CN104208312A - Drug for treating hyperlipidemia - Google Patents
Drug for treating hyperlipidemia Download PDFInfo
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- CN104208312A CN104208312A CN201410509511.6A CN201410509511A CN104208312A CN 104208312 A CN104208312 A CN 104208312A CN 201410509511 A CN201410509511 A CN 201410509511A CN 104208312 A CN104208312 A CN 104208312A
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Abstract
The invention discloses a drug for treating hyperlipidemia and belongs to the technical field of Chinese medicine. The drug for treating the hyperlipidemia is prepared from the following raw materials of, by weight, 32-68 parts of pilose asiabell roots, 32-68 parts of oriental waterplantain rhizome, 32-68 parts of cassia barks, 20-36 parts of herba ephedra, 20-36 parts of dried tangerine or orange peel, 12-24 parts of burdock, 12-24 parts of medicated leaven, 12-24 parts of semen cassia, and 6-48 parts of hawthorn. The drug for treating the hyperlipidemia is high in healing rate, small in dosage, simple in preparation process, and suitable for popularization and application.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of medicine for the treatment of hyperlipidemia and preparation method thereof.
Background technology
Hyperlipemia is commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people, although the light moderate of blood fat increases itself and does not cause malaise symptoms, but can slowly cause atherosclerosis and even coronary heart disease, apoplexy etc., cause the grievous injury of vitals, therefore finding safe, effective, economic Jiangzhi Recipe medicine has very important meaning.
How the appellation of Chinese medicine ahyperlipoidemia, belong to obesity, headache, dizzy, the category such as the thoracic obstruction, cardiopalmus by primary disease.The traditional Chinese medical science think hyperlipemia and liver,spleen,kidney three dirty in close relations, be the dirty void of liver,spleen,kidney three be this, water is wet, expectorant is turbid, blood stasis is target disease.Liver spleen kidney deficiency is the pathologic basis that hyperlipemia occurs, and the turbid blood stasis of expectorant is that hyperlipemia occurs, develops, lapses to the basic pathology with prognosis, can cause the thoracic obstruction, dizzy, cardiopalmus, apoplexy etc. and become disease generation.Expectorant is formed in spleen, also changes in spleen, and therefore invigorating the spleen for dissipating phlegm method, to the adjustment of blood fat, becomes the key point of Chinese medicine lipid metabolic disorder.
Summary of the invention
The technical problem to be solved in the present invention is to provide the medicine for the treatment of hyperlipidemia that a kind of good effect, cure rate are high, have no side effect.
The present invention treats the Chinese medicine of hyperlipidemia, and it is made up of the raw material of following weight portion: Radix Codonopsis 32-68, Rhizoma Alismatis 32-68, Cortex Cinnamomi 32-68, Herba Ephedrae 20-36, Pericarpium Citri Reticulatae 20-36, Fructus Arctii 12-24, Massa Medicata Fermentata 12-24, Semen Cassiae 12-24, Fructus Crataegi 6-48.
As preferably, Chinese medicine composition of the present invention can be made up of the raw material of following weight portion: Radix Codonopsis 32-60, Rhizoma Alismatis 40-60, Cortex Cinnamomi 32-60, Herba Ephedrae 21-36, Pericarpium Citri Reticulatae 20-30, Fructus Arctii 12-22, Massa Medicata Fermentata 12-24, Semen Cassiae 12-20, Fructus Crataegi 10-48.
As preferably, Chinese medicine composition of the present invention can be made up of the raw material of following weight portion: Radix Codonopsis 36-60, Rhizoma Alismatis 48-60, Cortex Cinnamomi 36-40, Herba Ephedrae 24-36, Pericarpium Citri Reticulatae 20-24, Fructus Arctii 12-20, Massa Medicata Fermentata 12-24, Semen Cassiae 12-16, Fructus Crataegi 12-48.
As preferably, Chinese medicine composition of the present invention can be made up of the raw material of following weight portion: Radix Codonopsis 60, Rhizoma Alismatis 60, Cortex Cinnamomi 40, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 12, Semen Cassiae 12, Fructus Crataegi 24.
As preferably, Chinese medicine composition of the present invention also can be made up of the raw material of following weight portion: Radix Codonopsis 48, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 16, Semen Cassiae 12, Fructus Crataegi 48.
As preferably, Chinese medicine composition of the present invention can also be made up of the raw material of following weight portion: Radix Codonopsis 36, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 36, Pericarpium Citri Reticulatae 20, Fructus Arctii 12, Massa Medicata Fermentata 24, Semen Cassiae 16, Fructus Crataegi 12.
The source of prescription Chinese crude drug, meridian distribution of property and flavor and effect are as follows:
Radix Codonopsis: another name: eastern party, platform party, the Lushui River party, mouth party.For the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Autumn excavates, and cleans, dries.
Concoct, removing impurity, cleans, runs through, cut sheet, dry.Nature and flavor, sweet, flat.Gui Jing, returns spleen, lung meridian.Function cures mainly invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Rhizoma Alismatis: another name, marshy land, Rhizoma Alismatis, car Herba Sonchi Oleracei, Saxidomus purpuratus, sky are bald, YIZHIHUA.Source, this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Excavate when winter, stem and leaf started withered, cleaning, drying, removing fibrous root and rough bark.Concoct, removing impurity, slightly soaks, runs through, cut sheet, dry.Nature and flavor, sweet, cold.Gui Jing, returns kidney, urinary bladder channel.Function cures mainly, diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Cortex Cinnamomi: be the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.Strip more than autumn, dry in the shade.Concoct, removing impurity and rough bark.Used time smashs to pieces.Nature and flavor, pungent, sweet, hot greatly.Gui Jing, returns kidney, spleen, the heart, Liver Channel.Function cures mainly, and mends fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Herba Ephedrae: color channel fiber crops, knot power root are the dry herb stem of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C. A. Mey. or ephedra equisetina Ephedra equisetina Bge..Tap green herb stem autumn, dry.Concoct: removing woody stems, undesirable root and impurity, cutting.Nature and flavor, pungent, micro-hardship, temperature.Gui Jing, returns lung, urinary bladder channel.Function cures mainly, diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.
Pericarpium Citri Reticulatae: another name, Pericarpium Citri tangerinae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.Concoct, removing impurity, shower water, runs through, and shredding is dried in the shade.Nature and flavor, bitter, pungent, temperature.Gui Jing, returns lung, spleen channel.Function cures mainly, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Arctii: another name, Fructus Arctii, evil are real.For the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..To gather during fruit maturation in autumn infructescence, dry, lay fruit, removing impurity, then dry.Concoct, removing impurity, cleaning, drying.Used time smashs to pieces.Fructus Arctii (parched): get clean Fructus Arctii, fries to slightly heaving according to frying method (appendix II D), micro-ly has fragrance.Used time smashs to pieces.Nature and flavor are pungent, bitter, cold.Attach to the lung and stomach meridians.Function cures mainly, dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Massa Medicata Fermentata: another name, Massa Medicata Fermentata.For the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.Concoct, get Massa Medicata Fermentata and put in pot that to fry to appearance be coke black, inner coke yellow, taking-up, slightly sprays a little clear water, cools.Nature and flavor, sweet; Pungent; Temperature; Nontoxic.Gui Jing, spleen; Stomach warp.Function cures mainly, invigorating the spleen and regulating the stomach; Promoting digestion and removing stagnation.Main retention of food and drink; Dyspepsia; Distension and fullness in the abdomen; Inappetence; Vomiting dysentery.
Semen Cassiae: another name, Horse hoof Semen Cassiae, blunt leaf Semen Cassiae, false Semen phaseoli radiati, Semen Cassiae.The dry mature seed of leguminous plant Semen Cassiae Cassia obtusifolia L. or little Semen Cassiae Cassia tora L..To gather autumn mature fruit, dry, lay seed, removing impurity.Semen Cassiae (parched): get clean Semen Cassiae, has fragrance according to frying method (appendix II D) stir-fry to micro-.Used time smashs to pieces.Nature and flavor, sweet, bitter, salty, be slightly cold.Gui Jing, returns liver, large intestine channel.Function cures mainly, clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Fructus Crataegi: be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Gather during fruit maturation in autumn, section, dry.Concoct, get clean Fructus Crataegi slice and put in pot, fry to surface coke brown, inner yellowish-brown.Nature and flavor, sour, sweet, tepor.Gui Jing, returns spleen, stomach, Liver Channel.Function cures mainly, promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Share can complement each other at above-mentioned all medical material, learn from other's strong points to offset one's weaknesses, promote drug effect, can blood fat reducing disappear addiction, invigorate blood circulation that it is turbid to rush down, have evident in efficacy to the treatment of hyperlipidemia, the advantage had no side effect; Through clinical verification, the total effective rate that the present invention treats hyperlipidemia is 100%.
Detailed description of the invention
Embodiment 1:
The medicine of the present embodiment treatment hyperlipidemia, is made up by weight of following raw materials according: Radix Codonopsis 60, Rhizoma Alismatis 60, Cortex Cinnamomi 40, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 12, Semen Cassiae 12, Fructus Crataegi 24.
Embodiment 2:
The medicine of the present embodiment treatment hyperlipidemia, is made up by weight of following raw materials according: Radix Codonopsis 48, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 16, Semen Cassiae 12, Fructus Crataegi 48.
Embodiment 3:
The medicine of the present embodiment treatment hyperlipidemia, is made up by weight of following raw materials according: Radix Codonopsis 36, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 36, Pericarpium Citri Reticulatae 20, Fructus Arctii 12, Massa Medicata Fermentata 24, Semen Cassiae 16, Fructus Crataegi 12.
Embodiment 4:
The medicine of the present embodiment treatment hyperlipidemia, is made up by weight of following raw materials according: Radix Codonopsis 68, Rhizoma Alismatis 68, Cortex Cinnamomi 68, Herba Ephedrae 20, Pericarpium Citri Reticulatae 24, Fructus Arctii 24, Massa Medicata Fermentata 12, Semen Cassiae 16, Fructus Crataegi 30.
Embodiment 5:
The medicine of the present embodiment treatment hyperlipidemia, is made up by weight of following raw materials according: Radix Codonopsis 40, Rhizoma Alismatis 40, Cortex Cinnamomi 60, Herba Ephedrae 20, Pericarpium Citri Reticulatae 24, Fructus Arctii 24, Massa Medicata Fermentata 12, Semen Cassiae 16, Fructus Crataegi 30.
In addition, the preparation method of above-described embodiment Chinese medicine is: by weight, take Radix Codonopsis, Rhizoma Alismatis, Cortex Cinnamomi, Herba Ephedrae, Pericarpium Citri Reticulatae, Fructus Arctii, Massa Medicata Fermentata, Semen Cassiae, Fructus Crataegi, drying and crushing, cross 100 mesh sieves, direct fill capsule or add pharmaceutically acceptable carrier and be prepared into tablet, granule or oral liquid.
the medicine zoopery that the present invention treats hyperlipidemia is as follows:
Choose KM mice in 4 week age, male and female half and half, feed with high lipid food modeling, after raising 10 weeks, superseded body weight is less than the mice of 50g, then mice is divided at random each 12 of model control group, positive controls and treatment group of the present invention.Model control group gives equal-volume 0.9% normal saline, and positive controls gives 1.5mg/kg/d rosuvastain calcium, and treatment group of the present invention gives medicine 0.5g/kg/d prepared by Example formulations, every day gavage three times, continue 8 weeks, period respectively organize still hello with high lipid food, every day gavage three times.Before and after treatment, Indexes Comparison adopts t inspection; Enumeration data adopts X2 inspection.
After administration terminates, detect serum total cholesterol TC, low-density lipoprotein cholesterol LDL-C, HDL-C HDL-C, triglyceride TG.See table 1
Table 1 each group of impact on lipid in rat blood (mmol/L)
Note: compare with model control group, * P < 0.05.Compare with positive controls, #P < 0.05.
T-CHOL in visible treatment group of the present invention, triglyceride, HDL-C have significant difference with low-density lipoprotein cholesterol level compared with model group.Treatment group low-density lipoprotein cholesterol level has significant difference compared with positive controls, and density lipoprotein-cholesterol level, higher than positive controls, has significant difference.The medicine that visible the present invention treats hyperlipidemia has the effect for reducing fat being better than Western medicine rosuvastain calcium.
drug effect of the present invention is further illustrated below by way of clinical experiment:
Participate in clinical trial patient 168 example, wherein men and women half and half.The course of disease the shortest half a year, the longest 10 years.Minimum 29 years old of age, maximum 68 years old, 48 years old mean age.All patients are divided into matched group and each 84 examples for the treatment of group at random.
Therapeutic Method:
Treatment group: give embodiment 1 capsule prepared by formula (capsule shells specification is No. 0 capsule shells).Each 2-4 grain, every day 3 times 30 days was 1 course for the treatment of.Serve on 3 courses for the treatment of.
Matched group: give the JIANGZHILINGPIAN containing 8 taste Chinese crude drugs such as Rhizoma Alismatis, Radix Polygoni Multiflori Preparata, Fructus Lycii, Rhizoma Polygonati, Fructus Crataegi, Semen Cassiae, Herba Taxilli and Fructus Rosae Laevigatae.A 4-6 sheet, every day 3 times 3 months is a course for the treatment of.
Criterion of therapeutical effect:
Cure: clinical symptoms, sign disappear, the every inspection of laboratory recovers normal.
Effective: clinical symptoms, sign disappear substantially, lipids detection reaches following any one person: TC decline >=20%, TG decline >=40%, HDL-C rising >=0.26mmol/L(10mg/dL), TC-HDL-C/HDL-C declines >=20%.
Effective: clinical symptoms, sign all take a favorable turn, lipids detection reaches following any one person: TC declines >=0% but < 20%, TG declines >=20% but < 40%, HDL-C rising >=0.104mmol/L(4mg/dL) but < 0.26mmol/L(10mg/dL), TC-HDL-C/HDL-C declines >=10% but < 20%.
Invalid: symptom, sign and the lipids detection person of being not improved after treatment.
Therapeutic outcome: see table 2
Table 2 liang group efficacy result
By the treatment of 3 months, cured substance rate of the present invention was up to 77.4%, and total effective rate is 100%, and the cure rate of conventional medicament JIANGZHILINGPIAN is only 40.5%, and total effective rate is 82.2%.Compared with visible and existing medicine, Chinese medicine of the present invention, has consumption few, short treating period, the advantage that cure rate is high.
Claims (6)
1. treat a medicine for hyperlipidemia, its spy is being that the raw material by containing, for example lower weight portion is made: Radix Codonopsis 32-68, Rhizoma Alismatis 32-68, Cortex Cinnamomi 32-68, Herba Ephedrae 20-36, Pericarpium Citri Reticulatae 20-36, Fructus Arctii 12-24, Massa Medicata Fermentata 12-24, Semen Cassiae 12-24, Fructus Crataegi 6-48.
2. the medicine for the treatment of hyperlipidemia according to claim 1, its spy is to be made up of the raw material containing, for example lower weight portion: Radix Codonopsis 32-60, Rhizoma Alismatis 40-60, Cortex Cinnamomi 32-60, Herba Ephedrae 21-36, Pericarpium Citri Reticulatae 20-30, Fructus Arctii 12-22, Massa Medicata Fermentata 12-24, Semen Cassiae 12-20, Fructus Crataegi 10-48.
3. the medicine for the treatment of hyperlipidemia according to claim 2, its spy is to be made up of the raw material containing, for example lower weight portion: Radix Codonopsis 36-60, Rhizoma Alismatis 48-60, Cortex Cinnamomi 36-40, Herba Ephedrae 24-36, Pericarpium Citri Reticulatae 20-24, Fructus Arctii 12-20, Massa Medicata Fermentata 12-24, Semen Cassiae 12-16, Fructus Crataegi 12-48.
4. the medicine for the treatment of hyperlipidemia according to claim 3, its spy is to be made up of the raw material containing, for example lower weight portion: Radix Codonopsis 60, Rhizoma Alismatis 60, Cortex Cinnamomi 40, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 12, Semen Cassiae 12, Fructus Crataegi 24.
5. the medicine for the treatment of hyperlipidemia according to claim 3, its spy is to be made up of the raw material containing, for example lower weight portion: Radix Codonopsis 48, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 24, Pericarpium Citri Reticulatae 24, Fructus Arctii 12, Massa Medicata Fermentata 16, Semen Cassiae 12, Fructus Crataegi 48.
6. the medicine for the treatment of hyperlipidemia according to claim 3, its spy is to be made up of the raw material containing, for example lower weight portion: Radix Codonopsis 36, Rhizoma Alismatis 48, Cortex Cinnamomi 36, Herba Ephedrae 36, Pericarpium Citri Reticulatae 20, Fructus Arctii 12, Massa Medicata Fermentata 24, Semen Cassiae 16, Fructus Crataegi 12.
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| CN201410509511.6A CN104208312A (en) | 2014-09-29 | 2014-09-29 | Drug for treating hyperlipidemia |
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| CN201410509511.6A CN104208312A (en) | 2014-09-29 | 2014-09-29 | Drug for treating hyperlipidemia |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943788A (en) * | 2016-06-16 | 2016-09-21 | 河南中医学院 | Application of sophora flower product in preparation of medicine for treating hyperlipidemia |
| CN115737733A (en) * | 2021-09-03 | 2023-03-07 | 北京中医药大学 | Traditional Chinese medicine compound for reducing blood fat |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1839944A (en) * | 2005-04-01 | 2006-10-04 | 北京昭翰医药科技研究所 | Granular composition for reducing blood fat and process for producing the same |
| CN102114142A (en) * | 2010-10-13 | 2011-07-06 | 孔祥军 | Traditional Chinese medicine oral decoction for treating hyperlipidemia |
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2014
- 2014-09-29 CN CN201410509511.6A patent/CN104208312A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839944A (en) * | 2005-04-01 | 2006-10-04 | 北京昭翰医药科技研究所 | Granular composition for reducing blood fat and process for producing the same |
| CN102114142A (en) * | 2010-10-13 | 2011-07-06 | 孔祥军 | Traditional Chinese medicine oral decoction for treating hyperlipidemia |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943788A (en) * | 2016-06-16 | 2016-09-21 | 河南中医学院 | Application of sophora flower product in preparation of medicine for treating hyperlipidemia |
| CN115737733A (en) * | 2021-09-03 | 2023-03-07 | 北京中医药大学 | Traditional Chinese medicine compound for reducing blood fat |
| CN115737733B (en) * | 2021-09-03 | 2023-12-22 | 北京中医药大学 | Traditional Chinese medicine composition for reducing blood fat |
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