CN105233266A - Spray for promoting wound healing - Google Patents
Spray for promoting wound healing Download PDFInfo
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- CN105233266A CN105233266A CN201510796710.4A CN201510796710A CN105233266A CN 105233266 A CN105233266 A CN 105233266A CN 201510796710 A CN201510796710 A CN 201510796710A CN 105233266 A CN105233266 A CN 105233266A
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to spray for promoting wound healing. The spray is prepared from the following raw materials in parts by weight: 10-18 parts of sargentodoxa cuneata, 20-30 parts of achyranthes aspera, 18-28 parts of cortex ailanthic, 10-20 parts of Chinese starjasmine stem, 8-18 parts of Japanese beauty-berry, 25-35 parts of carbonized hair, 9-18 parts of calamine, 10-22 parts of radix angelicae, 17-26 parts of sculellaria barbata, 10-22 parts of cinnabar, 15-30 parts of chrysophoron and 0.0002-0.008 part of recombinant human epidermal growth factor. The spray for promoting wound healing is reasonable in matching, capable of rapidly promoting wound healing, shorting healing time and reliving pain of patients, and free of toxic or side effect, and the disease does not reoccur.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of spray that can promote wound healing.
Background technology
Wound is unexpected injury more common in people's daily life, particularly war, vehicle accident, earthquake etc. in factories and miness accident and natural disaster all can bring the different accident trauma of weight, once there occurs weight not wait local wound, whether can obtain process correct in time, very large relation is had to later treatment, deal with improperly or process not in time, the misery of patient can be increased, wound surface can be there is hemorrhage, infect, pain, healing time is long, vital tissue is as tendon, neural, exposed bone and cicatrix hyperplasia etc., affect wound healing, what have fracture also can cause bone does not connect, osteomyelitis and be forced to amputation.
At present, western medicine local debridement, disinfection is usually used both at home and abroad, antibiotic infection control, strengthen autoimmune, carry out the cure healed, but due to foreign body debridement not easily thorough, the repetitious stimulation of sterilization medicinal liquid, adds the chronic lesion of antibiotic to human liver renal function, the decline of immunity, therefore, patient suffering is large, costly, and easy infection, healing is slow, and severe trauma that is especially open or closed fracture also easily causes bone does not connect, osteomyelitis, local tissue necrosis etc. and is forced to amputation.In addition, conventional Wound treatment method also comprises physiotherapy (as microwave, infrared ray, laser etc.), wet packing of drugs, nano silver antibiotic dressing, somatomedin etc., there is many deficiencies in these Therapeutic Method, as not obvious in pigmentation, drug allergy, curative effect etc., all can not effective wound healing and reduce complication.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of spray that can promote wound healing.
For achieving the above object, the present invention adopts following technical scheme:
The invention provides a kind of spray that can promote wound healing, be made up of the raw material of following weight portion: Caulis Sargentodoxae 10 ~ 18 parts, Radix Achyranthis 20 ~ 30 parts, Cortex Ailanthi 18 ~ 28 parts, Caulis Trachelospermi 10 ~ 20 parts, Folium Callicarpae Formosanae 8 ~ 18 parts, Crinis Carbonisatus 25 ~ 35 parts, Calamina 9 ~ 18 parts, the Radix Angelicae Dahuricae 10 ~ 22 parts, Herba Scutellariae Barbatae 17 ~ 26 parts, 10 ~ 22 parts, Cinnabaris, succinum 15 ~ 30 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
Of the present inventionly can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 100 ~ 300 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 12 ~ 16 times of volumetric concentrations is the alcoholic solution of 60 ~ 70%, is forced into 3 ~ 6kgf/cm
2, make its pressure uniform, and keep 3 ~ 7min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5 ~ 2h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Preferably, the spray that can promote wound healing of the present invention, is made up of the raw material of following weight portion: Caulis Sargentodoxae 12 ~ 16 parts, Radix Achyranthis 23 ~ 27 parts, Cortex Ailanthi 21 ~ 25 parts, Caulis Trachelospermi 13 ~ 17 parts, Folium Callicarpae Formosanae 11 ~ 15 parts, Crinis Carbonisatus 28 ~ 32 parts, Calamina 11 ~ 15 parts, the Radix Angelicae Dahuricae 14 ~ 18 parts, Herba Scutellariae Barbatae 19 ~ 23 parts, 12 ~ 20 parts, Cinnabaris, succinum 20 ~ 25 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
More preferably, the spray that can promote wound healing of the present invention, is made up of the raw material of following weight portion: Caulis Sargentodoxae 14 parts, Radix Achyranthis 25 parts, Cortex Ailanthi 23 parts, Caulis Trachelospermi 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, Calamina 13 parts, the Radix Angelicae Dahuricae 16 parts, Herba Scutellariae Barbatae 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
In raw material of the present invention, Caulis Sargentodoxae heat-clearing and toxic substances removing, promoting blood circulation and stopping pain; Radix Achyranthis heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, relieving stranguria by diuresis; Cortex Ailanthi heat clearing and damp drying, relieving diarrhea with astringents, hemostasis leukorrhagia stopping; Caulis Trachelospermi dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling; Folium Callicarpae Formosanae removing heat from blood is restrained, heat-clearing and toxic substances removing; Crinis Carbonisatus astringing to arrest bleeding, blood stasis dispelling, diuresis; Calamina detoxifies, removing dampness promoting tissue regeneration and ulcer healing; Radix Angelicae Dahuricae expelling wind and cold, understand things pain-stopping detumescence and apocenosis, dampness leukorrhagia stopping; Herba Scutellariae Barbatae heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, inducing diuresis to remove edema; Cinnabaris tranquilizing mind, heat-clearing and toxic substances removing; Succinum tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome; Recombinant human epidermal growth factor hemostasis and pain-relieving, removing toxic substances and promoting subsidence of swelling, promotion tissue regeneration, tool reparation and organize nascent capacity, can high efficiency anti-inflammatory, promote cytothesis and tissue newborn, impel the growth fast of the tissues such as muscle, epidermis, muscle arteries and veins, blood vessel, without cicatrix more.
Beneficial effect of the present invention is:
1, Caulis Sargentodoxae of the present invention, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and succinum, compatibility can keep the activity of recombinant human epidermal growth factor, recombinant human epidermal growth factor can also be helped to go deep into deep skin fast, remarkable accelerated wound healing, by such reasonable compatibility, can promote wound healing fast, reduce healing time, reduce patient suffering, have no side effect, do not recur.
2, recombinant human epidermal growth factor of the present invention can promote the synthesis of DNA, RNA and hydroxyproline in skin wound process of tissue reparation, the epidermis cell of differentiation-inducing maturation reverses and turns to epidermal stem cells, accelerate the generation of wound granulation tissue and epithelial propagation, thus shorten the healing time of wound surface, improve wound repair quality, there are soft skin, slow down aging, reduce the effect of wound surface cicatrization.
3, spray of the present invention has immunoregulation effect, can strengthen liver and gall cell autoimmunity function, and opposing poisoning intrusion, also can improve body non-specific immunity, increases the generation of antibody, has analgesic effect simultaneously.
4, spray thing of the present invention effectively can stop blooding, alleviate the pain that wound brings to patient, common dermatosis can be prevented and treated, and there is effect of control wound infection, suppuration and disunion, calming heart and tranquilizing mind, good curative effect can be played to bone surgery wound, skin injury etc., postoperative patient can be helped to be had a rest fully, be conducive to the healing of postoperative wound; The present invention carries out prescription according to traditional Chinese medical theory, makes the present invention can play therapeutical effect and does not worry again causing side effect.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
The spray of wound healing can be promoted, be made up of the raw material of following weight portion: Caulis Sargentodoxae 10 parts, Radix Achyranthis 30 parts, Cortex Ailanthi 18 parts, Caulis Trachelospermi 20 parts, Folium Callicarpae Formosanae 8 parts, Crinis Carbonisatus 35 parts, Calamina 18 parts, the Radix Angelicae Dahuricae 10 parts, Herba Scutellariae Barbatae 26 parts, 10 parts, Cinnabaris, succinum 30 parts, recombinant human epidermal growth factor 0.0008 part.
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 150 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 16 times of volumetric concentrations is the alcoholic solution of 60%, is forced into 5kgf/cm
2, make its pressure uniform, and keep 3min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 2h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Embodiment 2
The spray of wound healing can be promoted, be made up of the raw material of following weight portion: Caulis Sargentodoxae 12 parts, Radix Achyranthis 27 parts, Cortex Ailanthi 21 parts, Caulis Trachelospermi 17 parts, Folium Callicarpae Formosanae 11 parts, Crinis Carbonisatus 32 parts, Calamina 11 parts, the Radix Angelicae Dahuricae 18 parts, Herba Scutellariae Barbatae 19 parts, 20 parts, Cinnabaris, succinum 20 parts, recombinant human epidermal growth factor 0.0004 part.
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 100 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 15 times of volumetric concentrations is the alcoholic solution of 65%, is forced into 6kgf/cm
2, make its pressure uniform, and keep 4min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Embodiment 3
The spray of wound healing can be promoted, be made up of the raw material of following weight portion: Caulis Sargentodoxae 14 parts, Radix Achyranthis 25 parts, Cortex Ailanthi 23 parts, Caulis Trachelospermi 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, Calamina 13 parts, the Radix Angelicae Dahuricae 16 parts, Herba Scutellariae Barbatae 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 200 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 14 times of volumetric concentrations is the alcoholic solution of 65%, is forced into 5kgf/cm
2, make its pressure uniform, and keep 5min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 2h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Embodiment 4
The spray of wound healing can be promoted, be made up of the raw material of following weight portion: Caulis Sargentodoxae 16 parts, Radix Achyranthis 23 parts, Cortex Ailanthi 25 parts, Caulis Trachelospermi 13 parts, Folium Callicarpae Formosanae 15 parts, Crinis Carbonisatus 28 parts, Calamina 15 parts, the Radix Angelicae Dahuricae 14 parts, Herba Scutellariae Barbatae 23 parts, 12 parts, Cinnabaris, succinum 25 parts, recombinant human epidermal growth factor 0.0006 part.
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 250 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 13 times of volumetric concentrations is the alcoholic solution of 70%, is forced into 4kgf/cm
2, make its pressure uniform, and keep 6min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Embodiment 5
The spray of wound healing can be promoted, be made up of the raw material of following weight portion: Caulis Sargentodoxae 18 parts, Radix Achyranthis 20 parts, Cortex Ailanthi 28 parts, Caulis Trachelospermi 10 parts, Folium Callicarpae Formosanae 18 parts, Crinis Carbonisatus 25 parts, Calamina 18 parts, the Radix Angelicae Dahuricae 22 parts, Herba Scutellariae Barbatae 17 parts, 22 parts, Cinnabaris, succinum 15 parts, recombinant human epidermal growth factor 0.0002 part.
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 300 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 12 times of volumetric concentrations is the alcoholic solution of 60%, is forced into 3kgf/cm
2, make its pressure uniform, and keep 7min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 2h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
Test example 1: spray of the present invention is to the clinical efficacy promoting wound healing
1, case selection:
Selected in the postoperative of Affiliated Hospital of Medical Colleges Of Guilin diagnosis and treatment or the routine clinical observation of other trauma patients 420 since 2013 ~ 2014, injury types comprises minor operation otch, either shallow burn and scald, mucosal ulcer, diabetic foot, cervical erosion, hemorrhoid, anal fissure, decubital ulcer, traumatic injury wound surface, recurrent wound.Patient is divided into treatment group and matched group two groups at random, treatment group 210 example, matched group 210 example.Age for the treatment of group and matched group two groups of cases, sex, injury types and wound rank random distribution, without significant difference, have comparability, keep on a diet all on request for two groups.
2, medicament selection:
Treatment group patient uses the embodiment of the present invention 3 spray, and get spray (selecting dose according to wound length) and be evenly sprayed on site of injury, spray in every 4 hours once, 3 days is a course for the treatment of;
Matched group injection drug for diminishing inflammation and antibiosis 3 days is a course for the treatment of.
2 courses for the treatment of are treated in continuous smelting, contrast two groups of curative effects.
3, efficacy determination:
(1) fully recover: wound healing, form a scab and come off, without cicatrix;
(2) take a turn for the better: transudate reduces, and wound surface reduces area > 20%, depth shallower, without secretions, granulation tissue grows;
(3) invalid: wound surface area and the degree of depth are without change.
Note: effectively=recovery from illness+take a turn for the better.
4, result:
Table 1 treatment group and matched group comparitive study
| Group | Number of cases | Recovery from illness/example | Take a turn for the better/example | Invalid/example | Effective percentage/% | Recurrence |
| Treatment group | 210 | 132 | 78 | 0 | 100 | 0 |
| Matched group | 210 | 59 | 95 | 56 | 73.3 | 18 |
Above result display, the obvious effective rate for the treatment of group and total effective rate are apparently higher than matched group.
Table 2 treatment group and matched group recovery from illness comparitive study
The display of above result, treatment group 1 ratio of the fully recovering course for the treatment of is greater than matched group, illustrates that treatment group healing wound is quick.
Test example 2: the spray active testing data that can promote wound healing of the present invention
The present invention's 5 embodiments can be promoted that the spray of wound healing regularly carries out active testing, obtain the result as following table 3:
The table 3 spray active testing data that can promote wound healing of the present invention
As can be seen from data above, the spray activity-maintaining time that can promote wound healing of the present invention is permanent, and lasting rate at least can reach 3 years.
Claims (3)
1. can promote a spray for wound healing, it is characterized in that, be made up of the raw material of following weight portion: Caulis Sargentodoxae 10 ~ 18 parts, Radix Achyranthis 20 ~ 30 parts, Cortex Ailanthi 18 ~ 28 parts, Caulis Trachelospermi 10 ~ 20 parts, Folium Callicarpae Formosanae 8 ~ 18 parts, Crinis Carbonisatus 25 ~ 35 parts, Calamina 9 ~ 18 parts, the Radix Angelicae Dahuricae 10 ~ 22 parts, Herba Scutellariae Barbatae 17 ~ 26 parts, 10 ~ 22 parts, Cinnabaris, succinum 15 ~ 30 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part;
Described can promote that the preparation method of the spray of wound healing is as follows:
1) Caulis Sargentodoxae, Radix Achyranthis, Cortex Ailanthi, Caulis Trachelospermi, Folium Callicarpae Formosanae, Crinis Carbonisatus, Calamina, the Radix Angelicae Dahuricae, Herba Scutellariae Barbatae, Cinnabaris and Succinum powder are broken to 100 ~ 300 orders;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 12 ~ 16 times of volumetric concentrations is the alcoholic solution of 60 ~ 70%, is forced into 3 ~ 6kgf/cm
2, make its pressure uniform, and keep 3 ~ 7min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5 ~ 2h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, then adds recombinant human epidermal growth factor mix homogeneously.
2. the spray that can promote wound healing according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Caulis Sargentodoxae 12 ~ 16 parts, Radix Achyranthis 23 ~ 27 parts, Cortex Ailanthi 21 ~ 25 parts, Caulis Trachelospermi 13 ~ 17 parts, Folium Callicarpae Formosanae 11 ~ 15 parts, Crinis Carbonisatus 28 ~ 32 parts, Calamina 11 ~ 15 parts, the Radix Angelicae Dahuricae 14 ~ 18 parts, Herba Scutellariae Barbatae 19 ~ 23 parts, 12 ~ 20 parts, Cinnabaris, succinum 20 ~ 25 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
3. the spray that can promote wound healing according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Caulis Sargentodoxae 14 parts, Radix Achyranthis 25 parts, Cortex Ailanthi 23 parts, Caulis Trachelospermi 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, Calamina 13 parts, the Radix Angelicae Dahuricae 16 parts, Herba Scutellariae Barbatae 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
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| CN201510796710.4A CN105233266A (en) | 2015-11-18 | 2015-11-18 | Spray for promoting wound healing |
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| CN201510796710.4A CN105233266A (en) | 2015-11-18 | 2015-11-18 | Spray for promoting wound healing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007819A (en) * | 2017-03-30 | 2017-08-04 | 中南大学湘雅三医院 | A kind of spray containing cell polypeptide growth factor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107007819A (en) * | 2017-03-30 | 2017-08-04 | 中南大学湘雅三医院 | A kind of spray containing cell polypeptide growth factor |
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