CN102091309A - Pharmaceutical composition for treating bedsore and preparation method thereof - Google Patents
Pharmaceutical composition for treating bedsore and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating bedsore and a preparation method thereof. The pharmaceutical composition provided by the invention comprises the following crude medicines in parts by weight: 30-70 parts of rhizoma bletillae, 20-40 parts of kuh-seng, 20-40 parts of Chinese waxgourd peel, 20-40 parts of job's-tears seed, 5-30 parts of armand clematis stem, 5-30 parts of dried ginger, 10-50 parts of honeycomb, 5-30 parts of pepper, 5-30 parts of chilli, 10-50 parts of catechu, 10-40 parts of atractylodes rhizome, 20-80 parts of red halloysite, 10-60 parts of gallnut, 10-40 parts of chuanxiong rhizome and 5-40 parts of Japanese ampelopsis root. The pharmaceutical composition achieves the purpose of treating bedsore by sterilizing, promoting diuresis, detoxicating and promoting tissue regeneration, and the pharmaceutical composition has definite, stable and controllable curative effects on treating bedsore.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to pharmaceutical composition for the treatment of decubital ulcer and preparation method thereof.
Background technology
Decubital ulcer is the patient that long-term bed does not rise, owing to the weight of body and friction cause, because of the long-term pressurized of local organization, continuous ischemia, anoxia, malnutrition take place and cause tissue fester's necrosis, with the breakage of the shallow epidermis skin of limitation, the open sore part is prolonged more not to be the chronic skin infection class disease of main performance.The skin decubital ulcer is the problem of a universality in rehabilitation, nursing.Pilosity is born in no muscle parcel or Musclar layer is thin, lack the fatty tissue protection bone knuckle place of frequent pressurized again.
The forming process of decubital ulcer is divided into erythema phase and ulcer phase, and the ulcer phase can be divided into fester and dark ulcer again.Decubital ulcer is divided into 4 grades according to its pathological process, that is:
The red seal that finger pressure can not bleach appears in 1 grade-skin complete;
2 grades-epidermis or corium are impaired, but do not penetrate skin corium as yet;
3 grades-epidermis or corium are all impaired, penetrate subcutaneous tissue, but do not penetrate fascia and Musclar layer as yet;
The infringement of 4 grades-whole bark layer; Relate to muscle, bone.
The common treatment mode of decubital ulcer is: Drug therapy: as fibroblast growth factor, iodine tincture, polyactin, Chinese medicine ointment; Physiotherapy: as oxygen therapy, air fluidized bed therapy, artificial nursing; Pass through surgical operation therapy when serious, repair as operation and scrape drain, remove slough, the skin-grafting repairing is damaged etc.
The treatment decubital ulcer is an a great problem always, and above-mentioned Therapeutic Method is removing the necrotic tissue and promoting granulation effectively, and the normal protracted course of disease of wound surface easily causes systemic infection, has 60,000 people to die from the decubital ulcer complication approximately every year according to relevant bibliographical information.With Chinese medicine such as rhizome of chuanxiong ginseng and safflower wine, compound safflower wine, 11 side's wine treatment decubital ulcer, utilize the effect of its blood circulation promoting and blood stasis dispelling, detumescence removing obstruction in the collateral to relieve pain, convergence erosion prevention and muscle growing, but curative effect is limited more.
The present invention desires to provide a kind of brand-new medicine to be used for the treatment of decubital ulcer, based on sterilization, diuretic, detoxification, granulation promoting.
Summary of the invention
Technical problem solved by the invention provides a kind of brand-new medicinal composition and is used for the treatment of decubital ulcer.
The pharmaceutical composition that the present invention treats decubital ulcer is that Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sophorae Flavescentis, Exocarpium Benincasae, Semen Coicis, Caulis Clematidis Armandii, Rhizoma Zingiberis, Nidus Vespae, Pericarpium Zanthoxyli, Fructus Capsici, catechu, Rhizoma Atractylodis, Halloysitum Rubrum, Galla Chinensis, Rhizoma Chuanxiong, Radix Ampelopsis are that active component is formed, and reaches the purpose of sterilization, diuretic, detoxification, granulation promoting.
Particularly, pharmaceutical composition of the present invention is made up of following materials of weight proportions medicine:
30～70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of Exocarpium Benincasaes, 20～40 parts of Semen Coiciss, 5～30 parts of Caulis Clematidis Armandiis, 5～30 parts of Rhizoma Zingiberiss, 10～50 parts in Nidus Vespae, 5～30 parts in Pericarpium Zanthoxyli, 5～30 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.
Sum up through long-term clinical application, the consumption proportion of pharmaceutical composition of the present invention is further preferred: Pseudobulbus Bletillae (Rhizoma Bletillae) 40-60 part, 25～35 parts of Radix Sophorae Flavescentiss, 25～35 parts of Exocarpium Benincasaes, 25～35 parts of Semen Coiciss, 5～20 parts of Caulis Clematidis Armandiis, 5～20 parts of Rhizoma Zingiberiss, 20～40 parts in Nidus Vespae, 5～20 parts in Pericarpium Zanthoxyli, 5～20 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.The pharmaceutical composition curative effect of being made up of above-mentioned consumption proportion relation is more stable, controlled.
For treating the decubital ulcer of the different courses of disease, when using aforementioned pharmaceutical compositions, use the weight proportion relation of said fixing, decubital ulcer at the different courses of disease, the crude drug actual amount is adjusted accordingly, as when treating the decubital ulcer of 1 grade or 2 grades, the absolute dosage of crude drug is less; When treating the decubital ulcer of 3 grades or 4 grades, the consumption of raw material is relatively large; Also can be mixed with the fixed preparation of consumption, when using, be used for the decubital ulcer of 1 grade or 2 grades after the dilution, realize treating the purpose of different decubital ulcers to adopt the different pharmaceutical consumption.
For the ease of using, can on the basis of crude drug, add acceptable accessories and make external preparation commonly used.As powder, ointment, lotion, tincture, medicated wine.At the application characteristic of medicine of the present invention, also provide this preparation of drug combination method.
Method one: each crude drug is ground into fine powder, mix powder;
Method two: the supernatant liquid that each crude drug is obtained with the Spirit lixiviate, medicated wine;
Method three: each crude drug is leached the supernatant liquid that obtains with the ethanol of 50-100%v/v, tincture;
Method four: with each crude drug with water boiling and extraction after, add ethanol, obtain supernatant after leaving standstill, lotion; Or
Method five: with each crude drug with water boiling and extraction after, add ethanol, obtain supernatant after leaving standstill, fling to ethanol after, add ointment substrate commonly used, ointment.
Use said method and all can realize treating the purpose of decubital ulcer, but easy in response to the convenience of usefulness and preparation, the inventor is made into medicated wine more or tincture is used.
To sum up, using medicine composite for curing decubital ulcer provided by the invention has clear and definite therapeutic effect, and stable curative effect is controlled.
The specific embodiment
Below by specific description of embodiments of the present invention the explanation but do not limit the present invention.
The pharmaceutical composition that the present invention is used for the treatment of decubital ulcer is to be made up of following materials of weight proportions medicine:
30～70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of Exocarpium Benincasaes, 20～40 parts of Semen Coiciss, 5～30 parts of Caulis Clematidis Armandiis, 5～30 parts of Rhizoma Zingiberiss, 10～50 parts in Nidus Vespae, 5～30 parts in Pericarpium Zanthoxyli, 5～30 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.
The inventor is when the 4-5 clinical practice, in following weight proportion scope, adjust the consumption of crude drug, all can realize treating the skin ulcer purpose of cotton-padded mattress: Pseudobulbus Bletillae (Rhizoma Bletillae) 40-60 part, 25～35 parts of Radix Sophorae Flavescentiss, 25～35 parts of Exocarpium Benincasaes, 25～35 parts of Semen Coiciss, 5～20 parts of Caulis Clematidis Armandiis, 5～20 parts of Rhizoma Zingiberiss, 20～40 parts in Nidus Vespae, 5～20 parts in Pericarpium Zanthoxyli, 5～20 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.
For the ease of using, can on the basis of crude drug, add acceptable accessories and make external preparation commonly used.As powder, ointment, lotion, tincture, medicated wine.
Because when using powder and ointment, medicated powder or ointment are difficult for being eliminated at wound surface, can influence healing.So preferred lotion, tincture or the medicated wine of adopting promptly spreads upon on the bedsore wound; Or spread on wound surface after adopting lotion, tincture or medicated wine moistening sterile gauze, and can contact wound surface for a long time in order to medicine, reach therapeutic purposes.
Particularly, for treating the decubital ulcer of the different courses of disease, can adjust concentration to adapt to clinical demand when adopting lotion, tincture, medicated wine, as when decubital ulcer is 1 grade, be that the red seal that finger pressure can not bleach appears in skin complete, or when decubital ulcer was 2 grades, promptly epidermis or corium were impaired, but do not penetrate skin corium as yet, adopt the concentration of lotion, tincture, medicated wine to count 0.1-0.4g/g by crude drug; When decubital ulcer was 3 grades, promptly epidermis or corium were all impaired, penetrate subcutaneous tissue, but did not penetrate fascia and Musclar layer as yet, or when decubital ulcer is 4 grades, i.e. whole bark layer infringement; Relate to muscle, bone, the concentration that adopts lotion, tincture, medicated wine by crude drug at least greater than 0.41g/g.
Below beneficial effect by clinical statistics proof pharmaceutical composition of the present invention.
It is clinical that the inventor adopts pharmaceutical composition of the present invention to be applied to, and takes by weighing different amounts proportioning raw material at the decubital ulcer of different stage, and make lotion, tincture, medicated wine and use,
Prescription: during practical application, crude drug can adopt following weight proportion: 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 30 parts of Radix Sophorae Flavescentiss, 30 parts of Exocarpium Benincasaes, 30 parts of Semen Coiciss, 10 parts of Caulis Clematidis Armandiis, 10 parts of Rhizoma Zingiberiss, 30 parts in Nidus Vespae, 10 parts in Pericarpium Zanthoxyli, Fructus Capsici 10-15 part, 20 parts in catechu, 15 parts of Rhizoma Atractylodis, 50 parts of Halloysitum Rubrums, 25 parts of Galla Chinensiss, 20 parts of Rhizoma Chuanxiongs, 20 parts of Radix Ampelopsis.
Preparation method is as follows:
Medicated wine: each crude drug is doubly measured Spirit (the about 45-60 degree of alcoholic strength) lixiviate with 8-10, get the supernatant liquid that lixiviate obtains.
Tincture: it is that ethanol more than the 50%v/v leaches that each crude drug is doubly measured concentration with 8-10, gets and leaches the supernatant liquid that obtains.
Lotion: each crude drug is decocted with water 2 times, for the first time 8 times of water gagings, 1.5 hours, 6 times of water gagings, 1 hour for the second time filter decoction liquor, merge and concentrate, and adding ethanol to concentration of alcohol is 75%v/v, gets supernatant after staticly settling.
Using method: medicated wine, tincture or lotion can be contained in during use in the spray bottle, be painted on the erythema or the ulcer place of decubital ulcer.1-2 level decubital ulcer: preceding 3 days, spraying in common every 2-3 hour 1 time, spray 3-5 time and get final product later every day, cooperates decubital ulcer to stand up, do not oppress for a long time routine cares such as wound surface, cleaning, and 1 grade of decubital ulcer was cured in common 1 week, cured about 2 grades of general 3 weeks.3-4 level decubital ulcer: because of ulcer level darker, healing time is longer, preceding 2 weeks, spraying in common every 2-3 hour 1 time, spray 3-5 time every day later on and get final product, cooperate decubital ulcer to stand up, do not oppress for a long time routine cares such as wound surface, cleaning, 3 grades of decubital ulcers are cured about 3 months usually, 4 grades of decubital ulcers then need the longer time, may reach half a year.
Use aforementioned pharmaceutical compositions treatment decubital ulcer, the nearly 3 years surplus people of treatment 500 people, 1-2 level patients with bedsore probably accounts for 80%, no matter use which kind of exterior-applied formulation of pharmaceutical composition of the present invention, decubitus symptom all disappears, and the common fever symptom of decubital ulcer does not take place, and effective percentage is 100%, but the onset time of lotion is slower, and healing time is slower.Because the preparation method of lotion is complicated, and compares with medicated wine with tincture, onset is slower, so sum up through long-term clinical application, tincture and medicated wine are as good as on therapeutic effect, but from cost consideration, preferably prepare medicated wine with Spirit.
The statistical data of the medicated wine of application pharmaceutical composition of the present invention and 3 grades and 4 grades decubital ulcers of tincture treatment is as follows:
Annotate:
Transference cure: expression wound healing.
Sx: expression wound slough comes off, and grows granulation, but not healing fully.
Total effective rate is in transference cure and sx sum.
Use the patients with bedsore of 3 grades of medicine composite for curing of the present invention and 4 grades, patient's the ulcer degree of depth all alleviates to some extent, after using for 1 week, as seen downright bad organizing gradually comes off, the ulcer place begins to grow granulation tissue from the inside of wound, fill up the ulcer place gradually,, and the common lasting fever symptom of patients with bedsore does not take place all during the medication until wound healing.And with existing Western medicine relatively, Western medicine is normally in the healing of wound face, but the ulcer spot the inside still continue to fester, suppurate, rarely have granulation tissue to grow, so ulcer wound protracted course of disease always.
Model case:
1, man, 22 years old, because of the traffic accident lower extremity paralysis, decubital ulcer on the bed future trouble, decubital ulcer still had the wound of 5-6cm size can't heal through existing method treatment back at the rumpbone place, degree of depth 1-2cm, visible rumpbone more than lasting half a year always.Adopt pharmaceutical composition medicated wine of the present invention, be mixed with the concentration treatment of treatment 3 grades or 4 grades.1-2 week,, grow granulation in the ulcer depths behind the general two weeks every medicine of spraying in 2-3 hour; Spray 3-5 time every day later on, wound healed after 3 months, and the fever symptom does not take place.
2, man, 29 years old, lower extremity paralysis after 6 years old was suffered from decubital ulcer many years ago, and the left side buttocks has one to reach 15-17cm to the thigh place, and the ulcer mouth of the widest part 3-5cm is not seen the lower limb bone; Adopt pharmaceutical composition medicated wine of the present invention, be mixed with the concentration treatment of treatment 3 grades or 4 grades.1-2 week,, grow granulation in the ulcer depths behind the general two weeks every medicine of spraying in 2-3 hour; Spray 3-5 time every day later on, treated so far 6 months, but, the symptom of having a fever takes place because the patient because of adjusting the sitting posture of inclination to the left, heals as yet.
3, man, about 50 years old, the future trouble of paralysing all the year round decubital ulcer, before using Drug therapy of the present invention, hip joint, back large tracts of land decubital ulcer, the visible hip joint in ulcer place belongs to decubital ulcer more than 3 grades, and the back belongs to 2 grades of decubital ulcers, be in the situation of high fever more than 40 ℃ always, skin grafting was done in the affected part, still can't cure, after body temperature is controlled at about 38-39 ℃, can't bring down a fever the notice of being critically ill down always.The inventor adopts pharmaceutical composition medicated wine of the present invention, is mixed with the concentration treatment of treatment 3 grades or 4 grades.Use in back 2 days and bring down a fever, do not have the fever symptom during the medication.Hip joint ulcer depths begins to grow new granulation after the general week, wound recovery from illness after 2 months.The back decubital ulcer was fully recovered about 2 weeks.
Can find out that pharmaceutical composition of the present invention is in that to be used for the treatment of decubital ulcer all effective in cure through above-mentioned clinical statistics, and not see after the medication that the complication such as fever that decubital ulcer is common, wound healing are to grow granulation tissue from the wound depths, and fill up wound gradually until healing.
To sum up, pharmaceutical composition of the present invention is through clinical statistics observation for many years, determine with Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sophorae Flavescentis, Exocarpium Benincasae, Semen Coicis, Caulis Clematidis Armandii, Rhizoma Zingiberis, Nidus Vespae, Pericarpium Zanthoxyli, Fructus Capsici, catechu, Rhizoma Atractylodis, Halloysitum Rubrum, Galla Chinensis, Rhizoma Chuanxiong, Radix Ampelopsis to be crude drug at last behind the screening prescription, therapeutic effect decubital ulcer the best, and at the prescription of the decubital ulcer of different stage preparation variable concentrations to reach optimum therapeuticing effect, for the clinical treatment decubital ulcer provides a kind of brand-new selection.
Specify: the crude drug Fructus Capsici that the present invention adopts is because kind is a lot, and medicinal application Fructus Capsici of the present invention mainly is the capsaicin that utilizes wherein, when therefore Fructus Capsici is as crude drug, need to adopt the Fructus Capsici that pungent is arranged, dry product or bright product all can, as common Fructus Capsici (long handle green pepper) Capsicum frutescens L.var.conoides (Mill.) Bailey; Capsicum annuum var. fasciculatum (capsicum annum fasciculatum) Capsicum frutescens L.var.fasciculatum (Sturt.) Bailey; Capsicum frutescens L. var. acuminatum Fingh. (Dens Elephatis Fructus Capsici, elongated Fructus Capsici) Capsicum frutescens L.var.acuminatum Fingh.; Long pepper Capsicum frutescens L.var.longum Bailey etc.
Claims (7)
1. treat the pharmaceutical composition of decubital ulcer, it is characterized in that: it is made up of following materials of weight proportions medicine:
30～70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 20～40 parts of Radix Sophorae Flavescentiss, 20～40 parts of Exocarpium Benincasaes, 20～40 parts of Semen Coiciss, 5～30 parts of Caulis Clematidis Armandiis, 5～30 parts of Rhizoma Zingiberiss, 10～50 parts in Nidus Vespae, 5～30 parts in Pericarpium Zanthoxyli, 5～30 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.
2. the pharmaceutical composition of treatment decubital ulcer according to claim 1 is characterized in that: it is made up of following materials of weight proportions medicine:
Pseudobulbus Bletillae (Rhizoma Bletillae) 40-60 part, 25～35 parts of Radix Sophorae Flavescentiss, 25～35 parts of Exocarpium Benincasaes, 25～35 parts of Semen Coiciss, 5～20 parts of Caulis Clematidis Armandiis, 5～20 parts of Rhizoma Zingiberiss, 20～40 parts in Nidus Vespae, 5～20 parts in Pericarpium Zanthoxyli, 5～20 parts in Fructus Capsici, 10～50 parts in catechu, 10～40 parts of Rhizoma Atractylodis, 20～80 parts of Halloysitum Rubrums, 10～60 parts of Galla Chinensiss, 10～40 parts of Rhizoma Chuanxiongs, 5～40 parts of Radix Ampelopsis.
3. the pharmaceutical composition of treatment decubital ulcer according to claim 2 is characterized in that: it is made up of following materials of weight proportions medicine:
50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 30 parts of Radix Sophorae Flavescentiss, 30 parts of Exocarpium Benincasaes, 30 parts of Semen Coiciss, 10 parts of Caulis Clematidis Armandiis, 10 parts of Rhizoma Zingiberiss, 30 parts in Nidus Vespae, 10 parts in Pericarpium Zanthoxyli, Fructus Capsici 10-15 part, 20 parts in catechu, 15 parts of Rhizoma Atractylodis, 50 parts of Halloysitum Rubrums, 25 parts of Galla Chinensiss, 20 parts of Rhizoma Chuanxiongs, 20 parts of Radix Ampelopsis.
4. according to the pharmaceutical composition of each described treatment decubital ulcer of claim 1-3, it is characterized in that: described pharmaceutical composition is to be active component with Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sophorae Flavescentis, Exocarpium Benincasae, Semen Coicis, Caulis Clematidis Armandii, Rhizoma Zingiberis, Nidus Vespae, Pericarpium Zanthoxyli, Fructus Capsici, catechu, Rhizoma Atractylodis, Halloysitum Rubrum, Galla Chinensis, Rhizoma Chuanxiong, Radix Ampelopsis, adds the external preparation that acceptable accessories is made.
5. the pharmaceutical composition of treatment decubital ulcer according to claim 4 is characterized in that: described external preparation is powder, ointment, lotion, tincture, medicated wine.
6. the pharmaceutical composition of treatment decubital ulcer according to claim 5 is characterized in that:
When treating 1 grade or 2 grades of decubital ulcers, adopt the concentration of lotion, tincture, medicated wine to count 0.1-0.4g/g by crude drug;
When treating 3 grades or 4 grades of decubital ulcers, the concentration that adopts lotion, tincture, medicated wine by crude drug at least greater than 0.41g/g.
7. the preparation of drug combination method of each described treatment decubital ulcer of claim 1-6 is characterized in that: adopt the following steps preparation:
Each crude drug is ground into fine powder, mix powder; Or
The supernatant liquid that each crude drug is obtained with the Spirit lixiviate, medicated wine; Or
Each crude drug is leached the supernatant liquid that obtains with the ethanol of 50-100%v/v, tincture; Or
With each crude drug with water boiling and extraction after, add ethanol, obtain supernatant after leaving standstill, lotion;
With each crude drug with water boiling and extraction after, add ethanol, obtain supernatant after leaving standstill, fling to ethanol after, add ointment substrate commonly used, ointment.
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| CN102319404A (en) * | 2011-09-28 | 2012-01-18 | 王爱芹 | Preparation method of traditional Chinese medicine lotion for treating alcoholism-type bedsore |
| CN102327515A (en) * | 2011-09-28 | 2012-01-25 | 陈燕 | Method for preparing traditional Chinese medicine (TCM) lotion for treating edema bedsore |
| CN103566088A (en) * | 2013-10-31 | 2014-02-12 | 王凤华 | Method for preparing preparation for treating bedsore in clinical nursing |
| CN104127813A (en) * | 2014-07-24 | 2014-11-05 | 朱秀芳 | Traditional Chinese medicinal composition for curing qi-blood deficiency type bedsore and preparation method thereof |
| CN104922614A (en) * | 2015-07-22 | 2015-09-23 | 秦波 | Traditional Chinese medicine ointment for treating bedsores |
| CN105902660A (en) * | 2016-06-15 | 2016-08-31 | 张光昇 | Pharmaceutical composition for treating bedsores, diabetic feet and eczema |
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| CN105125731A (en) * | 2015-08-27 | 2015-12-09 | 陈红 | Traditional Chinese medicine composition for treating inflammatory infiltration period bedsore and preparing method of traditional Chinese medicine composition |
| CN105770089A (en) * | 2016-04-23 | 2016-07-20 | 王键 | Nursing medicine for treating bedsore |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102319404A (en) * | 2011-09-28 | 2012-01-18 | 王爱芹 | Preparation method of traditional Chinese medicine lotion for treating alcoholism-type bedsore |
| CN102327515A (en) * | 2011-09-28 | 2012-01-25 | 陈燕 | Method for preparing traditional Chinese medicine (TCM) lotion for treating edema bedsore |
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| CN103566088A (en) * | 2013-10-31 | 2014-02-12 | 王凤华 | Method for preparing preparation for treating bedsore in clinical nursing |
| CN103566088B (en) * | 2013-10-31 | 2016-01-06 | 刘增慧 | A kind of clinical care is used for the treatment of the preparation method of the medicament of decubital ulcer |
| CN104127813A (en) * | 2014-07-24 | 2014-11-05 | 朱秀芳 | Traditional Chinese medicinal composition for curing qi-blood deficiency type bedsore and preparation method thereof |
| CN104922614A (en) * | 2015-07-22 | 2015-09-23 | 秦波 | Traditional Chinese medicine ointment for treating bedsores |
| CN105902660A (en) * | 2016-06-15 | 2016-08-31 | 张光昇 | Pharmaceutical composition for treating bedsores, diabetic feet and eczema |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102091309B (en) | 2012-11-28 |
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