CN106908410A - Creatinine content on-line monitoring method and system in a kind of hemodialysis blood - Google Patents
Creatinine content on-line monitoring method and system in a kind of hemodialysis blood Download PDFInfo
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- CN106908410A CN106908410A CN201710282681.9A CN201710282681A CN106908410A CN 106908410 A CN106908410 A CN 106908410A CN 201710282681 A CN201710282681 A CN 201710282681A CN 106908410 A CN106908410 A CN 106908410A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 249
- 239000008280 blood Substances 0.000 title claims abstract description 248
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 196
- 238000012544 monitoring process Methods 0.000 title claims abstract description 116
- 229940109239 creatinine Drugs 0.000 title claims abstract description 98
- 238000001631 haemodialysis Methods 0.000 title claims abstract description 78
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 18
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- 239000000523 sample Substances 0.000 claims description 75
- 238000002329 infrared spectrum Methods 0.000 claims description 50
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 9
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000009738 saturating Methods 0.000 claims description 4
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- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
Abstract
The present invention relates to creatinine content on-line monitoring method and system in a kind of hemodialysis blood, blood sample testing model is set up using near infrared spectrometer and the changes of contents that hemodialysis dialyzer imports and exports creatinine in blood is monitored on-line, changes of contents rule according to creatinine in hemodialysis blood is monitored, prevented, avoiding hemodialysis accident from occurring, so as to provide scientific basis for the treatment of uremic patient, the purpose for improving patient's treatment of kidney disease level is reached.
Description
Technical field
It is more particularly to a kind of to use the present invention relates to creatinine content on-line monitoring method and system in a kind of hemodialysis blood
Creatinine content on-line monitoring method and system in the hemodialysis blood of near infrared spectrum detection.
Background technology
At present, blood purification in clinical treatment by widespread need.By taking kidney trouble dialysis treatment as an example, China there are about 200
Ten thousand End-stage Renal Disease Patients, 400,000 are receiving hemodialysis, and every year with the speed increase more than 10%, patient is controlled dialysis
The demand for the treatment of is very big.
Blood dialysis therapy is, using the principle of pellicle, the blood of patient and dialyzate to be introduced inside and outside dialyzer simultaneously
Side, solute gradient, osmotic gradient and the spread by means of film both sides by diffusion, convection current, remove toxin etc., by this
Method removes the excessive moisture and metabolic waste of internal retention, while leaving required material, corrects electrolyte and soda acid is flat
Weighing apparatus is disorderly.
Creatinine (CR) is the product of human muscle's metabolism, mainly by creatine by the irreversible slow shape of non-enzymatic dehydration
Into, then be discharged into blood, with homaluria, it is difficult by food effect, can be by glomerular filtration, seldom can quilt in renal tubule
Absorb again, creatinine includes serum creatinine and UCr, serum creatinine measurement renal function is more meaningful, and it is to comment that serum creatinine concentration is determined
The efficiency index of valency glomerular filtration rate(GFR, can effectively reflect the substantial damage degree of renal function, and clinically detection contributes to
Judge the state of an illness, it is significant.
When carrying out hemodialysis to the exceeded patient of creatinine content in blood, dialyzer need to be used.Dialyzer may go out
Now block or disrepair phenomenon.The reason for dialyzer is blocked mainly has：A, blood are oversize from the pump time in vitro, and this is that dialyzer is blocked
Main cause；B, heparin consumption are not enough, patient dialyse first heparin injection rate it is particularly significant, usually 0.2~0.5mg/
Kg, if test tube of hepari is insufficient first, adds heparin amount big also without positive effect again in dialysis；C, dialysis person itself because disease,
In ephrosis latter stage at end, blood viscosity increases.
Dialyzer be blocked after should change in time, otherwise extracorporal circulatory system stop, arterial blood line, vein bloody path also can therewith by
It is stifled, cause dialysis person's blood largely to lose, it is very harmful.And observe general 5~10 minutes of the process that dialyzer is blocked, in order to and
Shi Faxian dialyzer cloggings, it is necessary to monitored on-line to dialysis procedure, search out the Changing Pattern of haemoconcentration.Such as
When dialysis membrane is progressively blocked, the creatinine content in blood can gradually rise, when certain limit is exceeded with normal creatinine content,
Can in time be reminded by warning device, be prevented effectively from the generation of harm.
Furthermore, by monitoring the change of creatinine content in hemodialysis blood on-line, can in time find dialyzer breakage.Such as
When the hollow-fibre membrane of dialyzer occurs damaged, the creatinine content in blood can be reduced substantially, can be found in time by monitoring
Dialyzer is damaged, processes and avoid the generation of accident in time.
Prior art is prevented using electrical conductivity detection, haemoconcentration monitoring etc., but there is also certain shortcoming, is such as taken
The promptness of sample detection is not enough and generation is polluted, the high-precision sensor of concentration monitor needs, sensor probe may occur corruption
The generation of situations such as losing phenomenon and cause measured value inaccurate.
Near-infrared spectrum technique is the new technique for just growing up in recent years, is quickly to scan thing near infrared spectrometer
A kind of Instrumental Analysis means of the matter in the reflection, diffusing reflection or transmitted spectrum of 670~2526nm SPECTRAL REGIONs.Due near infrared light
Spectral analysis technology has that analyze speed is fast, efficiency high, sample are without chemical contamination, without sample pretreatment, online Non-Destructive Testing etc.
Advantage, is widely applied in fields such as food and agricultural products detections at present.But literature search does not find that it is applied to blood
Dialysis on-line monitoring field.
Therefore the advantage of Near Infrared Spectroscopy Detection Technology how is combined, the change of creatinine content in on-line monitoring hemodialysis blood
Change, find hemodialysis when blood in creatinine content Changing Pattern, find hemodialysis when blood in creatinine content change with Heart Rate,
Correlation between blood pressure, dialysate flow, creatinine content is in special circumstances such as the change under blocking or breakage in finding blood
One of rule, the problem as the area research.
The content of the invention
The present invention is to solve the problems, such as prior art, there is provided creatinine content on-line monitoring side in a kind of hemodialysis blood
Method and system, blood sample testing model is set up using near infrared spectrometer and monitor on-line creatinine in hemodialysis blood containing quantitative change
Change, reach the purpose that prevention hemodialysis accident occurs, improves treatment of kidney disease level.
The present invention provides creatinine content on-line monitoring method in a kind of hemodialysis blood, comprises the following steps：
1) the hemodialysis blood sample of different creatinine contents is prepared；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up creatinine content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) importing and exporting blood to hemodialysis dialyzer using on-line monitoring probe carries out near infrared spectra collection, saturating by what is gathered
The near infrared spectrum and step 3 of creatinine content in parser import or export blood) set up blood in creatinine content quantitatively differentiate
Model is compared, and quickly determines the creatinine content in dialyzer import and export blood to be checked.
In addition, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, including：The circulation of blood side,
Dialysis fluid side is circulated and dialyzer 4；The circulation of blood side includes that human body artery blood outlet side 1, blood pump 2, the monitoring of the first blood are visited
First 14, arterial circulation conduit 3, venous blood circulation conduit 6, human vein blood input side 8, the inspection of the first near infrared spectrum
Survey data circuit 16 and near infrared light spectrum monitoring instrument 17；The connection of arterial circulation conduit 3 human body artery blood outlet side 1 and thoroughly
The blood entry port of parser 4；The blood outlet of the connection dialyzer 4 of venous blood circulation conduit 6 and human vein blood input side 8；
First blood monitoring probe 14 is arranged on arterial circulation conduit 3 or venous blood circulation conduit 6；First near infrared spectrum
Detection data circuit 16 connects the first blood monitoring probe 14 and near infrared light spectrum monitoring instrument 17；Dialysis fluid side is circulated to be included, thoroughly
Analysis liquid bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line 13 and dialyzate recycling bin 15；Dialyzate enters
The dialyzate entrance of the mouth connection dialyzate of pipeline 11 bucket 9 and dialyzer 4；Dialyzate outlet line 13 connects the dialysis of dialyzer 4
Liquid is exported and dialyzate recycling bin 15；Dialysis liquid pump 10 is arranged in dialyzate inlet line 11；First blood monitoring probe 14
The near infrared spectrum of creatinine content in the collection import or export blood of dialyzer 4.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：The circulation of blood side also includes that the second blood monitors the near infrared spectrum detection data circuit 19 of probe 18 and second；First blood
Liquid monitoring probe 14 is arranged on arterial circulation conduit 3；Second blood monitoring probe 18 is arranged on venous blood circulation and leads
On pipe 6；Second near infrared spectrum detection data circuit 19 connects the second blood monitoring probe 18 and near infrared light spectrum monitoring instrument 17.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：First blood monitoring probe 14 gathers the near infrared spectrum of creatinine content in the import or export blood of dialyzer 4, through first
Near infrared spectrum detection data circuit 16 enters near infrared light spectrum monitoring instrument 17, with flesh in the hemodialysis blood based near infrared spectrum
Acid anhydride content quantitative differentiates that model is compared and obtains creatinine content and real time record in hemodialysis blood import and export blood.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：Creatinine content quantitatively differentiates that model refers to the hemodialysis for preparing different creatinine contents in hemodialysis blood based near infrared spectrum
Blood sample, spectra collection is carried out using near infrared spectrometer to the blood sample, so as to set up based near infrared spectrum
Creatinine content quantitatively differentiates model in hemodialysis blood.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：Creatinine content on-line monitoring system is provided with bubble capture monitor 7 in hemodialysis blood, is arranged on venous blood circulation conduit
On 6.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：First blood monitoring probe 14 or the second blood monitoring probe 18 include probing shell 21, blood channel 24, near-infrared receiving
Receive room 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at the both sides of probing shell 21,
Middle to run through probing shell 21 by blood channel 24, near-infrared receiving chamber 29 and near infrared emission room 32 pass through near-infrared receiving respectively
Batter 25 connects blood channel 24 near infrared emission hole 30, and near-infrared receiving batter 25 and near infrared emission hole 30 are coaxial；It is near red
Emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber 29 is received in near-infrared
The position in hole 25 is provided with near-infrared receiving closed tube 27；Near-infrared receiving chamber 29 is provided with circuit board 28 and is connected with near-infrared receiving closed tube 27；
Connector 23 is provided with outside probing shell 21, connector 23 connects near-infrared receiving chamber 29, near infrared emission by wire guide 22
Room 32 and outside；Blood channel 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole 30；First blood
Liquid monitoring probe 14 or the second blood monitoring probe 18 also include that two connection probing shells 21 of closure 26 form near red respectively
Outer receiving chamber 29 and near infrared emission room 32；Blood near infrared light monitoring blood channel 24, the spectral signal warp of collection
First blood monitoring probe the 14, second blood monitoring 18 inner leads of probe are drawn by connector 23 from conduit, are passed through respectively
First near infrared spectrum detection data circuit 16, the second near infrared spectrum detection data circuit 19 enter near infrared light spectrum monitoring instrument
17, obtain creatinine content and real time record in hemodialysis blood.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：Closure 26 is threadedly coupled with probing shell 21 by sealing；Connector 23, probing shell 21 and closure 26 be not using
Rust steel matter.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：Blood near infrared light normal transmission blood channel 24.
Further, the present invention also provides creatinine content on-line monitoring system in a kind of hemodialysis blood, can also have following
Feature：Creatinine content on-line monitoring system is provided with heparin pump 20 and is arranged on arterial circulation conduit 3 in hemodialysis blood；Prepare
Parenteral solution through heparin pump 20 inject blood.
Unaccounted technical characteristic and experimental procedure etc. are supporting using being carried out in ripe prior art in the present invention.
The beneficial effect of the invention
1st, by the content of creatinine in on-line real time monitoring blood, can quickly judge whether dialyzer blocks or break
Phenomenon is damaged, so as to process, prevent the generation of malpractice in time；
2nd, the detection time of on-line monitoring is short, and creatinine content data are more in the blood of acquisition, blood when helping to find out hemodialysis
The Changing Pattern of creatinine content in liquid, when helping to search out hemodialysis in blood creatinine content change with Heart Rate, blood pressure, thoroughly
Correlation between analysis blood flow, so that for the treatment of uremic patient provides scientific basis；
3rd, Fast nondestructive evaluation is really realized, compared with other monitoring methods, human error and systematic error are effectively reduced,
Model accuracy rate is high, improves operating efficiency；
4th, it is the prevention of ephrosis, treatment, first aid provide reliable technology and ensure that economy, social effect are huge.
Brief description of the drawings
Fig. 1 is creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the invention.
Fig. 2 is the structural representation of the blood monitoring probe in the present invention.
Reference:
1- human body artery blood outlet sides；2- blood pumps；3- arterial circulation conduits；4- dialyzers；5- hollow-fibre membranes；
6- venous blood circulation conduits；7- bubble capture monitors；8- human vein blood input sides；The clean dialyzate buckets of 9-；10- is saturating
Analysis liquid pump；11- dialyzate inlet lines；12- dialyzer dialysis fluid sides；13- dialyzate outlet lines；The blood of 14- first is monitored
Probe；The used dialyzate recycling bins of 15-；16- the first near infrared spectrum detection data circuits；17- near infrared light spectrum monitoring instruments；
The blood of 18- second monitoring probe；19- the second near infrared spectrum detection data circuits；20- heparin pumps；21- probing shells；22- leads
String holes；23- connectors；24- blood channels；25- near-infrared receiving batters；26- closures；27- near-infrared receiving closed tubes；28- circuits
Plate；29- near-infrared receiving chambers；30- near infrared emissions hole；31- near infrared emission pipes；32- near infrared emissions room；33- quartz glass
Glass.
Specific embodiment
The present invention will be further described with specific embodiment below in conjunction with the accompanying drawings.
Creatinine content on-line monitoring method in a kind of hemodialysis blood, comprises the following steps：
1) the hemodialysis blood sample of different creatinine contents is prepared, sample size meets the requirement for setting up Sample model；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up creatinine content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) importing and exporting blood to hemodialysis dialyzer using on-line monitoring probe carries out near infrared spectra collection, saturating by what is gathered
Parser imports and exports near infrared spectrum and the step 3 of creatinine content in blood) creatinine content quantitatively differentiates model in the blood set up
Compare, quickly determine the creatinine content in dialyzer import and export blood to be checked.
Fig. 1 is creatinine content on-line monitoring system schematic diagram in a kind of hemodialysis blood of the invention.
As shown in figure 1, creatinine content on-line monitoring system in a kind of hemodialysis blood, including：The circulation of blood side, dialysis fluid side
Circulation and dialyzer 4.Dialyzer 4 has hollow-fibre membrane 5 and dialysis fluid side 12.
The circulation of blood side includes：Human body artery blood outlet side 1, blood pump 2, the first blood monitoring probe 14, arterial blood
Circulation conduit 3, the second blood monitoring probe 18, venous blood circulation conduit 6, human vein blood input side 8, the first near-infrared
Spectral detection data circuit 16, the second near infrared spectrum detection data circuit 19 and near infrared light spectrum monitoring instrument 17.
The blood entry port of the connection human body artery blood of arterial circulation conduit 3 outlet side 1 and dialyzer 4.Venous blood
The blood outlet of the connection dialyzer 4 of circulation conduit 6 and human vein blood input side 8.First blood monitoring probe 14 is arranged on
On arterial circulation conduit 3.It is red near that first near infrared spectrum detection data circuit 16 connects the first blood monitoring probe 14
External spectrum monitor 17.Second blood monitoring probe 18 is arranged on venous blood circulation conduit 6.Second near infrared spectrum is detected
Data circuit 19 connects the second blood monitoring probe 18 and near infrared light spectrum monitoring instrument 17.
Dialysis fluid side circulation includes：Dialyzate bucket 9, dialysis liquid pump 10, dialyzate inlet line 11, dialyzate outlet line
13 and dialyzate recycling bin 15.The dialyzate entrance of the connection dialyzate of dialyzate inlet line 11 bucket 9 and dialyzer 4.Dialyzate
The dialyzate outlet of the connection dialyzer 4 of outlet line 13 and dialyzate recycling bin 15.Dialysis liquid pump 10 is arranged on dialyzate import
On pipeline 11.
First blood monitoring probe 14 gathers the near infrared spectrum of creatinine content in the import blood of dialyzer 4, near through first
Infrared spectrum detection data circuit 16 enters near infrared light spectrum monitoring instrument 17, with creatinine in the hemodialysis blood based near infrared spectrum
Content quantitative differentiates that model is compared and obtains creatinine content and real time record in hemodialysis blood inlet blood.Second blood monitoring probe
The near infrared spectrum of creatinine content, enters through the second near infrared spectrum detection data circuit 18 in the 18 collection exit bloods of dialyzer 4
Enter near infrared light spectrum monitoring instrument 17, quantitatively differentiating that model is compared with creatinine content in the hemodialysis blood based near infrared spectrum obtains
Creatinine content and real time record in hemodialysis blood exit blood.
The workflow of creatinine content on-line monitoring system in a kind of hemodialysis blood：The human body artery blood of blood side circulation
The blood of the output of outlet side 1 enters through the blood channel in blood pump 2, the first blood monitoring probe 14, arterial circulation conduit 3
Dialyzer 4, blood carries out solute and exchanges through the hollow-fibre membrane 5 in dialyzer 4 and dialyzate, then through venous blood circulation conduit
6th, in the second blood monitoring probe 18 blood channel, human vein blood input side 8 return to human body.It is dry that dialysis fluid side is circulated
Dialyzate in net dialyzate bucket 9 enters dialyzer dialysis fluid side 12 through dialyse liquid pump 10, dialyzate inlet line 11, and hollow
Blood in tunica fibrosa 5 carries out solute exchange, then enters used dialyzate recycling bin 15 through dialyzate outlet line 13；First
Blood monitoring probe the 14, second blood monitoring probe 18 gathers the near infrared spectrum of the blood that dialyzers 4 are imported and exported, respectively through the
One near infrared spectrum detection data circuit 16, the second near infrared spectrum detection data circuit 19 enter near infrared light spectrum monitoring instrument
17, quantitatively differentiate that model is compared with creatinine content in the hemodialysis blood based near infrared spectrum and obtain hemodialysis dialyzer import and export blood
Creatinine content and real time record in liquid.
Creatinine content quantitatively differentiates that model refers to prepare different creatinine contents in hemodialysis blood based near infrared spectrum
Hemodialysis blood sample, spectra collection is carried out using near infrared spectrometer to the blood sample, so as to set up based near infrared light
Creatinine content quantitatively differentiates model in the hemodialysis blood of spectrum.
Supervised through venous blood circulation conduit 6, the second blood monitoring probe 18, bubble capture from the blood out of dialyzer 4
Survey device 7, human vein blood input side 8 and return to human body.
The blood of the output of human body artery blood outlet side 1 is through blood pump 2, the first blood monitoring probe 14, heparin pump 20, artery
Blood circulation conduit 3 enters dialyzer 4；The parenteral solution of preparation injects blood through heparin pump 20.
Fig. 2 is the structural representation of the blood monitoring probe in the present invention.
As shown in Fig. 2 the first blood monitoring probe 14 and the second blood monitoring probe 18 are logical including probing shell 21, blood
Road 24, near-infrared receiving chamber 29 and near infrared emission room 32；Near-infrared receiving chamber 29 and near infrared emission room 32 are respectively provided at spy
The both sides of casing 21, it is middle that 32 points of probing shell 21, near-infrared receiving chamber 29 and near infrared emission room are run through by blood channel 24
Not Tong Guo near-infrared receiving batter 25 blood channel 24, near-infrared receiving batter 25 and near infrared emission are connected near infrared emission hole 30
Hole 30 is coaxial；Near infrared emission room 32 is provided near infrared emission pipe 31 in the position near infrared emission hole 30；Near-infrared receiving chamber
29 are provided with near-infrared receiving closed tube 27 in the position of near-infrared receiving batter 25；Near-infrared receiving chamber 29 is provided with circuit board 28 and near-infrared
Reception pipe 27 is connected.
It is provided with connector 23 outside probing shell 21, connector 23 connects near-infrared receiving chamber 29, near by wire guide 22
Infrared emission room 32 and outside；Blood channel 24 is provided with the covering near-infrared receiving of quartz glass 33 batter 25 and near infrared emission hole
30；First blood monitoring probe 14 or the second blood monitoring probe 18 also include that two connection probing shells 21 of closure 26 are distinguished
Form near-infrared receiving chamber 29 and near infrared emission room 32.
Blood near infrared light monitoring blood channel 24, the spectral signal of collection through the first blood monitoring probe 14,
Second blood monitoring 18 inner leads of probe are drawn by connector 23 from conduit, detect number through the first near infrared spectrum respectively
Enter near infrared light spectrum monitoring instrument 17 according to circuit 16, the second near infrared spectrum detection data circuit 19, obtain flesh in hemodialysis blood
Acid anhydride content and real time record.
Closure 26 is threadedly coupled with probing shell 21 by sealing.
Connector 23, probing shell 21 and closure 26 use stainless steel.
Blood near infrared light normal transmission blood channel 24.
Unaccounted technical characteristic and experimental procedure etc. are supporting using being carried out in ripe prior art in the present invention.
Although the present invention is disclosed as above with preferred embodiment, they be not for limiting the present invention, it is any to be familiar with
This area technical professional, without departing from the spirit and scope of the invention, change, remodeling, addition or the replacement made,
Still fall within the protection domain of technical solution of the present invention.
Claims (10)
1. creatinine content on-line monitoring method in a kind of hemodialysis blood, it is characterised in that：
The method comprises the following steps：
1) the hemodialysis blood sample of different creatinine contents is prepared；
2) spectra collection is carried out to above-mentioned blood sample using near infrared spectrometer；
3) set up creatinine content in the hemodialysis blood based near infrared spectrum and quantitatively differentiate model；
4) importing and exporting blood to hemodialysis dialyzer using on-line monitoring probe carries out near infrared spectra collection, the dialyzer that will be gathered
Import and export near infrared spectrum and the step 3 of creatinine content in blood) creatinine content quantitatively differentiates that model is carried out in the blood of foundation
Compare, determine the creatinine content in dialyzer import and export blood to be checked.
2. creatinine content on-line monitoring system in a kind of hemodialysis blood, it is characterised in that：Including the circulation of blood side, dialysis fluid side
Circulation and dialyzer (4)；
Described blood side circulation includes, human body artery blood outlet side (1), blood pump (2), the first blood monitoring probe (14),
Arterial circulation conduit (3), venous blood circulation conduit (6), human vein blood input side (8), the first near infrared spectrum
Detection data circuit (16) and near infrared light spectrum monitoring instrument (17)；The arterial circulation conduit (3) connects the human body and moves
The blood entry port of arteries and veins blood outlet side (1) and dialyzer (4)；The venous blood circulation conduit (6) connects the dialyzer (4)
Blood outlet and the human vein blood input side (8)；First blood monitoring probe (14) is arranged on the artery
On blood circulation conduit (3) or the venous blood circulation conduit (6)；The first near infrared spectrum detection data circuit (16)
Connect the monitoring of the first blood probe (14) and the near infrared light spectrum monitoring instrument (17)；
Described dialysis fluid side is circulated to be included, dialyzate bucket (9), dialysis liquid pump (10), dialyzate inlet line (11), dialyzate
Outlet line (13) and dialyzate recycling bin (15)；The dialyzate inlet line (11) connects dialyzate bucket (9) and institute
State the dialyzate entrance of dialyzer (4)；The dialyzate outlet line (13) connect the dialyzer (4) dialyzate outlet and
The dialyzate recycling bin (15)；Dialysis liquid pump (10) is arranged on the dialyzate inlet line (11)；
The near infrared light of creatinine content in described the first blood monitoring probe (14) collection dialyzer (4) import or export blood
Spectrum.
3. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：Described blood
Side circulation also includes that the second blood monitors probe (18) and the second near infrared spectrum detection data circuit (19)；First blood
Liquid monitoring probe (14) is arranged on the arterial circulation conduit (3)；Second blood monitoring probe (18) is arranged on
On the venous blood circulation conduit (6)；The second near infrared spectrum detection data circuit (19) connects second blood
Monitoring probe (18) and the near infrared light spectrum monitoring instrument (17).
4. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
The near infrared light of creatinine content in described the first blood monitoring probe (14) collection dialyzer (4) import or export blood
Spectrum, enters the near infrared light spectrum monitoring instrument (17), with based near through the first near infrared spectrum detection data circuit (16)
Creatinine content quantitatively differentiates that model comparison obtains hemodialysis blood and imports and exports creatinine content in blood in the hemodialysis blood of infrared spectrum
And real time record.
5. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Creatinine content quantitatively differentiates that model refers to prepare different creatinine contents in the described hemodialysis blood based near infrared spectrum
Hemodialysis blood sample, spectra collection is carried out to the blood sample using near infrared spectrometer, so as to set up based on near-infrared
Creatinine content quantitatively differentiates model in the hemodialysis blood of spectrum.
6. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Creatinine content on-line monitoring system is provided with bubble capture monitor (7) and is arranged on venous blood and follows in described hemodialysis blood
On ring conduit (6).
7. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Described the first blood monitoring probe (14) and/or the second blood monitoring probe (18) include probing shell (21), blood
Passage (24), near-infrared receiving chamber (29) and near infrared emission room (32)；Described near-infrared receiving chamber (29) and near-infrared are sent out
Penetrate room (32) and be respectively provided at probing shell (21) both sides, centre is by blood channel (24) through probing shell (21), near-infrared receiving
Receive room (29) and blood is connected near infrared emission hole (30) by near-infrared receiving batter (25) respectively near infrared emission room (32)
Passage (24), near-infrared receiving batter (25) and near infrared emission hole (30) are coaxial；Described near infrared emission room (32) is near red
The position of outgoing perforation (30) is provided near infrared emission pipe (31)；Described near-infrared receiving chamber (29) is in near-infrared receiving batter
(25) position is provided with near-infrared receiving closed tube (27)；Described near-infrared receiving chamber (29) is provided with circuit board (28) and near-infrared receiving
Closed tube (27) is connected；
Connector (23) is provided with outside described probing shell (21), the connector (23) connects near red by wire guide (22)
Outer receiving chamber (29), near infrared emission room (32) and outside；It is near that described blood channel (24) is provided with quartz glass (33) covering
Infrared receiver hole (25) and near infrared emission hole (30)；Described the first blood monitoring probe (14) or the second blood monitoring probe
(18) also include that two closures (26) connect probing shell (21), form near-infrared receiving chamber (29) and infrared emission room respectively
(32)；
Near infrared light monitors the blood in blood channel (24), the spectral signal of collection through the first blood monitoring probe (14),
Second blood monitoring probe (18) inner lead is drawn by connector (23) from conduit, is examined through the first near infrared spectrum respectively
Survey data circuit (16), the second near infrared spectrum detection data circuit (19) and enter near infrared light spectrum monitoring instrument (17), obtain blood
Creatinine content and real time record in saturating blood.
8. creatinine content on-line monitoring system in hemodialysis blood according to claim 7, it is characterised in that：
Described closure (26) is threadedly coupled with probing shell (21) by sealing；
Described connector (23), probing shell (21) and closure (26) use stainless steel.
9. creatinine content on-line monitoring system in hemodialysis blood according to claim 7, it is characterised in that：
Blood in described near infrared light normal transmission blood channel (24).
10. creatinine content on-line monitoring system in hemodialysis blood according to claim 2, it is characterised in that：
Creatinine content on-line monitoring system is provided with heparin pump (20) and is arranged on arterial circulation conduit in described hemodialysis blood
(3) on；The parenteral solution of preparation injects blood through heparin pump (20).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710282681.9A CN106908410B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for creatinine content in hemodialysis blood |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710282681.9A CN106908410B (en) | 2017-04-26 | 2017-04-26 | Online monitoring method and system for creatinine content in hemodialysis blood |
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| CN103721306A (en) * | 2012-10-16 | 2014-04-16 | B·布莱恩·阿维图姆股份公司 | Dialysis optimisation method |
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| CN206804517U (en) * | 2017-04-26 | 2017-12-26 | 上海健康医学院 | Creatinine content on-line monitoring system in a kind of hemodialysis blood |
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2017
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| RU2155074C2 (en) * | 1998-08-14 | 2000-08-27 | Главный военный клинический госпиталь им.акад.Н.Н. Бурденко | Method for examining quality of extrarenal blood clearance |
| CN2386827Y (en) * | 1998-09-11 | 2000-07-12 | 彭罗民 | Automatic blood dialyser |
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