled off, it is necessary to add the auxiliary agents such as ethanol.
The soluble polyurethane that the application is used, because itself being the form of liquid pair, without adding cosolvent, in formula Also viscosity will not be increased.Its product film forming procedure uses physical dryness film technique completely, at room temperature, by moisture evaporation, point Scattered ion knot gathers, and then film forming.
Residual moisture in polymeric matrix reduces the glass transition temperature of film as plasticizer.According to film forming mechanism, To cause film forming uniform, the application also determines least concentration in the formula of soluble polyurethane so that film forming is uniform.
The application prepares mud film using mineral matter kaolin and water-soluble titanium dioxide, is contained by the component for adjusting mud film Amount proportioning, controlled in about 15min-20min, meets consumer and is accustomed to using mud film the drying time of formula.The application is selected The soluble polyurethane selected is easy to use as film forming agent, without neutralization and low viscosity, is adapted to cold working, without adding hydrotropy Agent;There is good compatibility with all kinds of cosmetic compositions, it is naturally salubrious at high humidity with preferable elastic force retentivity, Non-greasy.
3 filming performances are preferred
The characteristics of the application is in order to meet mud film so that mud film can be in consumer's applying film custom time range 15-20min Film forming, and film forming is complete, easy tearing shaping, accomplish the same disposable skin care experience of mounted facial mask, the preferred film forming of the application Auxiliary agent.In order to allow moisture quickly to volatilize, soluble polyurethane macromolecule is allowed to assemble film forming, traditional method adds ethanol to carry Moisture evaporation speed is risen, this patent considers that ethanol skin care easily lifts consumer's allergy probability, have selected the mineral matter in mud film Component is adjusted to participate in moisture evaporation.
In order to lift the tearing performance of mud film, it is ensured that the integrality of tearing mud film, preferred development contributes to water-soluble poly The elasticity and toughness of urethane film forming and lifting film, compared for glycerine, propane diols, DPG, final choice DPG conduct This patent coalescents.
The membrane formation mechanism that this patent is proposed is that moisture evaporation passes through the active force combination film forming of hydrogen bond.
Glycerine is to effect of film formation model:Glycerine can be inserted on the hydrogen bond between PUD and PUD, prevent the formation of hydrogen bond, so that Destroy film forming.
Propane diols is to effect of film formation model:Propane diols can be inserted on the hydrogen bond between PUD and PUD, prevent the formation of hydrogen bond, So as to destroy film forming.
DPG is to effect of film formation model:DPG will not be inserted on the hydrogen bond between PUD and PUD, prevent hydrogen bond Formation, but be fitted on PUD chains, so as to help chain more flexible, film forming is more solid.
4 small pox formation mechenisms
Oily skin is easily caused acne, and 80% teenager is perplexed by acne problems, and paint is to cause in puberty Hormone it is disorderly.Skin doctor is gone to carry out in the patient of diagnosis and treatment, oiliness, acne liability skin problem account for 20%.
Oily skin is to perplex the problem of many people, and it is present in face, head, top of cleavage and the back of the body etc. this A little body parts often seen by people.Oily will not bring any aesthetic feeling:It is often thought of as fearful human communication disorders But be wilfully so noticeable again.It makes one to be difficult to stand and is sometimes also possible to cause that can not ignore to ask at heart Topic.
It is also a kind of real international pestilence:About 40% European women and 50% Asia women just by The puzzlement of Oily.Lightening skin is easily converted to the Oily for being easy to grow acne.
Oily is characterized in be controlled seborrhagia dyssecretosis by hormone.It causes skin unnatural glossy, usually Cause the discomfort of people:Face is shinny, and hair is glossy, produces a kind of greasy sensation and has no pure and fresh sense.
Effectively suppress the mechanism of acne formation, because sebum secretion is regulated and controled by male hormones, particularly testosterone Control, contain a kind of enzyme in sebocyte cell, 5- alpha-reductases, testosterone can be converted into dihydroxy testosterone by it (DHT), DHT produces influence to hair follicle activity, stimulates sebaceous glands, causes sebum excessive secretion.
Sebaceous glands excessive secretion is frequently accompanied by the breeding of flora, the Propiobacterium particularly produced in pore, flora Breeding causes pain, causes inflammation to be grown.Sebaceous glands excessive secretion and spongiocyte hyperkeratosis, cause to block pore, acne Propionibacterium belongs to anaerobic bacteria, in the environment of clogging of pores, causes bacterium amount reproduction, produces fatty acid enzyme, promotes aliphatic acid Formed, aggravate inflammation, form vicious circle.
This patent carries out endogenous acne mechanism using effect component, suppresses 5- alpha-reductases, suppresses acne propionic acid bar Bacterium, deep layer cleaning peels off excessive keratinization dead skin, dredges pore, so that small pox skin is repaired from inside and outside root, effective suppression The generation of acne processed.
5 acne-removing compositions
5.1 decoyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract (sepicontrol A5)
Decoyl glycine, methyl amimoacetic acid and the Ceylon's cassia tree bark extract that this patent is selected are based on as acne-removing component Each target spot progressive for causing skin unbalance effectively suppresses, and mainly occurs effect at following 5 aspects:
(1) suppress bacterium and lift immune defense, promote microprotein HBD2 expression, suppression is being finished class carefully to concentration Bacterium breeds, and confrontation causes unbalance, and the bacterium of the easy hair style skin of acne oil, its antibacterial activity is as follows:
(2) to anti-inflammatory, il-1 α, elastase inhibitor activity, anti-oxidizing activities can effectively be reduced;
Reduce the cell factor for inducing inflammation, il-1 α (1L-1 α) release, the inflammation that reduction skin irritatin is brought.
This patent has elastase inhibitor effect using decoyl glycine, methyl amimoacetic acid and Ceylon's cassia tree bark extract, subtracts Few inflammation simultaneously protects extracellular medium, shows the elastase inhibitor activity more stronger than zinc gluconate (positive control).
Using spectrum analysis quantitative analysis elastin laminin inhibitory activity:Under elastin laminin catabolic enzyme existence condition, N- A kind of methoxysuccinyl-Ala-Pro-knot propylhomoserin-para-nitrobenzene amino acid (colourless substance) discharge para- Nitrobenzene amino acid (a kind of coloring matter), in the quantitative DO/min of 410nm wave bands:% coloring matters reduction=%t elastoresistance albumen Decompose enzymatic activity.
(3) excessive keratinization is controlled, the expression of silk polyprotein is reduced;
Excessive keratinization can be effectively controlled, the protein expression water that keratinocyte proliferation demarcates thing is determined by silk polyprotein It is flat, so as to reduce blocking pore, reduce the generation of acne.
(4) suppress 5α-reductase activity, suppress the excessive secretion grease of sebaceous glands;
This patent reduces DHT (5 α-boldenone) content, so as to reduce 5 α-hero by suppressing 5α-reductase activity The generation of alkene diketone (ASD), suppresses sebaceous gland activity, reduces sebum secretion amount.
(5) lipase active, control peroxidating free fatty generation are suppressed.
This patent suppresses fatty enzyme effect, control easily quilt by decoyl glycine, methyl amimoacetic acid and Ceylon's cassia tree bark extract The free-fat of peroxidating is produced, and controls the reaction and stimulation of skin.
5.2 zinc pyrrolidone carboxylate
The zinc pyrrolidone carboxylate that this patent is selected has dual biological activity, 2-pyrrolidone-5-carboxylic acid and zinc.
Pyrrolidones hydroxy acid, also known as L-PCA, pyroglutamic acid, early in 1882, Haitinger found that pyrrolidones Carboxylic acid, it is glutamic acid, a kind of cyclisation product of the amino acid largely existed in plant substrates.
It is very high with the presence of the content in L-PCA, and human epidermal in all histoorgans of human body, positioned at epidermis In NMF (NMF), it plays a part of contact tie.
Energetic supersession
The presoma of α-ketoglutaric acid ester/tricarboxylic acid cycle.
Protein is synthesized
The presoma of collagen component amino acid-proline and hydroxy-proline.
Skin hydration is acted on
L-PCA can be combined with bioactive molecule and be turned into delivery vehicles, there are some researches show, compared with common salt, with The cationic activity that L-PCA is combined is greatly improved.
The 5.3 PCA- zinc mechanisms of action
PCA- zinc is the zinc salt of 2-pyrrolidone-5-carboxylic acid, a kind of to bring the work of zinc and L-PCA double effects simultaneously to skin Property material.
(1) 5α-reductase activity is suppressed
By with soft abundant, zinc chloride, PCA- zinc to 5α-reductase activity inhibitory action compare.
PCA- zinc can produce significant suppression to the activity of 5α-reductase, in low dosage (10-7M and 10-6M, PCA- zinc Effect dosage) can observe this effect, and suppress the activity of 5α-reductase than zinc chloride and it is soft it is abundant will be strong, be primarily due to It has good cell permeability.
(2) antibiotic effect
Harmful microorganism, Propiobacterium, the breeding of staphylococcus albus is to cause the Oily pain for being easy to grow acne The main cause of pain phenomenon.There is PCA- zinc antibacterial to contain zinc mainly due to it, and its antibiotic property is not via PCA- zinc for It is confirmed with the measure of the minimum inhibitory concentration (MIC) of bacterial strain.
PCA- zinc is as follows for the MIC value of different bacterium:
Bacterial strain PCA- zinc minimal inhibitory concentration (MIC) %
Propiobacterium 0.1%
Staphylococcus albus 0.5%
Staphylococcus aureus 0.7%
Pseudomonas aeruginosa 0.7%
Escherichia coli 0.7%
Candida 0.7%
Above-mentioned oil control and acne removal composition has the following advantages that:
1st, above-mentioned oil control and acne removal composition uses aqueous polyurethane for film-forming components, by selecting kaolin and titanium dioxide Combination, final optimization pass selects DPG as coalescents, prepares the mud film containing polyurethane, forms soft in hydration status Film, gently easily can be peeled off from skin surface, will not be minimally invasive caused by tearing is to skin, and can be adapted to sensitive skin, solution The problem of common mud film of having determined is difficult to clean.
2nd, above-mentioned oil control and acne removal composition is used to prepare tear-pull facial mask (mud film), can be widely used in facial mask, neck extensively Film, hand film, pin film, pleura, anal membrane;It can develop with cleaning oil-control, anti-acne can tearing mud membranization cosmetic.
3rd, above-mentioned oil control and acne removal composition selects soluble polyurethane as film forming agent, easy to use, without neutralizing and low Viscosity, is adapted to cold working, without adding cosolvent;There is good compatibility with all kinds of cosmetic compositions, have at high humidity There is preferable elastic force retentivity, naturally salubrious, non-greasy.
4th, above-mentioned oil control and acne removal composition is inhaled on the basis of tearing mud film is constituted using aqueous polyurethane using kaolin Attached oil-control, deep layer cleaning, while by forming polyurethane mantle, solving mud mask and blocking pore, it is difficult to the technology of cleaning Difficult point, and peeled off by tearing, the mechanism for being conducive to dead skin to remove, the prevention advantageously grown in oily skin acne and shield Reason.
5th, above-mentioned oil control and acne removal composition with the addition of capriloyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract and pyrroles Alkanone strong acid zinc, kaolin by outside absorption grease oil-control, capriloyl glycine, methyl amimoacetic acid, Ceylon's cassia tree bark extract and Pyrrolidones strong acid zinc is effectively pressed down by suppressing 5α-reductase, oil-control secretion for the propionibacterium acnes of small pox flesh System, effectively repairs the acne that oily skin is grown.
Brief description of the drawings
Fig. 1 is that tearing anti-acne mud film oil-control effect evaluates and tests figure;
Fig. 2 is that tearing anti-acne mud film acne-removing evaluates and tests figure.
Embodiment
For the ease of understanding the present invention, the present invention will be described more fully below.But, the present invention can be with perhaps More different form is realized, however it is not limited to embodiment described herein.On the contrary, the purpose for providing these embodiments is to make Understanding to the disclosure is more thorough comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases The arbitrary and all combination of the Listed Items of pass.
Raw material used in the present embodiment is as follows:
Soluble polyurethane, performance characteristic is that active matter is polyurethane 35, and content is 45%, is created purchased from Cohan.
Kaolin, particle diameter is 4000-6000 mesh, purchased from the connection iron of fine quality.
Titanium dioxide, particle diameter is 80-120 mesh, purchased from the connection iron of fine quality.
Anti-acne active matter is decoyl glycine & methyl amimoacetic acid & Ceylons cassia tree bark extract, purchased from plug Bick.
Component Active matter content scope
Decoyl glycine 22.5-27.5%
Methyl amimoacetic acid 7-9.5%
Ceylon's cassia tree bark extract 2.5-3.5%
First, the component proportion of embodiment and reference examples is as follows:
By control sample 1-5, embodiment 1-3 is separately added into 0.1wt% card ripples, 0.1% thickener 305, arginine 0.1%, Preservative PHL 1%, remainder is supplemented in 100% with deionized water.
By taking embodiment 1 as an example, preparing process is as follows:
1st, corresponding process water is weighed;
2nd, kaolin, titanium dioxide is weighed to be added to the water, its kaolin, titanium dioxide dispersed with stirring is uniform;
3rd, soluble polyurethane, DPG is added to stir with 30-60r/min;
4th, card ripple 20, arginine, thickener 305 are added, with 10000r/min homogeneous 5-10min;
5th, PCA- zinc is added, decoyl glycine & methyl amimoacetic acid & Ceylons cassia tree bark extract is stirred 10 minutes with 300r/min;
6th, temperature is decreased to less than 45 DEG C, adds preservative PHL, with 200r/min, stirs 5-10 minutes.
2nd, product testing
1 filming performance is evaluated and tested
2 oil-control performance evaluatings
The object that the present embodiment screening has obvious small pox skin carries out normal individual trial and assesses experiment, test object selection 18- Satisfactory volunteer is the people of study subject 18 within 30 years old, and every 3 people is divided into 1 group, is divided into 6 groups.6 groups of test object difference of this test Use above-mentioned control sample 3 (control-3), control sample 4 (control-4), control sample 5 (control-5), example sample 1 (Example-1), example sample 2 (Example-2), example sample 3 (Example-3), carry out oil-control effect evaluation and test.
As a result see following table and Fig. 1.
This patent passes through for control sample 1, control sample 2, control sample 3, control sample 4, control sample 5, example sample 1, example sample 2, example sample 3 carries out film forming test, and soluble polyurethane, DPG, kaolin, titanium dioxide energy are added according to example sample But it is enough preferably to form this mud mask drawn.
This patent is popped one's head in by fat content by German CK equipment and evaluated and tested, and with the addition of pyrrolidone sodium carboxylate zinc and decoyl Glycine & methyl amimoacetic acid & Ceylons cassia tree bark extract, embodiment 1, embodiment 2, embodiment 3 is superior to control in oil-control effect Sample 3, control sample 4, and incorrect ratio control sample 5.
3rd, acne-removing is evaluated and tested
The object that the present embodiment screening has obvious small pox skin carries out normal individual trial and assesses experiment, test object selection 18- Satisfactory volunteer is the people of study subject 18 within 30 years old, and every 3 people is divided into 1 group, is divided into 6 groups.6 groups of test object difference of this test Use above-mentioned control sample 3 (control-3), control sample 4 (control-4), control sample 5 (control-5), example sample 1 (Example-1), example sample 2 (Example-2), example sample 3 (Example-3), carry out oil control and acne removal effect evaluation and test.
Method of testing:
1) study subject is early, evening, this patent test sample on probation, uniform apply was wiped one's face with behind amino acid cleansing whey face cleaning portion Portion, stops 15-20min, test sample face do, water spray can film forming, facial mask tearing is removed, clear water is clean.
2) secreted by integrated test facial oil and observe small pox skin recovery situation and accordingly given a mark, and then evaluated Oil control and acne removal effect of this patent test sample, it is 28 days to try out assessment cycle, sees and wipes continuous skin improvement situation.
Test result:
3) subject, which has used anti-acne tearing mud film to carry out skin, improves assessment, and subjects skin's reaction is judged according to test Standard recording:
4) this patent test object is using test sample 1 day respectively, 2 days, 7 days, 14 days, 21 days, is observed within 28 days Assess marking result as follows.
5) its oil control and acne removal effect of this patent control sample 3, control sample 4, control sample 5, example sample 1, example sample 2, example 3 is such as Shown in Fig. 2.
This patent is by the way that for control sample 3, control sample 4, control sample 5, example sample 1, example sample 2, example sample 3 is scheduled to last The normal individual trial of 28 days is assessed, example sample 1, example sample 2, and example sample 3 is in the heating occurred for small pox skin, and itch is rubescent State is all more obvious efficiently to be improved;The blackhead occurred for small pox skin, the stage of hoary hair, oedema and useless fellow, can be compared with Good suppression and improvement;For acne print skin, example sample embodies preferably comprehensive improvement than control sample, and this patent is directed to small pox Skin maintenance has preferable effect.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.

Claims (10)

1. a kind of oil control and acne removal composition, it is characterised in that include the component of following parts by weight:
2. oil control and acne removal composition according to claim 1, it is characterised in that include the component of following parts by weight:
3. oil control and acne removal composition according to claim 1 or 2, it is characterised in that the anti-acne active matter includes as follows The component of mass percent:
Decoyl glycine 22.5-27.5%
Methyl amimoacetic acid 7-9.5%
Ceylon cassia tree bark extract 2.5-3.5%
Remaining is water.
4. the oil control and acne removal composition according to claim any one of 1-3, it is characterised in that the soluble polyurethane Active matter is polyurethane -35, and active matter content is 43-48wt%.
5. the oil control and acne removal composition according to claim any one of 1-3, it is characterised in that the kaolinic particle diameter is 4000-6000 mesh.
6. the oil control and acne removal composition according to claim any one of 1-3, it is characterised in that the particle diameter of the titanium dioxide For 80-120nm.
7. application of the oil control and acne removal composition described in claim any one of 1-6 in skin care item.
8. application according to claim 7, it is characterised in that the skin care item are facial mask.
9. application according to claim 8, it is characterised in that the facial mask is tear-pull mud film.
10. a kind of facial mask, it is characterised in that including the oil control and acne removal composition described in claim any one of 1-6.
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CN107823099A (en) * 2017-12-12 2018-03-23 王露 One kind removes acne print facial mask
CN108210446A (en) * 2018-03-28 2018-06-29 湖南御家化妆品制造有限公司 The cosmetics that composition and inhibition acne containing the composition induce
CN108478518A (en) * 2018-03-28 2018-09-04 湖南御家化妆品制造有限公司 A kind of composition and the acne-eliminating cosmetic containing the composition
CN109363976A (en) * 2018-11-21 2019-02-22 广州艾蓓生物科技有限公司 It is a kind of to lift compact facial mask and preparation method thereof
CN109806209A (en) * 2017-11-22 2019-05-28 台鉅生技股份有限公司 Aqueous acne isolation constituent, transparent acne isolation film and forming method thereof
CN110123736A (en) * 2019-06-27 2019-08-16 湖南御家化妆品制造有限公司 Composition and its application in the personal-care supplies of preparation oil-control moisturizing
CN110623883A (en) * 2019-10-23 2019-12-31 广州那比昂生物科技有限公司 Oil control composition and application thereof
CN111494277A (en) * 2020-04-28 2020-08-07 广州欧正化妆品技术研究院有限公司 Acne removing factor, acne removing soft mask gel and preparation method thereof
CN111671707A (en) * 2020-07-16 2020-09-18 林淑娴 Oil-control acne-removing mask and preparation method thereof
CN113057897A (en) * 2021-04-06 2021-07-02 上海黛芊信息科技有限公司 Skin protection film composition and application thereof
CN113425650A (en) * 2021-08-16 2021-09-24 深圳八零赞电子商务有限公司 Oil control composition containing plant active ingredients
CN115813823A (en) * 2022-12-16 2023-03-21 中新国际联合研究院 Liquid acne removal patch convenient to make up and preparation method and application thereof

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109806209B (en) * 2017-11-22 2022-07-05 台鉅生技股份有限公司 Aqueous acne barrier composition, transparent acne barrier film and forming method thereof
CN109806209A (en) * 2017-11-22 2019-05-28 台鉅生技股份有限公司 Aqueous acne isolation constituent, transparent acne isolation film and forming method thereof
CN107823099A (en) * 2017-12-12 2018-03-23 王露 One kind removes acne print facial mask
CN108210446A (en) * 2018-03-28 2018-06-29 湖南御家化妆品制造有限公司 The cosmetics that composition and inhibition acne containing the composition induce
CN108478518A (en) * 2018-03-28 2018-09-04 湖南御家化妆品制造有限公司 A kind of composition and the acne-eliminating cosmetic containing the composition
CN109363976A (en) * 2018-11-21 2019-02-22 广州艾蓓生物科技有限公司 It is a kind of to lift compact facial mask and preparation method thereof
CN110123736A (en) * 2019-06-27 2019-08-16 湖南御家化妆品制造有限公司 Composition and its application in the personal-care supplies of preparation oil-control moisturizing
CN110623883A (en) * 2019-10-23 2019-12-31 广州那比昂生物科技有限公司 Oil control composition and application thereof
CN111494277A (en) * 2020-04-28 2020-08-07 广州欧正化妆品技术研究院有限公司 Acne removing factor, acne removing soft mask gel and preparation method thereof
CN111671707A (en) * 2020-07-16 2020-09-18 林淑娴 Oil-control acne-removing mask and preparation method thereof
CN113057897A (en) * 2021-04-06 2021-07-02 上海黛芊信息科技有限公司 Skin protection film composition and application thereof
CN113425650A (en) * 2021-08-16 2021-09-24 深圳八零赞电子商务有限公司 Oil control composition containing plant active ingredients
CN115813823A (en) * 2022-12-16 2023-03-21 中新国际联合研究院 Liquid acne removal patch convenient to make up and preparation method and application thereof

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Address after: 410000 No. 390, Guyuan Road, Changsha hi tech Development Zone, Changsha City, Hunan Province

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