CN107011354A - 一种5‑单硝酸异山梨酯的制备方法 - Google Patents
一种5‑单硝酸异山梨酯的制备方法 Download PDFInfo
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- CN107011354A CN107011354A CN201710244534.2A CN201710244534A CN107011354A CN 107011354 A CN107011354 A CN 107011354A CN 201710244534 A CN201710244534 A CN 201710244534A CN 107011354 A CN107011354 A CN 107011354A
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- 0 C=NC1([C@]2*C[C@]1O)OC[C@]2O Chemical compound C=NC1([C@]2*C[C@]1O)OC[C@]2O 0.000 description 3
- MMWRGWQTAMNAFC-UHFFFAOYSA-N C1NC=CC=C1 Chemical compound C1NC=CC=C1 MMWRGWQTAMNAFC-UHFFFAOYSA-N 0.000 description 1
- UBYWOCTVOLCNLJ-OOJXKGFFSA-N C[C@H](CO)[C@H]([C@@H]1C)OC[C@@H]1O Chemical compound C[C@H](CO)[C@H]([C@@H]1C)OC[C@@H]1O UBYWOCTVOLCNLJ-OOJXKGFFSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
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CN201710244534.2A CN107011354B (zh) | 2017-04-14 | 2017-04-14 | 一种5-单硝酸异山梨酯的制备方法 |
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CN201710244534.2A CN107011354B (zh) | 2017-04-14 | 2017-04-14 | 一种5-单硝酸异山梨酯的制备方法 |
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CN107011354A true CN107011354A (zh) | 2017-08-04 |
CN107011354B CN107011354B (zh) | 2021-05-11 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110407846A (zh) * | 2018-04-26 | 2019-11-05 | 鲁南制药集团股份有限公司 | 一种5-单硝酸异山梨酯的制备方法 |
CN112174975A (zh) * | 2020-11-09 | 2021-01-05 | 鲁南贝特制药有限公司 | 一种单硝酸异山梨酯的绿色精制方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1609108A (zh) * | 2004-08-04 | 2005-04-27 | 鲁南制药股份有限公司 | 单硝酸异山梨酯的制备方法 |
CN102603760A (zh) * | 2011-01-24 | 2012-07-25 | 华东理工大学 | 一种抗心绞痛药物单硝酸异山梨醇酯的合成方法 |
CN103641840A (zh) * | 2013-11-28 | 2014-03-19 | 青岛黄海制药有限责任公司 | 一种5-单硝酸异山梨酯的合成与纯化方法 |
CN104892623A (zh) * | 2015-06-11 | 2015-09-09 | 山东新时代药业有限公司 | 一种5-单硝酸异山梨酯的制备方法 |
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2017
- 2017-04-14 CN CN201710244534.2A patent/CN107011354B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1609108A (zh) * | 2004-08-04 | 2005-04-27 | 鲁南制药股份有限公司 | 单硝酸异山梨酯的制备方法 |
CN102603760A (zh) * | 2011-01-24 | 2012-07-25 | 华东理工大学 | 一种抗心绞痛药物单硝酸异山梨醇酯的合成方法 |
CN103641840A (zh) * | 2013-11-28 | 2014-03-19 | 青岛黄海制药有限责任公司 | 一种5-单硝酸异山梨酯的合成与纯化方法 |
CN104892623A (zh) * | 2015-06-11 | 2015-09-09 | 山东新时代药业有限公司 | 一种5-单硝酸异山梨酯的制备方法 |
Non-Patent Citations (1)
Title |
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GHOLAM H. HAKIMELAHI等: "The synthesis and application of novel nitrating and nitrosating agents", 《HELVETICA CHIMICA ACTA》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110407846A (zh) * | 2018-04-26 | 2019-11-05 | 鲁南制药集团股份有限公司 | 一种5-单硝酸异山梨酯的制备方法 |
CN112174975A (zh) * | 2020-11-09 | 2021-01-05 | 鲁南贝特制药有限公司 | 一种单硝酸异山梨酯的绿色精制方法 |
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Inventor after: Liu Chundi Inventor after: Chen Chengfu Inventor after: Wang Yongzhen Inventor before: Zhang Guimin Inventor before: Chen Chengfu Inventor before: Wang Yongzhen |
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Effective date of registration: 20210408 Address after: 215600 No.77, Chang'an South Road, yangshe Town, Zhangjiagang City, Suzhou City, Jiangsu Province Applicant after: ZHANGJIAGANG HOSPITAL OF TRADITIONAL CHINESE MEDICINE Address before: 276005 No. 209 Hongqi Road, Shandong, Linyi Applicant before: Lunan Pharmaceutical Group Corp. |
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Effective date of registration: 20230417 Address after: 273400 Shandong city of Linyi province Feixian County North Ring Road No. 1 Patentee after: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Address before: 215600 No.77, Chang'an South Road, yangshe Town, Zhangjiagang City, Suzhou City, Jiangsu Province Patentee before: ZHANGJIAGANG HOSPITAL OF TRADITIONAL CHINESE MEDICINE |