KR20130060092A - Hydrogel patch for alleviating asthma and rhinitis, which is including aroma essential oils and natural extracts, which has the structure of multi-drug-diffusion-control-layer - Google Patents

Abstract

PURPOSE: A composition for treating asthma and rhinitis is provided to effectively treat various symptoms and diseases(headache, empyema, bronchitis) accompanied by rhinitis, and to ensure comfortable dose. CONSTITUTION: A patch composition for alleviating asthma and rhinitis comprises: a singular or multiple drug release control layers(A, B) which are prepared by coating a fabric with various pin hole sizes using a hydrogel adhesive containing aroma essential oil and a natural extract; and a drug protection layer. The patch composition is applied to chest, the lower portion of the nose, the bridge of the nose, neck, and bronchus. The multiple drug release control layer is dispersed in the hydrogel adhesive and is uniformly applied. [Reference numerals] (AA) Light mucous membrane; (BB) Skin layer; (CC) Aroma essential oil; (DD) Natural extract for alleviating inflammation; (EE) Natural extract for enhancing immunity

Description

Hydrogel patch for alleviating asthma and rhinitis, which is including aroma essential oils and natural extracts, which has the structure of multi-drug -diffusion-control-layer.}

Hydrogel patch containing aroma essential oils and natural extracts with asthma and non-inflammatory effects

In the present invention, in relieving and treating the symptoms of asthma or rhinitis caused by sensitive reaction to a specific antigen, it is possible to absorb the mucosal membranes in the nasal cavity and bronchus by releasing aroma essential oil fragrance particles and containing natural extracts as shown in FIG. It is composed of single- or multi-drug emission control layer coated on the fabric with various pinholes in the hydrogel adhesive that can be applied to the chest, nose, nose, neck, bronchus, etc. By designing percutaneous absorption and percutaneous absorption of natural extracts for 4 hours or longer, the drug persistence effect can be prepared to prevent the situation that causes respiratory distress at 2 am to 4 am due to asthma attacks. The pharmacological ingredients contained in the hydrogel adhesive balance the central nerve to help breathe comfort Jujube relates to an asthma and non-inflammatory patch composition consisting of aroma essential oils and natural extracts to alleviate inflammation, such as immune enhancement and rhinitis.

The cause of asthma and allergic rhinitis is a common cause of hypersensitivity reactions due to allergens (antigens), and breathing difficulty due to allergic inflammation of the bronchus is called asthma, and allergic inflammation in the nasal cavity. As a result of the loss of the normal function of the nose, causing four symptoms of sneezing, runny nose, itching, nasal congestion is called allergic rhinitis.

In the case of asthma attacks, the morning dip (morning dip) is mainly called the patient's exhaled air flow decreases from 2 am to 4 am due to coughing and difficulty breathing, and in the case of severe cases should seek night emergency room at dawn Difficulties arise.

Therefore, it is applied just before sleep to prevent breathing difficulty through bronchus due to asthma around 2-4 o'clock in the morning, so that inflammation of the bronchus or nose is maintained for about 4 hours, and the bronchial or red blood is blocked to prevent the bronchial hiding. Alleviating the phenomenon is of utmost importance.

Allergic rhinitis can be divided into seasonality that occurs only in certain seasons and perennial symptoms that persist throughout the year. Seasonality is caused by pollen, so it is called pollen, and permeability is the main antigen of dust, mites and fungi in the house. However, stress stimulation can be said to be highly involved in causing allergic rhinitis. Many stress stimuli affect the hypothalamus, which regulates immunity, endocrine, and autonomic nervous system through the central nervous system of the brain, confused to maintain homeostasis. This can lead to the production of antibodies that do not need to be produced, especially in the immune system, such as an overreaction of immunity, which can lead to antigenic reactions that can cause a variety of symptoms in response to blood vessels, nerves, glands and tissues. .

Investigations of the role of autonomic dysfunction in allergic rhinitis revealed that significant autonomic dysfunction was observed and that sympathetic nerve dysfunction was associated with allergic rhinitis because it requires balance of sympathetic and parasympathetic nerves to maintain proper function. It is known to have a pathophysiological role of.

As a therapeutic agent for alleviating such asthma and rhinitis, oral, inhalant, tolubuterol asthma patches and aromatherapy products using alternative oils are commercially available.

Oral solutions can cause side effects of gastrointestinal or liver disorders due to drug toxicity, and the drug itself can act as an antigen, resulting in asthma and rhinitis. In addition, it is difficult to administer to infants, children or unconscious patients, and in the case of asthma, which is suddenly seized at night, it is difficult to find a night emergency room or prescribe oral medicine for asthma treatment at a midnight operation pharmacy. Can follow.

Inhalation solvents have less side effects than oral use, but are difficult to apply to infants, children or unconscious patients, and have difficulty in prescribed prescription medicines at night seizures, and frequent inhalation using nebulizers. In the nasal mucosa of the red nasal mucosa, the nebulizer mist irritates the nasal mucosa, which can cause sneezing or additional inflammation of the nasal mucosa due to air pressure during inhalation.

Tolubuterol asthma patch, which is a transdermal absorption asthma treatment, has less side effects than oral and inhalation preparations.However, side effects such as skin irritation may occur due to the toxicity of transdermal drugs such as tolubuterol. It is not easy to prepare for the sudden relief of asthma and non-inflammatory symptoms that come with home medicine.

Meanwhile, aromatherapy, which has recently emerged as an alternative therapy, is a method of treating diseases of our body by using microparticles emitted from plants, and collecting oil particles that have a healing effect on our bodies from the microparticles of plants. This oil penetrates into the body through our nose or skin, resulting in various therapeutic effects. Aroma essential oils produced by extracting effective ingredients from humans are inhaled by fragrance molecules when they are inhaled to the bronchi, and then through the bronchiole to deliver essential oil molecules to the bloodstream to reach alveoli. It is absorbed into the bloodstream, binds to the olfactory nerve, and has been used as a folk remedy for the treatment of rhinitis and asthma by maintaining a proper olfactory response or balance of the central nerve. The properties of aromatic essential oils that have been proven so far are composed of organic substances including alcohols, aldehydes, esters, ketones, oxides, and the like. It has a soothing and coughing effect, and according to its composition ratio, it has a unique therapeutic effect on rhinitis, asthma and bronchitis. The method of applying such aromatherapy is commercially available as a burning method, such as aroma candles, or by putting the aroma fragrance in a small container and hang it around the neck. However, in these applications, in the case of aroma candles it is inconvenient to be used with people who do not want to be treated when used in a narrow space, and careless fire risks. In addition, in the case of an aroma necklace, there is a disadvantage to have an uncomfortable bed due to a foreign body when sleeping on the neck in the form of a necklace in preparation for asthma and rhinitis attacks in the container or at night.

Therefore, the present invention can improve the problems of the currently marketed asthma and non-inflammatory oral preparations, inhalants, tolubuterol asthma patch, aromatherapy products described above, the age of asthma and rhinitis patients, the condition of patients, treatment time, The present invention seeks to overcome the problem of the absence of prior art that can exhibit an appropriate therapeutic effect depending on the surrounding environment, sleep or activity state of the patient.

As mentioned above, it is possible to overcome the problems and inconveniences of currently available oral, inhalation, transdermal absorbents (tulobuterol patch), aroma essentials, etc. In order to have a therapeutic effect of phosphorus, it is intended to be included in the hydrogel adhesive to have three mechanisms of action in the treatment of asthma and rhinitis using ingredients derived from natural products.

In the treatment of asthma and rhinitis, ingredients with three mechanisms of action are essential oils that stabilize the central nervous system to improve the hypersensitivity reactions of asthma and rhinitis caused by autonomic nervous system disorders and inflammation relief from asthma and rhinitis Patch-type asthma that can absorb transdermal and transmucosal membranes by dispersing natural extracts with excellent anti-effects, and natural extracts with excellent effects on immune-enhancing in hydrogel adhesive to alleviate allergic reactions due to weakened immune control system. Non-depleting patches can be constructed.

On the other hand, the amount and rate of treatment of aromatherapy essential oil fragrance particles, asthma and rhinitis by using multiple drug release control layers that are controlled throughout the day depending on the age, condition, treatment time, surrounding environment, sleep or activity state of asthma and rhinitis patients Multiple drug release control layers are provided to control the absorption and rate of absorption of the natural extracts.As a result, the patient selects the number of layers of multiple drug release control layers according to asthma and non-inflammatory symptoms that can vary from patient to patient. The purpose is to be able to treat effectively. The multi-drug emission control layer is dispersed evenly as shown in F of FIG. 3 only within the time (about 4 hours to 24 hours) that the aroma essential oil can be coated in the hydrogel composed mostly of water. As in G of 3, the aroma essential oil is phase separated in the hydrogel so that it is positioned at the top in the hydrogel so that the aroma essential oil fragrance particles can be inhaled into the nasal cavity. It is important to control the HLB value and the amount of o / w surfactant in order to reduce the amount and to be absorbed into the intranasal transmucosal membrane in the form of fragrance particles. It is expected to be able.

As can be seen from the above, asthma and rhinitis relief patch according to the present invention greatly increases the four symptoms of sneezing, runny nose, itching, nasal congestion which are the four symptoms of respiratory distress and rhinitis due to airway obstruction which is the main symptom of asthma It consists of substances derived from natural products with three therapeutic effects (aroma essential oils for central nervous system stability, natural extracts for inflammation relief, and natural extracts for immune enhancement) to block the underlying pathological factors of asthma and non-inflammatory symptoms, And the treatment rate can be efficiently controlled by controlling the number of stages of the drug release control layer according to the age, condition, treatment time, surrounding environment, sleep or activity state of the non-inflammatory patient, and aroma particles of aroma essential oil Control phase separation in the formulation (G in FIG. 3) by adding an appropriate amount of o / w surfactant to deliver intensively into the nasal cavity Thereby it can have a more than effective aroma relieve asthma, rhinitis effect of essential oils. On the other hand, if such a hydrogel patch is used as a home medicine, it is possible to prepare for night asthma or late night seizures and difficulty in finding a clinic. In addition, there is an advantage that can be easily applied to infants, infants or unconscious patients who are difficult to use oral or inhalants.

1 is a schematic diagram of asthma and rhinitis relief patch.
Figure 2 is a perspective view of the transmucosal and transdermal absorption path of the essential oil and natural extracts.
Figure 3 is a perspective view of the phase separation process of the aromatic essential oil.
4 is an illustration of application of the attachment site of asthma and non-inflammatory patches.

In order to achieve the above object, the present invention provides an asthma and non-inflammatory patch of hydrogel adhesive that can effectively alleviate and treat the symptoms of asthma and rhinitis.

Specifically, the present invention is a single or multiple drug release control layer coated on the fabric having a variety of pinhole size hydrogel pressure-sensitive adhesive containing aroma essential oils and natural extracts effective in asthma and rhinitis (Fig. 1 A, B) ; It consists of a drug protective layer (Fig. 1C).

Multiple drug emission control layer (a-1, b-1 of Figure 1) is a non-woven fabric having a variety of pinholes and thickness, the base drug is coated with a hydrogel adhesive containing the drug in a nonwoven fabric, polyurethane film, polyvinyl chloride film fabric Double or triple lamination of additional drug emission control layer coated with hydrogel adhesive containing drug on non-woven fabric, polyurethane film, polyvinyl chloride film fabric with various pinhole sizes, patterns and thicknesses on top of the emission control layer Dispersion, treatment rate, asthma and aroma of essential oil fragrance particles using multiple drug emission control layers throughout the day depending on age, condition, treatment time, surroundings, sleep or activity status of asthma and rhinitis patients It is composed of multiple drug emission control layers to control the absorption and absorption rate of non-inflammatory natural extracts. The multiple drug release control layer can be staged and effective treatment by determining the number of layers of the multiple drug release control layer according to asthma and non-inflammatory symptoms that can vary from patient to patient. The hydrogel of the multi-drug emission control layer contains aroma essential oils and natural extracts, but the oily aroma essential oils may be dispersed due to the o / w surfactant in the hydrogel in the continuous phase of water. However, since the aroma essential oil is effectively absorbed into the nasal mucosa in the form of fragrance particles, the aroma essential oil is blended and applied as shown in F of FIG. While it is evenly distributed, it is important to allow the aromatic essential oils to be phase-separated in the hydrogel so as to be located on the hydrogel as shown in G of FIG. 3. Therefore, o / w surfactants such as polysorbate 20, polysorbate 60, and polysorbate 80 contain about 0.01 to 0.2% to disperse the aromatic essential oil within 4 hours to 24 hours of hydrogel formulation and application time. It can then be designed to induce phase separation. The natural extract of the pharmacological components in the hydrogel is water soluble and can maintain a uniform distribution in the hydrogel without the influence of the surfactant selected above.

On the other hand, the multiple drug emission control layer can be divided into the basic drug emission control layer (a-1 in Figure 1) and the additional drug emission control layer (b-1 in Figure 1), as shown in Figure 1, the basic drug emission control layer Because the pinhole size or pinhole spacing is smaller than the additional drug release control layer, the aroma essential fragrance particles to alleviate rhinitis and asthma symptoms are the basic drug release control layer (a-1 in Fig. 1) and the additional drug release control layer (Fig. 1). Since b-1) is passed through the nasal passage (Fig. 2D), the fragrance rate can be maintained continuously. Percutaneous absorption of natural extracts passes through the basic drug release control layer in the additional drug release control layer. Because it passes through the path to the percutaneous absorption (Fig. 2E) it can exhibit a continuous transdermal absorption pattern can exhibit a drug sustained effect of more than 4 hours.

In addition, the composition of the drug release control layer is configured to have three mechanisms of action in the treatment of asthma and rhinitis, and stabilizes the central nervous system balance to improve the hypersensitivity reaction of asthma and rhinitis caused by autonomic nervous system disorders Juju contains natural extracts that are effective in reducing inflammation caused by aroma essential oils and asthma and rhinitis, and natural extracts that are excellent in immune enhancement to complement allergic reactions due to weakened immune control system. It consists of patch-type asthma and non-inflammatory patches that are capable of transdermal and transmucosal absorption.

As the first composition in the drug release regulating layer, it contains aroma essential oil that stabilizes the central nervous system balance to improve the hypersensitivity reaction of asthma and rhinitis because asthma and rhinitis are caused by autonomic dysfunction Essential oils are selected from one or more of the following: eucalyptus, hyssop, oregano, frankin sense, niaoli, peppermint, lavender, tea tree, pine, cedarwood, geranium, sandalwood, carbomile, and 0.1% of the total composition. It contains -3.0% weight part.

Eucalyptus oil is extracted by steam distillation of fresh or partially dried leaves of eucalyptus species and contains 60-80% of cinemaol. Eucalyptus oil and cineol have antiseptic, expectorant and strong antibacterial effects against streptococci and are known to be the best decongestants by inhaling cold and catarrh symptoms. Schnaublet recommends topical inhalation for rhinitis, influenza, ear inflammation, sinusitis, and bronchitis.

The mechanism of action, such as respiratory congestion, is a reflex action by eucalyptus essential oils, and is thought to be related to nerve stimulation. In general, in asthma and rhinitis, the nasal and lower respiratory passages restrict the passage of air into the lungs due to vasoconstriction. Eucalyptus oil and cineol have the effect of reducing the surface tension between water and air in the lungs.

Cedarwood is extracted by steam distillation of cedarwood wood, bark roots, and sawdust, and contains 7-10% sesquiterpene ketones. Cedarwood's rich sesquiterpene ketones have an excellent mucolytic effect and are used to treat mucous secretions, coughs, and chronic bronchitis, diuretic, expectorant and sedative.

Cyprus oil is obtained by steam extraction from twigs and leaves of Cypress Seperviens obtained by pruning trees in autumn and is effective as a cough remedy for the management of acute and chronic bronchitis and whooping cough.

Pine oil is extracted by steam distillation of conifers, sprigs and pine cones of Scotch Pine, and pine leaf oil is widely used in pharmaceutical products as a cough and cold medicine, spray solution, nasal mucosa and analgesic ointment. Pine is very useful as an effective diuretic, as well as treating lung infections, Marguerit Mayry said. Pine oil is also an excellent expectorant, sedative and antiseptic, making it the best oil to clean lung cough and phlegm from colds, as well as for sinus and bronchial congestion, cough, asthma and bronchitis. Helps heal the virus, sterilization, sedation, deodorization, diuresis, expectorant, insecticide, redness.

The second composition in the drug release control layer, Moonjuran, Omija, Astronomical dong, Morel cabbage, Windproof, Eochocho, Carbomile, Horse riding, Situation mushroom, Earl of pear, Machihyun , An extract consisting of one or two or more raw materials consisting of Angelica, Doin, etc., containing 0.1 to 5.0% by weight of the total composition.

As a representative ingredient with anti-inflammatory action, Crinum asiaticum Linne var. Japonicum has long been used as a folk remedy for the purpose of treating joint pain, antipyretic, ulceration, local anti-inflammatory and antipyretic in Southeast Asia including Korea and Malaysia. In recent studies, lycorine from Moon Ju-ran has been shown to have sufficient anti-inflammatory effects by inhibiting PGE2, IL-6, and IL-8 release.

The third composition in the drug release regulating layer contains 0.1 ~ 5.0% by weight of natural extracts excellent in immunity enhancement in order to compensate for allergic reactions due to weakening of the immunomodulatory system, and echinacea as a natural extract for the above-mentioned immunity enhancement. , Astragalus, turmeric, cornus, Schisandra chinensis, garlic, red ginseng, etc. It is an extract consisting of one or two or more ingredients containing 0.1 to 5.0% by weight of the total composition.

Echinacea herb extract is an excellent representative ingredient for immune enhancement. Echinacea is known as a folk remedy used by North American Indians as a natural antibiotic and therapeutic agent for various infections. In Europe, it is used to enhance immune system and to increase natural healing ability against cold infections that infect the esophagus and larynx mucosa. I use it.

Echinacea is an advanced herb that is very helpful for strengthening the immune system, treating and preventing various inflammations, and for inflammation of the cold, bronchial and neck areas. It is known to promote the function of the immune system and to prevent infection of the respiratory organs. . Recent studies have shown that Echinacea promotes the activity and development of immune systems, increases the body's defenses against infections caused by bacteria and viruses, prevents the development of respiratory diseases related to colds and flu, and helps. It is known.

Asthma and non-inflammatory patches containing the composition (aroma essential oils for stabilizing the central nervous system, natural extracts for inflammation relief, natural extracts for immune augmentation) control the singularity of the drug release control layer having the structure as shown in FIG. It is configured to be able to effectively control the treatment speed and effect according to the age, condition, treatment time, surrounding environment, sleep or activity state of asthma and rhinitis patients.

By providing a variety of fabrics having a pinhole size and pattern and thickness of the fabric, such as a-1, b-1 of Figure 1, in the path through which the aroma essential oil fragrance particles are delivered to the lungs and nerves through the bronchus, It is possible to control the delivery concentration and speed of the aroma essential oil delivered to the nasal cavity, which is the initial absorption route, and the natural extract components of immune enhancement and inflammation relief according to the attachment location as shown in Fig. 4, such as chest, nose, nose, neck, neck, It can be applied to the bronchus to adjust the percutaneous absorption and transdermal absorption rate of natural extracts at the attachment position, so that the treatment effect that varies according to the patient's condition can be more effectively controlled.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are merely provided to more easily understand the present invention, and the present invention is not limited to the following examples.

(Example)

division Compounded raw material name Purpose of blending Example 1 Example 2 basic
Drug release
Control layer Acrylic Polymer Adhesive 4.0 6.0 gelatin Adhesive 2.0 2.0 Polyvinyl alcohol Adhesive 2.0 2.0 Dry Aluminum Hydroxide Cross-linking agent 0.08 0.08 glycerin Moisturizer 20.0 20.0 Butylene Glycol Moisturizer 5.0 5.0 Purified water solvent Balance Balance antiseptic antiseptic 0.2 0.2 Polysorbate 80 Surfactants 0.05 0.05 Other additives additive 0.5 0.5 Eucalyptus oil Congestion 0.3 0.5 Pine 0.2 0.3 Cedarwood Diuresis, expectoration, soothing 0.2 0.3 cypress Deodorization, Convergence 0.2 0.3 Moon Ju Ran Extract Anti-inflammatory 0.5 0.5 Relax Complex ^TM Pain relief 0.5 0.5 Imuno Complex ^TM Immune booster 0.5 0.5 Non-woven fabric Oil phase phase separation time Phase separation within 24 hours Add
Drug release
Control layer Acrylic Polymer Adhesive 4.0 6.0 gelatin Adhesive 2.0 2.0 Polyvinyl alcohol Adhesive 2.0 2.0 Dry Aluminum Hydroxide Cross-linking agent 0.08 0.08 glycerin Moisturizer 20.0 20.0 Butylene Glycol Moisturizer 5.0 5.0 Purified water solvent Balance Balance antiseptic antiseptic 0.2 0.2 Polysorbate 80 Surfactants 0.05 0.05 Other additives additive 0.5 0.5 Eucalyptus oil Congestion 0.3 0.5 Pine 0.2 0.3 Cedarwood Diuresis, expectoration, soothing 0.2 0.3 cypress Deodorization, Convergence 0.2 0.3 Moon Ju Ran Extract Anti-inflammatory 0.5 0.5 Relax Complex ^TM Pain relief 0.5 0.5 Imuno Complex ^TM Immune booster 0.5 0.5 Polyurethane film
Fabric thickness: 80micro
Pinhole Size: Male
Pinhole Pattern: 0.2mm Spacing fabric Oil phase phase separation time Phase separation within 24 hours

Relax Complex ^TM : The complex of ingredients mentioned above

Imuno Complex ^TM : Complex of ingredients mentioned above for immune boosting

A: basic drug release control layer
B: additional drug release control layer
C: Release Film
D: transmucosal absorption path
E: Percutaneous Absorption Path
F: stabilized hydrogel layer
G: phase separated hydrogel layer

Claims (7)

Hydrogel pressure-sensitive adhesive containing aroma essential oils and natural extracts effective for asthma and rhinitis is coated on the fabric having a variety of pinhole size of the single to multiple drug emission control layer (Fig. 1 A, B); It consists of a drug protective layer (Fig. 1C), and is applied to the chest, under the nose, nose, neck, bronchus, etc., and is a patch-type asthma and non-inflammation which can absorb the transmucosal and aroma essential oils of transdermal extracts of natural extracts. Patch composition.
In claim 1, the multi-drug emission control layer consisting of the hydrogel pressure-sensitive adhesive containing the aromatic essential oil and natural extracts (Fig. 1 A, B) is aroma essential oil and natural extract is dispersed in the hydrogel pressure-sensitive adhesive is applied uniformly There is a basic drug emission control layer (non-woven fabric with various pinhole sizes, patterns and thicknesses, so that patients can adjust the duration and divergence of the aroma essential oil fragrance particles, percutaneous permeation and absorption rate of natural extracts according to their condition) Polyurethane film, polyvinyl chloride film fabric coated with a hydrogel adhesive containing the drug) and one or more additional drug release control layer (various pinholes) that can emit aroma essential oil and natural extracts can be further adjusted in concentration Non-woven fabrics of size, pattern, and thickness, containing polyurethane, and polyvinyl chloride film Hydrogel asthma that is a pressure-sensitive adhesive further comprises a coating) and rhinitis relief hydrogel patch composition.
The method of claim 1, wherein the aroma essential oil in the hydrogel in the multi-drug emission control layer consisting of the hydrogel pressure-sensitive adhesive containing the aroma essential oil and natural extract (Fig. 1 A, B) is the formulation and application process time of the hydrogel Asthma is evenly dispersed in the hydrogel in the aqueous phase within about 24 hours, and phase separation takes place after about 24 hours, located above the hydrogel (G in Fig. 3), so that the aroma essential oil fragrance particles are intensively inhaled into the nasal cavity. And non-inflammatory hydrogel patch compositions.
According to claim 1, 2, the hydrogel pressure-sensitive adhesive multi-drug control layer containing aroma essential oils and natural extracts effective for asthma and rhinitis (Figs. 1 A, B) is an asthma caused by autonomic nervous system abnormalities And 0.1 ~ 3.0% by weight of aroma essential oil that stabilizes the central nervous system to improve the hypersensitivity reaction of rhinitis, 0.1 ~ 5.0% by weight of natural extract, excellent in alleviating inflammation caused by asthma and rhinitis. Asthma and non-inflammatory hydrogel patch composition comprising 0.1-5.0% by weight of natural extract, 0.01-0.2% by weight of o / w surfactant with excellent effect on immune enhancement in order to compensate for allergic and sensitive reactions.
According to claim 1, 2 and 4, as the aroma essential oil that stabilizes the central nervous system, eucalyptus, hyssop, oregano, frankin sense, niaoli, peppermint, lavender, tea tree, pine, cedar wood, An asthma and non-inflammatory hydrogel patch composition selected from one or two or more raw materials consisting of geranium, sandalwood, and carbomile, and containing 0.1 to 3.0% by weight of the total composition.
According to claim 1, 2 and 4, as a natural extract excellent in reducing the inflammation caused by asthma and rhinitis Munjuran, Schisandra chinensis, Astronomical dong, Morel cabbage, Windproof, Eoseongcho, Carbomile, Horse riding, Situation mushroom, Count Is selected from one or two or more raw materials consisting of, portrayal, Angelica, Doin, and the like, asthma and non-inflammatory hydrogel patch composition containing 0.1 to 5.0% by weight of the total composition.
      The total composition of claim 1, 2 and 4, wherein the extract is composed of one or two or more raw materials consisting of Echinacea, Astragalus, turmeric, Cornus, Schisandra chinensis, Garlic, Red ginseng, etc. Asthma and non-inflammatory hydrogel patch compositions containing ˜5.0% by weight.

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