CN109199895B - Smoothie acne-removing gel and preparation method thereof - Google Patents

Smoothie acne-removing gel and preparation method thereof Download PDF

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CN109199895B
CN109199895B CN201811252881.0A CN201811252881A CN109199895B CN 109199895 B CN109199895 B CN 109199895B CN 201811252881 A CN201811252881 A CN 201811252881A CN 109199895 B CN109199895 B CN 109199895B
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acne
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smoothie
salicylic acid
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CN109199895A (en
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林宇祺
范侨森
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Guangzhou Weihongqi Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Abstract

The invention discloses a smoothie acne-removing gel and a preparation method thereof, wherein the smoothie acne-removing gel is prepared from the following formula: humectant, acne removing agent, biological polysaccharide gum, antiseptic, pigment and water. The preparation method comprises mixing humectant, biological polysaccharide gum and acne removing agent uniformly, adding water, stirring, heating to dissolve completely, stirring, cooling to 40-45 deg.C, adding antiseptic and pigment, and stirring; and cooling to 32-37 ℃, adjusting the stirring speed to high-speed stirring, continuously cooling, cooling to room temperature, and keeping stirring for 25-45 min to obtain the product. The invention is the ice slush appearance acne-removing gel, has novel appearance and is rich in texture when in use; and the problem that the common hydrogel agent is difficult to thicken the salicylic acid is solved, so that the salicylic acid keeps good acne removing activity.

Description

Smoothie acne-removing gel and preparation method thereof
Technical Field
The invention relates to a cosmetic and a preparation method thereof, and in particular relates to a smoothie acne-removing gel and a preparation method thereof.
Background
With the continuous development of economy in China, the living standard of people is increasingly improved, so that the attention of people is changed from being full to other aspects of life. People who love beauty have the beauty, and the face is the centralized embodiment of beauty outside one person, so that face care is the most important thing, and the beauty and skin care industry is increasingly strengthened. Nowadays, the life rhythm is increasingly accelerated, the face of people is easy to grow acnes due to factors such as irregular life and the like, so that acne removing products are produced at the same time, and the market prospect is wide.
Acne, commonly called pox, is caused by the blockage of the pilosebaceous gland due to the hypersecretion of sebum by the sebaceous gland, and is more serious and causes bacterial infection and inflammation to result in suppuration. If the treatment is not proper, the acne marks can be left and are difficult to eliminate.
Nowadays, acne-removing products on the market are well-balanced, but the basically used substance with the acne-removing effect is salicylic acid, and the salicylic acid has the effect of peeling off cuticle, so that the salicylic acid is widely applied to the acne-removing products. But due to the structural characteristics of salicylic acid, the salicylic acid has strong acidity, and the hydrogel thickening agent basically does not resist strong acidity, so that the acne removing gel taking the salicylic acid as a main functional substance is difficult to thicken.
There are salicylic acid acne-removing gels thickened with carbomers in the prior art, such as: CN105250189A, but it is well known that most types of carbomers are not resistant to strong acid and strong ions, and are easy to collapse and thin the gel system; the carbomer has high requirements on the using and operating process, the carbomer needs to be soaked for at least 12 hours in advance in the production process, otherwise, the hydration degree is influenced, and the operation consumes long time; and neutralization is needed to thicken, and the neutralized system can reduce the efficacy of the salicylic acid and even completely lose the efficacy, which is suitable for the contrary.
Biological polysaccharide gum belongs to macromolecular saccharide polymer extracted from natural organisms, has good hydrophilic performance, can play a thickening role when being used in a cosmetic system, has a natural powerful moisturizing effect in the using process, and is safer and more environment-friendly compared with the traditional chemically synthesized macromolecular gel. For example, agarose, which is derived from natural agar and is a linear polymer, forms a good solid gel when dissolved in water under heating and then cooled, and forms a smoothie jelly-like appearance when treated by a specific process and is strongly inert to strong acids and strong ions.
A small part of the acne removing product uses other functional components to exert the acne removing effect, but most gel products are transparent and smooth hydrogel in appearance, have no layering feeling when being smeared, bring use fatigue to consumers after a long time, and are lack of novelty. Such as: CN107961188A in the invention discloses an acne-removing gel taking carbomer as a thickening system, which is a transparent gel. The existing acne removing products have the following defects that salicylic acid in the existing acne removing products is difficult to thicken and retain activity; in the prior art, the salicylic acid acne-removing gel is difficult to prepare in a time-saving and labor-saving manner; the existing acne-removing gel product is lack of novelty in appearance, has no texture when being smeared and is easy to cause use fatigue after being used for a long time.
Disclosure of Invention
One of the purposes of the invention is to provide the smoothie acne-removing gel.
The invention also aims to provide a preparation method of the smoothie acne-removing gel.
The technical scheme adopted by the invention is as follows:
the smoothie acne-removing gel is prepared from the following formula: 8-12% of humectant, 0.5-5% of salicylic acid or/and coated salicylic acid, 0.03-1.5% of biological polysaccharide gum, 0.1-0.5% of preservative, 0.0001-0.001% of pigment and the balance of water.
Further, the encapsulated salicylic acid is salicylic acid/gum arabic.
Further, the humectant is at least one selected from glycerin, propylene glycol and 1, 3-butanediol.
Further, the biological polysaccharide gum is at least one selected from agarose, xanthan gum, gellan gum, carrageenan and cellulose.
Further, the preservative is at least one selected from phenoxyethanol, ethylhexyl glycerol, caprylyl glycol and caprylyl hydroxamic acid.
Further, the pigment is at least one selected from carmine, lemon yellow, fruit green and brilliant blue.
The preparation method comprises the following steps:
1) uniformly mixing the humectant, the biological polysaccharide gum and the acne removing agent;
2) adding water into the mixture, stirring and heating to 90-95 ℃, and starting stirring and cooling after complete dissolution;
3) cooling to 40-45 ℃, adding a preservative and a pigment, and stirring at 200-300 rpm;
4) cooling to 32-37 ℃, adjusting the stirring speed to 600-700 rpm, stirring at a high speed, continuously cooling, cooling to room temperature, keeping the 600-700 rpm, and stirring for 25-45 min to obtain the final product;
the dosage ratio of the raw materials is 8-12% of humectant, 0.5-5% of acne removing agent, 0.03-1.5% of biological polysaccharide gum, 0.1-0.5% of preservative, 0.0001-0.001% of pigment and the balance of water;
the acne removing agent is salicylic acid or/and encapsulated salicylic acid.
Further, the humectant is at least one selected from glycerin, propylene glycol and 1, 3-butanediol.
Further, the biological polysaccharide gum is at least one selected from agarose, xanthan gum, gellan gum, carrageenan and cellulose.
Further, the preservative is at least one selected from phenoxyethanol, ethylhexyl glycerol, caprylyl glycol and caprylyl hydroxamic acid.
Further, the pigment is at least one selected from carmine, lemon yellow, fruit green and brilliant blue.
The smoothie acne-removing gel prepared by any one of the methods is smoothie-shaped gel in appearance.
The invention has the beneficial effects that:
(1) the existing acne-removing gel product is lack of novelty in appearance, has no texture when being smeared and is easy to cause use fatigue after being used for a long time. The invention is ice cream appearance acne-removing gel, which has novel appearance and rich texture when in use.
(2) The raw materials of the invention are more natural, safe and environment-friendly, and the cost is lower.
(3) The invention has simple and convenient process, saves time and labor for preparing the salicylic acid acne-removing gel, and is easier to dissolve and disperse compared with the traditional hydrogel.
(4) The smoothie acne-removing gel solves the problem that salicylic acid is difficult to thicken and retain activity; effectively thicken the salicylic acid, solve the problem that the common hydrogel agent is difficult to thicken the salicylic acid, and ensure that the salicylic acid keeps good acne-removing activity.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1 smoothie acne-removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
TABLE 1 concrete formulation of smoothie acne-removing gel of examples 1-6 (percentages are by weight)
Figure BDA0001842102780000031
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. mixing 3% glycerol, 3% propylene glycol, 6% 1, 3-butanediol, 0.5% salicylic acid, 0.8% agarose, and 0.05% xanthan gum, and stirring.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.5% phenoxyethanol and 0.0001% lemon yellow, and stirring at 250 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 650rpm, stirring at high speed, cooling to room temperature, maintaining 650rpm, stirring for half an hour, and discharging.
Example 2 smoothie acne-removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. mixing 6% glycerol, 3% propylene glycol, 3% 1, 3-butanediol, 1% salicylic acid, 1% agarose, and 0.04% carrageenan, and stirring.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.3% phenoxyethanol and 0.0001% lemon yellow, and stirring at 250 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 650rpm, stirring at high speed, cooling to room temperature, maintaining 650rpm, stirring for half an hour, and discharging.
Example 3 smoothie acne-removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. mixing 12% glycerol, 2% salicylic acid, 1.5% agarose and 0.03% cellulose, and stirring.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.1% phenoxyethanol and 0.0001% lemon yellow, and stirring at 250 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 650rpm, stirring at high speed, cooling to room temperature, maintaining 650rpm, stirring for half an hour, and discharging.
Example 4 Bingsha acne removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. 4% of glycerol, 4% of propylene glycol, 2% of 1, 3-butanediol, and 1% of encapsulated salicylic acid (salicylic acid/gum arabic, Beta-Hydroxyde of Basff)TMACSD), 0.1% gellan gum and 0.05% xanthan gum are mixed and stirred uniformly.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.5% phenoxyethanol and 0.0001% lemon yellow, and stirring at 250 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 650rpm, stirring at high speed, cooling to room temperature, maintaining 650rpm, stirring for half an hour, and discharging.
Example 5 Bingsha acne removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. mixing 3% glycerol, 6% propylene glycol, 3% 1, 3-butanediol, and 3% coated salicylic acid (salicylic acid/acacia gum, Beta-Hydroxyde of Basff)TMACSD), 0.3% gellan gum and 0.04% carrageenan, and uniformly mixing and stirring.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.3% phenoxyethanol and 0.0001% lemon yellow, and stirring at 300 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 600rpm, stirring, cooling to room temperature, stirring at 700rpm for half an hour, and discharging.
Example 6 Bingsha acne removing gel
The specific formula of the smoothie acne-removing gel in the embodiment is shown in table 1.
The preparation process of the smoothie acne-removing gel comprises the following steps:
1. mixing 2% glycerol, 4% propylene glycol, 4% 1, 3-butanediol, and 5% coated salicylic acid (salicylic acid/acacia gum, Beta-Hydroxyde of Basff)TMACSD), 0.5 percent of gellan gum and 0.03 percent of cellulose are mixed and stirred uniformly.
2. Adding water, stirring, heating to 95 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.1% phenoxyethanol and 0.0001% lemon yellow, and stirring at 200 rpm.
4. Cooling to 35 deg.C, adjusting stirring speed to 700rpm, stirring, cooling to room temperature, stirring at 600rpm for half an hour, and discharging.
Comparative example 1
Comparative example 1 in order to keep the formulation raw materials and the mixture ratio of the invention (as in example 2) substantially unchanged, a conventional preparation process was adopted.
The specific formulation of the acne removing gel of comparative example 1 is shown in table 2.
TABLE 2 concrete formulation of anti-acne jelly in comparative examples 1-3 (percentages are by weight)
Figure BDA0001842102780000051
Figure BDA0001842102780000061
Comparative example 1 a specific preparation method of the acne removing gel:
1. mixing 6% glycerol, 3% propylene glycol, 3% 1, 3-butanediol, 1% salicylic acid, 1% agarose, and 0.05% xanthan gum, and stirring.
2. Adding water, stirring, heating to 90 deg.C, dissolving completely, and cooling.
3. Cooling to 40-45 deg.C, adding 0.5% phenoxyethanol and 0.0001% lemon yellow, and stirring at 250 rpm.
4. And when the temperature is reduced to 38 ℃, discharging.
Comparative example 2
Comparative example 2 used a conventional hydrogel formulation and used a conventional manufacturing process.
The specific formulation of the acne removing gel of comparative example 2 is shown in table 2.
Comparative example 2 a specific preparation method of the acne removing gel:
1. mixing carbomer with cold water, soaking for 12 hr, and stirring until no obvious granule is formed.
2. Mixing 6% glycerol, 3% propylene glycol, 3% 1, 3-butanediol, 1% salicylic acid, and 0.05% xanthan gum, stirring, and adding into the above system.
3. Stirring and heating to 85 ℃, and stirring and cooling after complete dissolution.
4. Cooling to 40-45 deg.C, adding 2% triethanolamine, 0.5% phenoxyethanol, and 0.0001% lemon yellow, and stirring at 250 rpm.
5. And when the temperature is reduced to 38 ℃, discharging.
Comparative example 3
Comparative example 3 a conventional hydrogel formulation was used, and the process of the present invention was used.
The specific formulation of the acne removing gel of comparative example 3 is shown in table 2.
Comparative example 3 a specific preparation method of the acne removing gel:
1. mixing carbomer with cold water, soaking for 12 hr, and stirring until no obvious granule is formed.
2. Mixing 6% glycerol, 3% propylene glycol, 3% 1, 3-butanediol, 1% salicylic acid, and 0.05% xanthan gum, stirring, and adding into the above system.
3. Stirring and heating to 90 ℃, and stirring and cooling after complete dissolution.
4. Cooling to 40-45 deg.C, adding 2% triethanolamine, 0.5% phenoxyethanol, and 0.0001% lemon yellow, and stirring at 250 rpm.
5. Cooling to 35 deg.C, adjusting stirring speed to 650rpm, stirring at high speed, cooling to room temperature, maintaining 650rpm, stirring for half an hour, and discharging.
The smoothie acne-removing gel prepared by the invention is compared with the acne-removing gel prepared by the comparative examples 1-3 in appearance and effect evaluation.
First, appearance contrast
The smoothie acne-removing gel prepared in the embodiment 1-6 is all in a smoothie shape, the acne-removing gel prepared in the comparative example 1 is in a brittle gel shape, and the acne-removing gel prepared in the comparative examples 2-3 is in a smooth gel shape. In comparative examples 1 to 3, no ice-sandy acne removing gel can be prepared; only the specific formula and the specific process formula of the patent can prepare the acne-removing gel with a smoothie-shaped appearance.
Second, stability comparison
The cold resistance and heat resistance of the products of examples 1 to 6 and comparative examples 1 to 3 were measured at-15 ℃ and 45 ℃ respectively, and the stability of the products was measured under the treatment of a cold-hot cycle (a cycle, a continuous cycle standing test, in which the products were left at 45 ℃ for 24 hours and then at-15 ℃ for 24 hours).
Table 3 stability testing of the respective groups of products
Stability test Examples 1 to 6 Comparative example 1 Comparative example 2 Comparative example 3
Cold resistance at-15 deg.C No obvious change for 3 months No obvious change for 3 months Thinning after 4 weeks Thinning after 4 weeks
Heat resistance at 45 DEG C No obvious change for 3 months No obvious change for 3 months No obvious change for 3 months No obvious change for 3 months
Cold and heat cycle No obvious change in 6 cycles No obvious change in 6 cycles Thinning after 4 weeks Thinning after 4 weeks
The detection results are shown in table 3, the products prepared in the examples 1-6 of the invention have stable systems, are all ice sand-shaped translucent jelly during the test period, and have no obvious change after long-term storage (normal temperature for 3 years) and long-term destructive tests of cold resistance (-15 ℃) and heat resistance (45 ℃), and all sensory indexes and physical and chemical indexes meet the relevant national regulations.
Third, comparison of acne removing effects
Examples 1 to 6 and comparative examples 1 to 3 were used as test samples.
Test subjects: male: 25, female 25 (all ages 18-25, all face-chang pox-prone persons)
The tested part: the acne part of the face.
Coating area: 2cm is multiplied by 2cm (with the affected part as the center)
Coating amount: 5mg/cm2
The test method comprises the following steps:
the testee sits still, cleans and dries the face, selects a plurality of acnes with similar growth vigor, and respectively coats the affected parts with the acnes of the examples 1 to 6 and the acnes of the comparative examples 1 to 3. Every 24 hours for 7 consecutive days, contrast acne-removing effects were observed, and acne was stopped when completely eliminated.
The experimental result is shown in table 4, and it can be seen that the smoothie-appearance acne removing gel provided by the invention has a good acne removing effect, and when the gel is used for 2-3 times, more than 90% of testees can remove acnes. Is obviously superior to comparative examples 1-3. The smoothie acne-removing gel solves the problem that salicylic acid is difficult to thicken and retain activity; effectively thicken the salicylic acid, solve the problem that the common hydrogel agent is difficult to thicken the salicylic acid, and ensure that the salicylic acid keeps good acne-removing activity.
Table 4 comparison of acne removing effect of each group of products
Figure BDA0001842102780000081
Note: + + + + + indicates 1 use, with 90% of subjects receiving pox relief;
+ + + indicates 2-3 uses, with 90% of subjects receiving pox relief;
+ indicates 4-5 uses, 90% of subjects tested had pox eliminated;
+ means 6-7 uses, with 90% of subjects receiving pox relief;
-7 applications, with no more than 90% of the subjects with pox elimination.
Fourthly, comparing the preference of consumers
The test method comprises the following steps: 200 pox-prone volunteers were recruited, the samples from examples 1-6 were randomly distributed and feedback was recovered as questionnaires.
Questionnaire feedback test results:
the content of the tested acne-removing products is 42 percent, the content of the tested acne-removing products is 57 percent, and the content of the tested acne-removing products is only 1 percent
The ice-sand appearance was found to be 95% novel and the appearance was found to be 5% flat.
Feel attractive to the appearance and choose to purchase 73% of the trial, consider 16% of the purchase, and not be interested in 11% of the purchase
The ice-sand-like appearance was novel, 95% of the coating was strong, and 5% of the flat appearance was observed.
On trial, the acne removing effect is found to be 91% remarkable, the acne removing effect is found to be 7% effective but not remarkable, and the acne removing effect is found to be 2% ineffective.
Investigation shows that the smoothie acne-removing gel has the advantages of novel appearance, attractive effect on consumer eyeballs, texture in smearing and remarkable acne-removing effect.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (3)

1. The smoothie acne-removing gel is characterized by being prepared from the following formula: 8-12% of humectant, 0.5-5% of salicylic acid, 0.03-1.5% of biological polysaccharide gum, 0.1-0.5% of preservative, 0.0001-0.001% of pigment and the balance of water; wherein the biological polysaccharide gum is at least one of agarose, xanthan gum, gellan gum, carrageenan and cellulose; the humectant is at least one selected from glycerol, propylene glycol and 1, 3-butanediol;
the preparation method of the smoothie acne-removing gel comprises the following steps:
1) uniformly mixing the humectant, the biological polysaccharide gum and the acne removing agent;
2) adding water into the mixture, stirring and heating to 90-95 ℃, and starting stirring and cooling after complete dissolution;
3) cooling to 40-45 ℃, adding a preservative and a pigment, and stirring at 200-300 rpm;
4) cooling to 32-37 ℃, adjusting the stirring speed to 600-700 rpm, stirring at a high speed, continuously cooling, cooling to room temperature, keeping the 600-700 rpm, and stirring for 25-45 min to obtain the final product; the dosage ratio of the raw materials is 8-12% of humectant, 0.5-5% of acne removing agent, 0.03-1.5% of biological polysaccharide gum, 0.1-0.5% of preservative, 0.0001-0.001% of pigment and the balance of water; the acne removing agent is salicylic acid.
2. The smoothie acne removing gel according to claim 1, wherein the preservative is at least one selected from phenoxyethanol, ethylhexyl glycerol, caprylyl glycol and caprylyl hydroximic acid.
3. The smoothie acne-removing jelly according to claim 1, wherein the pigment is at least one selected from carmine, lemon yellow, fruit green and brilliant blue.
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CN108652989A (en) * 2018-06-27 2018-10-16 广州科缇生物科技有限公司 A kind of gel and preparation method thereof with acne-removing

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