CN107029212A - 用于制备胰岛素‑锌复合物的方法 - Google Patents

用于制备胰岛素‑锌复合物的方法 Download PDF

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Publication number
CN107029212A
CN107029212A CN201611166272.4A CN201611166272A CN107029212A CN 107029212 A CN107029212 A CN 107029212A CN 201611166272 A CN201611166272 A CN 201611166272A CN 107029212 A CN107029212 A CN 107029212A
Authority
CN
China
Prior art keywords
insulin
chain
amino acid
solution
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611166272.4A
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English (en)
Chinese (zh)
Inventor
L.安德烈森
R.R.E.汉森
P.杰佩森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN107029212A publication Critical patent/CN107029212A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201611166272.4A 2010-05-10 2011-05-09 用于制备胰岛素‑锌复合物的方法 Pending CN107029212A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10162368 2010-05-10
EP10162368.4 2010-05-10
US33349710P 2010-05-11 2010-05-11
US61/333497 2010-05-11
CN201180023303XA CN102883743A (zh) 2010-05-10 2011-05-09 用于制备胰岛素-锌复合物的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180023303XA Division CN102883743A (zh) 2010-05-10 2011-05-09 用于制备胰岛素-锌复合物的方法

Publications (1)

Publication Number Publication Date
CN107029212A true CN107029212A (zh) 2017-08-11

Family

ID=42732779

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201611166272.4A Pending CN107029212A (zh) 2010-05-10 2011-05-09 用于制备胰岛素‑锌复合物的方法
CN201180023303XA Pending CN102883743A (zh) 2010-05-10 2011-05-09 用于制备胰岛素-锌复合物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180023303XA Pending CN102883743A (zh) 2010-05-10 2011-05-09 用于制备胰岛素-锌复合物的方法

Country Status (12)

Country Link
US (5) US20130143803A1 (https=)
EP (1) EP2569002B1 (https=)
JP (2) JP6249773B2 (https=)
KR (2) KR20160105979A (https=)
CN (2) CN107029212A (https=)
AU (1) AU2011252127B2 (https=)
BR (1) BR112012028766A2 (https=)
CA (1) CA2795091A1 (https=)
ES (1) ES2612468T3 (https=)
MX (1) MX2012012943A (https=)
RU (1) RU2572214C2 (https=)
WO (1) WO2011141407A1 (https=)

Families Citing this family (21)

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EP2256130B1 (en) 2005-02-02 2013-09-25 Novo Nordisk A/S Novel insulin derivatives
ES2371361T3 (es) 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
EP2015770B1 (en) * 2006-05-09 2012-09-26 Novo Nordisk A/S Insulin derivative
WO2007128815A1 (en) 2006-05-09 2007-11-15 Novo Nordisk A/S Insulin derivative
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
EP2217621B1 (en) 2007-11-08 2015-04-22 Novo Nordisk A/S Insulin derivative
JP4959005B2 (ja) 2008-10-30 2012-06-20 ノボ・ノルデイスク・エー／エス 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN105188736A (zh) * 2013-03-20 2015-12-23 诺和诺德股份有限公司 胰岛素给药方案
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
JP6499184B2 (ja) * 2013-10-07 2019-04-10 ノヴォ ノルディスク アー／エス インスリン類似体の新規な誘導体
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
ES2630106T3 (es) 2014-10-07 2017-08-18 Cyprumed Gmbh Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos
WO2019110797A1 (fr) * 2017-12-07 2019-06-13 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un co-polyaminoacide
MX2020005916A (es) 2017-12-07 2020-10-19 Adocia Composiciones en forma de una solución acuosa inyectable que comprende amilina, un receptor agonista de amilina o un análogo de amilina y un copoliaminoácido.
JP2021512124A (ja) * 2018-02-01 2021-05-13 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Ｊｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． ヒトインスリンアナログのアシル化誘導体を含有する医薬組成物及びその調製方法
EP3805257A4 (en) 2018-05-24 2022-03-16 Jiangsu Hengrui Medicine Co., Ltd. METHOD OF PRODUCTION OF A PRECURSOR OF RECOMBINANT HUMAN INSULIN OR ANALOGUE THEREOF
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
KR20210102347A (ko) 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042194A (en) * 1962-04-30 1966-09-14 Olin Mathieson Insulin preparations
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
CN86101489A (zh) * 1985-03-12 1987-01-21 诺沃工业联合股票公司 制备新胰岛素肽及其长效注射液的方法
CN88102311A (zh) * 1987-04-23 1988-11-09 伊莱利利公司 人结晶胰岛素原及其生产方法
CN1829738A (zh) * 2003-08-05 2006-09-06 诺沃挪第克公司 新型胰岛素衍生物
WO2007074133A2 (en) * 2005-12-28 2007-07-05 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
WO2008152106A1 (en) * 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
US20090312236A1 (en) * 2008-06-13 2009-12-17 John Michael Beals Pegylated insulin lispro compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1212679B (de) * 1957-08-03 1966-03-17 Novo Terapeutisk Labor As Verfahren zur Herstellung von Insulinloesungen
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
HUT56857A (en) 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
IL93282A (en) 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
EP1132404A3 (en) * 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
US7097845B2 (en) * 1997-04-23 2006-08-29 Jacob Sten Petersen Combinations of antigen and mucosal binding component for inducing specific immunological tolerance
CA2531988C (en) 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1042194A (en) * 1962-04-30 1966-09-14 Olin Mathieson Insulin preparations
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
CN86101489A (zh) * 1985-03-12 1987-01-21 诺沃工业联合股票公司 制备新胰岛素肽及其长效注射液的方法
CN88102311A (zh) * 1987-04-23 1988-11-09 伊莱利利公司 人结晶胰岛素原及其生产方法
CN1829738A (zh) * 2003-08-05 2006-09-06 诺沃挪第克公司 新型胰岛素衍生物
WO2007074133A2 (en) * 2005-12-28 2007-07-05 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
CN101389650A (zh) * 2005-12-28 2009-03-18 诺沃-诺迪斯克有限公司 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
WO2008152106A1 (en) * 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
CN101677947A (zh) * 2007-06-13 2010-03-24 诺沃-诺迪斯克有限公司 包含胰岛素衍生物的药物制剂
US20090312236A1 (en) * 2008-06-13 2009-12-17 John Michael Beals Pegylated insulin lispro compounds

Also Published As

Publication number Publication date
RU2012148821A (ru) 2014-06-20
KR20130092972A (ko) 2013-08-21
JP2017203042A (ja) 2017-11-16
ES2612468T3 (es) 2017-05-17
EP2569002A1 (en) 2013-03-20
US20150250857A1 (en) 2015-09-10
JP2013526501A (ja) 2013-06-24
JP6249773B2 (ja) 2017-12-20
US20130143803A1 (en) 2013-06-06
US20240307503A1 (en) 2024-09-19
US20210060132A1 (en) 2021-03-04
CA2795091A1 (en) 2011-11-17
WO2011141407A1 (en) 2011-11-17
MX2012012943A (es) 2012-11-29
BR112012028766A2 (pt) 2017-06-13
US20170165327A1 (en) 2017-06-15
EP2569002B1 (en) 2016-10-26
CN102883743A (zh) 2013-01-16
RU2572214C2 (ru) 2015-12-27
KR20160105979A (ko) 2016-09-08
AU2011252127A1 (en) 2012-11-01
AU2011252127B2 (en) 2014-02-20

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