CN105233265A - Composition capable of promoting wound healing - Google Patents
Composition capable of promoting wound healing Download PDFInfo
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- CN105233265A CN105233265A CN201510796690.0A CN201510796690A CN105233265A CN 105233265 A CN105233265 A CN 105233265A CN 201510796690 A CN201510796690 A CN 201510796690A CN 105233265 A CN105233265 A CN 105233265A
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a composition capable of promoting wound healing. The composition is prepared from the following raw materials in parts by weight: 10-18 parts of humifuse euphorbia herb, 20-30 parts of folium et ramulus evodiae leptae, 18-28 parts of cortex ailanthi, 10-20 parts of herba taching, 8-18 parts of callicarpa bodinieri, 25-35 parts of carbonized hair, 9-18 parts of catechu, 10-22 parts of herba elsholtziae, 17-26 parts of radices trichosanthis, 10-22 parts of cinnabar, 15-30 parts of amber, and 0.0002-0.0008 part of recombinant human epidermal growth factor. The composition capable of promoting wound healing has the effects of clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis, eliminating swell and promoting granulation, resisting bacteria and easing pains, and repairing skin, and is capable of quickly promoting wound healing, reducing the curing time and reducing patient pain.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of compositions that can promote wound healing.
Background technology
Wound is unexpected injury more common in people's daily life, particularly war, vehicle accident, earthquake etc. in factories and miness accident and natural disaster all can bring the different accident trauma of weight, once there occurs weight not wait local wound, whether can obtain process correct in time, very large relation is had to later treatment, deal with improperly or process not in time, the misery of patient can be increased, wound surface can be there is hemorrhage, infect, pain, healing time is long, vital tissue is as tendon, neural, exposed bone and cicatrix hyperplasia etc., affect wound healing, what have fracture also can cause bone does not connect, osteomyelitis and be forced to amputation.
At present, western medicine local debridement, disinfection is usually used both at home and abroad, antibiotic infection control, strengthen autoimmune, carry out the cure healed, but due to foreign body debridement not easily thorough, the repetitious stimulation of sterilization medicinal liquid, adds the chronic lesion of antibiotic to human liver renal function, the decline of immunity, therefore, patient suffering is large, costly, and easy infection, healing is slow, and severe trauma that is especially open or closed fracture also easily causes bone does not connect, osteomyelitis, local tissue necrosis etc. and is forced to amputation.In addition, conventional Wound treatment method also comprises physiotherapy (as microwave, infrared ray, laser etc.), wet packing of drugs, nano silver antibiotic dressing, somatomedin etc., there is many deficiencies in these Therapeutic Method, as not obvious in pigmentation, drug allergy, curative effect etc., all can not effective wound healing and reduce complication.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions that can promote wound healing.
For achieving the above object, the present invention adopts following technical scheme:
The invention provides a kind of compositions that can promote wound healing, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 10 ~ 18 parts, three bifurcation hardships 20 ~ 30 parts, Cortex Ailanthi 18 ~ 28 parts, Folium Isatidis 10 ~ 20 parts, Folium Callicarpae Formosanae 8 ~ 18 parts, Crinis Carbonisatus 25 ~ 35 parts, 9 ~ 18 parts, catechu, Herba Moslae 10 ~ 22 parts, Radix Trichosanthis 17 ~ 26 parts, 10 ~ 22 parts, Cinnabaris, succinum 15 ~ 30 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
Further, the compositions that can promote wound healing of the present invention, is made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 12 ~ 16 parts, three bifurcation hardships 23 ~ 27 parts, Cortex Ailanthi 21 ~ 25 parts, Folium Isatidis 13 ~ 17 parts, Folium Callicarpae Formosanae 11 ~ 15 parts, Crinis Carbonisatus 28 ~ 32 parts, 11 ~ 15 parts, catechu, Herba Moslae 14 ~ 18 parts, Radix Trichosanthis 19 ~ 23 parts, 12 ~ 20 parts, Cinnabaris, succinum 20 ~ 25 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
Further, the compositions that can promote wound healing of the present invention, is made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 14 parts, bitter 25 parts of three bifurcations, Cortex Ailanthi 23 parts, Folium Isatidis 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, 13 parts, catechu, Herba Moslae 16 parts, Radix Trichosanthis 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
Preferably, compositions of the present invention is unguentum or spray.
In raw material of the present invention, Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, promoting blood circulation and hemostasis, dampness removing jaundice eliminating; The bitter heat-clearing and toxic substances removing of three bifurcations, expelling wind and removing dampness, eliminating stasis to stop pain; Cortex Ailanthi heat clearing and damp drying, relieving diarrhea with astringents, hemostasis leukorrhagia stopping; Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Folium Callicarpae Formosanae removing heat from blood is restrained, heat-clearing and toxic substances removing; Crinis Carbonisatus astringing to arrest bleeding, blood stasis dispelling, diuresis; Catechu is invigorated blood circulation and is cured the wound, hemostasia and promoting granulation sore; Herba Moslae relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach inducing diuresis to remove edema; Radix Trichosanthis clearing away heat and promoting production of body fluid, detumescence and apocenosis; Cinnabaris tranquilizing mind, heat-clearing and toxic substances removing; Succinum tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome; Recombinant human epidermal growth factor hemostasis and pain-relieving, removing toxic substances and promoting subsidence of swelling, promotion tissue regeneration, tool reparation and organize nascent capacity, can high efficiency anti-inflammatory, promote cytothesis and tissue newborn, impel the growth fast of the tissues such as muscle, epidermis, muscle arteries and veins, blood vessel, without cicatrix more.
Beneficial effect of the present invention is:
1, present composition compatibility rationally, select medicine to forbid, all medicines share, bring out the best in each other, effect is remarkable, play the effect of heat-clearing and toxic substances removing altogether.By above-mentioned raw materials medicament mixed together, reasonable compatibility medicine on prescription, each other to correct its bias, eliminate or reduce toxicity, increasing curative effect, play the comprehensive function of to complement each other between each medicine or opposing each other and yet also complement each other, make it extremely remarkable on wholistic therapy, play heat-clearing and toxic substances removing altogether, blood circulation promoting and blood stasis dispelling, detumescence and promoting granulation, antibacterial analgesia, repair effect of skin.
2, the present composition effectively can stop blooding, alleviate the pain that wound brings to patient, common dermatosis can be prevented and treated, and there is effect of control wound infection, suppuration and disunion, calming heart and tranquilizing mind, good curative effect can be played to bone surgery wound, skin injury etc., postoperative patient can be helped to be had a rest fully, be conducive to the healing of postoperative wound; The present invention carries out prescription according to traditional Chinese medical theory, makes the present invention can play therapeutical effect and does not worry again causing side effect.
3, compositions of the present invention has immunoregulation effect, can strengthen liver and gall cell autoimmunity function, and opposing poisoning intrusion, also can improve body non-specific immunity, increases the generation of antibody, has analgesic effect simultaneously.
4, recombinant human epidermal growth factor of the present invention can promote the synthesis of DNA, RNA and hydroxyproline in skin wound process of tissue reparation, the epidermis cell of differentiation-inducing maturation reverses and turns to epidermal stem cells, accelerate the generation of wound granulation tissue and epithelial propagation, thus shorten the healing time of wound surface, improve wound repair quality, there are soft skin, slow down aging, reduce the effect of wound surface cicatrization.
5, Herba Euphorbiae Humifusae of the present invention, three bifurcation hardships, Cortex Ailanthi, Folium Isatidis, Folium Callicarpae Formosanae, Crinis Carbonisatus, catechu, Herba Moslae, Radix Trichosanthis, Cinnabaris, succinum compatibility can keep the activity of recombinant human epidermal growth factor, recombinant human epidermal growth factor can also be helped to go deep into deep skin fast, remarkable accelerated wound healing.
6, compositions of the present invention can promote wound healing fast, reduces healing time, reduces patient suffering.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
The compositions of wound healing can be promoted, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 10 parts, bitter 30 parts of three bifurcations, Cortex Ailanthi 18 parts, Folium Isatidis 20 parts, Folium Callicarpae Formosanae 8 parts, Crinis Carbonisatus 35 parts, 18 parts, catechu, Herba Moslae 10 parts, Radix Trichosanthis 26 parts, 10 parts, Cinnabaris, succinum 30 parts, recombinant human epidermal growth factor 0.0008 part.
The preparation method of the compositions of wound healing can be promoted: by Herba Euphorbiae Humifusae, three bifurcation hardships, Cortex Ailanthi, Folium Isatidis, Folium Callicarpae Formosanae, Crinis Carbonisatus, catechu, Herba Moslae, Radix Trichosanthis, Cinnabaris, succinum, be prepared into unguentum by traditional boiling method, then recombinant human epidermal growth factor is mixed homogeneously with unguentum.
Embodiment 2
The compositions of wound healing can be promoted, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 12 parts, bitter 27 parts of three bifurcations, Cortex Ailanthi 21 parts, Folium Isatidis 17 parts, Folium Callicarpae Formosanae 11 parts, Crinis Carbonisatus 32 parts, 11 parts, catechu, Herba Moslae 18 parts, Radix Trichosanthis 19 parts, 20 parts, Cinnabaris, succinum 20 parts, recombinant human epidermal growth factor 0.0004 part.
Can promote that the preparation method of the compositions of wound healing is with embodiment 1.
Embodiment 3
The compositions of wound healing can be promoted, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 14 parts, bitter 25 parts of three bifurcations, Cortex Ailanthi 23 parts, Folium Isatidis 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, 13 parts, catechu, Herba Moslae 16 parts, Radix Trichosanthis 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
Can promote that the preparation method of the compositions of wound healing is with embodiment 1.
Embodiment 4
The compositions of wound healing can be promoted, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 16 parts, bitter 23 parts of three bifurcations, Cortex Ailanthi 25 parts, Folium Isatidis 13 parts, Folium Callicarpae Formosanae 15 parts, Crinis Carbonisatus 28 parts, 15 parts, catechu, Herba Moslae 14 parts, Radix Trichosanthis 23 parts, 12 parts, Cinnabaris, succinum 25 parts, recombinant human epidermal growth factor 0.0006 part.
The preparation method of the compositions of wound healing can be promoted: by Herba Euphorbiae Humifusae, three bifurcation hardships, Cortex Ailanthi, Folium Isatidis, Folium Callicarpae Formosanae, Crinis Carbonisatus, catechu, Herba Moslae, Radix Trichosanthis, Cinnabaris, succinum, be prepared into spray by traditional boiling method, then recombinant human epidermal growth factor is mixed homogeneously with spray.
Embodiment 5
The compositions of wound healing can be promoted, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 18 parts, bitter 20 parts of three bifurcations, Cortex Ailanthi 28 parts, Folium Isatidis 10 parts, Folium Callicarpae Formosanae 18 parts, Crinis Carbonisatus 25 parts, 18 parts, catechu, Herba Moslae 22 parts, Radix Trichosanthis 17 parts, 22 parts, Cinnabaris, succinum 15 parts, recombinant human epidermal growth factor 0.0002 part.
Can promote that the preparation method of the compositions of wound healing is with embodiment 4.
Test example 1: compositions of the present invention is to the clinical efficacy promoting wound healing
1, case selection:
Selected in the postoperative of local hospital therapy or the routine clinical observation of other trauma patients 400 since 2013 ~ 2014, injury types comprises minor operation otch, either shallow burn and scald, mucosal ulcer, diabetic foot, cervical erosion, hemorrhoid, anal fissure, decubital ulcer, traumatic injury wound surface, recurrent wound.Patient is divided into treatment group and matched group two groups at random, treatment group 200 example, matched group 200 example.Age for the treatment of group and matched group two groups of cases, sex, injury types and wound rank random distribution, without significant difference, have comparability, keep on a diet all on request for two groups.
2, medicament selection:
The unguentum that treatment group patient uses the embodiment of the present invention 3 obtained, uniform application is in site of injury to get unguentum (selecting ointment amount according to wound length), and within every 4 hours, smearing once, 3 days is a course for the treatment of;
Matched group injection drug for diminishing inflammation and antibiosis 3 days is a course for the treatment of.
2 courses for the treatment of are treated in continuous smelting, contrast two groups of curative effects.
3, efficacy determination:
(1) fully recover: wound healing, form a scab and come off, without cicatrix;
(2) take a turn for the better: transudate reduces, and wound surface reduces area > 20%, depth shallower, without secretions, granulation tissue grows;
(3) invalid: wound surface area and the degree of depth are without change.
Note: effectively=recovery from illness+take a turn for the better.
4, result:
Table 1 treatment group and matched group comparitive study
| Group | Number of cases | Recovery from illness/example | Take a turn for the better/example | Invalid/example | Effective percentage/% | Recurrence |
| Treatment group | 200 | 128 | 72 | 0 | 100 | 0 |
| Matched group | 200 | 59 | 76 | 65 | 67.5 | 12 |
Above result display, the obvious effective rate for the treatment of group and total effective rate are apparently higher than matched group.
Table 2 treatment group and matched group recovery from illness comparitive study
The display of above result, treatment group 1 ratio of the fully recovering course for the treatment of is greater than matched group, illustrates that treatment group healing wound is quick.
Test example 2: the compositions active testing data that can promote wound healing of the present invention
The present invention's 5 embodiments can be promoted that the compositions of wound healing regularly carries out active testing, obtain the result as following table 3:
The table 3 compositions active testing data that can promote wound healing of the present invention
As can be seen from data above, the compositions activity-maintaining time that can promote wound healing of the present invention is permanent, and lasting rate at least can reach 3 years.
Claims (4)
1. can promote a compositions for wound healing, it is characterized in that, be made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 10 ~ 18 parts, three bifurcation hardships 20 ~ 30 parts, Cortex Ailanthi 18 ~ 28 parts, Folium Isatidis 10 ~ 20 parts, Folium Callicarpae Formosanae 8 ~ 18 parts, Crinis Carbonisatus 25 ~ 35 parts, 9 ~ 18 parts, catechu, Herba Moslae 10 ~ 22 parts, Radix Trichosanthis 17 ~ 26 parts, 10 ~ 22 parts, Cinnabaris, succinum 15 ~ 30 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
2. the compositions that can promote wound healing according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 12 ~ 16 parts, three bifurcation hardships 23 ~ 27 parts, Cortex Ailanthi 21 ~ 25 parts, Folium Isatidis 13 ~ 17 parts, Folium Callicarpae Formosanae 11 ~ 15 parts, Crinis Carbonisatus 28 ~ 32 parts, 11 ~ 15 parts, catechu, Herba Moslae 14 ~ 18 parts, Radix Trichosanthis 19 ~ 23 parts, 12 ~ 20 parts, Cinnabaris, succinum 20 ~ 25 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
3. the compositions that can promote wound healing according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Herba Euphorbiae Humifusae 14 parts, bitter 25 parts of three bifurcations, Cortex Ailanthi 23 parts, Folium Isatidis 15 parts, Folium Callicarpae Formosanae 13 parts, Crinis Carbonisatus 30 parts, 13 parts, catechu, Herba Moslae 16 parts, Radix Trichosanthis 21 parts, 16 parts, Cinnabaris, succinum 23 parts, recombinant human epidermal growth factor 0.0005 part.
4. the compositions that can promote wound healing according to claims 1 to 3 any one, is characterized in that: described compositions is unguentum or spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510796690.0A CN105233265A (en) | 2015-11-18 | 2015-11-18 | Composition capable of promoting wound healing |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510796690.0A CN105233265A (en) | 2015-11-18 | 2015-11-18 | Composition capable of promoting wound healing |
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| CN105233265A true CN105233265A (en) | 2016-01-13 |
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Cited By (2)
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| CN106729631A (en) * | 2017-03-17 | 2017-05-31 | 河南中医药大学 | Treat the externally applied spray of intractable skin ulcer |
| CN109172740A (en) * | 2018-10-22 | 2019-01-11 | 王解生 | A kind of herbal composite promoting organization healing |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729631A (en) * | 2017-03-17 | 2017-05-31 | 河南中医药大学 | Treat the externally applied spray of intractable skin ulcer |
| CN109172740A (en) * | 2018-10-22 | 2019-01-11 | 王解生 | A kind of herbal composite promoting organization healing |
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