CN107074800B - 经取代的双环杂芳基化合物作为rxr促效剂 - Google Patents

经取代的双环杂芳基化合物作为rxr促效剂 Download PDF

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CN107074800B
CN107074800B CN201580014389.8A CN201580014389A CN107074800B CN 107074800 B CN107074800 B CN 107074800B CN 201580014389 A CN201580014389 A CN 201580014389A CN 107074800 B CN107074800 B CN 107074800B
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tetrahydro
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optionally substituted
tetramethyl
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CN107074800A (zh
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古让·兰加 马达范
马登哈利 兰加纳特·拉奥 贾格纳特
钱德拉谢卡尔·古德拉
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Connexios Life Sciences Pvt Ltd
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CN201580014389.8A 2014-01-14 2015-01-09 经取代的双环杂芳基化合物作为rxr促效剂 Active CN107074800B (zh)

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CN112047901B (zh) * 2020-09-21 2023-01-24 自然资源部第三海洋研究所 苯并噻唑杂萜类化合物及其衍生物以及制备方法与应用
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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098591A1 (de) * 1982-07-06 1984-01-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Neue heterocyclische Verbindungen und diese enthaltende Rodentizide
WO1994012880A2 (en) * 1992-11-25 1994-06-09 La Jolla Cancer Research Foundation Rxr homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
US5420145A (en) * 1993-03-22 1995-05-30 Koichi Shudo Carboxylic acid derivative
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
WO1998045242A1 (en) * 1997-04-08 1998-10-15 Hiroyuki Kagechika Retinoid activity regulators
WO2000066595A1 (en) * 1999-04-28 2000-11-09 Institute Of Medicinal Molecular Design. Inc. Heterocyclic carboxylic acid derivatives
US6624154B1 (en) * 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
WO2008030618A1 (en) * 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
JP2010111588A (ja) * 2008-11-04 2010-05-20 Okayama Univ 核内受容体リガンド
JP2010280585A (ja) * 2009-06-02 2010-12-16 Okayama Univ Rxr作動性物質を有効成分とする鎮痛剤
WO2012112623A2 (en) * 2011-02-14 2012-08-23 Sloan-Kettering Institute For Cancer Research Rxrg modulators for the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78888B (enExample) * 1982-07-06 1984-10-02 Hoffmann La Roche
WO1997012853A1 (en) * 1995-10-06 1997-04-10 Ligand Pharmaceuticals Incorporated Dimer-selective rxr modulators and methods for their use
DE102004026532A1 (de) * 2004-05-29 2006-01-05 Sanofi-Aventis Deutschland Gmbh Substituierte Oxazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
AU2006291234A1 (en) * 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
JP2009512637A (ja) * 2005-09-30 2009-03-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 異常脂血症、高コレステロール血症及び糖尿病の処置のためのrxrアゴニストとしてのジヒドロ−[1h]−キノリン−2−オン誘導体
WO2007041076A2 (en) * 2005-09-30 2007-04-12 Janssen Pharmaceutica N.V. 1,2,3,5-tetrahydro-cyclopental[c]quinolin-4-one derivatives as rxr agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes
CN101316827A (zh) * 2005-09-30 2008-12-03 詹森药业有限公司 作为rxr激动剂用于治疗异常脂肪血症、高胆固醇血症和糖尿病的杂环酰胺衍生物
PT2029572E (pt) * 2006-06-05 2011-02-09 Novartis Ag Compostos orgânicos

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0098591A1 (de) * 1982-07-06 1984-01-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Neue heterocyclische Verbindungen und diese enthaltende Rodentizide
WO1994012880A2 (en) * 1992-11-25 1994-06-09 La Jolla Cancer Research Foundation Rxr homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
US5420145A (en) * 1993-03-22 1995-05-30 Koichi Shudo Carboxylic acid derivative
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
WO1998045242A1 (en) * 1997-04-08 1998-10-15 Hiroyuki Kagechika Retinoid activity regulators
US6624154B1 (en) * 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
WO2000066595A1 (en) * 1999-04-28 2000-11-09 Institute Of Medicinal Molecular Design. Inc. Heterocyclic carboxylic acid derivatives
WO2008030618A1 (en) * 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
JP2010111588A (ja) * 2008-11-04 2010-05-20 Okayama Univ 核内受容体リガンド
JP2010280585A (ja) * 2009-06-02 2010-12-16 Okayama Univ Rxr作動性物質を有効成分とする鎮痛剤
WO2012112623A2 (en) * 2011-02-14 2012-08-23 Sloan-Kettering Institute For Cancer Research Rxrg modulators for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
3D- QSAR Studies on Retinoids of Anticarcinogenic Activity;Niu Huang et al.;《Journal o f Chinese Pharmaceutical Sciences》;19961231;第5卷(第3期);第121-126页 *
COMPARISON OF THE INHIBITORY EFFECTS OF RETINOIDS ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITIES IN CD-1 AND SENCAR MICE;WAN-RU CHAO et al.;《Cancer Letters》;19851231;第29卷;第43-48页 *
Modeling the Anticarcinogenic Action of Retinoids by Making Use of the OASIS Method. 3. Inhibition of the Induction of Ornithine Decarboxylase by Arotinoidst;Danail Bonchev et al.;《J. Med. Chem.》;19941231;第37卷(第15期);第2300-2307页 *
WAN-RU CHAO et al..COMPARISON OF THE INHIBITORY EFFECTS OF RETINOIDS ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITIES IN CD-1 AND SENCAR MICE.《Cancer Letters》.1985,第29卷第43-48页. *

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