CN106999933B - 微泡产生器装置、系统及其制造方法 - Google Patents

微泡产生器装置、系统及其制造方法 Download PDF

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Publication number
CN106999933B
CN106999933B CN201580062737.9A CN201580062737A CN106999933B CN 106999933 B CN106999933 B CN 106999933B CN 201580062737 A CN201580062737 A CN 201580062737A CN 106999933 B CN106999933 B CN 106999933B
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China
Prior art keywords
microfluidic
microbubble
microheater
microfluidic device
microbubble generator
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English (en)
Chinese (zh)
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CN106999933A (zh
Inventor
刘诚迅
P·波伊曼斯
L·拉哈
B·马吉德
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Interuniversitair Microelektronica Centrum vzw IMEC
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Interuniversitair Microelektronica Centrum vzw IMEC
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201580062737.9A 2014-11-19 2015-11-19 微泡产生器装置、系统及其制造方法 Active CN106999933B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193831 2014-11-19
EP14193831.6 2014-11-19
PCT/EP2015/077164 WO2016079269A1 (en) 2014-11-19 2015-11-19 Microbubble generator device, systems and method to fabricate

Publications (2)

Publication Number Publication Date
CN106999933A CN106999933A (zh) 2017-08-01
CN106999933B true CN106999933B (zh) 2019-10-18

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CN201580062737.9A Active CN106999933B (zh) 2014-11-19 2015-11-19 微泡产生器装置、系统及其制造方法

Country Status (6)

Country Link
US (1) US10124338B2 (cg-RX-API-DMAC7.html)
EP (1) EP3221049B1 (cg-RX-API-DMAC7.html)
JP (1) JP6594975B2 (cg-RX-API-DMAC7.html)
CN (1) CN106999933B (cg-RX-API-DMAC7.html)
CA (1) CA2967135A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016079269A1 (cg-RX-API-DMAC7.html)

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CN103945931B (zh) 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
EP3229959B1 (en) 2014-12-09 2019-05-15 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US11358144B2 (en) 2016-12-22 2022-06-14 Imec Vzw Microfluidic device for sorting out droplets
US11338291B2 (en) 2016-12-27 2022-05-24 Imec Vzw Jet flow power control for object sorting
CN109781975B (zh) * 2017-11-14 2022-05-06 河南乾坤科技有限公司 富集循环稀有细胞的试剂及方法
WO2019143611A1 (en) * 2018-01-16 2019-07-25 The Regents Of The University Of California In-situ sweat rate monitoring for normalization of sweat analyte concentrations
WO2020094848A1 (en) * 2018-11-08 2020-05-14 Katholieke Universiteit Leuven Screening and sorting of single cells
JP7278799B2 (ja) * 2019-02-28 2023-05-22 キヤノン株式会社 微細バブル生成装置、及び微細バブル生成方法
JP7277180B2 (ja) * 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成装置およびウルトラファインバブル生成方法
JP7278801B2 (ja) * 2019-02-28 2023-05-22 キヤノン株式会社 ウルトラファインバブル生成装置、及びウルトラファインバブルの製造方法
JP7277179B2 (ja) * 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成装置
JP7277176B2 (ja) * 2019-02-28 2023-05-18 キヤノン株式会社 ウルトラファインバブル生成方法、およびウルトラファインバブル生成装置
JP7317521B2 (ja) * 2019-02-28 2023-07-31 キヤノン株式会社 ウルトラファインバブル生成装置およびウルトラファインバブル生成方法
CN111617651B (zh) * 2019-02-28 2023-11-03 佳能株式会社 超精细气泡生成方法、超精细气泡生成装置和含有超精细气泡的液体
JP7282548B2 (ja) * 2019-02-28 2023-05-29 キヤノン株式会社 ウルトラファインバブル生成方法、およびウルトラファインバブル生成装置
JP7433840B2 (ja) * 2019-10-31 2024-02-20 キヤノン株式会社 ウルトラファインバブル含有液の作製装置、及びウルトラファインバブル含有液の作製方法
JP2021069993A (ja) * 2019-10-31 2021-05-06 キヤノン株式会社 ウルトラファインバブル生成装置およびその制御方法

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US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
CN1883031A (zh) * 2003-09-30 2006-12-20 特雷西特技术公司 制造片形结构的方法、特别是由硅制造片形结构的方法、所述方法的应用、和由此制备的片形结构、特别是由硅制造的片形结构
CN101360817A (zh) * 2005-10-10 2009-02-04 加州大学评议会 使生物材料和非生物材料形成图案用的微泡板
WO2010147078A1 (ja) * 2009-06-19 2010-12-23 国立大学法人東京大学 粒子を操作する方法及びマイクロ流体装置
CN103691384A (zh) * 2013-12-11 2014-04-02 华南师范大学 一种微泡发生器及其制作方法与应用

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JP2010533840A (ja) * 2007-07-13 2010-10-28 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ 改善された生物学的アッセイのための電場を用いる方法および器具
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US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
CN1883031A (zh) * 2003-09-30 2006-12-20 特雷西特技术公司 制造片形结构的方法、特别是由硅制造片形结构的方法、所述方法的应用、和由此制备的片形结构、特别是由硅制造的片形结构
CN101360817A (zh) * 2005-10-10 2009-02-04 加州大学评议会 使生物材料和非生物材料形成图案用的微泡板
WO2010147078A1 (ja) * 2009-06-19 2010-12-23 国立大学法人東京大学 粒子を操作する方法及びマイクロ流体装置
CN103691384A (zh) * 2013-12-11 2014-04-02 华南师范大学 一种微泡发生器及其制作方法与应用

Also Published As

Publication number Publication date
US20170341078A1 (en) 2017-11-30
JP2018504284A (ja) 2018-02-15
EP3221049A1 (en) 2017-09-27
EP3221049B1 (en) 2019-04-17
CA2967135A1 (en) 2016-05-26
WO2016079269A1 (en) 2016-05-26
JP6594975B2 (ja) 2019-10-23
US10124338B2 (en) 2018-11-13
CN106999933A (zh) 2017-08-01

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