CN107007819A - A kind of spray containing cell polypeptide growth factor - Google Patents

A kind of spray containing cell polypeptide growth factor Download PDF

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Publication number
CN107007819A
CN107007819A CN201710201191.1A CN201710201191A CN107007819A CN 107007819 A CN107007819 A CN 107007819A CN 201710201191 A CN201710201191 A CN 201710201191A CN 107007819 A CN107007819 A CN 107007819A
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China
Prior art keywords
parts
growth factor
cell polypeptide
polypeptide growth
spray
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CN201710201191.1A
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Chinese (zh)
Inventor
曹科
朱煜星
曹培国
龚恋
何东
伍拓
刘伶
樊小军
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Third Xiangya Hospital of Central South University
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Third Xiangya Hospital of Central South University
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Priority to CN201710201191.1A priority Critical patent/CN107007819A/en
Publication of CN107007819A publication Critical patent/CN107007819A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/10—Peat; Amber; Turf; Humus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486—Millettia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to medical spray technical field, more particularly to a kind of spray containing cell polypeptide growth factor, the TiO 2 particles of amino group are carried including surface, cell polypeptide growth factor, Nano silica sol, by peptide growth factor by physical absorption on TiO 2 particles, and by ultrasonic dispersion by TiO 2 particles, cell polypeptide growth factor, complex liquid is made in Nano silica sol, spray is sprayed on after skin surface, automatically form layer protecting film, after medicine is fully absorbed, it can facilitate and be come off from skin affected part, outer wound can be made, treatment, especially squamous carcinoma, diabetes etc. pass through radiotherapy, postoperative wound after chemotherapy quickly heals.

Description

A kind of spray containing cell polypeptide growth factor
Technical field
The present invention relates to medical spray technical field, more particularly to a kind of spray containing cell polypeptide growth factor.
Background technology
At present, clinically generally using absorbent cotton or gauze wrapping and the outer wound of covering and postoperative wound, but in dressing Incrustation wound is easily torn in journey, therefore the pain of patient can be increased.
In order to solve the above problems, existing medical application, medicine physics is infiltrated on nonwoven by it using nonwoven cloth material more On cloth, affected part is affixed on, percutaneous absorption plays drug effect.But the medical application of the type have it is volatile, caducous Feature, in addition, it is very slow to be directed to the postoperative wound healing after radiotherapy, chemotherapy such as squamous carcinoma, diabetes.
Therefore prior art still has larger room for improvement.
The content of the invention
It is an object of the invention to provide a kind of spray containing cell polypeptide growth factor, it, which has, can make outer wound, control Treat, the characteristics of especially postoperative wound after radiotherapy, chemotherapy such as squamous carcinoma, diabetes quickly heals.
To achieve the above object, the present invention uses following technical proposals：
A kind of spray containing cell polypeptide growth factor, including surface carry TiO 2 particles, the polypeptide of amino group Porcine HGF, Nano silica sol, by peptide growth factor by physical absorption on TiO 2 particles, and by super Complex liquid is made in TiO 2 particles, cell polypeptide growth factor, Nano silica sol by sound dispersion method.
Wherein, received in the complex liquid spray added with the humic acid for preventing from precipitating.
Wherein, the complex liquid spray includes plurality of Chinese, and its parts by weight is：5-10 parts of Sargent gloryvine, achyranthes aspera 10-20 Part, 10-15 parts of bark of tree of heaven, 5-10 parts of caulis trachelospermi, 10-20 parts of carbonized hair, 3-8 parts of calamine, 5-15 parts of amber.
Wherein, the preparation method of the complex liquid spray comprises the following steps：
1) Sargent gloryvine, achyranthes aspera, bark of tree of heaven, caulis trachelospermi, carbonized hair, calamine and amber are crushed to 100~300 mesh；
2) by step 1) obtained herb powder is put into pressure pan, then adds 12~16 times of volumetric concentrations of its weight For 60~70% ethanol solution, 3~6kgf/cm2 is forced into, makes its pressure uniform, and keeps 3~7min, recovers normal pressure, Obtain slurries；
3) slurries are heated to reflux, extracted 3 times, 1.5~2h, merges extract solution, ethanol is recovered under reduced pressure every time；
4) stand overnight, filter, filtrate is eluted by macroreticular resin, add and by ultrasonic dispersion by dioxy Change titanium particle, cell polypeptide growth factor, Nano silica sol and be made that complex liquid is well mixed to can obtain complex liquid spray.
Wherein, the parts by weight of Chinese medicine are in the complex liquid spray：3-8 parts of Sargent gloryvine, 8-15 parts of achyranthes aspera, bark of tree of heaven 5-10 Part, 3-8 parts of caulis trachelospermi, 8-15 parts of carbonized hair, 2-5 parts of calamine, 3-10 parts of amber.
Wherein, the parts by weight of Chinese medicine are in the complex liquid spray：7 parts of Sargent gloryvine, 12 parts of achyranthes aspera, 12 parts of bark of tree of heaven, trachelospermum jasminoide 7 parts of rattan, 15 parts of carbonized hair, 5 parts of calamine, 10 parts of amber.
Beneficial effect of the present invention：The present invention carries TiO 2 particles, the cell polypeptide growth of amino group including surface The factor, Nano silica sol, by peptide growth factor by physical absorption on TiO 2 particles, and pass through ultrasonic dispersion Complex liquid is made in TiO 2 particles, cell polypeptide growth factor, Nano silica sol, spray is sprayed on after skin surface, automatically Layer protecting film is formed, after medicine is fully absorbed, can facilitate and be come off from skin affected part, outer wound, treatment can be made, especially The postoperative wound after radiotherapy, chemotherapy such as squamous carcinoma, diabetes quickly heals.
Embodiment
The present invention is described in detail below.
A kind of spray containing cell polypeptide growth factor, including surface carry TiO 2 particles, the polypeptide of amino group Porcine HGF, Nano silica sol, by peptide growth factor by physical absorption on TiO 2 particles, and by super Complex liquid is made in TiO 2 particles, cell polypeptide growth factor, Nano silica sol by sound dispersion method, and spray is sprayed on skin table Behind face, layer protecting film is automatically formed, after medicine is fully absorbed, can facilitate and be come off from skin affected part, outer wound can be made, controlled Treat, the especially postoperative wound after radiotherapy, chemotherapy such as squamous carcinoma, diabetes quickly heals.
In the present embodiment, added with preventing the humic acid of precipitation from receiving in the complex liquid spray, with TiO 2 particles, Cell polypeptide growth factor, Nano silica sol together, can make drug effect control after surgery otch, wound and its around it is same When, spray can be easy to seal up for safekeeping for a long time again, will not precipitate, accumulate, lasting drug effect is kept.
Embodiment two, the present embodiment and the difference of embodiment one be, the complex liquid spray include it is a variety of in Medicine, its parts by weight is：20 parts, 15 parts of bark of tree of heaven, 10 parts of caulis trachelospermi, 20 parts of carbonized hair, 8 parts of calamine, 15 parts of amber.
In the present embodiment, the preparation method of the complex liquid spray comprises the following steps：
1) Sargent gloryvine, achyranthes aspera, bark of tree of heaven, caulis trachelospermi, carbonized hair, calamine and amber are crushed to 200 mesh；
2) by step 1) obtained herb powder is put into pressure pan, and then adding 15 times of volumetric concentrations of its weight is 60% ethanol solution, is forced into 5kgf/cm2, makes its pressure uniform, and keeps 6min, recovers normal pressure, obtains slurries；
3) slurries are heated to reflux, extracted 3 times, each 2h, merged extract solution, ethanol is recovered under reduced pressure；
4) stand overnight, filter, filtrate is eluted by macroreticular resin, add and by ultrasonic dispersion by dioxy Change titanium particle, cell polypeptide growth factor, Nano silica sol and be made that complex liquid is well mixed to can obtain complex liquid spray.
Embodiment three, the present embodiment and the difference of embodiment one be, the weight of Chinese medicine in the complex liquid spray Part it is：3 parts of Sargent gloryvine, 8 parts of achyranthes aspera, 5 parts of bark of tree of heaven, 3 parts of caulis trachelospermi, 8 parts of carbonized hair, 2 parts of calamine, 3 parts of amber..
The preparation method of the complex liquid spray comprises the following steps：
1) Sargent gloryvine, achyranthes aspera, bark of tree of heaven, caulis trachelospermi, carbonized hair, calamine and amber are crushed to 100 mesh；
2) by step 1) obtained herb powder is put into pressure pan, and then adding 12 times of volumetric concentrations of its weight is 60% ethanol solution, is forced into 3kgf/cm2, makes its pressure uniform, and keeps 3min, recovers normal pressure, obtains slurries；
3) slurries are heated to reflux, extracted 3 times, each 1.5h, merged extract solution, ethanol is recovered under reduced pressure；
4) stand overnight, filter, filtrate is eluted by macroreticular resin, add and by ultrasonic dispersion by dioxy Change titanium particle, cell polypeptide growth factor, Nano silica sol and be made that complex liquid is well mixed to can obtain complex liquid spray.
Example IV, the present embodiment and the difference of embodiment one be, the weight of Chinese medicine in the complex liquid spray Part it is：7 parts of Sargent gloryvine, 12 parts of achyranthes aspera, 12 parts of bark of tree of heaven, 7 parts of caulis trachelospermi, 15 parts of carbonized hair, 5 parts of calamine, 10 parts of amber.
The preparation method of the complex liquid spray comprises the following steps：
1) Sargent gloryvine, achyranthes aspera, bark of tree of heaven, caulis trachelospermi, carbonized hair, calamine and amber are crushed to 150 mesh；
2) by step 1) obtained herb powder is put into pressure pan, and then adding 13 times of volumetric concentrations of its weight is 65% ethanol solution, is forced into 4kgf/cm2, makes its pressure uniform, and keeps 5min, recovers normal pressure, obtains slurries；
3) slurries are heated to reflux, extracted 3 times, each 1.5h, merged extract solution, ethanol is recovered under reduced pressure；
4) stand overnight, filter, filtrate is eluted by macroreticular resin, add and by ultrasonic dispersion by dioxy Change titanium particle, cell polypeptide growth factor, Nano silica sol and be made that complex liquid is well mixed to can obtain complex liquid spray.
Above content is only presently preferred embodiments of the present invention, for one of ordinary skill in the art, according to the present invention's Thought, will change in specific embodiments and applications, and this specification content should not be construed as to the present invention Limitation.

Claims (6)

1. a kind of spray containing cell polypeptide growth factor, including TiO 2 particles, polypeptide of the surface with amino group are thin The intracellular growth factor, Nano silica sol, it is characterised in that：By peptide growth factor by physical absorption on TiO 2 particles, And TiO 2 particles, cell polypeptide growth factor, Nano silica sol are made by complex liquid by ultrasonic dispersion.
2. a kind of spray containing cell polypeptide growth factor according to claim 1, it is characterised in that：The complex liquid spray Received in agent added with the humic acid for preventing from precipitating.
3. a kind of spray containing cell polypeptide growth factor according to claim 1, it is characterised in that：The complex liquid spray Agent includes plurality of Chinese, and its parts by weight is：5-10 parts of Sargent gloryvine, 10-20 parts of achyranthes aspera, 10-15 parts of bark of tree of heaven, caulis trachelospermi 5-10 Part, 10-20 parts of carbonized hair, 3-8 parts of calamine, 5-15 parts of amber.
4. a kind of spray containing cell polypeptide growth factor according to claim 3, it is characterised in that：The complex liquid spray The preparation method of agent comprises the following steps：
1) Sargent gloryvine, achyranthes aspera, bark of tree of heaven, caulis trachelospermi, carbonized hair, calamine and amber are crushed to 100~300 mesh；
2) by step 1) obtained herb powder is put into pressure pan, then add 12~16 times of volumetric concentrations of its weight for 60~ 70% ethanol solution, is forced into 3~6kgf/cm2, makes its pressure uniform, and keeps 3~7min, recovers normal pressure, is starched Liquid；
3) slurries are heated to reflux, extracted 3 times, 1.5~2h, merges extract solution, ethanol is recovered under reduced pressure every time；
4) stand overnight, filter, filtrate is eluted by macroreticular resin, add and by ultrasonic dispersion by titanium dioxide grain Son, cell polypeptide growth factor, Nano silica sol are made that complex liquid is well mixed to can obtain complex liquid spray.
5. a kind of spray containing cell polypeptide growth factor according to claim 3, it is characterised in that：The complex liquid spray The parts by weight of Chinese medicine are in agent：3-8 parts of Sargent gloryvine, 8-15 parts of achyranthes aspera, 5-10 parts of bark of tree of heaven, 3-8 parts of caulis trachelospermi, carbonized hair 8-15 Part, 2-5 parts of calamine, 3-10 parts of amber.
6. a kind of spray containing cell polypeptide growth factor according to claim 3, it is characterised in that：The complex liquid spray The parts by weight of Chinese medicine are in agent：7 parts of Sargent gloryvine, 12 parts of achyranthes aspera, 12 parts of bark of tree of heaven, 7 parts of caulis trachelospermi, 15 parts of carbonized hair, calamine 5 Part, 10 parts of amber.
CN201710201191.1A 2017-03-30 2017-03-30 A kind of spray containing cell polypeptide growth factor Pending CN107007819A (en)

Priority Applications (1)

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CN201710201191.1A CN107007819A (en) 2017-03-30 2017-03-30 A kind of spray containing cell polypeptide growth factor

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Application Number Priority Date Filing Date Title
CN201710201191.1A CN107007819A (en) 2017-03-30 2017-03-30 A kind of spray containing cell polypeptide growth factor

Publications (1)

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CN107007819A true CN107007819A (en) 2017-08-04

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1137491A (en) * 1996-01-23 1996-12-11 石永湘 Water quality treating chemicals
CN101513523A (en) * 2009-03-18 2009-08-26 周建大 Medicine containing cell polypeptide growth factor and preparation method thereof
CN105233266A (en) * 2015-11-18 2016-01-13 桂林华诺威基因药业有限公司 Spray for promoting wound healing

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1137491A (en) * 1996-01-23 1996-12-11 石永湘 Water quality treating chemicals
CN101513523A (en) * 2009-03-18 2009-08-26 周建大 Medicine containing cell polypeptide growth factor and preparation method thereof
CN105233266A (en) * 2015-11-18 2016-01-13 桂林华诺威基因药业有限公司 Spray for promoting wound healing

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Application publication date: 20170804