CN107108745B - 抗bace1的抗体和其用于神经疾病免疫疗法的用途 - Google Patents
抗bace1的抗体和其用于神经疾病免疫疗法的用途 Download PDFInfo
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- CN107108745B CN107108745B CN201580061968.8A CN201580061968A CN107108745B CN 107108745 B CN107108745 B CN 107108745B CN 201580061968 A CN201580061968 A CN 201580061968A CN 107108745 B CN107108745 B CN 107108745B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081966P | 2014-11-19 | 2014-11-19 | |
| US62/081,966 | 2014-11-19 | ||
| PCT/US2015/061401 WO2016081639A1 (en) | 2014-11-19 | 2015-11-18 | Antibodies against bace1 and use thereof for neural disease immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107108745A CN107108745A (zh) | 2017-08-29 |
| CN107108745B true CN107108745B (zh) | 2021-01-12 |
Family
ID=54782820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580061968.8A Active CN107108745B (zh) | 2014-11-19 | 2015-11-18 | 抗bace1的抗体和其用于神经疾病免疫疗法的用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10882920B2 (https=) |
| EP (2) | EP3221364B1 (https=) |
| JP (1) | JP6859259B2 (https=) |
| CN (1) | CN107108745B (https=) |
| WO (1) | WO2016081639A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
| RU2763916C2 (ru) | 2015-09-23 | 2022-01-11 | Дженентек, Инк. | Оптимизированные варианты анти-vegf антител |
| WO2019075097A1 (en) * | 2017-10-11 | 2019-04-18 | Board Of Regents, The University Of Texas System | PD-L1 HUMAN ANTIBODIES AND METHODS OF USE |
| WO2019094608A1 (en) | 2017-11-08 | 2019-05-16 | Denali Therapeutics Inc. | Anti-bace1 antibodies and methods of use thereof |
| EP3768726B1 (en) | 2018-03-23 | 2024-10-30 | Board of Regents, The University of Texas System | Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor |
| CN119101158A (zh) | 2018-03-23 | 2024-12-10 | 得克萨斯州大学系统董事会 | 人pd-l2抗体及其使用方法 |
| WO2019182867A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor |
| CN108760661B (zh) * | 2018-09-08 | 2023-06-09 | 重庆科技学院 | 一种石油废水重金属离子多通道检测芯片 |
| AR117453A1 (es) * | 2018-12-20 | 2021-08-04 | Genentech Inc | Fc de anticuerpos modificados y métodos para utilizarlas |
| CN113508134B (zh) * | 2019-02-22 | 2024-12-03 | 安维达生物科技公司 | 白蛋白结合抗体及其用途 |
| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| FI4045533T3 (fi) | 2020-03-26 | 2024-02-02 | Univ Vanderbilt | Ihmisen monoklonaalisia vasta-aineita vakavalle akuutille koronavirus 2 -hengityselinoireyhtymälle (sars-cov-2) |
| WO2021195326A1 (en) * | 2020-03-26 | 2021-09-30 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| MX2022013499A (es) | 2020-04-27 | 2023-01-16 | Twist Bioscience Corp | Bibliotecas de ácidos nucleicos variantes para coronavirus. |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064836A1 (en) * | 2010-11-10 | 2012-05-18 | Genentech, Inc. | Methods and compositions for neural disease immunotherapy |
| CN103974709A (zh) * | 2011-10-14 | 2014-08-06 | 霍夫曼-拉罗奇有限公司 | Bace1的肽抑制剂 |
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| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
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| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
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| EP3845565A2 (en) | 2021-07-07 |
| US20210206877A1 (en) | 2021-07-08 |
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| EP3221364A1 (en) | 2017-09-27 |
| US10882920B2 (en) | 2021-01-05 |
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| JP6859259B2 (ja) | 2021-04-14 |
| US11746160B2 (en) | 2023-09-05 |
| US20170362339A1 (en) | 2017-12-21 |
| EP3845565A3 (en) | 2021-09-08 |
| WO2016081639A1 (en) | 2016-05-26 |
| JP2018505651A (ja) | 2018-03-01 |
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