ES2760923T3 - Composiciones y métodos para mejorar la curación y la regeneración de huesos y tejidos blandos - Google Patents
Composiciones y métodos para mejorar la curación y la regeneración de huesos y tejidos blandos Download PDFInfo
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| EP3858392B1 (en) * | 2015-02-03 | 2024-01-03 | Matoke Holdings Limited | Antimicrobial fibers and compositions |
| EP3386448B1 (en) * | 2015-12-11 | 2020-09-02 | Poly-Med Inc. | Synthetic implant device replicating natural tissue structure and methods of making same |
| FR3063886B1 (fr) * | 2017-03-14 | 2019-04-12 | Cousin Biotech | Prothese implantable, notamment pour la chirurgie parietale |
| CN107459662B (zh) * | 2017-09-06 | 2020-09-08 | 青岛农业大学 | 一种纳米复合水凝胶的制备方法 |
| GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
| CN107715176A (zh) * | 2017-10-31 | 2018-02-23 | 无锡中科光远生物材料有限公司 | 一种促进骨再生的纳米纤维涂层支架的制备方法 |
| CN109432497B (zh) * | 2019-01-05 | 2021-10-19 | 西安点云生物科技有限公司 | 一种甲壳素纳米晶须/羟基磷灰石复合人工骨材料及其制备方法和在3d打印中的应用 |
| CN109675101B (zh) * | 2019-01-05 | 2021-08-10 | 西安点云生物科技有限公司 | 一种甲壳素纳米晶须/羟基磷灰石复合材料及其制备方法和在3d打印人工骨中的应用 |
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| US12076462B2 (en) | 2019-09-11 | 2024-09-03 | Warsaw Orthopedic, Inc. | Hydratable compositions comprising macroparticles and methods of making them |
| CN111407755A (zh) * | 2020-04-30 | 2020-07-14 | 重庆医科大学附属口腔医院 | 视黄酸在牙齿发育中的应用 |
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| DE3827561C1 (enExample) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| JPH07504106A (ja) * | 1992-02-28 | 1995-05-11 | コラーゲン コーポレイション | 注射可能なセラミック組成物及びそれらの製造及び使用のための方法 |
| CN1045719C (zh) * | 1993-04-10 | 1999-10-20 | 北京市西城区华新生化技术研究所 | 口服接骨和治骨质疏松液 |
| CN1140089A (zh) * | 1995-07-07 | 1997-01-15 | 段和平 | 胶原蛋白口服液及其制备方法 |
| US20020081732A1 (en) | 2000-10-18 | 2002-06-27 | Bowlin Gary L. | Electroprocessing in drug delivery and cell encapsulation |
| US6300315B1 (en) * | 1999-08-28 | 2001-10-09 | Ceramedical, Inc. | Mineralized collagen membrane and method of making same |
| CN1409636A (zh) | 1999-12-09 | 2003-04-09 | 威凯托陵科有限公司 | 蜂蜜基伤口敷料 |
| NZ505514A (en) | 2000-06-30 | 2003-02-28 | Bee & Herbal New Zealand Ltd | Method of manufacturing a wound dressing for the application of honey |
| AU2002950744A0 (en) | 2002-08-13 | 2002-09-12 | Medihoney Pty Ltd | Composition |
| BRPI0415741B1 (pt) * | 2003-11-07 | 2013-07-23 | composições de tabaco e métodos de fabricação de uma composição de tabaco | |
| CN1709502A (zh) * | 2005-07-15 | 2005-12-21 | 北京东方兴企食品工业技术有限公司 | 一种复合型关节改善口服液 |
| ITRM20050585A1 (it) * | 2005-11-23 | 2007-05-24 | Mavi Sud S R L | Nanofibrille di chitina spray-dried, metodo di produzione ed usi. |
| CN1994274A (zh) * | 2006-01-04 | 2007-07-11 | 吴天祥 | 仿生精液化妆品 |
| US8524265B2 (en) * | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
| US20100166854A1 (en) * | 2006-10-30 | 2010-07-01 | Rutgers, The State University Of New Jersey | Electrospun matrices for delivery of hydrophilic and lipophilic compounds |
| CN101283783B (zh) * | 2007-01-25 | 2011-09-21 | 钟世杰 | 食用保健胶晶及其制备方法 |
| WO2008109165A2 (en) * | 2007-03-07 | 2008-09-12 | New York University | Mineralized guided bone regeneration membranes and methods of making the same |
| US7998498B2 (en) | 2008-01-22 | 2011-08-16 | Michael Szycher | Antimicrobial material and method for making the same |
| US8367094B2 (en) | 2008-01-22 | 2013-02-05 | Michael Szycher | Antimicrobial material and method for making the same |
| JP2010095454A (ja) * | 2008-10-14 | 2010-04-30 | Cyclochem:Kk | 抗菌組成物 |
| GB2474851A (en) * | 2009-10-27 | 2011-05-04 | Univ Bolton | Wound dressing comprising anti-microbial honey encapsulated within biocompatible and biodegradable fibre, and the fibre's production |
| CN101879248A (zh) * | 2010-05-21 | 2010-11-10 | 郭景龙 | 一种具有补血作用的药物组合物 |
| GB2484319A (en) * | 2010-10-06 | 2012-04-11 | Univ Bolton | Electrospinning fibres comprising honey and biocompatible polymer |
| US9101508B2 (en) * | 2011-12-07 | 2015-08-11 | Esmaeil Mirzaei | Electro spun nanofibrous wound dressing and a method of synthesizing the same |
| GB2519072B (en) * | 2013-10-07 | 2019-12-04 | Welland Medical Ltd | Composition comprising collagen and honey |
-
2015
- 2015-08-05 WO PCT/US2015/043789 patent/WO2016022670A1/en not_active Ceased
- 2015-08-05 JP JP2017527194A patent/JP6861151B2/ja active Active
- 2015-08-05 KR KR1020177005687A patent/KR102511882B1/ko active Active
- 2015-08-05 US US14/818,662 patent/US10258717B2/en active Active
- 2015-08-05 EP EP15829615.2A patent/EP3185905B1/en active Active
- 2015-08-05 EP EP19199349.2A patent/EP3656401A1/en active Pending
- 2015-08-05 ES ES15829615T patent/ES2760923T3/es active Active
- 2015-08-05 CN CN201580054031.8A patent/CN107106695B/zh active Active
- 2015-08-05 AU AU2015301070A patent/AU2015301070B2/en active Active
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2019
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2021
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| WO2016022670A1 (en) | 2016-02-11 |
| US20190224380A1 (en) | 2019-07-25 |
| KR102511882B1 (ko) | 2023-03-17 |
| EP3656401A1 (en) | 2020-05-27 |
| US20160038646A1 (en) | 2016-02-11 |
| JP6861151B2 (ja) | 2021-04-21 |
| US10258717B2 (en) | 2019-04-16 |
| AU2015301070B2 (en) | 2021-01-28 |
| EP3185905B1 (en) | 2019-09-25 |
| CN107106695B (zh) | 2021-02-23 |
| US20210308337A1 (en) | 2021-10-07 |
| AU2015301070A1 (en) | 2017-03-16 |
| EP3185905A4 (en) | 2018-04-04 |
| BR112017002259A2 (pt) | 2017-11-21 |
| CN107106695A (zh) | 2017-08-29 |
| KR20170042621A (ko) | 2017-04-19 |
| EP3185905A1 (en) | 2017-07-05 |
| CA2957263A1 (en) | 2016-02-11 |
| NZ729417A (en) | 2024-02-23 |
| JP2017526739A (ja) | 2017-09-14 |
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