CN107095995A - A kind of pharmaceutical composition and preparation method for treating gastritis and gastric ulcer - Google Patents
A kind of pharmaceutical composition and preparation method for treating gastritis and gastric ulcer Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention relates to a kind of Chinese medicine composition for adjusting functions of intestines and stomach and its preparation method and application.The Chinese medicine composition including the following raw material by being made：Rhizoma atractylodis, the bark of official magnolia, dried orange peel, the dried immature fruit of citron orange, the banksia rose, fructus amomi, melanoidin malt, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS, pinellia, cuttle bone, blood clam, the membrane of a chicken's gizzard, licorice.Raw material used in the present invention is parts of generic medicinal plants, ample supply and prompt delivery, is easy to get, and finished product combines modern vanguard technology production using pure Chinese medicine formula.The composition not only can be with invigorating the spleen to clear away damp pathogen, the effect of regulating qi-flowing for eliminating phlegm, can be with stomach invigorating, nourishing the stomach, effect of appetizing；Each component collocation is reasonable, and the treatment for disease is safer, more effective.The formulations such as the capsule, granule, powder, oral agents and the decoction that are further made using composition of the present invention are adapted to long-term taking.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind treats gastritis and Gastric Ulcer Treatment composition and its preparation
Method.
Background technology
With the development of social modernization's process, social competition is fierce, and rhythm of life is fast, and work and study pressure is big, spirit
Anxiety, lives irregular, diet is unhealthy, the incidence of disease more and more higher of disease of digestive system；Along with the passing of time a variety of causes damages
Impairment of the spleen cause is weakness of the spleen and the stomach, and the lower agent of misuse, and the inducement such as damage middle-jiao yang, function of the spleen and stomach, the incidence of disease of gastrointestinal dysfunction increases.Control at present
The method for treating stomach trouble is a lot, is roughly divided into treatment by Chinese herbs, western medicine and the combination of Chinese tradiational and Western medicine.Suitable invigorating the spleen to dry is in Chinese traditional treatment
It is main.
Spleen occupies middle Jiao, and in stomach phase table.Stomach trouble is with the dysfunction and stomach Qi rising received, become thoroughly decomposed, based on stomach Qi upward reversal
Want pathological change.Clinic is with deficiency of food, and gastral cavity is swollen or pain, evil of vomitting, hiccup, and belch etc. is common sympton.
The spleen has the function to transport and transform nutrients, including transporting and transforming nutrients from foodstuff is precise and tiny and transmitting and distributing the fluids.So-called taste, be human diet nutriment intake,
Digestion, the organ for absorbing, being distributed.The lesion of spleen is main with transporting, liter cleaning function dereliction of duty, causes water paddy, water are wet not transport, digests work(
It can decline, water retention changes source deficiency, and the failure of the spleen to keep the blood flowing within the vessels." the spleen being adverse to dampness " is said, source for《Plain Questions declares five gas opinion》,
Zhang Jingyue is noted：" spleen pertaining to the earth, it should be wet, and wet victory then hinders muscle, therefore dislikes wet.”《Plain Questions is discussed when hiding gas method》In " spleen hardship is wet, anxious food
When bitter flavor having drying effect " refers to treatment spleen wet card, amara eliminating dampness is used.The wet card of spleen be by affection of exogenous damp, or eating cold and uncooked food excessively, it is or interior wet tired
Spleen, so that transporting and transforming function of the spleen and stomach mistake department, disturbance in ascending and descending, water is wet to stop gathering, and the tired body of common body is tired, heaviness of the head as if it were tightly bandaged, abdominal fullness and distention, big loose stool
Let out, very then edema, and wet card is touching, normal many accompanying symptoms.Modern medical diagnosis is gastritis, gastric ulcer.
For gastric erosion and the patient of gastric perforation, typically using operative treatment, operative treatment brings pain and warp to patient
Ji burden.The most toxic side effect of doctor trained in Western medicine medication and adverse reaction, and application is narrow, curative effect is nor very significantly, taking stopgap measures and not controlling
This, easily recurrence.Therefore, better, more excellent and smaller toxic side effect reinforcing spleen to promote digestion class tcm product is prepared to seem very
It is important.
The content of the invention
The purpose of the present invention be treat both principal and secondary aspect of disease there is provided a kind of not only warm stomach, nourishing the stomach, appetizing pharmaceutical composition, can be with
Nurse one's health the pharmaceutical composition of the all-digestive tract of enteron aisle；Therapeutic effect is good, efficiency high, human body is had no toxic side effect have regulation stomach
The pharmaceutical composition of intestines effect.
The present invention provides a kind of Chinese medicine composition for adjusting functions of intestines and stomach, by being made including following composition：Rhizoma atractylodis, the bark of official magnolia,
Dried orange peel, the dried immature fruit of citron orange, the banksia rose, fructus amomi, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, pinellia, cuttle bone, blood clam, the membrane of a chicken's gizzard, licorice.
Preferably, composition composition of the present invention is made by following composition：By including 8-12 parts of rhizoma atractylodis, bark of official magnolia 8-12
Part, 8-12 parts of dried orange peel, 8-12 parts of the dried immature fruit of citron orange, 8-12 parts of the banksia rose, 8-12 parts of fructus amomi, 8-12 parts of melanoidin malt, 8-12 parts of charred FRUCTUS CRATAEGI, burnt god
Bent 8-12 parts, 8-12 parts of pinellia, 12-18 parts of cuttle bone, 12-18 parts of blood clam, 8-12 parts of the membrane of a chicken's gizzard, 8-12 parts of systems of licorice
.
Further preferably, composition of the present invention is made by the raw material including following parts by weight：9-11 parts of rhizoma atractylodis, the bark of official magnolia
9-11 parts, 9-11 parts of dried orange peel, 9-11 parts of the dried immature fruit of citron orange, 9-11 parts of the banksia rose, 9-11 parts of fructus amomi, 9-11 parts of melanoidin malt, 9-11 parts of charred FRUCTUS CRATAEGI,
9-11 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 9-11 parts of pinellia, 14-17 parts of cuttle bone, 14-17 parts of blood clam, 9-11 parts of the membrane of a chicken's gizzard, licorice 9-11
Part.
Still more preferably, composition of the present invention is made by the raw material including following parts by weight：10 parts of rhizoma atractylodis, the bark of official magnolia
10 parts, 10 parts of dried orange peel, 10 parts of the dried immature fruit of citron orange, 10 parts of the banksia rose, 10 parts of fructus amomi, 10 parts of melanoidin malt, 10 parts of charred FRUCTUS CRATAEGI, 10 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, ginger
10 parts of the tuber of pinellia, 15 parts of cuttle bone, 15 parts of blood clam, 10 parts of the membrane of a chicken's gizzard, 10 parts of licorice
The composition can pass through commercially available purchase.
Present invention also offers the preparation method of above-mentioned composition, comprise the following steps：Each composition is weighed according to proportioning, is used
Ethanol/water solution refluxing extraction, filtering, filtrate concentration is drying to obtain.
Preferably, described preparation method comprises the following steps：According to proportioning weigh each composition according to proportioning weigh it is each into
Point, extracted 2-3 times with alcohol reflux, the 30-85% of 6-15 times of medicinal material weight ethanol is added every time, 2-3 is extracted for the first time small
When, second of extraction 1-2 hours, third time is extracted 1-2 hours, and filtering, merging filtrate flings to ethanol, is concentrated, dry, is produced.
It is further preferred that described preparation method comprises the following steps：Each composition is weighed according to proportioning according to proportioning to claim
Each composition is taken, is extracted 3 times with alcohol reflux, the 50-75% of 8-10 times of medicinal material weight ethanol is added every time, is extracted for the first time
2.5 hours, second of extraction 1.5 hours, third time is extracted 1.5 hours, and filtering, merging filtrate flings to ethanol, is concentrated into relative
Density is 1.12-1.23, dries, produces.
Present invention also offers the preparation containing above-mentioned composition, said preparation is individually composed by above-mentioned composition or has combination
Thing and pharmaceutically acceptable carrier or excipient composition.
Described preparation is capsule, granule, powder, oral agents or decoction.
Described capsule filling auxiliary material is lactose, microcrystalline cellulose, starch, cyclodextrin etc..
Described granule filling auxiliary material is Icing Sugar, dextrin, maltodextrin, starch, lactose etc..
Described oral liquid sweetener auxiliary material is sucrose, Aspartame；Preservative is sodium benzoate, potassium sorbate.
The decocting method of described decoction：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and washing first adds water
1200-1800mL decocts blood clam 25-40 minute, adds the medicinal material continuation of remaining immersion 20-40 minutes in addition to fructus amomi
Big fire is decocted 10-20 minutes, then with being cooked by slow fire 25-55 minutes, the rear fructus amomi that adds is decocted 5-15 minutes, obtains decoction 300-
900mL, divides 2-3 times and takes.
Above-mentioned preparation can be prepared using conventional preparation process.
Present invention also offers application of the above-mentioned composition in the health products and medicine for preparing regulation stomach.
The present invention is provided in Halth-care composition：
Rhizoma atractylodis：This product is feverfew Atractylis lancea Atractylodes lancea (Thunb.) D C. or Atractylis chinensis
Atractylodes chinensis (DC.) Koidz. dry rhizome.Pound, season in autumn two excavates, remove silt and do, hit palpus
Root.Record in《Chinese Pharmacopoeia》Version first page 161 in 2015.
The bark of official magnolia：This product is Magnoliacea plant bark of official magnolia Magnolia officinalis Rehd.Et Wils. or Magnolia bilola
Magnolia officinalis Rehd.et Wils.var.bilobaRehd.et Wils. drying dry hide, root skin and branch
Skin.4~June strips, root skin and branch skin Directly Dried in Shadow；Dry hide put in boiling water it is micro- boil after, bank up dark and damp place, " sweating " to inner surface
When becoming puce or sepia, steam soft, take out, be rolled into tubular, dry.Record in《Chinese Pharmacopoeia》Version first in 2015
Page 251.
Dried orange peel：This product is rutaceae orange Citrus reticulata Blanco and its drying and ripening of variety
Pericarp.Medicinal material is divided into " dried orange peel " and " citrus chachiensis hortorum ".Harvesting ripe fruit, strips pericarp, dries or low temperature drying.Record in《In
State's pharmacopeia》Version first page 191 in 2015.
The dried immature fruit of citron orange：This product is rutaceae bitter orange Citrus aurantium ' L. and its plants handful mutation or sweet orange Citrus
Sinensis Osbeck drying young fruit.5~June, collected from the fruit fallen, removes impurity, and crosscutting from middle part is two halves, is dried
Or low temperature drying, smaller directly dries or low temperature drying.Record in《Chinese Pharmacopoeia》Version first page 247 in 2015.
The banksia rose：This product is feverfew banksia rose Aucklandia lappa Decne. dry root.Autumn, the excavation of season in winter two,
Silt and fibrous root are removed, segment, big vertical profile again hits tertia into valve after drying.Record in《Chinese Pharmacopoeia》Version in 2015
One page 62.
Fructus amomi：This product is zingiberaceous plant amomum viosum Amomwm villosum Lour., green shell sand Amomum villosum
Lour.var.xanthioides T.L.Wu et Senjen's or SEMEN AMOMI LONGILIGULA Amomum longiligulare T.L.Wu is dry
Dry ripening fruits.Harvest, dry or low temperature drying when summer, two season of autumn fruit maturation.Record in《Chinese Pharmacopoeia》Version in 2015
One page 253.
Melanoidin malt：The ripening fruits that malt is grass barley Hordeum vulgareL. is through the dry big gun of germination
Processed goods processed.After wheat is soaked in water, suitable epidemic disaster is kept, when young shoot length is to about 5mm, is dried or low temperature drying.It is burnt
Malt is to take net malt, according to the method for frying (《Chinese Pharmacopoeia》Version general rule 0213 in 2015) fry to burnt brown, cool, weed out grey bits.
This product shape such as malt, surface coke brown has focal spot.There are burnt odor gas, mildly bitter flavor.Record in《Chinese Pharmacopoeia》Version first in 2015
Page 156.
Charred FRUCTUS CRATAEGI：Hawthorn is rosaceous plant large-fruited Chinese hawthorn Crataegus pimiatificia Bge.var.m ajor N,
E.Br, or hawthorn Crataegus pinnatifida Bge, white peony root dry mature fruit.Harvest, cut during autumn fruit maturation
Piece, is dried.Charred FRUCTUS CRATAEGI is to take net hawthorn, according to the method for frying (《Chinese Pharmacopoeia》Version general rule 0213 in 2015) fry to surface coke brown,
Internal yellowish-brown.This product shape such as haw flakes, surface coke brown, internal yellowish-brown.There is burnt odor gas.Record in《Chinese Pharmacopoeia》2015
Year version first page 31.
Stir-baked MASSA FERMENTATA MEDICI-NALIS：Medicated Leaven is that the medicines such as peppery few, sweet wormwood, almond add the herbal leaven through fermenting after the mixing of people's flour.Six god
Bent (stir-bake to brown) takes Medicated Leaven, is cut into small pieces, and shines《Chinese Pharmacopoeia》Version the 4th in 2015 is fried method (general rule 0213) and fried to surface
Coke black, the inside frying is into coke yellow.
Pinellia：The tuber of pinellia is aroid the tuber of pinellia Pinellia ternata (Thunb.) Breit. dried pieces
Stem.Summer, the excavation of season in autumn two, clean, remove crust and fibrous root, dry.This product is the Preparation process product of the tuber of pinellia.【Preparation method】Take net half
Summer, size is separated, be soaked in water to it is interior without the dry heart when, take out；It is another to take ginger section decoct soup, plus rock is well-done altogether with the tuber of pinellia in vain, takes
Go out, dry, or dry in the air to half-dried, dry；Or shave, dry.Per the net tuber of pinellia of 100kg, with ginger 25kg, white rock 12.5kg.Receive
It is loaded in《Chinese Pharmacopoeia》Version first page 120 in 2015.
Cuttle bone：Also known as cuttlebone.This product is Sepiidae animal sepiella maindroni de Rochebrune Sepiella main dronide
Rochebrune or golden cuttlefish Sepie esculenta Hoyle drying inner casing.The bone-shaped inner casing of cuttlefish fish is collected, is cleaned,
Dry.Record in《Chinese Pharmacopoeia》Version first page 294 in 2015.
Blood clam：This product is blood clam section animal blood clam Area subcrenata Lischke, the intoxicated Area granosa of mud
The intoxicated Area inflate Reeve of Linnaeus or stalwart shell.Autumn, spring next year in Winter Solstice fish for, and clean, put in boiling water and slightly boil, go
Meat, is dried.Record in《Chinese Pharmacopoeia》Version first page 70 in 2015.
The membrane of a chicken's gizzard：This product is in Phasianidae animal family chicken Callus gallus domesticus Brisson drying ballast
Wall.Kill after chicken, take out chicken gizzard, immediately inwall under capsule, cleaning, drying.Record in《Chinese Pharmacopoeia》Version first the 193rd in 2015
Page.
Licorice：This product is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix
Glycyrrhiza inflate Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Spring, autumn two
Season excavates, and removes fibrous root, dries.Record in《Chinese Pharmacopoeia》Version first page 86 in 2015.
Fang Xie：Stomach trouble is mostly Spleen-Qi Deficiency, and damp evil is invaded, the spleen being blocked by dampness, in addition overstrain and eating and drinking without temperance, transporting imbalance,
Performance with gastral cavilty make it is swollen based on, have concurrently vomit inverse, feeling of fullness, pain etc. card, therefore side using rhizoma atractylodis, the bark of official magnolia as monarch, two medicine phases must for use, it is dry
Wet invigorating the spleen, except the foul gas of middle Jiao, up to strengthening the spleen and stomach, promotees transporting, the effect of promoting the circulation of qi dampness elimination de-swelling.It is aided with the dried immature fruit of citron orange, pinellia, dried orange peel,
Strengthen eliminating dampness, stopping nausea and vomiting by lowering the adverse flow of QI, the work(of dissolving lump and resolving mass.Assistant is with fructus amomi, the banksia rose, and promoting the circulation of qi invigorating the spleen, Charred Triplet, the membrane of a chicken's gizzard stomach strengthening and digestion promoting are led
It is stagnant, stopping nausea and vomiting by lowering the adverse flow of QI, blood clam, cuttle bone relieving haperacidity analgesic；Licorice is makes, relieving spasm to stop pain, all medicines share, play altogether dehumidifying resolving sputum,
The effect of spleen benefiting and stimulating the appetite, regulating qi-flowing for relieving pain, consumer product dredge stasis, relieving haperacidity preventing or arresting vomiting.
What technical scheme of the present invention was obtained has the beneficial effect that：
Present invention applicant is in research Chinese traditional herbs and on the basis of having consulted substantial amounts of pharmacy data, by for many years
Experience, therefrom have found can long-term taking, regulation functions of intestines and stomach effect is good, and the Chinese medicine that has no side effect and determining most preferably is matched somebody with somebody
Than.The effect of composition not only has invigorating the spleen to clear away damp pathogen, regulating qi-flowing for eliminating phlegm, also with stomach invigorating, nourishing the stomach, effect of appetizing；Each group
Divide collocation reasonable, the treatment for disease is safer, more effective.
Raw material used in the present invention is parts of generic medicinal plants, ample supply and prompt delivery, is easy to get, and finished product is combined modern using pure Chinese medicine formula
Vanguard technology is produced.The capsule that is further made using composition of the present invention, granule, powder, oral agents and
The formulations such as decoction are adapted to long-term taking.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
No special explanation of the present invention, the concentration of the ethanol solution is percent by volume.
A kind of composition and capsule for treating gastritis and Gastric Ulcer Treatment of embodiment 1
Raw material：Rhizoma atractylodis 12g, bark of official magnolia 12g, dried orange peel 12g, dried immature fruit of citron orange 12g, banksia rose 12g, fructus amomi 12g, melanoidin malt 12g, charred FRUCTUS CRATAEGI
12g, stir-baked MASSA FERMENTATA MEDICI-NALIS 12g, pinellia 12g, cuttle bone 18g, blood clam 18g, the membrane of a chicken's gizzard 12g, licorice 12g.
The preparation method of composition：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and 3 are extracted with alcohol reflux
It is secondary, 85% ethanol of 10 times of medicinal material weight is added every time, is extracted 3 hours for the first time, is extracted 1.5 hours for the second time, third time
Extract 1.5 hours, filtering, merging filtrate flings to ethanol, it is 1.23 to be concentrated into relative density, dries, produces medicinal extract 48.3g.
The preparation method of capsule：Gained medicinal extract composition is added into starch 20g, superfine silica gel powder 5g, according to conventional Chinese medicine
The formulation method of capsule is crushed, and granulation, dry packing obtains taking the capsule of three consumptions.
Embodiment 2：A kind of composition and granule for treating gastritis and Gastric Ulcer Treatment
Raw material：Rhizoma atractylodis 11g, bark of official magnolia 11g, dried orange peel 11g, dried immature fruit of citron orange 11g, banksia rose 11g, fructus amomi 11g, melanoidin malt 11g, charred FRUCTUS CRATAEGI
11g, stir-baked MASSA FERMENTATA MEDICI-NALIS 11g, pinellia 11g, cuttle bone 17g, blood clam 17g, the membrane of a chicken's gizzard 11g, licorice 11g.
The preparation method of composition：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and 3 are extracted with alcohol reflux
It is secondary, 75% ethanol of 10 times of medicinal material weight is added every time, is extracted 2.5 hours for the first time, and 1.5 hours, the 3rd are extracted for the second time
Secondary to extract 1.5 hours, filtering, merging filtrate flings to ethanol, is concentrated into relative density 1.20, dries, produces medicinal extract 41.8g.
The preparation method of granule：By above-mentioned gained medicinal extract and Icing Sugar 2g Icing Sugar, and 19.6g dextrin is according to conventional Chinese medicine system
Particle is made in the method for agent, dries, and sterilizes, and packaging obtains taking the granule of three consumptions.
Embodiment 3：A kind of composition and granule for treating gastritis and Gastric Ulcer Treatment
Raw material：Rhizoma atractylodis 8g, bark of official magnolia 8g, dried orange peel 8g, dried immature fruit of citron orange 8g, banksia rose 8g, fructus amomi 8g, melanoidin malt 8g, charred FRUCTUS CRATAEGI 8g, burnt god
Bent 8g, pinellia 8g, cuttle bone 12g, blood clam 12g, the membrane of a chicken's gizzard 8g, licorice 8g.
The preparation method of composition：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and 2 are extracted with alcohol reflux
It is secondary, 30% ethanol of 6 times of medicinal material weight is added every time, is extracted 2 hours for the first time, is extracted 1 hour for the second time, and third time is extracted
1 hour, filtering, merging filtrate flung to ethanol, is concentrated into relative density 1.11, dries, produces medicinal extract 25.6g.
The preparation method of granule：By above-mentioned gained medicinal extract and Icing Sugar, and 15.6g dextrin is according to the side of conventional Chinese medicine preparation
Particle is made in method, dries, and sterilizes, and packaging obtains taking the granule of three consumptions.
Embodiment 4：A kind of composition and oral agents for treating gastritis and Gastric Ulcer Treatment
Raw material：Rhizoma atractylodis 9g, bark of official magnolia 9g, dried orange peel 9g, dried immature fruit of citron orange 9g, banksia rose 9g, fructus amomi 9g, melanoidin malt 9g, charred FRUCTUS CRATAEGI 9g, burnt god
Bent 9g, pinellia 9g, cuttle bone 14g, blood clam 14g, the membrane of a chicken's gizzard 9g, licorice 9g.
The preparation method of composition：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and 2 are extracted with alcohol reflux
It is secondary, 50% ethanol of 8 times of medicinal material weight is added every time, is extracted 2.5 hours for the first time, is extracted 1.5 hours for the second time, third time
Extract 1.5 hours, filtering, merging filtrate flings to ethanol, is concentrated into relative density 1.15, dry, produce medicinal extract 31.5g.
The preparation method of oral agents：Medicinal extract is dissolved in 100mL water, 90% ethanol precipitation is used, refrigeration centrifugation is obtained clearly
Liquid, is concentrated into 60mL, adds sucrose 3g, sterilizes, and packaging obtains the oral liquid formulations of three consumptions.
Embodiment 5：A kind of composition for treating gastritis and Gastric Ulcer Treatment
Raw material：Rhizoma atractylodis 10g, bark of official magnolia 10g, dried orange peel 10g, dried immature fruit of citron orange 10g, banksia rose 10g, fructus amomi 10g, melanoidin malt 10g, charred FRUCTUS CRATAEGI
10g, stir-baked MASSA FERMENTATA MEDICI-NALIS 10g, pinellia 10g, cuttle bone 15g, blood clam 15g, the membrane of a chicken's gizzard 10g, licorice 10g.
The preparation method of composition：Each composition is weighed according to proportioning according to proportioning and weighs each composition, and 3 are extracted with alcohol reflux
It is secondary, 60% ethanol of 10 times of medicinal material weight is added every time, is extracted 2.5 hours for the first time, and 1.5 hours, the 3rd are extracted for the second time
Secondary to extract 1.5 hours, filtering, merging filtrate flings to ethanol, is concentrated into relative density 1.18, dries, produces medicinal extract 49.9g.
Embodiment 6：A kind of composition and decoction for treating gastritis and Gastric Ulcer Treatment
Raw material：Rhizoma atractylodis 10g, bark of official magnolia 10g, dried orange peel 10g, dried immature fruit of citron orange 10g, banksia rose 10g, fructus amomi 10g, melanoidin malt 10g, charred FRUCTUS CRATAEGI
10g, stir-baked MASSA FERMENTATA MEDICI-NALIS 10g, pinellia 10g, cuttle bone 15g, blood clam 15g, the membrane of a chicken's gizzard 10g, licorice 10g.
The preparation method of decoction：Each composition, which is weighed, according to proportioning according to proportioning weighs each composition, washing, first add water 1500mL
Blood clam 30 minutes is decocted, the medicinal material for adding remaining immersion 30 minutes in addition to fructus amomi continues big fire and decocted 15 minutes, then
With being cooked by slow fire 35 minutes, the rear fructus amomi that adds is decocted 10 minutes, is obtained decoction 750mL, is a staggering amount, takes in three times.
Compliance test result
In May, 2014 in October, 2016 is selected in 232 out-patients of hospital admission.Meet CFDA in 2012 to issue
Cloth《Chinese medical disease Standardization of diagnosis and curative effect》.It is divided into two groups by random digits table.Treatment group 116, it is average 47.6 years old；The course of disease
5 months to 29 years.Control group 116, it is average 46.8 years old；The course of disease 10 months to 27 years.All cases are through clinical syndrome differentiation parting
For epigastric pain patient, and regarding the state of an illness, checked respectively through gastroscope or upper digestive tract barivm meal fluoroscopy (screem), B ultrasound, pathology etc. exclude Digestive or
Epigastric pain caused by other malignant tumours, acute and chronic pancreatitis, appendicitis, courage system or stone in urinary system etc..Two groups of patients are in property
Not, no significant difference (P in terms of age, the course of disease, incidence>0.05).
Method:Using random, parallel positive drug control design method, 232 gastritis and patients w ith peptic ulcer disease are divided at random
Enter treatment group and control group.Curative effect index is tcm syndrome total mark, and secondary efficacy index integrates for tcm symptom individual event,
2 groups of therapeutic scheme efficacy results use chi square test.Control group 116 gives the treatment such as Omeprazole, Amoxicillin, Domperidone, controls
Treatment group 116 gives this case patented invention medicine composite for curing, and 7d is 1 course for the treatment of, two groups continuously treat 4 courses for the treatment of after sentence
Constant current modulation is imitated.As a result treatment group's total effective rate is 98%, and control group is 91%, the statistically significant (P of difference<0.05).Two groups of trouble
Gastral cavilty portion pain, vexed ruffian or turgor, belch, pantothenic acid, gastric upset, nausea and vomiting shape case significantly reduce (P before relatively treating in person
<0.01), the statistically significant (P of comparing difference between group<0.05).
1. two groups of patients with gastric disease curative effects of table
The result of table 1. shows that treatment group's clinical efficacy is slightly better than control group (P<0.05), and treatment group adverse reaction case
It is 0, and control group adverse reaction occurs 2.
2. two groups of patients with gastric disease symptoms of table, which improve, to be compared
The result of table 2. shown after treatment, gastral cavilty portion pain, vexed ruffian or turgor in two groups of patients, belch, pantothenic acid, noisy
Disease, nausea and vomiting shape case significantly reduce (P before relatively treating<0.01), the statistically significant (P of comparing difference between group<0.05).
Conclusion shows that present invention treatment epigastric pain effect is notable.
Clinical case：
Case 1, Zhao, female, 40 years old age, Hebei Hengshui City people do electronic gastroscopy in hospital, and inspection result shows
Show：Stomach bottom:Mucus lake amount is medium, clear；Body of stomach:Mucous hyperemia, oedema, the big curved visible point-like that is dispersed in are rotten to the corn, pleat marshalling,
Antrum is congested, oedema, and four walls are visible to be dispersed in flat protuberance, and top is rotten to the corn, slightly concave to fall into, and wriggles active.HP is detected：It is positive.
Chronic superficial gastritis is diagnosed as with rotten to the corn.Once treated in multiple hospitals, took multi-medicament, but all do not improve.In 17
Begin to use the Chinese medicine composition of the present invention after individual month, started to take the traditional Chinese herbal decoction of the embodiment of the present invention 6 May 15, often
Secondary oral 250ml, 3 times a day.Take after 10 days, symptom disappears, in hospital's further consultation after one month, through electronic gastroscopy, knot
Fruit shows：Gastric body mucosa is smooth, has no ulcer and bleeding, and antrum is smooth, has no bleeding and ulcer, and wriggling can.HP is detected：
It is negative.Patient has fully recovered, follow-up 2 years, no relapse.
Case 2, money, man, 43 years old, Ningbo of Zhejiang people, gastroscope result was shown：Body of stomach：Smooth mucosal, piebald shape；Stomach angle：
It is curved, it is seen that to be dispersed in congested erosion；Antrum：It is congested rotten to the corn with being dispersed in mucous membrane sheet hyperemia water.The aobvious positive of HP detections.Symptom
For upper abdomen distending pain after meal, sample pain is burnt, is erosive gastritis through hospital's tentative diagnosis, once took plurality of Chinese and Western medicine,
But effect is not notable, and symptom will soon recur after taking a turn for the better, and typically can not continue 1 month, it is impossible to effect a radical cure, recurrent exerbation is existing
1 year.Start to take the traditional Chinese herbal decoction of the embodiment of the present invention 6 in patient after half a year, take after 7 days, symptom is clearly better, rear following the service
After 10 days, symptom disappears.Through hospital's further consultation, fully recover.Follow-up so far, no relapse.
Case 3, poplar, man, 51 years old, existing 8 years with atrophic gastritis, gastroscope result was shown：Atrophic gastritis mucous membrane
Red and white, based on white, blood vessel is seen through.Gastritis class medicine, such as Omeprazole are taken throughout the year, but can not reach radical cure
Effect.Start to take traditional Chinese herbal decoction of the present invention in October, 2014, take after 15 days, symptom has been alleviated, the rear following the service present invention
Decoction, is taken and is almost recovered after one month, through hospital diagnosis, and atrophic gastritis has been fully recovered, follow-up so far, no relapse.
Case 4, Mr. Wang, male, 38 years old, people from Jilin Province, often stomachache, continues 6 years, work and study pressure, it is impossible to normally eat
Meal, the phenomenon for often having sour regurgitation stomachache gasteremphraxis, is diagnosed as superficial gastritis through institute of traditional Chinese medicine of county, takes a variety for the treatment of superficial gastritis
Medicine, including Chinese medicine and Western medicine, but can not effect a radical cure be changeable, has a surplus within 6 years.Start to take this hair in March, 2015
The traditional Chinese herbal decoction of bright embodiment 6, takes after 10 days, symptom mitigation, and symptom disappears substantially after 5 days, through Zhejiang Provincial People's Hospital
Further consultation, has fully recovered, follow-up so far, no relapse.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for adjusting functions of intestines and stomach, it is characterised in that by being made including the following raw material：It is rhizoma atractylodis, the bark of official magnolia, old
Skin, the dried immature fruit of citron orange, the banksia rose, fructus amomi, melanoidin malt, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS, pinellia, cuttle bone, blood clam, the membrane of a chicken's gizzard, licorice.
2. Chinese medicine composition according to claim 1, it is characterised in that be made by the raw material including following parts by weight：It is grey
8-12 parts of art, 8-12 parts of the bark of official magnolia, 8-12 parts of dried orange peel, 8-12 parts of the dried immature fruit of citron orange, 8-12 parts of the banksia rose, 8-12 parts of fructus amomi, 8-12 parts of melanoidin malt,
8-12 parts of charred FRUCTUS CRATAEGI, 8-12 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 8-12 parts of pinellia, 12-18 parts of cuttle bone, 12-18 parts of blood clam, the membrane of a chicken's gizzard 8-12
Part, 8-12 parts of licorice.
3. Chinese medicine composition according to claim 1, it is characterised in that be made by the raw material including following parts by weight：It is grey
9-11 parts of art, 9-11 parts of the bark of official magnolia, 9-11 parts of dried orange peel, 9-11 parts of the dried immature fruit of citron orange, 9-11 parts of the banksia rose, 9-11 parts of fructus amomi, 9-11 parts of melanoidin malt,
9-11 parts of charred FRUCTUS CRATAEGI, 9-11 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 9-11 parts of pinellia, 14-17 parts of cuttle bone, 14-17 parts of blood clam, the membrane of a chicken's gizzard 9-11
Part, 9-11 parts of licorice.
4. Chinese medicine composition according to claim 1, it is characterised in that be made by the raw material including following parts by weight：It is grey
10 parts of art, 10 parts of the bark of official magnolia, 10 parts of dried orange peel, 10 parts of the dried immature fruit of citron orange, 10 parts of the banksia rose, 10 parts of fructus amomi, 10 parts of melanoidin malt, 10 parts of charred FRUCTUS CRATAEGI, Jiao
10 parts of Divine Comedy, 10 parts of pinellia, 15 parts of cuttle bone, 15 parts of blood clam, 10 parts of the membrane of a chicken's gizzard, 10 parts of licorice.
5. the preparation method of any Chinese medicine compositions of claim 1-4, it is characterised in that weigh each composition according to proportioning,
Ethanol/water solution refluxing extraction is used, is filtered, filtrate concentration is drying to obtain.
6. preparation method according to claim 5, it is characterised in that weigh each composition according to proportioning and weighed respectively according to proportioning
Composition, is extracted 2-3 times with alcohol reflux, and the 30-85% of 6-15 times of medicinal material weight ethanol is added every time, 2-3 is extracted for the first time
Hour, second of extraction 1-2 hours, third time is extracted 1-2 hours, and filtering, merging filtrate flings to ethanol, is concentrated, dry, i.e.,
.
7. a kind of Chinese medicine preparation, it is characterised in that be individually composed by any Chinese medicine compositions of claim 1-4, or by group
Compound and pharmaceutically acceptable carrier or excipient composition；The preparation is capsule, granule, powder, oral agents or soup
Agent.
8. Chinese medicine preparation according to claim 7, it is characterised in that the capsule filling auxiliary material is lactose, crystallite fibre
Tie up element, starch, cyclodextrin；The granule filling auxiliary material is Icing Sugar, dextrin, maltodextrin, starch, lactose；The oral liquid
Sweetener auxiliary material is sucrose, Aspartame；Preservative is sodium benzoate, potassium sorbate.
9. the preparation method of Chinese medicine preparation described in claim 7 or 8, it is characterised in that the decocting method of the decoction：According to
Each composition is weighed than weighing each composition according to proportioning, and washing, the 1200-1800mL that first adds water decocts blood clam 25-40 minute, then plus
The medicinal material for entering remaining immersion 20-40 minutes in addition to fructus amomi continues big fire and decocted 10-20 minutes, then with being cooked by slow fire 25-55
Minute, the rear fructus amomi that adds is decocted 5-15 minutes, is obtained decoction 300-900mL, is divided 2-3 times and take.
10. Chinese medicine preparation described in any compositions of claim 1-4 or claim 7 or 8 is preparing the guarantor of regulation stomach
Application in strong product and medicine.
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| CN108273023A (en) * | 2018-03-19 | 2018-07-13 | 宋宝昌 | A kind of traditional Chinese powder medicine for treating acute, chronic gastritis and gastric ulcer |
| CN108355104A (en) * | 2018-05-17 | 2018-08-03 | 李雪 | A kind of Chinese medicine of tcm internal medicine treatment peptic ulcer |
| CN112641902A (en) * | 2021-01-22 | 2021-04-13 | 李三军 | A Chinese medicinal composition for treating gastropathy, and its preparation method |
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| KR20080094982A (en) * | 2007-04-23 | 2008-10-28 | 강릉대학교산학협력단 | Composition comprising powder of tangerine peel or the extract thereof for treating and preventing gastrointestinal disease |
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| JP3977724B2 (en) * | 2001-11-06 | 2007-09-19 | ロート製薬株式会社 | Pharmaceutical composition |
| KR20080094982A (en) * | 2007-04-23 | 2008-10-28 | 강릉대학교산학협력단 | Composition comprising powder of tangerine peel or the extract thereof for treating and preventing gastrointestinal disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108273023A (en) * | 2018-03-19 | 2018-07-13 | 宋宝昌 | A kind of traditional Chinese powder medicine for treating acute, chronic gastritis and gastric ulcer |
| CN108355104A (en) * | 2018-05-17 | 2018-08-03 | 李雪 | A kind of Chinese medicine of tcm internal medicine treatment peptic ulcer |
| CN112641902A (en) * | 2021-01-22 | 2021-04-13 | 李三军 | A Chinese medicinal composition for treating gastropathy, and its preparation method |
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