CN107073110A - 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展 - Google Patents

使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展 Download PDF

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Publication number
CN107073110A
CN107073110A CN201580047920.1A CN201580047920A CN107073110A CN 107073110 A CN107073110 A CN 107073110A CN 201580047920 A CN201580047920 A CN 201580047920A CN 107073110 A CN107073110 A CN 107073110A
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CN
China
Prior art keywords
patient
seq
antibody
secukinumab
antigen
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Pending
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CN201580047920.1A
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English (en)
Chinese (zh)
Inventor
S·姆珀福
H·理查德斯
G·里戈兹奥
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54186247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN107073110(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Priority to CN202210788000.7A priority Critical patent/CN115957326A/zh
Priority to CN202210786909.9A priority patent/CN115944734A/zh
Priority to CN202110368292.4A priority patent/CN113069542A/zh
Publication of CN107073110A publication Critical patent/CN107073110A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Oncology (AREA)
CN201580047920.1A 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展 Pending CN107073110A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202210788000.7A CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202110368292.4A CN113069542A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462048512P 2014-09-10 2014-09-10
US62/048,512 2014-09-10
PCT/IB2015/056871 WO2016038538A1 (en) 2014-09-10 2015-09-08 Use of il-17 antagonists to inhibit the progression of structural damage in psoriatic arthritis patients

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN202210788000.7A Division CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A Division CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202110368292.4A Division CN113069542A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Publications (1)

Publication Number Publication Date
CN107073110A true CN107073110A (zh) 2017-08-18

Family

ID=54186247

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201580047920.1A Pending CN107073110A (zh) 2014-09-10 2015-09-08 使用il‑17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210788000.7A Pending CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202110368292.4A Pending CN113069542A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A Pending CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202210788000.7A Pending CN115957326A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202110368292.4A Pending CN113069542A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展
CN202210786909.9A Pending CN115944734A (zh) 2014-09-10 2015-09-08 使用il-17拮抗剂抑制银屑病关节炎患者的结构损伤进展

Country Status (22)

Country Link
US (2) US11278618B2 (enExample)
EP (2) EP3191120B1 (enExample)
JP (4) JP2017528465A (enExample)
KR (3) KR20170045240A (enExample)
CN (4) CN107073110A (enExample)
AU (2) AU2015313827C1 (enExample)
BR (1) BR112017003332A2 (enExample)
CA (1) CA2960754A1 (enExample)
DK (1) DK3191120T3 (enExample)
ES (1) ES2981697T3 (enExample)
FI (1) FI3191120T3 (enExample)
HR (1) HRP20240921T1 (enExample)
HU (1) HUE067081T2 (enExample)
LT (1) LT3191120T (enExample)
MX (1) MX2017003216A (enExample)
PL (1) PL3191120T3 (enExample)
PT (1) PT3191120T (enExample)
RS (1) RS65851B1 (enExample)
RU (1) RU2697383C2 (enExample)
SI (1) SI3191120T1 (enExample)
SM (1) SMT202400285T1 (enExample)
WO (1) WO2016038538A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111032691A (zh) * 2017-08-23 2020-04-17 伊莱利利公司 生殖器银屑病的治疗
CN111344043A (zh) * 2017-11-02 2020-06-26 诺华股份有限公司 使用白细胞介素-17(il-17)拮抗剂治疗肌腱病的方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3191120T3 (fi) * 2014-09-10 2024-07-10 Novartis Ag Il-17-antagonistien käyttö rakennevaurion etenemisen estämiseksi nivelpsoriaasipotilailla
CN108350068A (zh) 2015-10-27 2018-07-31 Ucb生物制药私人有限公司 使用抗-il-17a/f抗体的治疗方法
US10676522B2 (en) * 2017-05-05 2020-06-09 Novartis Ag Methods of selectively treating asthma using IL-17 antagonists
US20200385453A1 (en) * 2019-06-04 2020-12-10 Janssen Biotech, Inc. Safe and Effective Method of Treating Psoriatic Arthritis with Anti-IL23 Specific Antibody
KR102604172B1 (ko) 2019-12-05 2023-11-22 아주대학교산학협력단 펩타이드 또는 이의 혼합물을 유효성분으로 함유하는 베체트병 또는 류마티스 관절염 예방 또는 치료용 약학조성물
KR102394378B1 (ko) 2020-10-14 2022-05-03 한림대학교 산학협력단 피부 각질세포에서의 아릴탄화수소 수용체 억제자(AhRR) 과발현 방법
EP4305062A1 (en) 2021-03-12 2024-01-17 Janssen Biotech, Inc. Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2006013107A1 (en) * 2004-08-05 2006-02-09 Novartis Ag Il-17 antagonistic antibodies
WO2012082573A1 (en) * 2010-12-13 2012-06-21 Novartis Ag Predictive methods and methods of treating arthritis using il-17 antagonists
WO2013077907A1 (en) * 2011-11-21 2013-05-30 Novartis Ag Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles
CN103936854A (zh) * 2014-04-30 2014-07-23 北京精益泰翔技术发展有限公司 抗il-17a单克隆抗体及其制备与应用

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GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
PL1963368T6 (pl) 2005-12-13 2021-02-08 Eli Lilly And Company Przeciwciała anty-IL-17
CA2637166A1 (en) 2006-01-31 2007-10-18 Novartis Ag Il-17 antagonistic antibodies for treating cancer
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
BRPI0813262A2 (pt) 2007-06-20 2015-04-14 Schering Corp Biomarcadores de destruição de articulação para terapia de doença inflamatória de articulação anti-il-17a
US7856118B2 (en) 2007-07-20 2010-12-21 The Procter & Gamble Company Methods for recommending a personal care product and tools therefor
CA2737636A1 (en) 2008-09-29 2010-04-01 Roche Glycart Ag Antibodies against human il17 and uses thereof
MX356279B (es) * 2010-10-08 2018-05-22 Novartis Ag Star Métodos para el tratamiento de soriasis usando antagonistas de il-17.
AU2011325134B2 (en) * 2010-11-05 2014-10-23 Novartis Ag Methods of treating rheumatoid arthritis using IL-17 antagonists
FI3191120T3 (fi) * 2014-09-10 2024-07-10 Novartis Ag Il-17-antagonistien käyttö rakennevaurion etenemisen estämiseksi nivelpsoriaasipotilailla

Patent Citations (5)

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WO2006013107A1 (en) * 2004-08-05 2006-02-09 Novartis Ag Il-17 antagonistic antibodies
WO2012082573A1 (en) * 2010-12-13 2012-06-21 Novartis Ag Predictive methods and methods of treating arthritis using il-17 antagonists
WO2013077907A1 (en) * 2011-11-21 2013-05-30 Novartis Ag Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles
CN104011223A (zh) * 2011-11-21 2014-08-27 诺华股份有限公司 使用il-17拮抗剂及psa应答或非应答等位基因治疗银屑病性关节炎(psa)的方法
CN103936854A (zh) * 2014-04-30 2014-07-23 北京精益泰翔技术发展有限公司 抗il-17a单克隆抗体及其制备与应用

Non-Patent Citations (3)

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ALICE B. GOTTLIEB等: ""Secukinuma Shows Substantial Improvement In Both Psoriasis Symptoms and Physica Functioning In Moderate-to-severe Plaque Psoriasis Patients with Psoriati Arthritis: A Subanalysis Of a Phase 3 Multicenter, Double-blind Placebo-controlled Study"", 《2013 ACR/ARHP ANNUAL MEETING》 *
JOSHUA E WEITZ等: ""Ustekinumab:targeting the IL-17 pathway to improve outcomes in psoriatic arthritis"", 《EXPERT OPINION ON BIOLOGICAL THERAPY》 *
SARAH L.GAFFEN等: ""The IL-23-1L-17 immune axis: from mechani sms to therapeutic testing"", 《IMMUNOLOGY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111032691A (zh) * 2017-08-23 2020-04-17 伊莱利利公司 生殖器银屑病的治疗
CN111344043A (zh) * 2017-11-02 2020-06-26 诺华股份有限公司 使用白细胞介素-17(il-17)拮抗剂治疗肌腱病的方法

Also Published As

Publication number Publication date
RU2017107501A3 (enExample) 2019-03-12
AU2015313827C1 (en) 2018-08-30
EP3191120B1 (en) 2024-04-10
SI3191120T1 (sl) 2024-10-30
EP4406969A3 (en) 2024-11-27
US20170281762A1 (en) 2017-10-05
RU2697383C2 (ru) 2019-08-13
FI3191120T3 (fi) 2024-07-10
AU2015313827A1 (en) 2017-02-16
JP7288927B2 (ja) 2023-06-08
JP2025024104A (ja) 2025-02-19
EP4406969A2 (en) 2024-07-31
CN113069542A (zh) 2021-07-06
RU2017107501A (ru) 2018-10-10
PT3191120T (pt) 2024-07-16
CN115944734A (zh) 2023-04-11
US11278618B2 (en) 2022-03-22
AU2015313827B2 (en) 2018-02-15
LT3191120T (lt) 2024-07-25
US20220313818A1 (en) 2022-10-06
KR20230170796A (ko) 2023-12-19
JP2023109973A (ja) 2023-08-08
HRP20240921T1 (hr) 2024-10-11
CN115957326A (zh) 2023-04-14
RS65851B1 (sr) 2024-09-30
ES2981697T3 (es) 2024-10-10
SMT202400285T1 (it) 2024-09-16
PL3191120T3 (pl) 2024-08-26
JP2021152021A (ja) 2021-09-30
JP7591092B2 (ja) 2024-11-27
AU2018201410A1 (en) 2018-03-22
CA2960754A1 (en) 2016-03-17
KR20260087713A (ko) 2026-06-11
WO2016038538A1 (en) 2016-03-17
KR20170045240A (ko) 2017-04-26
HUE067081T2 (hu) 2024-09-28
MX2017003216A (es) 2017-05-23
BR112017003332A2 (pt) 2017-11-28
EP3191120A1 (en) 2017-07-19
DK3191120T3 (da) 2024-07-15
JP2017528465A (ja) 2017-09-28

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