CN107007735B - Medicinal incense for regulating heart and preparation method thereof - Google Patents

Medicinal incense for regulating heart and preparation method thereof Download PDF

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CN107007735B
CN107007735B CN201710132229.4A CN201710132229A CN107007735B CN 107007735 B CN107007735 B CN 107007735B CN 201710132229 A CN201710132229 A CN 201710132229A CN 107007735 B CN107007735 B CN 107007735B
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heart
regulating
chinese medicinal
medicinal materials
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CN107007735A (en
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齐国旺
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Dalian Yaojiu Biotechnology Co ltd
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Dalian Yaojiu Biotechnology Co ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/725Ziziphus, e.g. jujube
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Abstract

The invention discloses a medicine incense for regulating the heart and a preparation method thereof, wherein the preparation method of the medicine incense for regulating the heart comprises the following steps: (1) pretreatment: (2) soaking in wine; (3) mixing the materials; (4) pressing and forming; (5) and (5) drying at low temperature. The medicinal incense for regulating the heart and the preparation method thereof damage the fiber structure of the medicinal materials through superfine grinding and nanocrystallization of the medicinal materials, are easy to bond and form during processing, and simultaneously, the nanometer-scale Chinese medicinal materials can accelerate the diffusion of the medicinal factors during combustion and reduce the residual ash during combustion. Through the reasonable compatibility of the traditional Chinese medicinal materials, the medicinal incense absorbs the medicinal factors through skin and smell during combustion, so that the function of regulating the heart can be achieved. The medicine incense for regulating the heart prepared by the invention has the advantages of high safety, full combustion, good sterilization performance, lasting combustion time and the like, and has the effect of regulating the heart.

Description

Medicinal incense for regulating heart and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine incense, in particular to a medicine incense for regulating the heart and a preparation method thereof.
Background
Heart disease is a general term for heart disease, and is classified according to its etiology: congenital heart disease and acquired heart disease. The acquired heart disease refers to the disease caused by the external or internal factors of the body after birth, and mainly comprises the following types: coronary heart disease caused by coronary arteriosclerosis, rheumatic heart disease, hypertensive heart disease, infectious heart disease, endocrine heart disease, hematologic heart disease, and nutritional metabolic heart disease. The traditional Chinese medicine considers that the causes of the diseases are manifold and closely related to the change of the whole body. The main aspects are that the heart vessel is blocked and the disease is caused by qi stagnation and blood stasis, chest yang deficiency and phlegm turbidity generation caused by aged body weakness, deficiency of vital qi, viscera function damage, imbalance of yin, yang and qi and blood, and factors such as seven-emotion internal injury, improper diet, cold stimulation, overstrain and rest degree. Among them, the dysfunction of qi and blood in zang-fu organs, meridians and collaterals, and the disruption of the balance of yin, yang and constipation are the intrinsic causes of the disease. Internal causes are the basis of onset of disease, and external causes are the condition of onset of disease.
China has a thousand years history of incense, and the incense can integrate the spirituality of the world, can be happy, and can be adjusted. Many spices are important drugs for traditional Chinese medicine. It has long been known that aromatherapy can beautify, relieve pain, relieve fatigue, relieve depression, and the like. The book of Ben Cao gang mu of Li Shizhen of Ming Dynasty records the use of "Lingxiang" as a medicine. The incense is used as medicine and is fragrant medicine and fragrant tea. The treatment of the incense is to utilize the aromatic smell and the healing capacity of the pure natural medicine, and the incense is absorbed by the olfactory organ or the skin of a person and acts through the nerve and the circulatory system, so that the body, the mind and the spirit of the person are balanced and unified. The fragrance can be absorbed through human skin or mouth and nose due to the characteristics of easy penetration, high fluidity and high absorbability, thereby achieving the effect of being absorbed by human body. Chemical essence is added into the daily incense in the market, so that the daily incense can cause harm to human bodies after being used for a long time. Therefore, the effectiveness of the traditional Chinese medicine for regulating the heart function is researched, and the medicine fragrance which is free from toxic and side effects and can regulate the heart is prepared.
Disclosure of Invention
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of a drug incense for regulating heart comprises the following steps:
(1) pre-treating;
(2) soaking in wine;
(3) mixing the materials;
(4) pressing and forming;
(5) and (5) drying at low temperature.
Preferably, the preparation method of the drug incense for regulating the heart comprises the following steps:
(1) pretreatment: primarily crushing the traditional Chinese medicinal materials into 10-20 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily pulverized Chinese medicinal materials in 50-60% (v/v) Chinese liquor for 1-3 hr, filtering, and oven drying at low temperature to obtain Chinese medicinal materials soaked in the Chinese liquor;
(3) mixing materials: adding the wine soaked traditional Chinese medicinal materials and the adhesive into a stirrer, stirring for 15 minutes at 200 revolutions per minute, stirring at 25-35 ℃, adding water, and stirring for 40-60 minutes at 25-35 ℃ at 200 revolutions per minute to obtain a mixed material;
(4) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 2-5MPa for 1-10 s at 45-60 deg.C, and demolding to obtain medicinal fragrance product for regulating heart;
(5) and (3) low-temperature drying: and (3) sending the primary drug fragrance product for regulating the heart into an oven, and drying at the temperature of 60-80 ℃ for 4-6 hours to obtain a finished drug fragrance product for regulating the heart.
Preferably, the preparation method of the drug incense for regulating the heart comprises the following steps:
(1) pretreatment: primarily crushing the traditional Chinese medicinal materials into 10-20 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily pulverized Chinese medicinal materials in 50-60% (v/v) Chinese liquor for 1-3 hr, filtering, and oven drying at low temperature to obtain Chinese medicinal materials soaked in the Chinese liquor;
(3) superfine grinding: soaking the traditional Chinese medicinal materials in wine and a dispersion medium according to the mass ratio of 1: (2-4) uniformly mixing, adding into an ultrafine pulverizer, and pulverizing at 25-35 deg.C for 30-40 min to obtain ultrafine pulverized Chinese medicinal materials;
(4) nano-crystallization: pulverizing superfine pulverized Chinese medicinal materials with nanometer collider, pulverizing into nanometer powder at 130MPa and 300rpm, and drying at 60-80 deg.C for 10-14 hr to obtain nanometer Chinese medicinal powder;
(5) mixing materials: adding the nanometer Chinese medicinal powder, adhesive and combustion improver into a stirrer, stirring at 200 r/min for 15 min at 25-35 deg.C, adding water, and stirring at 25-35 deg.C at 200 r/min for 40-60 min to obtain a mixture;
(6) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 2-5MPa for 1-10 s at 45-60 deg.C, and demolding to obtain medicinal fragrance product for regulating heart;
(7) and (3) low-temperature drying: and (3) sending the primary drug fragrance product for regulating the heart into an oven, and drying at the temperature of 60-80 ℃ for 4-6 hours to obtain a finished drug fragrance product for regulating the heart.
Preferably, the traditional Chinese medicinal materials comprise the following traditional Chinese medicines in parts by weight: 1-3 parts of mulberry twig, 1-3 parts of cassia twig, 1-3 parts of angelica dahurica, 3-5 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 3-5 parts of agilawood, 3-5 parts of dalbergia wood, 3-5 parts of sandalwood, 3-5 parts of dipsacus root, 5-8 parts of ligusticum chuanxiong hort, 5-8 parts of salvia miltiorrhiza, 5-8 parts of caulis spatholobi, 3-5 parts of radix scrophulariae, 3-5 parts of radix ophiopogonis, 5-8 parts of safflower, 5-8 parts of radix paeoniae rubra, 3-5 parts of radix saposhnikoviae, 5-8 parts of spina date seed, 5-8 parts of poria cocos, 5-8 parts of allium macrostemon, 3-5 parts of angelica sinensis, 3-5.
Preferably, the dispersing medium in step (3) is an aqueous sucrose ester solution.
Preferably, the adhesive in the step (5) is glutinous rice flour and/or sodium alginate, and more preferably, the adhesive is the mixture of glutinous rice flour and sodium alginate in a mass ratio of (1-10): 1.
Preferably, the combustion improver in the step (5) is tea seed powder.
Preferably, the mass ratio of the Chinese medicinal materials to the white spirit in the step (2) is 1: (1-3).
The invention provides a medicine incense for regulating the heart, which is prepared by adopting the method.
The medicinal incense for regulating the heart and the preparation method thereof damage the fiber structure of the medicinal materials through superfine grinding and nanocrystallization of the medicinal materials, are easy to bond and form during processing, and simultaneously, the nanometer-scale Chinese medicinal materials can accelerate the diffusion of the medicinal factors during combustion and reduce the residual ash during combustion. Through the reasonable compatibility of the traditional Chinese medicinal materials, the medicinal incense absorbs the medicinal factors through skin and smell during combustion, so that the function of regulating the heart can be achieved. The medicine incense for regulating the heart prepared by the invention has the advantages of high safety, full combustion, good sterilization performance, lasting combustion time and the like, and has the effect of regulating the heart.
Detailed Description
The sterilization performance detection basis is as follows: 2.1.3.5 in Disinfection Specification (2002 edition).
The sterilization performance detection method comprises the following steps: select volume 20m3And carrying out a field disinfection test in an unmanned room. And (5) sampling natural bacteria in the air for 5 minutes before disinfection after the room is closed, and taking the sampled natural bacteria as a control before disinfection. For each test, 3 samples of one example were ignited in the chamber for sterilization, and 2 hours after sterilization, the natural bacteria in the air in the chamber were sampled for 5 minutes. And (3) placing the sampling plate at 37 ℃ for culturing for 48 hours, observing the colony number, repeating the experiment for 3 times, and calculating the natural bacteria extinction rate.
The burning test method of the finished drug fragrance product for regulating the heart comprises the following steps: weighing the finished product of the drug incense with the weight of about 2.0g, burning till the end, recording the burning time and collecting the burning weight.
Ramulus Mori is dried tender branch of Morns alba L.
Cassia twig, a dried twig of Cinnamomum cassia Cassia Presl of Lauraceae.
Radix Angelicae Dahuricae is dried root of Angelica Dahurica (Fisch. exHOffm.) Benth.et hook.f. of Umbelliferae.
Astragalus membranaceus (Fisch.) Bge dried root of Astragalus membranaceus (Mongolian) Hsiao (Leguminosae).
Coptidis rhizoma is dried rhizome of Coplis chinensis Franch of Ranunculaceae.
Agilawood, Latin school name: aquilariaagallocha (Lour.) Roxb, a dicotyledonous plant Aquilaria a agallocha (Lour.) Roxb, is a secretion of fungi in the self-repairing process after being damaged by nature (such as lightning stroke, wind break, worm damage and the like) or being artificially damaged, and the condensed secretion is the Aquilaria agallocha.
Dalbergia wood, Latin school name: dalbergia odorifera is dried heartwood of trunk and root of Dalbergia odorifera T.Chen of Leguminosae.
Sandalwood, Latin school name: santalum album linn is heartwood of Santalum album L. trunk of Santalum of Santalwood of Santalaceae.
Dipsacus root, the root of Dipsacus asperoides C.Y.Cheng et T.M.ai, a perennial herb.
Rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanxiong Hort of Umbelliferae.
Salvia miltiorrhiza, is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae.
Spatholobus stem, Latin scientific name: millettiaretic uiatabenth, a dried vine of the leguminous plant Spatholobus subelectus Dunn.
Figwort root, Latin scientific name: figwortroot, which is a dried root of Scrophularia ningpoensis Hemsl.
Radix Ophiopogonis is dried root tuber of Ophiopogon japonica (Thunb.) Ker-Gawl. of Liliaceae.
Carthami flos, which is dried flower of Carthamus tinctorius L.
Radix Paeoniae Rubra is dried root of Paeonia lactiflora pall.
Ledebouriella root, a dried root of the plant Saposhnikovia divaricata (Turcz.) switzerland, of the family umbelliferae, schischchk.
Spina date seed, Latin scientific name: ziziphus jujuba mill, var. spinosa, a dried mature seed of Ziziphus jujuba mill, var. spinosa (Bunge) Hu ex h.f.chou, a rhamnaceae plant.
Tuckahoe, Latin science name: wolfiporia cos is dried sclerotium of Wolf, a fungus Poria cocos cos (Schw.) of Polyporaceae.
Bulbus Allii Macrostemi is dried bulb of Allium macrostemon Bge of Liliaceae.
Angelica sinensis (Oliv.) Diels is dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae
Rhizoma Corydalis is dried tuber of Corydalis yanhusno W.T.Wang of Papaveraceae.
Notoginseng radix is dried root and rhizome of Panax notoginseng (Burk.) F.H.Chen of Araliaceae.
The glutinous rice flour is water-milled glutinous rice flour provided by Heizhou Jintanjiangnan milling Co., Ltd, and has a particle size of 100-120 meshes.
The sucrose ester is sucrose ester provided by Hangzhou Rulin chemical Co., Ltd, model number SE 11. The preparation method of the sucrose ester solution comprises the following steps: taking a certain amount of sucrose ester, adding into water with the temperature of 40 ℃, and stirring for 20 minutes at 40 revolutions per minute to obtain the sucrose ester.
The tea seed powder is natural tea seed powder provided by Shenzhen Shen Longgang region Pinghu colorful chemical product Jing-nutrient part, and has a particle size of 120 meshes.
Sodium alginate, CAS No.: 31581-02-9, and is made from food-grade sodium alginate supplied by Shandong Asia Henry Biotech Co.
PEG-400, CAS number: 25322-68-3, pharmaceutical grade PEG-400 from Federal Fine chemical Co., Ltd, Guangdong.
Ethanol, CAS No.: 64-17-5.
Glycerol, CAS number: 56-81-5.
The coarse crusher is a CSJ-300 type coarse crusher manufactured by Kataiji mechanical manufacturing company of Jiangyin city.
The ultrafine grinder is an ultrafine grinder with model WFJ-15, which is manufactured by Kataiji mechanical manufacturing company Limited in Jiangyin.
The nanometer collider is a nanometer collider with model number NCJJ-200/150 produced by gallery general machinery manufacturing Limited.
Example 1
The medicine fragrance raw materials for regulating the heart (parts by weight): 2 parts of mulberry twig, 2 parts of cassia twig, 2 parts of angelica dahurica, 4 parts of astragalus mongholicus, 4 parts of coptis chinensis, 4 parts of agilawood, 4 parts of rosewood, 4 parts of sandalwood, 4 parts of dipsacus root, 6 parts of ligusticum wallichii, 6 parts of salvia miltiorrhiza, 6 parts of caulis spatholobi, 4 parts of radix scrophulariae, 4 parts of radix ophiopogonis, 6 parts of safflower carthamus, 6 parts of radix paeoniae rubra, 4 parts of radix sileris, 6 parts of spina date seed, 6 parts of poria cocos, 6 parts of allium macrostemon, 4 parts of angelica sinensis, 4 parts of rhizoma corydalis, 2 parts of pseudo-ginseng.
A preparation method of a drug incense for regulating heart comprises the following steps:
(1) pretreatment: preliminarily crushing the traditional Chinese medicinal materials into 10 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily crushed traditional Chinese medicinal materials in 52-degree white spirit for 2 hours, wherein the mass ratio of the traditional Chinese medicinal materials to the white spirit is 1:2, filtering by using 300-mesh filter cloth, and drying filter residues at 70 ℃ for 5 hours to obtain wine-soaked traditional Chinese medicinal materials;
(3) mixing materials: adding the wine-soaked traditional Chinese medicinal materials, the adhesive and the tea seed powder into a stirrer, stirring for 15 minutes at 200 revolutions per minute, stirring at the temperature of 30 ℃, adding 25 parts by weight of water, and stirring for 50 minutes at the temperature of 30 ℃ at 200 revolutions per minute to obtain a mixed material;
(4) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 4MPa for 5 seconds at 50 ℃, and demolding to obtain a drug fragrance primary product for regulating the heart;
(5) and (3) low-temperature drying: and (3) sending the primary drug fragrance product for regulating the heart into an oven, and drying at 70 ℃ for 5 hours to obtain a finished drug fragrance product for regulating the heart, wherein the length of the drug fragrance product is 24cm, and the diameter of the drug fragrance product is 3 mm.
The adhesive in the step (4) is glutinous rice flour.
Example 2
The medicine fragrance raw materials for regulating the heart (parts by weight): 2 parts of mulberry twig, 2 parts of cassia twig, 2 parts of angelica dahurica, 4 parts of astragalus mongholicus, 4 parts of coptis chinensis, 4 parts of agilawood, 4 parts of rosewood, 4 parts of sandalwood, 4 parts of dipsacus root, 6 parts of ligusticum wallichii, 6 parts of salvia miltiorrhiza, 6 parts of caulis spatholobi, 4 parts of radix scrophulariae, 4 parts of radix ophiopogonis, 6 parts of safflower carthamus, 6 parts of radix paeoniae rubra, 4 parts of radix sileris, 6 parts of spina date seed, 6 parts of poria cocos, 6 parts of allium macrostemon, 4 parts of angelica sinensis, 4 parts of rhizoma corydalis, 2 parts of pseudo-ginseng.
A preparation method of a drug incense for regulating heart comprises the following steps:
(1) pretreatment: preliminarily crushing the traditional Chinese medicinal materials into 10 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily crushed traditional Chinese medicinal materials in 52-degree white spirit for 2 hours, wherein the mass ratio of the traditional Chinese medicinal materials to the white spirit is 1:2, filtering by using 300-mesh filter cloth, and drying filter residues at 70 ℃ for 5 hours to obtain wine-soaked traditional Chinese medicinal materials;
(3) superfine grinding: soaking the traditional Chinese medicinal materials in wine and a dispersion medium according to the mass ratio of 1: 3, uniformly mixing, adding into an ultrafine grinder, grinding for 30 minutes at 30 ℃, and drying for 12 hours at 70 ℃ to obtain ultrafine ground traditional Chinese medicinal materials;
(4) mixing materials: adding the superfine crushed traditional Chinese medicinal materials, the adhesive and the tea seed powder into a stirrer, stirring for 15 minutes at 200 revolutions per minute, stirring at the temperature of 30 ℃, adding 25 parts by weight of water, and stirring for 50 minutes at the temperature of 30 ℃ at 200 revolutions per minute to obtain a mixed material;
(5) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 4MPa for 5 seconds at 50 ℃, and demolding to obtain a drug fragrance primary product for regulating the heart;
(6) and (3) low-temperature drying: and (3) sending the primary drug fragrance product for regulating the heart into an oven, and drying at 70 ℃ for 5 hours to obtain a finished drug fragrance product for regulating the heart, wherein the length of the drug fragrance product is 24cm, and the diameter of the drug fragrance product is 3 mm.
The dispersion medium in the step (3) is water.
The adhesive in the step (4) is glutinous rice flour.
Example 3
The medicine fragrance raw materials for regulating the heart (parts by weight): 2 parts of mulberry twig, 2 parts of cassia twig, 2 parts of angelica dahurica, 4 parts of astragalus mongholicus, 4 parts of coptis chinensis, 4 parts of agilawood, 4 parts of rosewood, 4 parts of sandalwood, 4 parts of dipsacus root, 6 parts of ligusticum wallichii, 6 parts of salvia miltiorrhiza, 6 parts of caulis spatholobi, 4 parts of radix scrophulariae, 4 parts of radix ophiopogonis, 6 parts of safflower carthamus, 6 parts of radix paeoniae rubra, 4 parts of radix sileris, 6 parts of spina date seed, 6 parts of poria cocos, 6 parts of allium macrostemon, 4 parts of angelica sinensis, 4 parts of rhizoma corydalis, 2 parts of pseudo-ginseng.
A preparation method of a drug incense for regulating heart comprises the following steps:
(1) pretreatment: preliminarily crushing the traditional Chinese medicinal materials into 10 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily crushed traditional Chinese medicinal materials in 52-degree white spirit for 2 hours, wherein the mass ratio of the traditional Chinese medicinal materials to the white spirit is 1:2, filtering by using 300-mesh filter cloth, and drying filter residues at 70 ℃ for 5 hours to obtain wine-soaked traditional Chinese medicinal materials;
(3) superfine grinding: soaking the traditional Chinese medicinal materials in wine and a dispersion medium according to the mass ratio of 1: 3, uniformly mixing, adding into an ultrafine grinder, and grinding for 30 minutes at 30 ℃ to obtain ultrafine ground traditional Chinese medicinal materials;
(4) nano-crystallization: pulverizing the superfine pulverized Chinese medicinal materials with a nanometer collider, pulverizing the Chinese medicinal materials into nanometer powder at 130MPa and 300rpm, and drying at 70 deg.C for 12 hr to obtain nanometer Chinese medicinal powder;
(5) mixing materials: adding the nano-scale traditional Chinese medicine powder, the adhesive and the tea seed powder into a stirrer, stirring for 15 minutes at 200 revolutions per minute, stirring at the temperature of 30 ℃, adding 25 parts by weight of water, and stirring for 50 minutes at the temperature of 30 ℃ at 200 revolutions per minute to obtain a mixed material;
(6) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 4MPa for 5 seconds at 50 ℃, and demolding to obtain a drug fragrance primary product for regulating the heart;
(7) and (3) low-temperature drying: and (3) sending the primary drug fragrance product for regulating the heart into an oven, and drying at 70 ℃ for 5 hours to obtain a finished drug fragrance product for regulating the heart, wherein the length of the drug fragrance product is 24cm, and the diameter of the drug fragrance product is 3 mm.
The dispersion medium in the step (3) is water.
The adhesive in the step (5) is glutinous rice flour.
Example 4
Essentially the same as example 3, except that:
the dispersion medium in the step (3) is a sucrose ester aqueous solution with the mass fraction of 1%.
Example 5
Essentially the same as example 3, except that:
and (4) the dispersion medium in the step (3) is absolute ethyl alcohol.
Example 6
Essentially the same as example 3, except that:
the dispersion medium in the step (3) is glycerol.
Example 7
Essentially the same as example 3, except that:
the dispersing medium in the step (3) is PEG-400.
Example 8
Essentially the same as example 4, except that:
the dispersion medium in the step (3) is a sucrose ester water solution with the mass fraction of 0.5%.
Example 9
Essentially the same as example 4, except that:
the dispersion medium in the step (3) is sucrose ester water solution with the mass fraction of 1.5%.
Example 10
Essentially the same as example 4, except that:
the adhesive in the step (5) is sodium alginate. And (3) a sterilization performance test result: the natural bacteria extinction rate is 79% in 1 hour; the combustion performance test results are as follows: the burning time was 57min/24cm, and the weight of the burning residue was 52mg/24 cm.
Example 11
Essentially the same as example 4, except that:
the adhesive in the step (5) is formed by mixing glutinous rice flour and sodium alginate according to a mass ratio of 5: 1. And (3) a sterilization performance test result: the natural bacteria extinction rate in 1 hour is 91%, and the combustion performance test result is as follows: the burning time was 72min/24cm and the weight of the burning residue was 30mg/24 cm.
Test example 1
The bactericidal properties of the drugs for regulating the heart obtained in examples 1 to 9 were examined, and the results are shown in table 1.
Table 1: bactericidal performance test result table
Figure GDA0002535079630000091
Figure GDA0002535079630000101
Example 3 uses the ultra-micro pulverization and nanocrystallization technology, and the sterilization effect is superior to that of examples 1 and 2, because the ultra-micro pulverization and nanocrystallization technology of the traditional Chinese medicine enables the medicine powder to reach the nanometer level, and the pharmaceutical chemical factors are fully released in the combustion process, so that the good sterilization effect is achieved.
Example 4 adopts sucrose ester aqueous solution with mass fraction of 1% as dispersion medium in the process of superfine grinding, and the combustion effect is better than that of examples 3 and 5-7, and the dispersion medium in the prior art is usually water, ethanol, glycerol, PEG-400, etc. the inventors of the present invention unexpectedly found that the sucrose ester aqueous solution has good effect, because the good dispersion performance of the sucrose ester aqueous solution enables the traditional Chinese medicine particles in the superfine grinding process to be fully dispersed, the sizes of the medicine particles are uniform, the traditional Chinese medicine powder in the nanometer process reaches nanometer level, and the drug molecules can be fully released in the combustion process.
Example 4 the combustion effect of the drug fragrance was better than those of examples 8 and 9 at a concentration of 1% in the aqueous solution of sucrose ester.
Test example 2
The burning performance of the medicine for regulating the heart obtained in examples 1 to 9 was examined, and the specific results are shown in Table 2.
TABLE 2 burn test of heart-modifying drug fragrance
Figure GDA0002535079630000102
Figure GDA0002535079630000111
Example 3 uses the ultra-fine pulverization and nanocrystallization techniques, and the combustion effect is superior to that of examples 1 and 2, because the ultra-fine pulverization and nanocrystallization techniques of the traditional Chinese medicine enable the powder to be uniformly mixed, the internal gaps of the medicine fragrance are small, and the combustion time is long and the combustion is sufficient.
Example 4 adopts sucrose ester aqueous solution with a mass fraction of 1% as a dispersion medium in the process of superfine grinding, and the combustion effect is better than that of examples 3 and 5-7, because the good dispersion property of the sucrose ester aqueous solution enables the traditional Chinese medicine particles to be uniform in the process of superfine grinding, and the materials can be fully dispersed in the process of mixing the materials, thereby reducing the internal gaps of the medicine fragrance.
Example 4 the combustion effect of the drug fragrance was better than those of examples 8 and 9 at a concentration of 1% in the aqueous solution of sucrose ester.
Test example 3
The therapeutic effects of the drugs for regulating the heart obtained in examples 1 to 11 were examined.
The test method comprises the following steps: 220 patients with heart disease aged 20-60 years were selected, randomly divided into 11 groups of 20, and subjected to moxibustion with 5 drugs per day using the herbal incense for heart modulation prepared in examples 1-11, respectively. The data of the treatment effect after 60 days are shown in Table 3.
Patient symptoms: intermittent pulse, choking pain in the anterior chest, palpitations and movement, and color Doppler diagnosis in hospitals.
Treatment criteria were:
(1) the effect is shown: the symptoms are eliminated, the appetite is increased, the physical strength is increased, and the life is as normal people.
(2) The method has the following advantages: the symptoms are partially eliminated, the appetite is increased, and the physical strength is slightly recovered.
(3) And (4) invalidation: no obvious change of symptoms
Table 3: patient condition data sheet
Figure GDA0002535079630000112
Figure GDA0002535079630000121

Claims (5)

1. The preparation method of the medicine incense for regulating the heart is characterized by comprising the following steps:
(1) pretreatment: primarily crushing the traditional Chinese medicinal materials into 10-20 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily pulverized Chinese medicinal materials in 50-60% (v/v) Chinese liquor for 1-3 hr, filtering, and oven drying at low temperature to obtain Chinese medicinal materials soaked in the Chinese liquor;
(3) superfine grinding: soaking the traditional Chinese medicinal materials in wine and a dispersion medium according to the mass ratio of 1: (2-4) uniformly mixing, adding into an ultrafine pulverizer, and pulverizing at 25-35 deg.C for 30-40 min to obtain ultrafine pulverized Chinese medicinal materials;
(4) nano-crystallization: pulverizing superfine pulverized Chinese medicinal materials with nanometer collider, pulverizing into nanometer powder at 130MPa and 300rpm, and drying at 60-80 deg.C for 10-14 hr to obtain nanometer Chinese medicinal powder;
(5) mixing materials: adding the nanometer Chinese medicinal powder, adhesive and combustion improver into a stirrer, stirring at 200 r/min for 15 min at 25-35 deg.C, adding water, and stirring at 25-35 deg.C at 200 r/min for 40-60 min to obtain a mixture;
(6) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 2-5MPa for 1-10 s at 45-60 deg.C, and demolding to obtain medicinal fragrance product for regulating heart;
(7) and (3) low-temperature drying: sending the primary drug fragrance product for regulating heart into an oven, and drying at 60-80 deg.C for 4-6 hr to obtain the final drug fragrance product for regulating heart;
the adhesive is prepared from glutinous rice flour and sodium alginate in a mass ratio of (1-10): 1;
the dispersion medium is sucrose ester aqueous solution;
the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 1-3 parts of mulberry twig, 1-3 parts of cassia twig, 1-3 parts of angelica dahurica, 3-5 parts of astragalus membranaceus, 3-5 parts of coptis chinensis, 3-5 parts of agilawood, 3-5 parts of dalbergia wood, 3-5 parts of sandalwood, 3-5 parts of dipsacus root, 5-8 parts of ligusticum chuanxiong hort, 5-8 parts of salvia miltiorrhiza, 5-8 parts of caulis spatholobi, 3-5 parts of radix scrophulariae, 3-5 parts of radix ophiopogonis, 5-8 parts of safflower, 5-8 parts of radix paeoniae rubra, 3-5 parts of radix saposhnikoviae, 5-8 parts of spina date seed, 5-8 parts of poria cocos, 5-8 parts of allium macrostemon, 3-5 parts of angelica sinensis, 3-5.
2. The method for preparing a heart-regulating medicinal fragrance according to claim 1, wherein the combustion improver in step (5) is tea seed powder.
3. The preparation method of the heart-regulating medicinal incense according to claim 1, wherein the mass ratio of the Chinese medicinal materials to the white spirit in the step (2) is 1: (1-3).
4. The method for preparing a heart-regulating herbal incense according to claim 1, wherein the method for preparing the heart-regulating herbal incense comprises the following steps:
(1) pretreatment: preliminarily crushing the traditional Chinese medicinal materials into 10 meshes by using a coarse crusher;
(2) soaking in wine: soaking the primarily crushed traditional Chinese medicinal materials in 52-degree white spirit for 2 hours, wherein the mass ratio of the traditional Chinese medicinal materials to the white spirit is 1:2, filtering by using 300-mesh filter cloth, and drying filter residues at 70 ℃ for 5 hours to obtain wine-soaked traditional Chinese medicinal materials;
(3) superfine grinding: soaking the traditional Chinese medicinal materials in wine and a dispersion medium according to the mass ratio of 1: 3, uniformly mixing, adding into an ultrafine grinder, and grinding for 30 minutes at 30 ℃ to obtain ultrafine ground traditional Chinese medicinal materials;
(4) nano-crystallization: pulverizing the superfine pulverized Chinese medicinal materials with a nanometer collider, pulverizing the Chinese medicinal materials into nanometer powder at 130MPa and 300rpm, and drying at 70 deg.C for 12 hr to obtain nanometer Chinese medicinal powder;
(5) mixing materials: adding the nano-scale traditional Chinese medicine powder, the adhesive and the tea seed powder into a stirrer, stirring for 15 minutes at 200 revolutions per minute, stirring at the temperature of 30 ℃, adding 25 parts by weight of water, and stirring for 50 minutes at the temperature of 30 ℃ at 200 revolutions per minute to obtain a mixed material;
(6) and (3) pressing and forming: adding the mixed material into a membrane press, keeping the pressure at 4MPa for 5 seconds at 50 ℃, and demolding to obtain a drug fragrance primary product for regulating the heart;
(7) and (3) low-temperature drying: sending the primary drug fragrance product for regulating the heart into an oven, and drying at 70 ℃ for 5 hours to obtain a finished drug fragrance product for regulating the heart, wherein the length of the drug fragrance product is 24cm, and the diameter of the drug fragrance product is 3 mm;
the dispersion medium in the step (3) is a sucrose ester aqueous solution with the mass fraction of 1%;
the adhesive in the step (5) is formed by mixing glutinous rice flour and sodium alginate according to a mass ratio of 5: 1;
the medicine fragrance raw materials for regulating the heart comprise the following components in parts by weight: 2 parts of mulberry twig, 2 parts of cassia twig, 2 parts of angelica dahurica, 4 parts of astragalus mongholicus, 4 parts of coptis chinensis, 4 parts of agilawood, 4 parts of rosewood, 4 parts of sandalwood, 4 parts of dipsacus root, 6 parts of ligusticum wallichii, 6 parts of salvia miltiorrhiza, 6 parts of caulis spatholobi, 4 parts of radix scrophulariae, 4 parts of radix ophiopogonis, 6 parts of safflower carthamus, 6 parts of radix paeoniae rubra, 4 parts of radix sileris, 6 parts of spina date seed, 6 parts of poria cocos, 6 parts of allium macrostemon, 4 parts of angelica sinensis, 4 parts of rhizoma corydalis, 2 parts of pseudo-ginseng.
5. A medicated incense for regulating the heart, prepared by the method of any one of claims 1 to 4.
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