CN106983923A - Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood - Google Patents
Urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood Download PDFInfo
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- CN106983923A CN106983923A CN201710282693.1A CN201710282693A CN106983923A CN 106983923 A CN106983923 A CN 106983923A CN 201710282693 A CN201710282693 A CN 201710282693A CN 106983923 A CN106983923 A CN 106983923A
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- 238000012544 monitoring process Methods 0.000 title claims abstract description 116
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- 238000001631 haemodialysis Methods 0.000 title claims abstract description 78
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 16
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1613—Profiling or modelling of patient or predicted treatment evolution or outcome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
The present invention relates to urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood, blood sample testing model is set up using near infrared spectrometer and the changes of contents that hemodialysis dialyzer imports and exports urea nitrogen in blood is monitored on-line, monitored, prevented according to the changes of contents rule of urea nitrogen in hemodialysis blood, avoiding hemodialysis accident from occurring, so as to provide scientific basis for the treatment of uremic patient, the purpose for improving patient's treatment of kidney disease level is reached.
Description
Technical field
The present invention relates to urea nitrogen content on-line monitoring method and system in a kind of hemodialysis blood, more particularly to one kind is adopted
Urea nitrogen content on-line monitoring method and system in the hemodialysis blood detected near infrared spectrum.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, every year with the speed increase more than 10%, and patient is controlled dialysis
The demand for the treatment of is very big.
Blood dialysis therapy is the principle using pellicle, and the blood of patient and dialyzate are introduced inside and outside dialyzer simultaneously
Side, by means of solute gradient, osmotic gradient and the spread of film both sides, by diffusion, convection current, removes toxin etc., by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaving required material, corrects electrolyte and soda acid is flat
Weighing apparatus is disorderly.
Urea is the main dead end product of human body protein metabolism, and amino acid deamination produces NH3And C02, both are in liver
Middle urea synthesis, every gram of protein metabolism produces about 0.3 gram of urea nitrogen.Usual kidney is the major organs of excretion urea, urea
Can reabsorption in each section of tubule after glomerular filtration.Normal adult's empty stomach urea nitrogen be 3.2~7.1mmol/L (9~
20mg/d1).Various parenchymal lesion of the kidney, such as glomerulonephritis, interstitial nephritis, acute or chronic renal failure can make blood
Urea nitrogen increases.If excluding kidney other factor, urea nitrogen 21.4mmol/L (60mg/d1) is one of uremia diagnosis index.
When patient exceeded to urea nitrogen content in blood carries out hemodialysis, dialyzer need to be used.Dialyzer may
Appearance is blocked or disrepair phenomenon.The reason for dialyzer is blocked mainly has：A, blood are oversize from the pump time in vitro, and this is that dialyzer is blocked up
The main cause of plug；B, heparin consumption are not enough, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~
0.5mg/kg, if test tube of hepari is insufficient first, additional heparin amount is big also without positive effect again in dialysis；C, dialysis person itself because
In disease, nephrosis whole latter stage, blood viscosity increases.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the changing rule of haemoconcentration.Such as
When dialysis membrane is progressively blocked, the urea nitrogen content in blood can gradually rise, when with normal urea nitrogen content more than a fixed limit
When spending, it can in time be reminded by warning device, be prevented effectively from the generation of harm.
Furthermore, by monitoring the change of urea nitrogen content in hemodialysis blood on-line, dialyzer breakage can be found in time.
When hollow-fibre membrane such as dialyzer occurs damaged, the urea nitrogen content in blood can be reduced substantially, can be timely by monitoring
It was found that dialyzer is damaged, the generation of accident is handled and avoided in time.
Prior art is prevented using electrical conductivity detection, haemoconcentration monitoring etc., but there is also certain shortcoming, is such as taken
The promptness of sample detection is not enough and producing pollution, concentration monitor needs high-precision sensor, sensor probe to occur corruption
Lose phenomenon and cause the generation for situations such as measured value is inaccurate.
Near-infrared spectrum technique is the new technique just grown up in recent years, is quickly to scan thing near infrared spectrometer
A kind of Instrumental Analysis means of the matter in the reflection, diffusing reflection or transmitted spectrum of 670~2526nm SPECTRAL REGIONs.Due near infrared light
Spectral analysis technology has that analyze speed is fast, efficiency high, sample are without chemical contamination, without sample pretreatment, online Non-Destructive Testing etc.
Advantage, is widely applied in fields such as food and agricultural products detections at present.But literature search does not find that it is applied to blood
Dialysis on-line monitoring field.
Therefore the change of urea nitrogen content in the advantage of Near Infrared Spectroscopy Detection Technology, on-line monitoring hemodialysis blood how is combined
Change, find hemodialysis when blood in urea nitrogen content changing rule, find hemodialysis when blood in urea nitrogen content change and patient
Urea nitrogen content is under special circumstances such as blocking or breakage in correlation between heart rate, blood pressure, dialysate flow, searching blood
Changing rule, one of the problem as the area research.
The content of the invention
The present invention is to be monitored on-line to solve the problem of prior art is present there is provided urea nitrogen content in a kind of hemodialysis blood
Method and system, set up blood sample testing model using near infrared spectrometer and monitor on-line containing for urea nitrogen in hemodialysis blood
Amount change, reaches that the purpose for the treatment of of kidney disease level occurs, improved for prevention hemodialysis accident.
Urea nitrogen content on-line monitoring method in a kind of hemodialysis blood of offer of the present invention, comprises the following steps：
1) the hemodialysis blood sample of different urea nitrogen contents is prepared；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) blood is imported and exported to hemodialysis dialyzer using on-line monitoring probe and carries out near infrared spectra collection, by the saturating of collection
The near infrared spectrum of urea nitrogen content and step 3 in parser import or export blood) urea nitrogen content is quantified in the blood set up
Differentiate that model is compared, quickly determine that dialyzer to be checked imports and exports the urea nitrogen content in blood.
In addition, the present invention also provides urea nitrogen content on-line monitoring system in a kind of hemodialysis blood, including the circulation of blood side,
Dialysis fluid side is circulated and dialyzer 4；The circulation of blood side includes, and human body artery blood outlet side 1, blood pump 2, the monitoring of the first blood are visited
First 14, arterial circulation conduit 3, venous blood circulation conduit 6, human vein blood input side 8, the inspection of the first near infrared spectrum
Survey data circuit 16 and near infrared light spectrum monitoring instrument 17；Arterial circulation conduit 3 connects human body artery blood outlet side 1 and saturating
The blood entry port of parser 4；The blood outlet of the connection dialyzer 4 of venous blood circulation conduit 6 and human vein blood input side 8；
First blood monitoring probe 14 is arranged on arterial circulation conduit 3 or venous blood circulation conduit 6；First near infrared spectrum
Detect that data circuit 16 connects the first blood monitoring probe 14 and near infrared light spectrum monitoring instrument 17；Dialysis fluid side circulation includes, thoroughly
Analyse liquid bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line 13 and dialyzate recycling bin 15；Dialyzate enters
The dialyzate entrance of the mouth connection dialyzate of pipeline 11 bucket 9 and dialyzer 4；Dialyzate outlet line 13 connects the dialysis of dialyzer 4
Liquid is exported and dialyzate recycling bin 15；Dialysis liquid pump 10 is arranged in dialyzate inlet line 11；First blood monitoring probe 14
Gather the near infrared spectrum of urea nitrogen content in the blood of the import or export of dialyzer 4.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：The circulation of blood side also includes, the second blood monitoring probe 18 and the second near infrared spectrum detection data circuit 19；First
Blood monitoring probe 14 is arranged on arterial circulation conduit 3；Second blood monitoring probe 18 is arranged on venous blood circulation
On conduit 6；Second near infrared spectrum detection data circuit 19 connects the second blood monitoring probe 18 and near infrared light spectrum monitoring instrument
17。
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：First blood monitoring probe 14 gathers the near infrared spectrum of urea nitrogen content in the import or export blood of dialyzer 4, warp
First near infrared spectrum detection data circuit 16 enters near infrared light spectrum monitoring instrument 17, with the hemodialysis blood based near infrared spectrum
Middle urea nitrogen content quantitatively differentiates that model is compared and obtains hemodialysis blood and import and export urea nitrogen content and to record in real time in blood.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：Urea nitrogen content quantitatively differentiates that model refers to prepare different urea nitrogen contents in hemodialysis blood based near infrared spectrum
Hemodialysis blood sample, using near infrared spectrometer to the blood sample carry out spectra collection, so as to set up based on near-infrared
Urea nitrogen content quantitatively differentiates model in the hemodialysis blood of spectrum.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：Urea nitrogen content on-line monitoring system is provided with bubble capture monitor 7 in hemodialysis blood, is arranged on venous blood circulation
On conduit 6.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：First blood monitoring probe 14 and/or the second blood monitoring probe 18 include probing shell 21, blood channel 24, near
Infrared receiver room 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at probing shell 21
Both sides, middle to run through probing shell 21 by blood channel 24, near-infrared receiving chamber 29 and near infrared emission room 32 are respectively by near
Infrared receiver hole 25 connects blood channel 24 near infrared emission hole 30, and near-infrared receiving batter 25 and near infrared emission hole 30 are same
Axle；Near infrared emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber 29 is near
The position in infrared receiver hole 25 is provided with near-infrared receiving closed tube 27；Near-infrared receiving chamber 29 is provided with circuit board 28 and near-infrared receiving closed tube
27 connections；The outside of probing shell 21 is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29 by wire guide 22, near red
Outer bay 32 and outside；Blood channel 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole 30；
First blood monitoring probe 14 or the second blood monitoring probe 18 also include two connection difference shapes of probing shell 21 of closure 26
Into near-infrared receiving chamber 29 and near infrared emission room 32；Blood near infrared light monitoring blood channel 24, the spectrum of collection
Signal is drawn through the first blood monitoring probe the 14, second blood monitoring 18 inner leads of probe by connector 23 from conduit,
Detect that data circuit 16, the second near infrared spectrum detection data circuit 19 enter near infrared spectrum through the first near infrared spectrum respectively
Monitor 17, obtains in hemodialysis blood urea nitrogen content and records in real time.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：Closure 26 is threadedly coupled with probing shell 21 by sealing；Connector 23, probing shell 21 and closure 26 are used
Stainless steel.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：Blood near infrared light normal transmission blood channel 24.
Further, the present invention urea nitrogen content on-line monitoring system in a kind of hemodialysis blood is also provided, can also have with
Lower feature：Urea nitrogen content on-line monitoring system is provided with heparin pump 20 in hemodialysis blood, is arranged on arterial circulation conduit 3
On；The parenteral solution of preparation injects blood through heparin pump 20.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the present invention.
The beneficial effect of invention
1st, by the content of urea nitrogen in on-line real time monitoring blood, can quickly judge dialyzer whether occur block or
Disrepair phenomenon, so as to handle, prevent the generation of malpractice in time；
2nd, the detection time of on-line monitoring is short, and urea nitrogen content data are more in the blood of acquisition, when helping to find out hemodialysis
The changing rule of urea nitrogen content in blood, when helping to search out hemodialysis in blood urea nitrogen content change with Heart Rate,
Correlation between blood pressure, dialysate flow, so as to provide scientific basis for the treatment of uremic patient；
3rd, Fast nondestructive evaluation is really realized, compared with other monitoring methods, human error and systematic error are effectively reduced,
Model accuracy rate is high, improves operating efficiency；
4th, the prevention, treatment, first aid for nephrosis provide reliable technology guarantee, and economy, social effect are huge.
Brief description of the drawings
Fig. 1 is urea nitrogen content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the present invention.
The structural representation that Fig. 2 pops one's head in for the blood monitoring in the present invention.
Reference:
1- human body artery blood outlet sides；2- blood pumps；3- arterial circulation conduits；4- dialyzers；5- hollow-fibre membranes；
6- venous blood circulation conduits；7- bubble capture monitors；8- human vein blood input sides；The clean dialyzate buckets of 9-；10- is saturating
Analyse liquid pump；11- dialyzate inlet lines；12- dialyzer dialysis fluid sides；13- dialyzate outlet lines；The blood of 14- first is monitored
Probe；The used dialyzate recycling bins of 15-；The near infrared spectrums of 16- first detect data circuit；17- near infrared light spectrum monitoring instruments；
The blood of 18- second monitoring probe；The near infrared spectrums of 19- second detect data circuit；20- heparin pumps；21- probing shells；22- is led
String holes；23- connectors；24- blood channels；25- near-infrared receiving batters；26- closures；27- near-infrared receiving closed tubes；28- circuits
Plate；29- near-infrared receiving chambers；30- near infrared emissions hole；31- near infrared emission pipes；32- near infrared emissions room；33- quartz glass
Glass.
Embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
A kind of urea nitrogen content on-line monitoring method in hemodialysis blood, this method comprises the following steps：
1) the hemodialysis blood sample of different urea nitrogen contents is prepared, sample size, which is met, sets up wanting for Sample model
Ask；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) blood is imported and exported to hemodialysis dialyzer using on-line monitoring probe and carries out near infrared spectra collection, by the saturating of collection
Parser imports and exports near infrared spectrum and the step 3 of urea nitrogen content in blood) urea nitrogen content quantitatively differentiates in the blood of foundation
Model is compared, and quickly determines that dialyzer to be checked imports and exports the urea nitrogen content in blood.
Fig. 1 is urea nitrogen content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the present invention.
As shown in figure 1, urea nitrogen content on-line monitoring system in a kind of hemodialysis blood, including：The circulation of blood side, dialyzate
Circulate and dialyzer 4 side.Dialyzer 4 has hollow-fibre membrane 5 and dialysis fluid side 12.
The circulation of blood side includes：Human body artery blood outlet side 1, blood pump 2, the first blood monitoring probe 14, arterial blood
Circulation conduit 3, the second blood monitoring probe 18, venous blood circulation conduit 6, human vein blood input side 8, the first near-infrared
Spectral detection data circuit 16, the second near infrared spectrum detection data circuit 19 and near infrared light spectrum monitoring instrument 17.
The blood entry port of the connection human body artery blood of arterial circulation conduit 3 outlet side 1 and dialyzer 4.Venous blood
The blood outlet of the connection dialyzer 4 of circulation conduit 6 and human vein blood input side 8.First blood monitoring probe 14 is arranged on
On arterial circulation conduit 3.First near infrared spectrum detection data circuit 16 connects the first blood monitoring probe 14 and near red
External spectrum monitor 17.Second blood monitoring probe 18 is arranged on venous blood circulation conduit 6.Second near infrared spectrum is detected
Data circuit 19 connects the second blood monitoring probe 18 and near infrared light spectrum monitoring instrument 17.
Dialysis fluid side circulation includes：Dialyzate bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line
13 and dialyzate recycling bin 15.The dialyzate entrance of the connection dialyzate of dialyzate inlet line 11 bucket 9 and dialyzer 4.Dialyzate
The dialyzate outlet of the connection dialyzer 4 of outlet line 13 and dialyzate recycling bin 15.Dialysis liquid pump 10 is arranged on dialyzate import
On pipeline 11.
First blood monitoring probe 14 gathers the near infrared spectrum of urea nitrogen content in the import blood of dialyzer 4, through first
Near infrared spectrum detection data circuit 16 enters near infrared light spectrum monitoring instrument 17, with being urinated in the hemodialysis blood based near infrared spectrum
Plain nitrogen content quantitatively differentiates that model is compared and obtains in hemodialysis blood inlet blood urea nitrogen content and record in real time.Second blood is supervised
The near infrared spectrum of urea nitrogen content, data are detected through the second near infrared spectrum in the first 18 collection exit blood of dialyzer 4 of probing
Circuit 18 enters near infrared light spectrum monitoring instrument 17, and mould is quantitatively differentiated with urea nitrogen content in the hemodialysis blood based near infrared spectrum
Type, which is compared, to be obtained in hemodialysis blood exit blood urea nitrogen content and records in real time.
The workflow of urea nitrogen content on-line monitoring system in a kind of hemodialysis blood：The human body artery blood of blood side circulation
The blood that liquid outlet side 1 is exported enters through the blood channel in blood pump 2, the first blood monitoring probe 14, arterial circulation conduit 3
Enter dialyzer 4, blood carries out solute through the hollow-fibre membrane 5 in dialyzer 4 and dialyzate and exchanged, then is led through venous blood circulation
Pipe 6, the blood channel in the second blood monitoring probe 18, human vein blood input side 8 return to human body.Dialysis fluid side circulation
Dialyzate in clean dialyzate bucket 9 enters dialyzer dialysis fluid side 12 through dialyse liquid pump 10, dialyzate inlet line 11, with
Blood in hollow fiber film 5 carries out solute exchange, then enters used dialyzate recycling bin 15 through dialyzate outlet line 13；The
One blood monitoring probe the 14, second blood monitoring probe 18 gathers the near infrared spectrum for the blood that dialyzer 4 is imported and exported, and passes through respectively
First near infrared spectrum detection data circuit 16, the second near infrared spectrum detection data circuit 19 enter near infrared light spectrum monitoring instrument
17, quantitatively differentiate that model is compared with urea nitrogen content in the hemodialysis blood based near infrared spectrum and obtain the import and export of hemodialysis dialyzer
Urea nitrogen content and recorded in real time in blood.
Urea nitrogen content quantitatively differentiates that model refers to that preparing different urea nitrogens contains in hemodialysis blood based near infrared spectrum
The hemodialysis blood sample of amount, spectra collection is carried out using near infrared spectrometer to the blood sample, so as to set up based near red
Urea nitrogen content quantitatively differentiates model in the hemodialysis blood of external spectrum.
The blood come out from dialyzer 4 is supervised through venous blood circulation conduit 6, the second blood monitoring probe 18, bubble capture
Survey device 7, human vein blood input side 8 and return to human body.
The blood that human body artery blood outlet side 1 is exported is through blood pump 2, the first blood monitoring probe 14, heparin pump 20, artery
Blood circulation conduit 3 enters dialyzer 4；The parenteral solution of preparation injects blood through heparin pump 20.
The structural representation that Fig. 2 pops one's head in for the blood monitoring in the present invention.
As shown in Fig. 2 the first blood monitoring probe 14 and the second blood monitoring probe 18 include probing shell 21, blood and led to
Road 24, near-infrared receiving chamber 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at spy
The both sides of casing 21, it is middle that 32 points of probing shell 21, near-infrared receiving chamber 29 and near infrared emission room are run through by blood channel 24
Blood channel 24, near-infrared receiving batter 25 and near infrared emission are not connected near infrared emission hole 30 by near-infrared receiving batter 25
Hole 30 is coaxial；Near infrared emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber
29 are provided with near-infrared receiving closed tube 27 in the position of near-infrared receiving batter 25；Near-infrared receiving chamber 29 is provided with circuit board 28 and near-infrared
Reception pipe 27 is connected.
The outside of probing shell 21 is provided with connector 23, and connector 23 connects near-infrared receiving chamber 29 by wire guide 22, near
Infrared emission room 32 and outside；Blood channel 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole
30；First
First blood monitoring probe 14 and the second blood monitoring probe 18 also include two connection probing shells of closure 26
21 form near-infrared receiving chamber 29 and near infrared emission room 32 respectively.
Blood near infrared light monitoring blood channel 24, the spectral signal of collection through the first blood monitoring probe 14,
Second blood monitoring 18 inner leads of probe are drawn by connector 23 from conduit, detect number through the first near infrared spectrum respectively
Enter near infrared light spectrum monitoring instrument 17 according to circuit 16, the second near infrared spectrum detection data circuit 19, obtain urinating in hemodialysis blood
Plain nitrogen content is simultaneously recorded in real time.
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Connector 23, probing shell 21 and closure 26 use stainless steel.
Blood near infrared light normal transmission blood channel 24.
Unaccounted technical characteristic and experimental procedure etc. are carried out supporting using ripe prior art in the present invention.
Although the present invention is disclosed as above with preferred embodiment, they be not for limiting the present invention, it is any to be familiar with
This area technical professional, without departing from the spirit and scope of the invention, the variations, modifications, additions or substitutions made,
Still fall within the protection domain of technical solution of the present invention.
Claims (10)
1. urea nitrogen content on-line monitoring method in a kind of hemodialysis blood, it is characterised in that：
Comprise the following steps：
1) the hemodialysis blood sample of different urea nitrogen contents is prepared；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up urea nitrogen content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) near infrared spectra collection is carried out to hemodialysis dialyzer import or export blood using on-line monitoring probe, by the saturating of collection
The near infrared spectrum of urea nitrogen content and step 3 in parser import or export blood) urea nitrogen content is quantified in the blood set up
Differentiate that model is compared, determine that dialyzer to be checked imports and exports the urea nitrogen content in blood.
2. urea nitrogen content on-line monitoring system in a kind of hemodialysis blood, it is characterised in that：Including the circulation of blood side, dialyzate
Circulate and dialyzer (4) side；
Described blood side circulation includes, human body artery blood outlet side (1), blood pump (2), the first blood monitoring probe (14),
Arterial circulation conduit (3), venous blood circulation conduit (6), human vein blood input side (8), the first near infrared spectrum
Detect data circuit (16) and near infrared light spectrum monitoring instrument (17)；The arterial circulation conduit (3) connects the human body and moved
The blood entry port of arteries and veins blood outlet side (1) and dialyzer (4)；The venous blood circulation conduit (6) connects the dialyzer (4)
Blood outlet and the human vein blood input side (8)；The first blood monitoring probe (14) is arranged on the artery
On blood circulation conduit (3) or the venous blood circulation conduit (6)；The first near infrared spectrum detection data circuit (16)
Connect the first blood monitoring probe (14) and the near infrared light spectrum monitoring instrument (17)；
Described dialysis fluid side circulation includes, dialyzate bucket (9), dialysis liquid pump (10), dialyzate inlet line (11), dialyzate
Outlet line (13) and dialyzate recycling bin (15)；The dialyzate inlet line (11) connects the dialyzate bucket (9) and institute
State the dialyzate entrance of dialyzer (4)；The dialyzate outlet line (13) connect the dialyzer (4) dialyzate outlet and
The dialyzate recycling bin (15)；Dialysis liquid pump (10) is arranged on the dialyzate inlet line (11)；
The near-infrared of urea nitrogen content in described the first blood monitoring probe (14) collection dialyzer (4) import or export blood
Spectrum.
3. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：Described blood
The circulation of liquid side also includes, the second blood monitoring probe (18) and the second near infrared spectrum detection data circuit (19)；Described first
Blood monitoring probe (14) is arranged on the arterial circulation conduit (3)；The second blood monitoring probe (18) is set
On the venous blood circulation conduit (6)；The second near infrared spectrum detection data circuit (19) connects second blood
Liquid monitoring probe (18) and the near infrared light spectrum monitoring instrument (17).
4. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：Described
The near infrared spectrum of urea nitrogen content in one blood monitoring probe (14) collection dialyzer (4) import or export blood, through described
First near infrared spectrum detection data circuit (16) enters the near infrared light spectrum monitoring instrument (17), with based near infrared spectrum
Urea nitrogen content quantitatively differentiates that model is compared and obtains hemodialysis blood and import and export urea nitrogen content and real-time in blood in hemodialysis blood
Record.
5. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Urea nitrogen content quantitatively differentiates that model refers to prepare different urea nitrogens in the described hemodialysis blood based near infrared spectrum
The hemodialysis blood sample of content, spectra collection is carried out using near infrared spectrometer to the blood sample, so as to set up based near
Urea nitrogen content quantitatively differentiates model in the hemodialysis blood of infrared spectrum.
6. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Urea nitrogen content on-line monitoring system is arranged on venous blood provided with bubble capture monitor (7) in described hemodialysis blood
On circulation conduit (6).
7. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 3, it is characterised in that：
Described the first blood monitoring probe (14) and/or the second blood monitoring probe (18) include probing shell (21), blood
Passage (24), near-infrared receiving chamber (29) and near infrared emission room (32)；Described near-infrared receiving chamber (29) and near-infrared hair
Penetrate room (32) and be respectively provided at probing shell (21) both sides, it is middle that probing shell (21), near-infrared receiving are run through by blood channel (24)
Receive room (29) and blood is connected near infrared emission hole (30) by near-infrared receiving batter (25) respectively near infrared emission room (32)
Passage (24), near-infrared receiving batter (25) and near infrared emission hole (30) are coaxial；Described near infrared emission room (32) is near red
The position of outer launch hole (30) is provided near infrared emission pipe (31)；Described near-infrared receiving chamber (29) is in near-infrared receiving batter
(25) position is provided with near-infrared receiving closed tube (27)；Described near-infrared receiving chamber (29) is provided with circuit board (28) and near-infrared receiving
Closed tube (27) is connected；
Connector (23) is provided with outside described probing shell (21), the connector (23) connects near red by wire guide (22)
Outer receiving chamber (29), near infrared emission room (32) and outside；Described blood channel (24) is near provided with quartz glass (33) covering
Infrared receiver hole (25) and near infrared emission hole (30)；Described the first blood monitoring probe (14) or the second blood monitoring probe
(18) also include two closure (26) connection probing shells (21), form near-infrared receiving chamber (29) and near infrared emission respectively
Room (32)；
Blood near infrared light monitoring blood channel (24), the spectral signal of collection through the first blood monitoring probe (14),
Second blood monitoring probe (18) inner lead is drawn by connector (23) from conduit, is examined respectively through the first near infrared spectrum
Survey data circuit (16), the second near infrared spectrum detection data circuit (19) and enter near infrared light spectrum monitoring instrument (17), obtain blood
Urea nitrogen content and recorded in real time in saturating blood.
8. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 7, it is characterised in that：
Described closure (26) is threadedly coupled with probing shell (21) by sealing；
Described connector (23), probing shell (21) and closure (26) uses stainless steel.
9. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 7, it is characterised in that：
Blood in described near infrared light normal transmission blood channel (24).
10. urea nitrogen content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Urea nitrogen content on-line monitoring system is provided with heparin pump (20) in described hemodialysis blood：Arterial circulation is arranged on to lead
Manage on (3)；The parenteral solution of preparation injects blood through heparin pump (20).
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| CN201710282693.1A CN106983923B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen content in hemodialysis blood |
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| CN201710282693.1A CN106983923B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for urea nitrogen content in hemodialysis blood |
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| CN106983923B CN106983923B (en) | 2023-09-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113694280A (en) * | 2021-09-02 | 2021-11-26 | 山东威高血液净化制品股份有限公司 | Method for monitoring toxin content distribution in-vitro dialyzer in real time |
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| JPH06327767A (en) * | 1993-05-10 | 1994-11-29 | Shinton Chem Ind Corp Ltd | Device and method for conducting dialysis immediately and properly |
| CN1419918A (en) * | 2001-11-21 | 2003-05-28 | 广州中医药大学第二临床医学院 | Chinese medicine dialysate for maintenance hemodialysis of chronic renal failure, and preparing method thereof |
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2017
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| JPH06327767A (en) * | 1993-05-10 | 1994-11-29 | Shinton Chem Ind Corp Ltd | Device and method for conducting dialysis immediately and properly |
| CN1419918A (en) * | 2001-11-21 | 2003-05-28 | 广州中医药大学第二临床医学院 | Chinese medicine dialysate for maintenance hemodialysis of chronic renal failure, and preparing method thereof |
| US20080015487A1 (en) * | 2006-02-22 | 2008-01-17 | Henry Ford Health System | System and Method for Delivery of Regional Citrate Anticoagulation to Extracorporeal Blood Circuits |
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| CN113694280A (en) * | 2021-09-02 | 2021-11-26 | 山东威高血液净化制品股份有限公司 | Method for monitoring toxin content distribution in-vitro dialyzer in real time |
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