CN107106695B - 用于增强骨和软组织的愈合和再生的组合物和方法 - Google Patents

用于增强骨和软组织的愈合和再生的组合物和方法 Download PDF

Info

Publication number
CN107106695B
CN107106695B CN201580054031.8A CN201580054031A CN107106695B CN 107106695 B CN107106695 B CN 107106695B CN 201580054031 A CN201580054031 A CN 201580054031A CN 107106695 B CN107106695 B CN 107106695B
Authority
CN
China
Prior art keywords
composition
biodegradable polymer
parts
weight
honey
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580054031.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN107106695A (zh
Inventor
G.L.鲍林
I.A.罗德里格斯
B.W.伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smile Microbion Corp
University of Memphis
Original Assignee
Smile Microbion Corp
University of Memphis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smile Microbion Corp, University of Memphis filed Critical Smile Microbion Corp
Publication of CN107106695A publication Critical patent/CN107106695A/zh
Application granted granted Critical
Publication of CN107106695B publication Critical patent/CN107106695B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222Gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645Connective tissue
    • A61L27/365Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)
CN201580054031.8A 2014-08-05 2015-08-05 用于增强骨和软组织的愈合和再生的组合物和方法 Active CN107106695B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462033599P 2014-08-05 2014-08-05
US62/033599 2014-08-05
PCT/US2015/043789 WO2016022670A1 (en) 2014-08-05 2015-08-05 Compositions and methods for enhancing healing and regeneration of bone and soft tissue

Publications (2)

Publication Number Publication Date
CN107106695A CN107106695A (zh) 2017-08-29
CN107106695B true CN107106695B (zh) 2021-02-23

Family

ID=55264490

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580054031.8A Active CN107106695B (zh) 2014-08-05 2015-08-05 用于增强骨和软组织的愈合和再生的组合物和方法

Country Status (9)

Country Link
US (3) US10258717B2 (enExample)
EP (2) EP3656401A1 (enExample)
JP (1) JP6861151B2 (enExample)
KR (1) KR102511882B1 (enExample)
CN (1) CN107106695B (enExample)
AU (1) AU2015301070B2 (enExample)
CA (1) CA2957263A1 (enExample)
ES (1) ES2760923T3 (enExample)
WO (1) WO2016022670A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2535666B (en) 2014-04-30 2017-03-29 Matoke Holdings Ltd Antimicrobial compositions
CA2975197A1 (en) * 2015-02-03 2016-08-11 Matoke Holdings Limited Antimicrobial fibers and compositions
CA3007935A1 (en) * 2015-12-11 2017-06-15 Poly-Med, Inc. Synthetic implant device replicating natural tissue structure and methods of making same
FR3063886B1 (fr) * 2017-03-14 2019-04-12 Cousin Biotech Prothese implantable, notamment pour la chirurgie parietale
CN107459662B (zh) * 2017-09-06 2020-09-08 青岛农业大学 一种纳米复合水凝胶的制备方法
GB201716986D0 (en) 2017-10-16 2017-11-29 Matoke Holdings Ltd Antimicrobial compositions
CN107715176A (zh) * 2017-10-31 2018-02-23 无锡中科光远生物材料有限公司 一种促进骨再生的纳米纤维涂层支架的制备方法
CN109432497B (zh) * 2019-01-05 2021-10-19 西安点云生物科技有限公司 一种甲壳素纳米晶须/羟基磷灰石复合人工骨材料及其制备方法和在3d打印中的应用
CN109675101B (zh) * 2019-01-05 2021-08-10 西安点云生物科技有限公司 一种甲壳素纳米晶须/羟基磷灰石复合材料及其制备方法和在3d打印人工骨中的应用
CA3142151A1 (en) * 2019-05-30 2020-12-03 Lifecell Corporation Biologic breast implant
EP3771454B1 (en) * 2019-07-29 2022-11-16 Shanghai Ninth Peoples Hospital Affiliated Shanghai Jiaotong University School of Medicine Sealing device for repairing perforation of maxillary sinus mucosa
EP4027949A4 (en) * 2019-09-11 2023-06-14 Warsaw Orthopedic, Inc. HYDRATABLE COMPOSITIONS COMPRISING MACROPARTICLES AND METHODS OF MAKING THEM
CN111407755A (zh) * 2020-04-30 2020-07-14 重庆医科大学附属口腔医院 视黄酸在牙齿发育中的应用
CN114681678B (zh) * 2020-12-31 2023-04-18 广州迈普再生医学科技股份有限公司 纳米纤维海绵及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077630A (zh) * 1993-04-10 1993-10-27 北京市西城区华新生化技术研究所 水溶活性胶原蛋白(骨利特)口服药
CN1140089A (zh) * 1995-07-07 1997-01-15 段和平 胶原蛋白口服液及其制备方法
CN1709502A (zh) * 2005-07-15 2005-12-21 北京东方兴企食品工业技术有限公司 一种复合型关节改善口服液
CN1994274A (zh) * 2006-01-04 2007-07-11 吴天祥 仿生精液化妆品
CN101283783A (zh) * 2007-01-25 2008-10-15 钟世杰 食用保健胶晶及其制备方法
GB2484319A (en) * 2010-10-06 2012-04-11 Univ Bolton Electrospinning fibres comprising honey and biocompatible polymer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827561C1 (enExample) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
ES2167330T3 (es) * 1992-02-28 2002-05-16 Cohesion Tech Inc Composiciones ceramicas inyectables y su procedimiento de preparacion y de utilizacion.
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
USRE42755E1 (en) 1999-12-09 2011-09-27 Apimed Medical Honey Limited Honey based wound dressing
NZ505514A (en) 2000-06-30 2003-02-28 Bee & Herbal New Zealand Ltd Method of manufacturing a wound dressing for the application of honey
AU2002950744A0 (en) 2002-08-13 2002-09-12 Medihoney Pty Ltd Composition
US8469036B2 (en) * 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
ITRM20050585A1 (it) * 2005-11-23 2007-05-24 Mavi Sud S R L Nanofibrille di chitina spray-dried, metodo di produzione ed usi.
US8524265B2 (en) * 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
EP2079416A4 (en) * 2006-10-30 2012-06-27 Univ Rutgers ELECTROSPIN MATRICES FOR DISPENSING HYDROPHILIC AND LIPOPHILLE COMPOUNDS
US20090022811A1 (en) * 2007-03-07 2009-01-22 Legeros Racquel Z Mineralized guided bone regeneration membranes and methods of making the same
US7998498B2 (en) 2008-01-22 2011-08-16 Michael Szycher Antimicrobial material and method for making the same
US8367094B2 (en) 2008-01-22 2013-02-05 Michael Szycher Antimicrobial material and method for making the same
JP2010095454A (ja) * 2008-10-14 2010-04-30 Cyclochem:Kk 抗菌組成物
GB2474851A (en) * 2009-10-27 2011-05-04 Univ Bolton Wound dressing comprising anti-microbial honey encapsulated within biocompatible and biodegradable fibre, and the fibre's production
CN101879248A (zh) * 2010-05-21 2010-11-10 郭景龙 一种具有补血作用的药物组合物
US9101508B2 (en) * 2011-12-07 2015-08-11 Esmaeil Mirzaei Electro spun nanofibrous wound dressing and a method of synthesizing the same
GB2519072B (en) * 2013-10-07 2019-12-04 Welland Medical Ltd Composition comprising collagen and honey

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077630A (zh) * 1993-04-10 1993-10-27 北京市西城区华新生化技术研究所 水溶活性胶原蛋白(骨利特)口服药
CN1140089A (zh) * 1995-07-07 1997-01-15 段和平 胶原蛋白口服液及其制备方法
CN1709502A (zh) * 2005-07-15 2005-12-21 北京东方兴企食品工业技术有限公司 一种复合型关节改善口服液
CN1994274A (zh) * 2006-01-04 2007-07-11 吴天祥 仿生精液化妆品
CN101283783A (zh) * 2007-01-25 2008-10-15 钟世杰 食用保健胶晶及其制备方法
GB2484319A (en) * 2010-10-06 2012-04-11 Univ Bolton Electrospinning fibres comprising honey and biocompatible polymer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Fabrication, Structure, and Properties of Chitin Whisker-Reinfor;Anyarat Watthanaphanit et al.;《Journal of Applied Polymer Science》;20080423;第110卷;第890–899页 *

Also Published As

Publication number Publication date
AU2015301070B2 (en) 2021-01-28
CA2957263A1 (en) 2016-02-11
NZ729417A (en) 2024-02-23
US10258717B2 (en) 2019-04-16
CN107106695A (zh) 2017-08-29
US20210308337A1 (en) 2021-10-07
WO2016022670A1 (en) 2016-02-11
KR20170042621A (ko) 2017-04-19
EP3185905A4 (en) 2018-04-04
EP3185905A1 (en) 2017-07-05
JP2017526739A (ja) 2017-09-14
EP3185905B1 (en) 2019-09-25
AU2015301070A1 (en) 2017-03-16
KR102511882B1 (ko) 2023-03-17
JP6861151B2 (ja) 2021-04-21
BR112017002259A2 (pt) 2017-11-21
EP3656401A1 (en) 2020-05-27
US20160038646A1 (en) 2016-02-11
US20190224380A1 (en) 2019-07-25
ES2760923T3 (es) 2020-05-18

Similar Documents

Publication Publication Date Title
CN107106695B (zh) 用于增强骨和软组织的愈合和再生的组合物和方法
US20230293776A1 (en) Composite material for tissue restoration
JP7445273B2 (ja) 組織修復のための繊維-ヒドロゲル複合材料の手術用メッシュ
JP2021522938A (ja) 細胞及び組織の送達のためのナノファイバー−ハイドロゲル複合体
US9295691B2 (en) Method for repairing or replacing damaged tissue
Alimohammadi et al. Electrospun nanofibrous membranes for preventing tendon adhesion
US20100331980A1 (en) Aligned scaffolding system for skeletal muscle regeneration
JP6196217B2 (ja) 筋線維断片を利用した筋組織再生
CN106999635A (zh) 软骨修复用移植物支架及其制造方法
JP2018511622A5 (enExample)
KR20180018000A (ko) 주사 가능한 3차원 나노섬유 스캐폴드 및 이의 제조방법
CN112999430B (zh) 口腔修复膜及其制备方法
Lu et al. Janus sponge/electrospun fibre composite combined with EGF/bFGF/CHX promotes reconstruction in oral tissue regeneration
US20240374786A1 (en) Nanofiber and microfiber hybrid aerogels
Naghibzadeh Nanofibers for Skin Regeneration.
Patel Characterisation of Chitosan/PVA/PVP Crossed-linked Nanofibrous Scaffolds for the Potential Application in Dermal Tissue Engineering
BR112017002259B1 (pt) Composição compreendendo um polímero biodegradável e um mel, e métodos de preparação da referida composição e para a preparação de uma membrana ou uma membrana de múltiplas camadas
Anton et al. Types of barrier-membrane in periodontal therapy of guided tissue regeneration
Griffanti Automated aspiration-ejection of protein based hydrogels for tissue engineering applications
Mansourzadeh et al. Role of Tissue Scaffolds in Skin Wound Healing: A Systematic Review
Team A New Biomimetic Synthetic Absorbable Dural Substitute

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant