CN107072964A - 与低hlb表面活性剂在生产包含rapalog的合成纳米颗粒中之用途相关的方法和组合物 - Google Patents

与低hlb表面活性剂在生产包含rapalog的合成纳米颗粒中之用途相关的方法和组合物 Download PDF

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Publication number
CN107072964A
CN107072964A CN201580059855.4A CN201580059855A CN107072964A CN 107072964 A CN107072964 A CN 107072964A CN 201580059855 A CN201580059855 A CN 201580059855A CN 107072964 A CN107072964 A CN 107072964A
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less
nonionic surfactant
composition
hlb value
equal
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Chinese (zh)
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康林·奥尼尔
阿伦·P·格里泽
大卫·H·阿尔特罗伊特
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Cartesian Therapeutics Inc
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Selecta Biosciences Inc
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Priority to CN202210754468.4A priority Critical patent/CN115212186A/zh
Priority to CN202210754573.8A priority patent/CN115212187A/zh
Publication of CN107072964A publication Critical patent/CN107072964A/zh
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
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CN201580059855.4A 2014-11-05 2015-11-05 与低hlb表面活性剂在生产包含rapalog的合成纳米颗粒中之用途相关的方法和组合物 Pending CN107072964A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210754468.4A CN115212186A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物
CN202210754573.8A CN115212187A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462075864P 2014-11-05 2014-11-05
US201462075866P 2014-11-05 2014-11-05
US62/075,866 2014-11-05
US62/075,864 2014-11-05
PCT/US2015/059349 WO2016073798A1 (en) 2014-11-05 2015-11-05 Methods and compositions related to the use of low hlb surfactants in the production of synthetic nanocarriers comprising a rapalog

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CN202210754468.4A Division CN115212186A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物
CN202210754573.8A Division CN115212187A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物

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CN107072964A true CN107072964A (zh) 2017-08-18

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CN201580059855.4A Pending CN107072964A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在生产包含rapalog的合成纳米颗粒中之用途相关的方法和组合物
CN201580060789.2A Active CN107072965B (zh) 2014-11-05 2015-11-05 与具有处于稳定的超饱和状态之雷帕霉素的合成纳米颗粒相关的方法和组合物
CN202110403075.4A Pending CN113244191A (zh) 2014-11-05 2015-11-05 与具有处于稳定的超饱和状态之雷帕霉素的合成纳米颗粒相关的方法和组合物
CN202210754573.8A Pending CN115212187A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物
CN202210754468.4A Pending CN115212186A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物

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CN201580060789.2A Active CN107072965B (zh) 2014-11-05 2015-11-05 与具有处于稳定的超饱和状态之雷帕霉素的合成纳米颗粒相关的方法和组合物
CN202110403075.4A Pending CN113244191A (zh) 2014-11-05 2015-11-05 与具有处于稳定的超饱和状态之雷帕霉素的合成纳米颗粒相关的方法和组合物
CN202210754573.8A Pending CN115212187A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物
CN202210754468.4A Pending CN115212186A (zh) 2014-11-05 2015-11-05 与低hlb表面活性剂在包含rapalog的合成纳米颗粒中之用途相关的方法和组合物

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CN115484931A (zh) * 2020-03-11 2022-12-16 西莱克塔生物科技公司 与合成纳米载体相关的方法和组合物
CN115916193A (zh) * 2020-04-14 2023-04-04 西莱克塔生物科技公司 用于诱导自噬的方法和组合物
US12194078B2 (en) 2017-03-11 2025-01-14 Cartesian Therapeutics, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
TWI877967B (zh) * 2023-12-28 2025-03-21 訊聯生物科技股份有限公司 包含小分子核糖核酸及奈米載體之組合物、包含其的醫藥組成物及其用途
US12472167B2 (en) 2013-05-03 2025-11-18 Cartesian Therapeutics, Inc. Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both Type 1 and Type IV hypersensitivity
US12553041B2 (en) 2019-06-04 2026-02-17 Cartesian Therapeutics Inc. Formulations and doses of pegylated uricase

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KR20140041505A (ko) 2011-04-29 2014-04-04 셀렉타 바이오사이언시즈, 인크. 조절 b 세포 유도를 위한 관용원성 합성 나노운반체
JP2014521687A (ja) 2011-07-29 2014-08-28 セレクタ バイオサイエンシーズ インコーポレーテッド 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア
WO2015025538A1 (ja) * 2013-08-20 2015-02-26 サンノプコ株式会社 バイオエタノール発酵工程用添加剤及びバイオエタノールの製造方法
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JP6774591B2 (ja) * 2015-02-17 2020-10-28 サンノプコ株式会社 バイオエタノール発酵工程用添加剤及びバイオエタノールの製造方法
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KR102341902B1 (ko) * 2016-09-09 2021-12-21 카오카부시키가이샤 디카르복실산 결정 및 그 제조 방법
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JP2022518504A (ja) * 2019-01-24 2022-03-15 ジェネレーション バイオ カンパニー 閉端ｄｎａ（ｃｅｄｎａ）ならびに遺伝子療法または核酸療法に関連する免疫応答を低減させる方法における使用
CN114126666A (zh) 2019-04-28 2022-03-01 西莱克塔生物科技公司 用于治疗针对病毒转移载体具有预先存在的免疫力的对象的方法
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CA3237037A1 (en) 2021-11-14 2023-05-19 Cartesian Therapeutics, Inc. Multiple dosing with viral vectors
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