CN107029146B - 一种清肺化痰补气健脾养肺的中药组合物及其制备方法 - Google Patents
一种清肺化痰补气健脾养肺的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种清肺化痰、补气健脾且具有养肺功效的中药组合物及其制备方法，该组合物的原料包括白果、金银花、茯苓、橘红、桔梗、罗汉果、昆布、山药、黄芥子、紫苏籽、白扁豆、百合、薏苡仁、鱼腥草、陈皮、杏仁、玉竹、蒲公英、莱菔子、莲子、甘草等21味中草药。本发明的中药组合物将上述中药成分通过合理比例进行复配，使其达到清肺化痰、补气健脾、治咳喘之功效，同时达到理气宽中、养肺润肺的效果。
Description
技术领域
本发明涉及中药技术领域，具体涉及一种清肺化痰补气健脾养肺的中药组合物及其制备方法。
背景技术
肺的主要生理功能是主气司呼吸。中医理论认为，肺主行水，朝百脉，主治节。肺气以宣发肃降为基本运行形式。肺在五脏六腑中位置最高，覆盖诸脏，故有：“华盖”之称；肺叶娇嫩，不耐寒热燥湿诸邪之侵，肺又上通鼻窍，外合皮毛，与自然界息息相通，易受外邪侵袭，故有“娇脏”之称。
肺主呼吸的功能，实际上是肺气的宣发与肃降作用在气体交换过程中的具体表现：肺气宣发，浊气得以呼出；肺气肃降，清气得以吸入。肺气的宣发与肃降作用协调有序，则呼吸均匀通畅。肺气失宣或肺气失降，则人会有呼吸异常的表现。
肺热是风热邪毒犯肺，或外感风寒入里化热导致的肺失清肃，出现恶寒、发热、咳嗽等症状。临床以发热、咳嗽、胸痛、咯痰量多，气味腥臭为主要症状。现代医学中的呼吸道感染、急慢性支气管炎发作等呼吸系统疾病都有可能出现肺热病症。中医认为，肺乃娇脏，润肺有助肺部的保健；此外，肺为贮痰之器，脾为生痰之源。中医上所谓“清肺”意指滋养阴液，清除肺热、肺火，临床表现为干咳少痰、咽燥咯血、咳嗽气喘、鼻干唇燥等症状的患者便需要养阴清肺。如果不及时清除肺热，患者容易反复咳嗽，甚至将病变扩散到邻近的小支气管，诱发肺炎、肺气肿等重大疾病。对于痰多痰稠的患者以致于影响呼吸的患者，还需对症进行化痰祛痰。
公开号为CN 1554407A的中国专利文献公开了一种清肺化痰止咳平喘的药物及其制备方法，其是以麻黄、石膏、地龙、牛蒡子、葶苈子、牛黄、炒苦杏仁、羚羊角为原料，采用醇提取及粉碎等制备方法按比例配制的清肺化痰止咳平喘的药物制剂，用于上呼吸道感染，急性支气管炎和慢性支气管炎的急性发作，以及肺部感染引起的咳嗽痰稠、喘息气急等症的清肺消炎。
公开号为CN 103585499A的中国专利文献公开了一种治疗清肺化痰的中药组合物及其制备方法和应用，所述中药组合物的原料药配比为大青叶1000-1500g、鱼腥草500-700g、桑白皮350-500g、葶苈子350-500g、天竺黄200-300g、浙贝母300-400g，清肺化痰的药理作用显著。
公开号为CN 105169102A的中国专利文献公开了一种清肺汤，采用的原料药材分别是：羊蹄草15份、一枝黄花15份、鱼腥草15份、金银花12份、连翘15份、薄荷10份、荆芥10份、杏仁12份、薏苡15份、桃仁10份、黄芩10份、芦根20份、天花粉15份、大黄15份。所述清肺汤具有疏风清肺、化痰泄热的功效，用于肺炎、胸痛、咳嗽痰白或黄具有确切效果。
对于肺热咳嗽、痰多痰浓的患者，肺热乃生痰根源，且不清肺热则咳嗽易反复发作，因此对此病症应该清肺化痰双管齐下。目前中医药领域还需要能够深入肺脏内部来清除肺热、化痰祛痰，并具有养肺功效的中药组合物。
发明内容
本发明的目的在于提供一种清肺化痰、补气健脾且具有养肺功效的中药组合物，以针对肺热咳嗽、痰多痰浓的患者，其能够深入肺部清肺化痰双管齐下，取得治标治本的功效。本发明还提供了所述中药组合物的制备方法。
为实现上述目的，本发明的一个方面提供了一种清肺化痰补气健脾养肺的中药组合物，所述中药组合物的原料按重量份数包括下列组分：
白果25-36份，金银花26-33份、茯苓28-35份，橘红15-25份、桔梗25-35份，罗汉果15-28份，昆布28-32份，山药15-28份、黄芥子26-34份，紫苏籽28-33份，白扁豆25-35份，百合25-32份，薏苡仁28-35份，鱼腥草18-23份，陈皮15-25份，杏仁15-25份，玉竹15-23份、蒲公英18-25份，莱菔子15-25份，莲子18-25份、甘草1-4份。
进一步的，所述中药组合物的原料按重量份数包括下列组分：
白果28-33份，金银花28-32份、茯苓30-33份，橘红18-23份、桔梗28-33份，罗汉果18-23份，昆布28-32份，山药18-25份、黄芥子28-33份，紫苏籽28-31份，白扁豆28-33份，百合28-32份，薏苡仁28-32份，鱼腥草18-21份，陈皮18-23份，杏仁18-23份，玉竹18-23份、蒲公英18-22份，莱菔子18-23份，莲子18-22份、甘草2-4份。
进一步的，所述中药组合物的原料按重量份数包括下列组分：
白果28-31份，金银花28-31份、茯苓30-32份，橘红18-21份、桔梗28-31份，罗汉果18-22份，昆布30-32份，山药18-22份、黄芥子28-30份，紫苏籽28-31份，白扁豆28-32份，百合28-30份，薏苡仁28-30份，鱼腥草20-21份，陈皮19-22份，杏仁18-21份，玉竹18-22份、蒲公英20-22份，莱菔子18-21份，莲子19-22份、甘草2-3份。
在一个实施方案中，所述中药组合物的原料按重量份数包括下列组分：
白果28份，金银花28份、茯苓32份，橘红20份、桔梗28份，罗汉果22份，昆布30份，山药18份、黄芥子29份，紫苏籽31份，白扁豆31份，百合30份，薏苡仁28份，鱼腥草20份，陈皮22份，杏仁18份，玉竹21份、蒲公英20份，莱菔子18份，莲子19份、甘草3份。
在另一个实施方案中，所述中药组合物的原料按重量份数包括下列组分：
白果30份，金银花30份、茯苓30份，橘红20份、桔梗30份，罗汉果20份，昆布30份，山药20份、黄芥子30份，紫苏籽30份，白扁豆30份，百合30份，薏苡仁30份，鱼腥草20份，陈皮20份，杏仁20份，玉竹20份、蒲公英20份，莱菔子20份，莲子20份、甘草3份。
白果：又名鸭脚子、灵眼、佛指柑，银杏、公孙树子，是银杏的种仁。白果果仁除含有淀粉、蛋白质、脂肪、糖类之外，还含有维生素C、核黄素、胡萝卜素、钙、磷、铁、钾、镁等微量元素以及银杏酸、白果酚、五碳多糖，脂固醇等成分，营养丰富，而且对于益肺气、治咳喘、止带虫、缩小便、平皴皱、护血管、增加血流量、带下、白浊等疾病具有良好的医用效果和食疗作用。
金银花：又名忍冬。药材金银花为忍冬科忍冬属植物忍冬及同属植物干燥花蕾或带初开的花。金银花自古被誉为清热解毒的良药。它性甘寒气芳香，甘寒清热而不伤胃，芳香透达又可祛邪。金银花既能宣散风热，还善清解血毒，用于各种热性病，如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症，均效果显著。
茯苓：为多孔菌科真菌茯苓的干燥菌核。《本草纲目》中记载：茯苓气味淡而渗，其性上行，生津液，开腠理，滋水源而下降，利小便，故张洁古谓其属阳，浮而升，言其性也；东垣谓其为阳中之阴，降而下，言其功也。其味甘、淡，性平；归心、肺、脾、肾经，用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。具有补气健脾的作用。
橘红：为芸香科植物橘及其栽培变种的干燥外层果皮。其味辛、苦，性温；归肺、脾经。具有理气宽中，燥湿化痰之功效。用于咳嗽痰多，食积伤酒，呕恶痞闷。
桔梗：别名包袱花、铃铛花、僧帽花，是多年生草本植物，其根可入药，有止咳祛痰、宣肺、排脓等作用，中医常用药。
罗汉果：葫芦科多年生藤本植物的果实，被人们誉为“神仙果”。其主要功效是能止咳化痰。果实营养价值很高，含丰富的维生素C以及糖甙、果糖、葡萄糖、蛋白质、脂类等。
昆布：亦称“黑菜”、“鹅掌菜”、“五掌菜”等。为海带科植物海带或翅藻科植物昆布(鹅掌菜)的干燥叶状体。昆布性味寒、咸，有软坚散结、消肿利水、润下消痰之功。临床上用于甲状腺肿、颈淋巴结肿、支气管炎、肺结核、咳嗽和老年性白内障等，亦试用于治疗癌症。
山药：山药又称薯蓣、土薯、山薯蓣、怀山药、淮山、白山药，是《中华本草》收载的草药，为薯蓣科植物山药干燥根茎。山药具有滋养强壮，助消化，敛虚汗，止泻之功效，主治脾虚腹泻、肺虚咳嗽、糖尿病消渴、小便短频、遗精、妇女带下及消化不良的慢性肠炎。具有补气健脾的作用。
黄芥子：黄芥子是十字花科植物芥的干燥成熟种子，是常用的中药材，性温、味辛。有润肺化痰、消肿止痛、温中散寒、利水化瘀、通经络、消肿毒之功效，主治胃寒呕吐、心腹疼痛、肺寒咳嗽、痹症、喉痹、流痰、跌打损伤等症。
紫苏籽：唇形科植物紫苏的种子，具有一定的药用价值，具有下气，清痰，润肺，宽肠的功效。
白扁豆：一年生缠绕草本植物扁豆的成熟种子。白扁豆味甘，性微温，有健脾化湿，利尿消肿，清肝明目等功效。《中国药典》记载：白扁豆“健脾胃，清暑湿。用于脾胃虚弱、暑湿泄泻、白带”。具有补气健脾的作用。
百合：百合科百合属多年生草本球根植物，鳞茎含丰富淀粉，可食，亦作药用。百合除含有蛋白质、脂肪、还原糖、淀粉、钙、磷、铁、维生素B、维生素C等营养素外，还含有如秋水仙碱等多种生物碱。具有良好的营养滋补之功，而且还对秋季气候干燥而引起的多种季节性疾病有一定的防治作用。百合具有养心安神，润肺止咳的功效。
薏苡仁：为禾本科植物薏苡的干燥成熟种仁。味甘、淡，性凉。归脾、胃、肺经。有利渗透湿，健脾止泻，除痹，排脓，解毒散结的作用。用于水肿，脚气，小便不利，脾虚泄泻，湿痹拘挛，肺痈，肠痈；赘疣，癌肿。
鱼腥草：鱼腥草是《中国药典》收录的草药，草药来源为三白草科植物蕺菜的干燥地上部分。鱼腥草味辛，性寒凉，归肺经。能清热解毒、消肿疗疮、利尿除湿、清热止痢、健胃消食，用治实热、热毒、湿邪、疾热为患的肺痈、疮疡肿毒、痔疮便血、脾胃积热等。现代药理实验表明，本品具有抗菌、抗病毒、提高机体免疫力、利尿等作用。
陈皮：芸香科植物橘及其栽培变种的干燥成熟果皮。采摘成熟果实，剥取果皮，晒干或低温干燥。味苦、辛，性温。归肺、脾经。具有理气健脾，燥湿化痰之功效。
杏仁：杏仁是蔷薇科杏的种子，主要含有蛋白质、脂肪、糖、微量苦杏仁苷。脂肪的组成中主要是油酸和亚油酸。苦，微温；有小毒，具有止咳平喘之效。本品主入肺经。味苦能降，且兼疏利开通之性，降肺气之中兼有宣肺之功而达止咳平喘，为治咳喘之要药。
玉竹：为百合科多年生草本植物。植物的根茎可供药用，中药名亦为玉竹。玉竹具养阴、润燥、清热、生津、止咳等功效。用作滋补药品，主治热病伤阴、虚热燥咳、心脏病、糖尿病、结核病等症，并可作高级滋补食品、佳肴和饮料，具有保健作用。
蒲公英：菊科多年生草本植物。蒲公英植物体中含有蒲公英醇、蒲公英素、胆碱、有机酸、菊糖等多种健康营养成分。性味甘，微苦，寒。归肝、胃经。有利尿、缓泻、退黄疸、利胆等功效。治感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎等。
莱菔子：为十字花科植物萝卜的干燥成熟种子。性辛、甘、平，归肺、脾、胃经。具有消食除胀，降气化痰之功效。
莲子：为睡莲科植物莲的干燥成熟种子。具有补脾止泻，止带，益肾涩精，养心安神之功效。常用于脾虚泄泻，带下，遗精，心悸失眠。具有补气健脾的作用。
甘草：豆科、甘草属多年生草本，根与根状茎粗壮，是一种补益中草药。气微，味甜而特殊。功能主治清热解毒、祛痰止咳、脘腹等。常用于治疗气喘咳嗽。
本发明的清肺化痰补气健脾养肺的中药组合物可以按照上述重量份数采用常规的煎煮等方式服用，也可以制成丸剂、片剂进行服用。
本发明的另一个方面提供了一种上述清肺化痰补气健脾养肺的中药组合物的制备方法，所述制备方法包括下列步骤：
S100：提取：按上述重量份数分别称取白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子，然后将上述原料成分放入提取罐中，加水进行提取得到第一提取液；其中加入的水的重量与所述白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子的总重量的重量比为4～6：1；
S200：浓缩：将步骤S100得到的第一提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的第一浓缩液的密度为1.08～1.25g/ml；
S300：醇沉：在步骤S200得到的所述第一浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的第一醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述第一浓缩液的体积之比为1.8～3.3：1；
S400：粉碎：按上述重量份数取金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草；将金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草清洗晾干后进行粉碎处理得到混合碎片；
S500：混合：将步骤S300得到的第一醇沉上清液均匀喷洒至步骤S400得到的混合碎片上；
S600：干燥：对附着有第一醇沉上清液的混合碎片进行烘干处理即可得到所述中药组合物；所述烘干处理的温度为40℃～55℃。
上述清肺化痰补气健脾养肺的中药组合物还可以通过如下制备方法制备，所述制备方法包括下列步骤：
S100：提取：按上述重量份数分别称取白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子、莲子、金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草，然后将上述各原料成分均放入提取罐中，加水进行提取得到混合提取液；其中加入的水的重量与所述各原料成分的总重量的重量比为4～6：1；
S200：浓缩：将步骤S100得到的混合提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的混合浓缩液的密度为1.08～1.25g/ml；
S300：醇沉：在步骤S200得到的所述混合浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的混合醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述混合浓缩液的体积之比为1.8～3.3：1；
S400：干燥：将步骤S300得到的混合醇沉上清液喷雾干燥得到混合粉状物；所述混合粉状物即为所述中药组合物。
进一步的，所述制备方法还包括下述步骤：
S500：在所述混合粉状物中加入调味剂，然后制成片剂、丸剂和胶囊。
其中，步骤S100中的提取重复多次，最好为2～4次，最后将多次滤液混合得到所述提取液。
其中，所述提取步骤中每次提取时间为1.5～2.5小时。
本发明方法具有如下优点：
(1)本发明的清肺化痰补气健脾养肺的中药组合物将白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子、莲子、金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草通过合理比例进行复配，使各组分之间的药效产生协同作用，使其达到清肺化痰、补气健脾、治咳喘之功效，同时达到理气宽中、养肺润肺的效果。
(2)本发明的中药组合物的制备方法易于制造，工艺化程度高，成本较低。
具体实施方式
以下实施例用于说明本发明，但不用来限制本发明的范围。如非特别说明，下述实施例中所用的原料和设备均为市售。
实施例1
本实施例的清肺化痰补气健脾养肺的中药组合物的制备方法包括下述步骤：
S100：提取：称取30份白果、30份茯苓、20份橘红、30份桔梗、20份罗汉果、30份黄芥子、30份紫苏籽、30份白扁豆、30份薏苡仁、20份陈皮、20份杏仁、20份莱菔子和20份莲子，然后将上述原料成分放入提取罐中，加入5倍水加热回流进行提取得到第一提取液；其中加入的水的重量与所述白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子的总重量的重量比为5：1；本实施例中仅提取一次，提取时间为2.5小时；
S200：浓缩：将步骤S100得到的第一提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的第一浓缩液的密度为1.2g/ml；
S300：醇沉：在步骤S200得到的所述第一浓缩液中加入食用酒精(75％)进行醇沉处理，取醇沉处理得到的第一醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述第一浓缩液的体积之比为2.3：1；
S400：粉碎：取30份金银花、30份昆布、20份山药、30份百合、20份鱼腥草、20份玉竹、20份蒲公英和3份甘草；将金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草清洗晾干后进行粉碎处理得到混合碎片；
S500：混合：将步骤S300得到的第一醇沉上清液均匀喷洒至步骤S400得到的混合碎片上；本实施例中喷洒分5次进行，喷洒时对混合碎片进行搅拌以保证喷洒均匀；
S600：干燥：对附着有第一醇沉上清液的混合碎片进行烘干处理即可得到所述中药组合物；所述烘干处理的温度为50℃。
S700：对得到的中药组合物进行包装，每袋3～5克，使用时袋泡即可。
实施例2
本实施例的清肺化痰补气健脾养肺的中药组合物的制备方法包括下述步骤：
S100：提取：称取28份白果、32份茯苓、20份橘红、28份桔梗、22份罗汉果、29份黄芥子、31份紫苏籽、31份白扁豆、28份薏苡仁、22份陈皮、18份杏仁、18份莱菔子和19份莲子，然后将上述原料成分放入提取罐中，加入4倍水加热回流进行提取得到第一提取液；其中加入的水的重量与所述白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子的总重量的重量比为4：1；本实施例中提取两次，每次均加入2倍的水，每次提取时间均为2小时，将两次滤液混合得到第一提取液；
S200：浓缩：将步骤S100得到的第一提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的第一浓缩液的密度为1.23g/ml；
S300：醇沉：在步骤S200得到的所述第一浓缩液中加入食用酒精(75％)进行醇沉处理，取醇沉处理得到的第一醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述第一浓缩液的体积之比为2.5：1；
S400：粉碎：取28份金银花、30份昆布、18份山药、30份百合、20份鱼腥草、21份玉竹、20份蒲公英和3份甘草；将金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草清洗晾干后进行粉碎处理得到混合碎片；
S500：混合：将步骤S300得到的第一醇沉上清液均匀喷洒至步骤S400得到的混合碎片上；本实施例中喷洒分4次进行，喷洒时对混合碎片进行搅拌以保证喷洒均匀；
S600：干燥：对附着有第一醇沉上清液的混合碎片进行烘干处理即可得到所述中药组合物；所述烘干处理的温度为48℃。
S700：对得到的中药组合物进行包装，每袋3～5克，使用时袋泡即可。
实施例3
本实施例的清肺化痰补气健脾养肺的中药组合物的制备方法包括下述步骤：
S100：提取：分别称取31份白果、32份茯苓、21份橘红、28份桔梗、18份罗汉果、28份黄芥子、31份紫苏籽、32份白扁豆、29份薏苡仁、19份陈皮、21份杏仁、18份莱菔子、22份莲子、28份金银花、30份昆布、22份山药、30份百合、20份鱼腥草、22份玉竹、20份蒲公英和3份甘草，然后将上述各原料成分均放入提取罐中，加入6倍水进行提取得到混合提取液；
S200：浓缩：将步骤S100得到的混合提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的混合浓缩液的密度为1.15g/ml；
S300：醇沉：在步骤S200得到的所述混合浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的混合醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述混合浓缩液的体积之比为2.8：1；
S400：干燥：将步骤S300得到的混合醇沉上清液喷雾干燥得到混合粉状物；所述混合粉状物即为所述中药组合物。
S500：将混合粉状物采用常用的工艺制成胶囊剂、片剂、颗粒剂、散剂、丸剂(包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸或滴丸)等。
实施例4
本实施例的清肺化痰补气健脾养肺的中药组合物的制备方法包括下述步骤：
S100：提取：分别称取36份白果、28份茯苓、18份橘红、25份桔梗、15份罗汉果、32份黄芥子、28份紫苏籽、32份白扁豆、32份薏苡仁、23份陈皮、18份杏仁、18份莱菔子、22份莲子、33份金银花、30份昆布、15份山药、32份百合、20份鱼腥草、23份玉竹、25份蒲公英和4份甘草，然后将上述各原料成分均放入提取罐中，加入6倍水进行提取得到混合提取液；本实施例中提取共进行3次，每次提取时间为2.5小时；
S200：浓缩：将步骤S100得到的混合提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的混合浓缩液的密度为1.21g/ml；
S300：醇沉：在步骤S200得到的所述混合浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的混合醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述混合浓缩液的体积之比为2.5：1；
S400：干燥：将步骤S300得到的混合醇沉上清液喷雾干燥得到混合粉状物；所述混合粉状物即为所述中药组合物。
S500：在所述混合粉状物中加入调味剂，然后采用常用的工艺制成胶囊剂、片剂、颗粒剂、散剂、丸剂(包括水丸、蜜丸、糖衣丸、胶丸、肠溶丸或滴丸)等。调味剂最好为木糖醇或低聚果糖。
下面是本发明的中药组合物清肺化痰补气健脾止咳平喘的临床试验结果。
1、临床观察对象
肺热导致的肺失清肃，出现发热、咳嗽、胸痛、咯痰量多且稠，颜色发黄，气味腥臭等症状，且咳嗽反复发作，久治不愈的患者：观察45例，其中男24例，女21例，全部为成年人。
2、治疗方法
本发明袋装泡喝药物：每袋4g。使用方法：每天一袋，一日3～5次，连服10天为一疗程，最多观察3疗程。治疗期间少吃肉类、糯米类、辛辣、油腻食品及海鲜，禁酒。效果判断：临床表现全部消除且随访3个月未复发者为痊愈；消除30％以上且随访3个月虽复发但较前减轻者为有效；其它为无效。
3、治疗结果
痊愈38例，占84.4％；有效7例，占15.6％；无效0例。
上述临床试验结果显示，本发明的中药组合物能够补气健脾，对于清肺化痰止咳平喘有很好的疗效。
虽然，上文中已经用一般性说明及具体实施例对本发明作了详尽的描述，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。
Claims (10)
1.一种清肺化痰的中药组合物，其特征在于，所述中药组合物针对成年人；所述中药组合物的原料按重量份数由下列组分组成：
白果25-36份，金银花26-33份、茯苓28-35份，橘红15-25份、桔梗25-35份，罗汉果15-28份，昆布28-32份，山药15-28份、黄芥子26-34份，紫苏籽28-33份，白扁豆25-35份，百合25-32份，薏苡仁28-35份，鱼腥草18-23份，陈皮15-25份，杏仁15-25份，玉竹15-23份、蒲公英18-25份，莱菔子15-25份，莲子18-25份、甘草1-4份。
2.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物的原料按重量份数由下列组分组成：
白果28-33份，金银花28-32份、茯苓30-33份，橘红18-23份、桔梗28-33份，罗汉果18-23份，昆布28-32份，山药18-25份、黄芥子28-33份，紫苏籽28-31份，白扁豆28-33份，百合28-32份，薏苡仁28-32份，鱼腥草18-21份，陈皮18-23份，杏仁18-23份，玉竹18-23份、蒲公英18-22份，莱菔子18-23份，莲子18-22份、甘草2-4份。
3.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物的原料按重量份数由下列组分组成：
白果28-31份，金银花28-31份、茯苓30-32份，橘红18-21份、桔梗28-31份，罗汉果18-22份，昆布30-32份，山药18-22份、黄芥子28-30份，紫苏籽28-31份，白扁豆28-32份，百合28-30份，薏苡仁28-30份，鱼腥草20-21份，陈皮19-22份，杏仁18-21份，玉竹18-22份、蒲公英20-22份，莱菔子18-21份，莲子19-22份、甘草2-3份。
4.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物的原料按重量份数由下列组分组成：
白果28份，金银花28份、茯苓32份，橘红20份、桔梗28份，罗汉果22份，昆布30份，山药18份、黄芥子29份，紫苏籽31份，白扁豆31份，百合30份，薏苡仁28份，鱼腥草20份，陈皮22份，杏仁18份，玉竹21份、蒲公英20份，莱菔子18份，莲子19份、甘草3份。
5.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物的原料按重量份数由下列组分组成：
白果30份，金银花30份、茯苓30份，橘红20份、桔梗30份，罗汉果20份，昆布30份，山药20份、黄芥子30份，紫苏籽30份，白扁豆30份，百合30份，薏苡仁30份，鱼腥草20份，陈皮20份，杏仁20份，玉竹20份、蒲公英20份，莱菔子20份，莲子20份、甘草3份。
6.根据权利要求1-5中任一项所述的中药组合物的制备方法，其特征在于，所述制备方法包括如下步骤：
S100：提取：按上述重量份数分别称取白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子，然后将上述原料成分放入提取罐中，加水进行提取得到第一提取液；其中加入的水的重量与所述白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子和莲子的总重量的重量比为4～6：1；
S200：浓缩：将步骤S100得到的第一提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的第一浓缩液的密度为1.08～1.25g/ml；
S300：醇沉：在步骤S200得到的所述第一浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的第一醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述第一浓缩液的体积之比为1.8～3.3：1；
S400：粉碎：按上述重量份数取金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草；将金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草清洗晾干后进行粉碎处理得到混合碎片；
S500：混合：将步骤S300得到的第一醇沉上清液均匀喷洒至步骤S400得到的混合碎片上；
S600：干燥：对附着有第一醇沉上清液的混合碎片进行烘干处理即可得到所述中药组合物；所述烘干处理的温度为40℃～55℃。
7.根据权利要求1-5中任一项所述的中药组合物的制备方法，其特征在于，所述制备方法包括如下步骤：
S100：提取：按上述重量份数分别称取白果、茯苓、橘红、桔梗、罗汉果、黄芥子、紫苏籽、白扁豆、薏苡仁、陈皮、杏仁、莱菔子、莲子、金银花、昆布、山药、百合、鱼腥草、玉竹、蒲公英和甘草，然后将上述各原料成分均放入提取罐中，加水进行提取得到混合提取液；其中加入的水的重量与所述各原料成分的总重量的重量比为4～6：1；
S200：浓缩：将步骤S100得到的混合提取液静置沉淀后取上层清液，然后对所述上层清液进行浓缩处理，浓缩处理后得到的混合浓缩液的密度为1.08～1.25g/ml；
S300：醇沉：在步骤S200得到的所述混合浓缩液中加入食用酒精进行醇沉处理，取醇沉处理得到的混合醇沉上清液备用；所述醇沉处理中加入的食用酒精的体积与所述混合浓缩液的体积之比为1.8～3.3：1；
S400：干燥：将步骤S300得到的混合醇沉上清液喷雾干燥得到混合粉状物；所述混合粉状物即为所述中药组合物。
8.根据权利要求7所述的制备方法，其特征在于，所述制备方法还包括如下步骤：
S500：在所述混合粉状物中加入调味剂，然后制成片剂、丸剂和胶囊。
9.根据权利要求6-8中任一项所述的制备方法，其特征在于，步骤S100中的提取重复2～4次，最后将多次滤液混合得到所述提取液。
10.根据权利要求9所述的制备方法，其特征在于，所述提取步骤中每次提取时间为1.5～2.5小时。
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