CN105943788A - Application of sophora flower product in preparation of medicine for treating hyperlipidemia - Google Patents
Application of sophora flower product in preparation of medicine for treating hyperlipidemia Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract
The invention relates to application of a sophora flower product in preparation of medicine for treating hyperlipidemia. The treatment medicine problem of hyperlipidemia can be effectively solved. The method comprises the steps that fresh sophora flowers are obtained, cleaned and dried under vacuum and then evenly mixed with soil-fried Huai rhizoma dioscoreae, pachyrhizua angulatus, rose flowers, pericarpium citri reticulatae and licorice roots, the mixture is smashed into fine powder, namely the sophora flower product, and the product is packaged and sterilized. The sophora flower product is prepared from rich raw materials, is easy to prepare and is used for treating hyperlipidemia effectively and applied in preparation of medicine for treating hyperlipidemia, innovation of hyperlipidemia treating medicine is achieved, and economic and social benefits are remarkable.
Description
Technical field
The present invention relates to medicine, the precious application in preparation treatment hyperlipidemia medicine of a kind of Flos Sophorae.
Background technology
Hyperlipemia refers to that blood lipid level is too high, can directly cause the disease of some serious harm healths, and such as atherosclerosis, coronary heart disease, pancreatitis etc., hyperlipemia can be divided into constitutional and Secondary cases two class.Constitutional is with congenital and heredity is relevant, it is due to single-gene defect or polygenes defect, make the transhipment of participation lipoprotein and the receptor of metabolism, enzyme or apolipoprotein caused by abnormal, or cause due to environmental factors (diet, nutrition, medicine) with by the mechanism of the unknown.The multiple metabolic disorder disease (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal cortex function are hyperfunction) of being born in of Secondary cases, or with other factor age, sex, season, drink, smoking, diet, physical exertion, psychentonia, emotional activity etc. relevant.
The clinical manifestation of hyperlipemia be mainly lipid intradermal deposition caused by xanthoma and lipid blood vessel endothelium deposit caused by arteriosclerosis.Although hyperlipemia can cause xanthoma, but its incidence rate the highest；And atherosclerotic generation and development are the most progressive a kind of processes.The most under normal conditions, most of patients non-evident sympton and abnormal sign.Many people are owing to being just found to have blood plasma lipoprotein level rising when other reasons carries out blood biochemical inspection.
Though the existing multi-medicament having treatment hyperlipemia, but for various reasons, its use and curative effect are the most unsatisfactory, and therefore, the medicine developing new treatment hyperlipemia is conscientiously to solve the technical problem that.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the purpose of the present invention is just to provide the precious application in preparation treatment hyperlipidemia medicine of a kind of Flos Sophorae, can effectively solve the medicine for treatment problem of hyperlipidemia.
The technical scheme that the present invention solves is, the precious application in preparation treatment hyperlipidemia medicine of a kind of Flos Sophorae, this Flos Sophorae treasure is to take fresh Flos Sophorae, cleans, vacuum drying, then mix homogeneously with parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China, Pachyrhizua angulatus, Flos Rosae Rugosae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, be ground into fine powder, be Flos Sophorae precious (powder), packaging, sterilizing.
Abundant raw material of the present invention, preparation method is simple, is effective to treat hyperlipemia, it is achieved the precious application in preparation treatment hyperlipidemia medicine of Flos Sophorae, is the innovation on treatment hyperlipidemia, and economic and social benefit is notable.
Detailed description of the invention
Below in conjunction with concrete condition, the detailed description of the invention of the present invention is elaborated.
The present invention is in being embodied as, the precious application in preparation treatment hyperlipidemia medicine of a kind of Flos Sophorae, this Flos Sophorae treasure is to take fresh Flos Sophorae, clean, 60 DEG C of vacuum drying, then mix homogeneously with parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China, Pachyrhizua angulatus, Flos Rosae Rugosae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, were ground into the fine powder of 100 mesh sieves, it is Flos Sophorae precious (powder), packaging, sterilizing, fresh Flos Sophorae is 321 0.5 0.3 0.2 with the weight ratio of parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China, Pachyrhizua angulatus, Flos Rosae Rugosae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
In said components, wherein Flos Sophorae is fabaceous flower and alabastrum, and fresh Flos Sophorae refers to the fresh Flos Sophorae gathered from Sophora japonica L., Flos Sophorae bitter in the mouth, and property is put down, nontoxic, has effect of heat clearing away, removing heat from blood, hemostasis, blood pressure lowering.Haematemesis, hematuria, bleeding hemorrhoids, wind heat conjunctival congestion, hypertension, hyperlipemia, the tuberculosis of cervical lymph nodes, sclerosis of blood vessels, stool band blood, diabetes, retinitis, psoriasis etc. there is significant curative effect；Can with anthelmintic, control pharyngitis.Flos Sophorae can strengthen the resistance of blood capillary, reduces vascular permeability, and fragility blood vessel can be made to recover elastic function, thus blood fat reducing and prevent sclerosis of blood vessels.
Parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China is RHIIZOMA DIOSCOREAE fr0m Henan of China east wall soil or humus flava usta (known technology), to strengthen effect of spleen reinforcing stomach invigorating.
Pachyrhizua angulatus: Pachyrhizua angulatus is pulse family, the mutation (Classification system: Pueraria lobata (Willd.) Ohwi var.thomsonii (Benth.) Vaniot der Maesen) of Pueraria Pueraria lobota, Chinese medicine name, cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles from the beginning of, rash go out smooth, epidemic febrile disease is thirsty, quench one's thirst, have loose bowels, dysentery, hypertension, coronary heart disease.
Flos Rosae Rugosae hardship sweet, micro-, temperature.Return liver, spleen channel, promoting QI circulation for relieving depression, and blood, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, fall and flutter the pain of injury.
Pericarpium Citri Reticulatae bitter in the mouth, pungent, warm in nature, return lung, spleen channel, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Glycyrrhizae feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc..
The efficient combination of said components, supports mutually, has effect of blood fat reducing, it is effective to treat hyperlipemia, realizing the precious application in preparation treatment hyperlipidemia medicine of Flos Sophorae, and achieve extraordinary Advantageous Effects through site test and application, relevant testing data is as follows:
1 experiment material
1.1 laboratory animals and environment
Rat, germline: Wistar, grade: SPF level, male, 180-220g, the quality certification number: 37005400000040, it is provided that unit: Lukang Medical Co., Ltd., Shandong.Laboratory animal uses credit number 2015-005.Feedstuff is sterilization feedstuff, and bedding and padding are sterilization bedding and padding, are provided by Henan Province's Experimental Animal Center.Drinking-water is sterilized distilled water.Rearing conditions: temperature 20～25 DEG C, relative humidity 40%～60%, natural lighting, 6, every cage, conventional raising, change bedding and padding every other day.
1.2 experimental drugs and reagent
Flos Sophorae is precious, and Henan university of TCM laboratory provides, every bag of 10g, each 1-2 bag, three times a day；；Simvastatin Tablets, Shandong, Shandong anti-Pharmaceutical Group Saite Co., Ltd；Normal saline, Henan Shuan Hehuali pharmaceutcal corporation, Ltd produces；Propylene glycol, Tianjin Zhi Yuan chemical reagent company limited；Tween 80, Tianjin Fu Yu Fine Chemical Co., Ltd；NaTDC, Beijing extensive and profound in meaning star biology Co., Ltd；Propylthiouracil Tablets, Shanghai Zhaohui Pharmaceutical Co., Ltd.；Cholesterol, Wu County, Shanghai biochemistry factory；T-CHOL (T-CHO) testing cassete, Bioengineering Research Institute is built up in Nanjing；Triglyceride (TG) testing cassete, Bioengineering Research Institute is built up in Nanjing；HDL-C (HDL-C) testing cassete, Bioengineering Research Institute is built up in Nanjing；Low-density lipoprotein cholesterol (LDL-C) testing cassete, Bioengineering Research Institute is built up in Nanjing.
The configuration of higher fatty acid breast: oil phase: Adeps Sus domestica 25g, cholesterol 10g, Propylthiouracil Tablets 1g, tween 80 25ml；Aqueous phase: distilled water 30ml, 1.2-propylene glycol 20ml, NaTDC 2g.Preparation method: oil phase: Adeps Sus domestica 25g puts in the beaker of 200ml, is heated to 100 DEG C, adds cholesterol 10g fusing, adds Propylthiouracil Tablets 1g, fully adds tween 80 25ml after mixing；Aqueous phase: distilled water 30ml joins in 200ml beaker, 60 DEG C of water-bath water-baths, add 1,2-PD 20ml, NaTDC 2g and fully dissolve；Then aqueous phase is added oil phase, be sufficiently stirred for, put 4 DEG C of Refrigerator stores after cooling standby.
The configuration of high lipid food: Adeps Sus domestica 10%, yolk powder 5%, cholesterol 1%, propylthiouracil 0.2%.NaTDC 0.5%, sucrose 5%, the proportional arrangement of normal feedstuff 78.3%
1.3 experimental apparatus
FA (N)/JA (N) series electronic balance, Shanghai Min Qiao precision instrument company limited；HWS12 type electric-heated thermostatic water bath, Shanghai Yiheng Scientific Instruments Co., Ltd；KDC-160HR High speed refrigerated centrifuge, Zhong Jia branch company of Keda Innovation Co., Ltd；680 type microplate reader, BIO-RAD company of the U.S.；Adjustable pipette, Shanghai Lei Bo Analytical Instrument Co., Ltd.
1.4 statistical procedures methods
Data analysis SPSS17.0 medical statistics bag carries out the statistical procedures of data information, measurement data average ± standard deviationRepresenting, comparing employing one factor analysis of variance between each group, the neat person of variance test uses LSD method, and heterogeneity of variance person checks by Games-Howell method, and ranked data use Ridit inspection.
Experimental technique and result
Take body weight 180-200g male rat 60, be randomly divided into 5 groups, often group 12.Wherein make hyperlipemia model for 4 groups, gavage Flos Sophorae treasure suspension (8g/kg, 4g/kg of large and small dosage respectively the morning, 0.4g/ml, 0.2g/ml, 2ml/100g), the normal saline (2ml/100g) of Simvastatin Tablets suspension (1.67mg/kg) and same volume, administration group gives relative medicine the morning, and afternoon is to hypercholesterolemia breast 2ml/100g；Give high lipid food every day to feed simultaneously, be administered once a day, successive administration 21 days.Another group is blank group, does not make hyperlipemia model, only fills the normal saline of same volume.Weigh weekly once, adjust dosage according to body weight.Within latter 2 hours, pluck eyeball in administration on the 21st and take blood, 3000r/min is centrifuged 5min, separates serum, measures biochemical indicator in-20 DEG C of freezen protective after subpackage, for measuring serum total cholesterol, triglyceride, High-density Lipoprotein-cholesterol, low-density lipoprotein cholesterol level, result is shown inTable 1.Taking liver organization after weighing a little, add normal saline in the ratio of 1:9, be placed in glass homogenate tube, whole process operates on ice；3 000rpm min after grinding completely- 1Centrifugal 15min, prepares liver homogenate, surveys liver homogenate TC, TG level, and result is shown inTable 2.After rat extracting blood, de-cervical vertebra is put to death, and solution takes liver, weighs, and calculates liver index (liver proportion=liver weight/body weight × 100%), and result is shown inTable 3.The each group of tissue taking liver median lobe same area, 4% paraformaldehyde fixes, paraffin embedding, section, and Hematoxylin-eosin (HE) dyes, and observes liver organization morphological change.
The mensuration of 2.1 (1) cholesterol
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 10 minutes for 37 DEG C, 510nm, microplate reader measures each hole absorbance.
Computing formula: serum medium liquid sample computing formula: microplate reader colorimetric: cholesterol amount (mmol/L)=(the blank OD value of sample OD value) ÷ (the blank OD value of standard OD value) × calibration object concentration (5.17mmol/L).
(2) mensuration of triglyceride
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 10 minutes for 37 DEG C, 510nm, microplate reader measures each hole absorbance.
Computing formula: serum medium liquid sample computing formula: microplate reader colorimetric: cholesterol amount (mmol/L)=(the blank OD value of sample OD value) ÷ (the blank OD value of standard OD value) × calibration object concentration (2.26mmol/L).
(3) mensuration of high-density protein cholesterol (HDL-C)
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 5 minutes for 37 DEG C, 546nm, microplate reader measures each hole absorbance A 2.
Computing formula: serum medium liquid sample computing formula: microplate reader colorimetric: HDL-C (mmol/L)={ (sample A2 value sample A1 value) (the blank A1 value of blank A2 value) } ÷ { (standard A2 value standard A1 value) (the blank A1 value of blank A2 value) } × calibration object concentration (1.8mmol/L).
(4) mensuration of low-density protein cholesterol (LDL-C)
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 5 minutes for 37 DEG C, 546nm, microplate reader measures each hole absorbance A 2.
Computing formula: serum medium liquid sample computing formula: microplate reader colorimetric: HDL-C (mmol/L)={ (sample A2 value sample A1 value) (the blank A1 value of blank A2 value) } ÷ ({ (standard A2 value standard A1 value) (the blank A1 value of blank A2 value) } × calibration object concentration (4.3mmol/L).
(5) mensuration of cholesterol in tissue
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 10 minutes for 37 DEG C, 510nm, microplate reader measures each hole absorbance.
Computing formula: sample computing formula in tissue: microplate reader colorimetric: cholesterol amount (mmol/L)=(the blank OD value of sample OD value) ÷ (the blank OD value of standard OD value) × calibration object concentration (5.17mmol/L) ÷ testing protein concentration
(6) mensuration of triglyceride in tissue
Reagent composition and preparation (96T)
Operation table:
After mixing, hatching 10 minutes for 37 DEG C, 510nm, microplate reader measures each hole absorbance.
Computing formula: serum medium liquid sample computing formula: microplate reader colorimetric: cholesterol amount (mmol/L)=(the blank OD value of sample OD value) ÷ (the blank OD value of standard OD value) × calibration object concentration (2.26mmol/L) ÷ testing protein concentration
3 results
Table 1Flos Sophorae precious on rats of hyperlipoidemic modle serum TC, TG, HDLC and LDLC level impact (Mmol/ml, n=12)
* p < 0.05 compared with model group is represented；* represents p < 0.01 compared with model group
FromUpper tableCan be seen that, compared with blank group, in model group serum, TC, TG and LDLC level significantly raises (P < 0.01), and serum hdl C level significantly reduces (P < 0.01), illustrates to make the success of hyperlipidemia model；Compared with model group, large and small dosage Flos Sophorae treasure group and simvastatin group all can significantly reduce serum TC, TG and LDLC level (P < 0.01), notable rising HDLC level (P < 0.01).It is strong for organizing effect for reducing blood fat with heavy dose of Flos Sophorae treasure.
Table 2The precious impact on rats of hyperlipoidemic modle liver pulp TC, TG level of Flos Sophorae
* p < 0.05 compared with model group is represented；* represents p < 0.01 compared with model group
FromUpper tableCan be seen that, compared with blank group, model group liver homogenate TC and TG content significantly raise (P < 0.01), and the existing lipopexia of liver is described；Compared with model group, large and small dosage Flos Sophorae treasure group and simvastatin group all can significantly reduce TG level in liver homogenate TC (P < 0.01).It is strong for organizing in fall liver homogenate TG horizontal force in TC with heavy dose of Flos Sophorae treasure.
Table 3The precious impact on rats of hyperlipoidemic modle liver index of Flos Sophorae
* p < 0.05 compared with model group is represented；* represents p < 0.01 compared with model group
FromUpper tableCan be seen that, compared with blank group, model group rats liver index significantly raises (P < 0.01)；Compared with model group, heavy dose of Flos Sophorae treasure group and simvastatin group all can significantly reduce Hyperlipidemia rat liver index (P < 0.01), and low dose of Flos Sophorae treasure's group can obviously reduce liver index (P < 0.05).Organize fall liver index with heavy dose of Flos Sophorae treasure to act as by force.
Table 4The precious impact on rats of hyperlipoidemic modle body weight of Flos Sophorae (g,)
* p < 0.05 compared with model group is represented；* represents p < 0.01 compared with model group
FromUpper tableCan be seen that, compared with blank group, the body weight at the 7th, 14,21 days model group rats increases notable the lowest (P < 0.01)；Compared with model group, large and small dosage Flos Sophorae treasure group and simvastatin group all can significantly increase the body weight (P < 0.01) of Hyperlipidemia rat.
Table 5The precious impact (unit: individual) on rats of hyperlipoidemic modle liver of Flos Sophorae
"-" is normal；"+" mild fatty degeneration；" ++ " moderate steatosis；" +++ " severe steatosis.
ByTable 1It can be seen that check through Ridit, compared with blank group, there is the pathological change (P < 0.01) of significant steatosis in model group rats liver, illustrates to make hyperlipemia model success.Compared with model group, heavy dose of Flos Sophorae treasure organizes the pathological change (P < 0.01) that all can significantly alleviate rat liver, and low dose of Flos Sophorae treasure organizes the pathological change (P < 0.05) that all can substantially alleviate rat liver.
Each group liver organization morphologic observation: blank group rat liver situation the most without exception, lobules of liver structure is normal, intracellular has no that fat drips；Model group rats lobules of liver is destructurized, and hepatic cell fattydegeneration is serious, is full of large and small fat and drips, hepatocyte extremely swelling, and circular, volume compared with normal substantially increases, and is full of significant quantities of fat cavity, exactly likes foam cell in kytoplasm, and boundary is unclear；Simvastatin group rats'liver leaflet structure is normal, and in less hepatocyte, visible tiny fat drips, and hepatic steatosis is inconspicuous；It is normal that heavy dose of Flos Sophorae treasure organizes rats'liver leaflet structure, and big fat drips less, and little fat drips and is dispersed in distribution, and hepatic steatosis significantly alleviates；It is normal that middle dosage Flos Sophorae treasure organizes rats'liver leaflet structure, and big fat drips less, and little fat drips and is dispersed in distribution, and hepatic steatosis substantially alleviates；Low dose of Flos Sophorae treasure organizes big Adips Mus and becomes hepatocyte extremely swelling, and circular, volume compared with normal substantially increases, and is full of significant quantities of fat cavity, exactly likes foam cell in kytoplasm, and boundary is unclear.
Clinical data
According to " Chinese Journal of Cardiology " compileCommittee's meetingDyslipidemia Preventing Countermeasures special topic group " dyslipidemia remedial proposal " hyperlipemia diagnostic criteria execution .TC >=5.20mmol/L, TG >=1.7mmol/L, LDL-C >=3.80mmol/L, HDL-C≤0.88mmol/L, one Indexes Abnormality of any of which is light-duty；There is a 2-3 item Indexes Abnormality, and often occur that dizziness, the symptom such as dizzy, unable are medium-sized.Formulating the standard of this observation with reference to " new Chinese medicine guideline of clinical investigations " Chinese Herbs evaluation criteria: effective: clinical symptom disappearance, sign recovers dinner substantially, and TC level declines > 20%, TG > 40%, HDL-C level rises > 0.26mmol/L；Effective: clinical symptoms and sign disappear substantially, TC level decline >=10%--20%, TG level decline >=1%--40%, HDL-C level rises > 0.10mmol/L--0.26mmol/L.
This observation amount to hyperlipemia 68 example light, medium-sized, the maleest 42 examples, female 26 example, age 42-66 year.The course of disease 6 months 2 years.Flos Sophorae is precious: 1-2 bag every time, boiled water is taken after mixing it with water, three times a day.Every bag of 10g. mono-month is a course for the treatment of.The course for the treatment of terminates: 68 examples high hyperlipidemia patient light, medium-sized, and 10 examples are effective, 53 examples are effective, and 5 examples are invalid.Total effective rate 92.6%.
Conclusion
Fully proving through above-mentioned experiment, large and small dosage Flos Sophorae treasure group and simvastatin group all can significantly reduce serum TC, TG and LDLC level, notable rising HDLC level.Greatly, low dose of Flos Sophorae treasure organizes the TG level in liver homogenate TC that all can significantly reduce, heavy dose of Flos Sophorae treasure organizes and all can significantly reduce Hyperlipidemia rat liver index, low dose of Flos Sophorae treasure's group can obviously reduce liver index, greatly, low dose of Flos Sophorae treasure organizes the body weight that all can significantly increase Hyperlipidemia rat, heavy dose of Flos Sophorae treasure organizes the pathological change that all can significantly alleviate rat liver, low dose of Flos Sophorae treasure organizes the pathological change that all can substantially alleviate rat liver, it is strong for organizing effect for reducing blood fat with heavy dose of Flos Sophorae treasure, can be effectively used for the medicine of preparation treatment hyperlipemia, realize the precious application in preparation treatment hyperlipidemia medicine of Flos Sophorae, there is the using value of reality, economic and social benefit is notable.
Claims (1)
1. the precious application in preparation treatment hyperlipidemia medicine of Flos Sophorae, this Flos Sophorae treasure is, take fresh Flos Sophorae, clean, 60 DEG C of vacuum drying, then mix homogeneously with parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China, Pachyrhizua angulatus, Flos Rosae Rugosae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, it is ground into the fine powder of 100 mesh sieves, is Flos Sophorae precious, packaging, sterilizing, fresh Flos Sophorae is 321 0.5 0.3 0.2 with the weight ratio of parching with earth RHIIZOMA DIOSCOREAE fr0m Henan of China, Pachyrhizua angulatus, Flos Rosae Rugosae, Pericarpium Citri Reticulatae and Radix Glycyrrhizae.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888697A (en) * | 2018-10-15 | 2018-11-27 | 河南中医药大学 | A kind of Chinese scholartree mountain celery lipid-loweringing powder for treating hyperlipidemia |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058511A (en) * | 1991-06-13 | 1992-02-12 | 杨光福 | The compound method of a kind of health protection tea |
| CN101829237A (en) * | 2010-05-28 | 2010-09-15 | 辽宁省中医药研究院 | Medicament for treating hyperlipermia caused by phlegm-turbidity and blood stasis syndrome and preparation process thereof |
| CN102488772A (en) * | 2011-12-21 | 2012-06-13 | 许从玉 | Chinese herbal composition for preventing or treating hyperlipemia |
| CN103494997A (en) * | 2013-10-18 | 2014-01-08 | 河南中医学院 | Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes |
| CN104208312A (en) * | 2014-09-29 | 2014-12-17 | 崔银方 | Drug for treating hyperlipidemia |
-
2016
- 2016-06-16 CN CN201610428625.7A patent/CN105943788A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058511A (en) * | 1991-06-13 | 1992-02-12 | 杨光福 | The compound method of a kind of health protection tea |
| CN101829237A (en) * | 2010-05-28 | 2010-09-15 | 辽宁省中医药研究院 | Medicament for treating hyperlipermia caused by phlegm-turbidity and blood stasis syndrome and preparation process thereof |
| CN102488772A (en) * | 2011-12-21 | 2012-06-13 | 许从玉 | Chinese herbal composition for preventing or treating hyperlipemia |
| CN103494997A (en) * | 2013-10-18 | 2014-01-08 | 河南中医学院 | Traditional Chinese sophora flower medicine for treating hyperglycemia and diabetes |
| CN104208312A (en) * | 2014-09-29 | 2014-12-17 | 崔银方 | Drug for treating hyperlipidemia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888697A (en) * | 2018-10-15 | 2018-11-27 | 河南中医药大学 | A kind of Chinese scholartree mountain celery lipid-loweringing powder for treating hyperlipidemia |
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Application publication date: 20160921 |